NFL Week 16 Odds And Lines Comparisons At US Sportsbooks

Written By Juan Carlos Blanco on December 27, 2020
NFL Week 16 odds lines moneyline total over under

Three teams from the AFC and three teams from the NFC have clinched playoff berths with just two regular season weekends left in the season. Teams already in will be jockeying for position when it comes to seeding, and many other teams will be trying to squeeze into the field. Here is a live look at NFL Week 16 odds for what should be an exciting long holiday weekend.

Week 16 started Friday as the Saints ripped the Vikings, 52-33. A triple-header on Saturday saw the Buccaneers shred the Lions, the 49ers upset the Cardinals, and the Dolphins pull out a miracle win over the Raiders.

Notable Sunday matchups include a Colts versus Steelers showdown, an Eagles versus Cowboys battle in Dallas that will help sort out the lowly NFC East, a Rams versus Seahawks tilt in which Seattle clinches the NFC West crown with a victory, and a Titans versus Packers primetime face-off at Lambeau.

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NFL Week 16 odds

Week 16 lines comparisons from the top US sportsbooks.

Friday, Dec. 25

Minnesota Vikings at New Orleans Saints (-6.5) – 4:30 p.m. ET

The Vikings pushed themselves to the brink of postseason elimination with a second consecutive loss Week 15, as they dropped a 33-27 decision to the Bears. The Saints commemorated the return of Drew Brees in their showdown with the Chiefs, but they, too, came up just short by a 32-29 margin.

The going gets even tougher for the Vikings in this matchup, as the Saints have been elite versus both the run and pass in the second half of the season. Even in Sunday’s loss to the Chiefs, New Orleans held KC to a modest 4.5 yards per play while sacking Patrick Mahomes a season-high four times and limiting him to his second-lowest completion percentage (55.3) of the season. Kirk Cousins has already tied a career high with 13 interceptions and lost five fumbles, foreboding numbers when facing New Orleans’ attacking unit.

The Saints have an easier task in front of them, at least on paper. Minnesota’s defense has never quite found its stride this season. The Vikes’ 252.4 passing yards and 125.6 rushing yards per game allowed represent increases of 25.4 and 13.9 yards, respectively, compared to 2019 numbers. Brees clearly seemed to be working out some rust versus a stingy Chiefs secondary while completing just 15 of 34 passes and operating without Michael Thomas (IR-ankle), but he picked it up as the game went along and could be in much better form in this one.

Oddsmakers are expecting a relatively comfortable New Orleans win here. The Saints are currently listed at .

Saturday, Dec. 26

Tampa Bay Buccaneers (-12) at Detroit Lions – 1 p.m. ET


The Buccaneers continued their march toward the postseason Sunday with a comeback 31-27 win over the Falcons, one that saw Tampa Bay overcome a 17-0 halftime deficit. The Lions continued to fight hard under interim coach Darrell Bevell in a tough matchup against the Titans, but the injury-hampered Matthew Stafford and his teammates came up short by a 46-25 score.

Tom Brady has demonstrated he’s capable of spearheading or taking a back seat in Bruce Arians’ offense if the situation calls for it. This matchup may let him do a bit of both. The Lions are ranked in the bottom 10 in both passing yards (264.1) and rushing yards (137.3) allowed per game. Ronald Jones remains on the COVID-19 reserve list and will not play Saturday, though the Bucs appear to be in more than adequate shape with Leonard Fournette (two TDs Sunday) leading the backfield.

Say this for Bevell – he’ll keep the Lions offense aggressive down to the last play of this season it appears. Matthew Stafford, injured ribs and thumb be damned, was slinging it versus Tennessee and could be right back at it in this contest. After all, the state of Detroit’s defense is such that Bevell knows he needs to try and pile up as many points as possible. The Buccaneers secondary has sprung more than its fair share of leaks and could be subject to some deep shots to Marvin Jones and Quintez Cephus in particular.

The Buccaneers are unsurprisingly favored comfortably and are currently listed at .

San Francisco 49ers at Arizona Cardinals (-6) – 4:30 p.m. ET


The 49ers met up with one of their legendary rivals Sunday in the Cowboys, marking the first time in the series the two squads played with each sporting a losing record. Dallas won a wild game by a 41-33 score. Meanwhile, the Cardinals prevailed over the Eagles in a barn burner of their own, 33-26.

Cold water has been thrown on the prospect of Jimmy Garoppolo (IR-ankle) returning for either of the final two regular-season contests, but George Kittle (IR-foot) will finally be back for the Niners. The rest of the news on the injury front for San Fran isn’t pretty as QB Nick Mullens is out, as is RB Raheem Mostert. CJ Beathard will get the nod at QB for the Niners.

The Cardinals are in exponentially better shape, both on the injury front and record-wise. Sunday’s win pushed their mark to 8-6 and kept Arizona alive for everything from a Wild Card berth to division crown. Arizona will face a San Fran defense that’s a shell personnel-wise of the one they saw in the opener due to multiple season-ending injuries. The numbers still look solid on paper for the Niners, but Kyler Murray is also a more dangerous and consistent quarterback than he was in the first game of his second season.

Oddsmakers are actually envisioning a relatively competitive game. The Cardinals are currently listed as home favorites.

Miami Dolphins (-2) at Las Vegas Raiders – 8:15 p.m. ET


The Dolphins inched ever closer to clinching a playoff berth and knocked their hated rivals, the Patriots, out of postseason contention in the process with a 22-12 win Sunday. The Raiders came ever closer to meeting the same fate as New England when they started the Week 15 slate off with a 30-27 overtime loss to the Chargers.

Miami played without DeVante Parker (hamstring), Jakeem Grant (hamstring), Myles Gaskin (reserve/COVID-19) and Mike Gesicki (shoulder) on Sunday. Even getting half of the missing quartet back would certainly improve their odds against a desperate Raiders team. Gaskin is off the COVID list and is expected to play. Parker and Gesicki are questionable.

Savon Ahmed and Matt Breida did do an exemplary job filling in for Gaskin on Sunday, and Vegas has been a giving run defense to the tune of 125.8 rushing yards per game and 4.99 RB yards per carry allowed. Meanwhile, Tua Tagovailoa is poised to face a banged up Raiders secondary.

For the reeling Raiders, the health of Derek Carr is the most pertinent question at present. The veteran suffered what was termed a significant groin injury against the Chargers but it is likely he will play Saturday night. Marcus Mariota was excellent in his stead against Los Angeles, but there’s something to be said for springing an above-average running quarterback on a defense mid-game.

Josh Jacobs could see an even heftier workload than usual with the extra two days of rest and due to Miami yielding 145.7 rushing yards per game and 5.1 yards per rush on the road.

With Miami traveling cross country on a short week with at least a couple of key absences still likely and Vegas having plenty of urgency, the line currently sits at for Miami.

Sunday, Dec. 27

Cleveland Browns (-6.5) at New York Jets – 1 p.m. ET


The Browns continued to illustrate the drastic difference between this year’s squad and the one they sported in a lost 2019 season under the deposed Freddie Kitchens. Playing on a short week after a heartbreaking loss to the Ravens, Cleveland handled the Giants easily on Sunday night for their 10th win. Then, the Jets notched what would be considered the biggest upset of the season, recording their first win of the campaign on the road against a Rams team boasting the No. 1 defense in the league.

Browns head coach Kevin Stefanski would do well to at least send the Rams a Christmas basket this week for giving him some hard evidence to show his squad about the dangers of underestimating any NFL opponent. Cleveland’s players would have likely been a lot more skeptical had New York not shocked Los Angeles. On the other hand, that could also very well prove to be the peak of the season for Adam Gase’s squad. New York still can’t stop the deep pass in particular, and Baker Mayfield’s recent body of work (71.4 percent completion rate, 8:1 TD:INT over last three games) supports the notion he could capitalize.

New York leveraged mistake-free football on offense and surprisingly disciplined play on defense to notch their upset victory Sunday. Whether they can manage that in back-to-back games is very much up for debate. Sam Darnold has thrown at least one interception or lost a fumble in half of his 10 contests, while the Browns rank in the top half of the league with 20 takeaways (10 INTs, 10 recovered fumbles). Cleveland’s Myles Garrett-led ferocious pass rush could also be a problem – the Browns have collected 36 sacks in 13 games, while the Jets have given up a matching 36 and are ranked 29th in adjusted sack rate surrendered (8.5 percent).

Oddsmakers are giving Gang Green at least a modicum of respect following their first win. Cleveland is “only” listed as road favorites.

Sunday, 12/27 Update: Cleveland has lost its top four receivers in Jarvis Landry, Rashard Higgins, KhaDarel Hodge and Donovan Peoples-Jones due to close contact with a COVID-19-infected individual, knocking the quartet out for this game and leaving Mayfield with journeyman Marvin Hall as his No. 1 wideout against New York. The development naturally resulted in some significant line movement, although Cleveland is by and large still nearly a touchdown favorite.

New York Giants (-10) at Baltimore Ravens – 1 p.m. ET


The Giants were forced to play their second game in three weeks without Daniel Jones (ankle) and paid the price, sporting an unremarkable offense under Colt McCoy in a 20-6 loss to the Browns on Sunday night. The Ravens continued the righting of their ship and stayed in the thick of the AFC playoff picture by handling business versus the lowly Jaguars, 40-14.

The Giants moved up and down the field a few times against Cleveland and McCoy actually generated serviceable numbers, but giving the ball up on downs twice was part of the issue. Jones appears to be a 50/50 proposition for this contest as the week begins. Irrespective of which quarterback is under center, the challenge is a lofty one – Baltimore is allowing the ninth-fewest total yards per game (343.7) and has recorded 20 takeaways (eight INTs, 12 fumble recoveries).

The Ravens may have some issues deploying their run-centric offense with consistent success against the G-Men. New York is yielding the fourth-fewest rushing yards per game (86.1) and fifth-lowest yards per carry (3.9) on the road. Even Nick Chubb rushed for just 3.3 yards per carry Sunday night against the Giants. Naturally, Lamar Jackson is an X-factor, but even he has a daunting task on paper with respect to one of the central tenets of his skill set – New York has given up the fifth-fewest rushing yards (165) to QBs and done so at a minuscule 2.7 yards per attempt.

With Jones’ status very much in question for the time being, the Ravens are currently listed as home favorites.

Sunday, 12/27 Update: Jones is now expected to start for New York, but the G-Men remain sizable underdogs.

Indianapolis Colts (-1) at Pittsburgh Steelers – 1 p.m. ET


The Colts may have had a bit more trouble than anticipated against the undermanned Texans, but Indy managed a 27-20 victory that propelled it into a first-place tie with the Titans in the AFC South. The Steelers dropped a third consecutive game Monday night, falling to the Bengals by a 27-17 score in a game that would have qualified as the biggest upset of the week if not for the Jets’ victory over the Rams a day prior.

Indianapolis’ defense continues to see a downgrade in performance as the season unfolds. Depending to what degree the Steelers can right their offensive ship Monday night, there could be some trouble for the Colts in this road matchup. Indy has given up an average of 28.6 points over its last five contests. Moreover, they’ve allowed 415.7 total yards per contest over the last three, despite the short-handed Texans serving as the opponent for two of those games.

The Colts will face a Steelers defense that could be due for a bit of regression but is still one of the top units in the league. Pittsburgh has lost two near-elite linebackers in Devin Bush and Bud Dupree since Week 6 due to torn ACLs. Moreover, Bush’s fill-in Robert Spillane, who’d been doing an excellent job in his teammate’s stead, is on IR himself until at least Week 17. The scheme and the remaining healthy bodies continue to make the Steelers a very tough out against both the run and pass, however.

In what is one of the most intriguing matchups of the week, the Steelers are currently listed at .

Sunday, 12/27 Update: James Conner returns for Pittsburgh after a one-game absence due to a quadriceps injury, but given the running back’s significantly decreased profile in the offense in recent games, the Steelers’ outlook as narrow underdogs persists.

Cincinnati Bengals at Houston Texans (-7.5) – 1 p.m. ET


The Bengals treated a Monday night contest against the division-rival Steelers as their Super Bowl and emerged with a 27-17 victory that was nearly as shocking as the Jets’ victory over the Rams 24 hours earlier. The Texans will look to bounce back from yet another defeat, as they gave the division-rival Colts plenty of trouble Sunday before falling by a 27-20 score.

Late-season matchups between two non-contending teams with questionable defenses can always be interesting, so even the sputtering Bengals attack could potentially find success here. The Texans continue to field the AFC’s worst run defense (150.5 rushing yards per game allowed), but unfortunately for Cincinnati, it’s ill equipped to capitalize unless Joe Mixon (foot) is back from injured reserve.

However, Zac Taylor’s squad does have the talent at receiver to potentially take advantage of a Houston secondary that’s giving up 268.0 passing yards per game at home, has snagged a league-low three interceptions and has given up the NFL’s fifth-highest completion percentage (69.33).

The Texans could choose to attack through either the ground or air themselves. The Bengals enter Monday night’s game against Pittsburgh ranked in the bottom 10 against the run and pass as well. Deshaun Watson continues to find ways to get it done despite the absence of Will Fuller (suspension), throwing for a combined 614 yards in the two games he’s played thus far without the speedy wideout but with an available Brandin Cooks. David Johnson is also coming off a season-high 11 receptions versus Indianapolis, potentially portending a bigger passing game role over the last two games.

Despite just two wins separating these teams going into Monday night, oddsmakers currently have the Texans as big home favorites.

Atlanta Falcons at Kansas City Chiefs (-11) – 1 p.m. ET


The Falcons further cemented their reputation as the 2020 kings of the second-half collapse Sunday, blowing a 17-0 halftime lead against the Buccaneers in route to a 31-27 loss. The Chiefs got every bit the battle they would have expected from the Saints in the Superdome but prevailed by a 32-29 margin.

The Falcons could well be without Julio Jones (hamstring) yet again for this game, although the perennial Pro Bowler recently took a platelet-rich injection and has stated he has intentions on playing in at least one of Atlanta’s two remaining games. They could certainly use the hand in trying to keep up with a KC squad that’s averaging an NFL-high 427.9 total yards per contest. However, at issue is the fact the Chiefs defense has also been one of the league’s best at limiting receiver production and the Falcons aren’t exactly very well suited to attacking a more vulnerable run defense that’s yielded 137.2 rushing yards per home game.

The Chiefs offense is such that it typically doesn’t have to worry about matchups. Even while going against the Saints’ elite defense Sunday, Kansas City still put up 32 points and compiled 411 total yards.

A Falcons unit that just gave up a season-high 390 yards to Tom Brady on Sunday is therefore about as inviting a target as it gets for Patrick Mahomes and his pass-catching weapons. Then, while Clyde Edwards-Helaire suffered both an ankle sprain and hip strain Week 15, Le’Veon Bell stands at the ready to helm the backfield following a 62-yard, one-touchdown day on the ground versus New Orleans.

Unsurprisingly, a Chiefs team still battling for the No. 1 seed and playing at home in this matchup is currently listed as a home favorite.

Sunday, 12/27 Update: Both Edwards-Helaire and Jones remain out for the Chiefs and Falcons, respectively, while Tyreek Hill sports a questionable designation as of Sunday morning due to a hamstring injury but is expected to play. With Le’Veon Bell a capable fill-in for a what is a pass-heavy offense anyhow, Kansas City remains as strong a favorite across the board.

Chicago Bears (-9.5) at Jacksonville Jaguars – 1 p.m. ET


The Bears moved into the final NFC playoff speed for the time being with a 33-27 win over the Vikings on Sunday, Chicago’s second straight victory. The Jaguars did some maneuvering of their own with their 40-14 loss to the Ravens, only in their case, it was to position themselves for the No. 1 pick in April’s draft, a development partly made possible by Jets’ shocking upset of the Rams later in the day.

Mitchell Trubisky continued a strong stretch of play against Minnesota and now the matchup gets even more favorable for the 2017 third overall pick. The Jaguars just gave up 243 yards and three touchdowns to Lamar Jackson, hardly a prolific passer. Jacksonville yields 271.7 passing yards per game and an NFL-high 8.1 yards per attempt. They’re also vulnerable on the ground, where the Jags have allowed more rushing yards per game (146.5) than all but the Texans and Cowboys. They’ll run into a red-hot David Montgomery, who’s playing the best ball of his young career with averages of 108.5 rushing yards and a jaw-dropping 6.1 yards per carry over the last four games.

Gardner Minshew’s first full game back as the starter was nothing to write home about, with a good chunk of his 226 passing yards coming after the game was out of reach versus the Ravens. Chicago’s defense isn’t quite on Baltimore’s level overall, but the Bears will represent another unpleasant matchup. The Bears can get after the quarterback pretty effectively (33 sacks), while the Jags have given up 37 sacks after allowing Minshew to be brought down five times Week 15.

With the Bears having plenty to play for and the Jaguars perhaps incentivized to an extent to lose out, Chicago is currently listed as a solid road favorite.

Sunday, 12/27 Update: Mike Glennon will start for the Jaguars in place of Gardner Minshew, but naturally, the Jaguars remain clear underdogs.

Denver Broncos at Los Angeles Chargers (-2.5) – 4:05 p.m. ET


The Broncos were no match for the red-hot Bills on Saturday afternoon, dropping a 48-19 decision to Buffalo. The Chargers were able to notch a second straight victory at the expense of the division-rival Raiders, pulling off a 30-27 overtime win Thursday night.

Denver is nowhere near as inept as it may have looked against Buffalo. The Chargers naturally aren’t the Bills, so there should be a more palatable path to offensive success in this spot. Neither team is alive for the postseason, either, so caution could be thrown to the wind by an already aggressive Drew Lock.

However, Los Angeles restricts wideout production with the best of them, tying with the Chiefs for fewest receptions surrendered (149) to the position. The backfield duo of Melvin Gordon and Phillip Lindsay could be in for a much more productive afternoon, however – the Bolts have given up 123.8 rushing yards per game and 4.82 RB yards per carry.

The Chargers arguably have a better all-around matchup against a Denver defense that’s down multiple secondary members and is also now yielding the fifth-most rushing yards per game (134.6). Justin Herbert’s top two wideouts, Keenan Allen and Mike Williams, will have had extra time to rest up for this contest after having played through hamstring and back issues, respectively, in Week 15. The two notably combined for a 14-166-2 line in a wild Week 8 one-point loss against what was a healthier Denver secondary.

Oddsmakers are expecting another hotly contested game despite the lack of postseason motivation on either side. The host Chargers are currently listed at .

Sunday, 12/27 Update: Allen is a game-time decision for Los Angeles due to the hamstring injury and is reportedly trending toward sitting out, but as of early Sunday morning, the Chargers remain narrow favorites. Meanwhile, Lindsay has been placed on injured reserve by the Broncos.

Carolina Panthers (-1) at Washington Football Team – 4:05 p.m. ET


The Panthers put together a strong all-around defensive effort versus the Packers on Saturday night, but it wasn’t enough to prevent a 24-16 road loss. Meanwhile, Washington saw its four-game winning streak snapped against the Seahawks with Dwayne Haskins and not Alex Smith (calf) under center, but the Football Team still sits atop the NFC East by a game.

Carolina will be facing its former coach in Ron Rivera for the first time, and they could be walking into a proverbial hornet’s nest. Despite the narrow 20-15 loss to Seattle on Sunday, Washington continues to arguably sport a playoff-caliber defense that’s still allowing the fourth-fewest total yards (312.6) per game. Washington has also proven to have an especially opportunistic secondary (13 INTs), making the task a challenging one for the Panthers’ Teddy Bridgewater. Naturally, a return to action by Christian McCaffrey (thigh) would benefit the entire offense, although it’s worth noting Rivera’s squad is also yielding a modest 112.4 rushing yards per game and 4.08 RB yards per carry.

Smith may have a solid chance of jumping back into action this week and Rivera has already confirmed he’ll be the starter once he’s healthy. Haskins continued to display some of the same troubling turnover tendencies against the Seahawks that have plagued him thus far in his young career. There is a silver lining in that the Panthers have only managed five interceptions all season. Then, even if Antonio Gibson (toe) remains out for this game, Washington could find success on the ground against a defense that gave up 145 yards and a touchdown to Aaron Jones on Saturday and allows 4.8 yards per carry to RBs.

Oddsmakers have pegged this game as one of the week’s closest. The line currently sits at for the hosts.

Sunday, 12/27 Update: McCaffrey is expected to remain out of action Sunday,  while Terry McLaurin is doubtful for Washington because of an ankle injury. However, Antonio Gibson is expected to return from a two-game absence and fill his usual role. Even without McLaurin, who’s clearly head and shoulders above any other wideout on the team, Washington remains a narrow favorite.

Philadelphia Eagles (-3) at Dallas Cowboys – 4:25 p.m. ET


The Eagles almost made it 2-for-2 with Jalen Hurts at the helm in Week 15, falling just short against the Cardinals by a 33-26 score. The Cowboys were involved in a high-scoring affair of their own and came out ahead, besting the 49ers by a 41-33 score and positioning themselves for this key contest in the process.

The Eagles will now unleash Hurts on a vulnerable Cowboys defense that’s ranked in the bottom half of the league in rushing yards surrendered to QBs (280) and that’s given up more passing yards at home (232.7 per game) than on the road (210.9). However, Philadelphia’s true key to success in this contest could well be Miles Sanders. The Cowboys defense has been trampled on the ground most of the season, yielding an NFL-high 161.8 rushing yards per game, including 181.7 in the last three.

The Cowboys will look to exploit a questionable Philly front seven as well. Ezekiel Elliott was a surprise late inactive due to a calf injury Sunday and Tony Pollard took advantage to the tune of 132 total yards (69 rushing, 63 receiving) and a pair of rushing scores. Pollard showed more explosiveness than Elliott has in weeks and could well draw the start again here versus an Eagles defense that surrenders 125.6 rushing yards per game.

The ‘Boys could stay in contention for the division crown here with a win, but for the moment, they’re currently listed at .

Sunday, 12/27 Update: DeSean Jackson (ankle) has been activated from injured reserve and should therefore suit up for the Eagles, while Elliott is expected to return from his one-game absence for the Cowboys. Nevertheless, the projected advantage for Philly has only grown throughout the week as bettors go in on the Eagles.

Los Angeles Rams at Seattle Seahawks (-1.5) – 4:25 p.m. ET


The Rams are undoubtedly grateful for the absence of fans this season after helping facilitate the Jets’ first win of the season Sunday, and on Los Angeles’ home field no less. Meanwhile, the Seahawks had a successful cross-country trip to the nation’s capital, emerging with a 20-15 win over Washington to make this Week 16 battle a potential division-clinching game.

Focus or motivation won’t be an issue for the Rams in this divisional battle, due to both their Week 15 outcome and the importance of this game to their postseason chances. Jared Goff notably had no trouble with Seattle’s pass defense in Los Angeles’ Week 10 win, throwing for 302 yards on 8.2 yards per attempt without an interception. The Seahawks secondary is playing much better of late, however, with their improvement coinciding with Jamal Adams finally getting back to health. The matchup on the ground will be much less appealing. Seattle allows the third-fewest rushing yards per game (94.6) and yields just 3.9 RB yards per rush.

The Seahawks only mustered 16 points versus Los Angeles in that aforementioned first meeting, with Russell Wilson throwing two interceptions. Despite Sam Darnold surprisingly finding success at times against Los Angeles on Sunday, the Rams secondary remains elite and is the primary reason for the team giving up the fewest passing yards per game (192.0) by far. L.A. was especially impressive against D.K. Metcalf in a Week 10 game where they held the second-year star to a season-low two receptions and 28 yards.

In what should be one of the most competitive games of the week, the host Seahawks are currently listed at .

Sunday, 12/27 Update: Cam Akers will be out for Los Angeles, a significant development on the field given how well the rookie had played in the lead-back role of late. However, the line has remained steady despite the news, with no real appreciable move toward Seattle evident as of early Sunday morning.

Tennessee Titans at Green Bay Packers – 8:20 p.m. ET


The Titans got some fight from the short-handed Lions in Week 15 but ultimately pulled away by a 46-25 score. The Packers also had to scrap for their win but hung on against the Panthers on Saturday night, 24-16, to clinch the NFC North.

Tennessee remains in a battle with the Colts for the AFC South crown, as both teams will enter Week 15 tied atop the division standings. The Titans will have a tough task trying to further cement their position against a Packers team that has been particularly good against the pass and is still gunning for the conference’s No. 1 seed. However, Green Bay’s deficiencies against the run could prove particularly problematic against Derrick Henry, who’s now put up between 133 and 215 rushing yards in four of the last five games. Meanwhile, the Pack is surrendering 4.52 yards per carry to RBs.

Green Bay should have plenty of chances to attack downfield against a Titans secondary that’s constantly given up big plays on the back end. Tennessee is allowing 276.0 passing yards per game, although a lot of their troubles have actually come at home. Nevertheless, the Pack leads the NFL with 34 pass plays of greater than 25 yards and has a fully healthy receiving corps. Then, Aaron Jones could have a solid chance of putting together a strong encore performance after racking up 145 yards versus Carolina. The Titans have given up 121.2 rushing yards per game and 4.5 yards per carry on the road.

This marquee interconference matchup should draw plenty of betting interest. Currently, the Packers are listed as home favorites.

Monday, Dec. 28

Buffalo Bills at New England Patriots – 8:15 p.m. ET


The Bills continued their fine season with a remarkable division-clinching 48-19 victory against the Broncos on Saturday afternoon. Meanwhile, the Patriots, who have long dominated the AFC East, fell out of playoff contention 24 hours later against another upstart division rival – the Dolphins.

Buffalo has a complete offense that has the capability of transcending any matchup at this stage of the season. Josh Allen has an 8:1 TD:INT over his last three games, with 375- and 359-yard tallies in two of those contests. The Patriots lost Stephon Gilmore for the rest of the season in Sunday’s game, weakening what has been an impressive pass defense. However, the path to success against New England still tilts much heavier toward the ground, where they’ve allowed 133.0 rushing yards per game and just yielded 250 to Miami.

The Patriots passing game has often been missing in action under Cam Newton, and the Bills opportunistic secondary has now yielded just 202.7 passing yards per game over the last three contests. Buffalo now has 12 interceptions, while Newton has thrown 10 picks in 13 games. There’s a chance Bill Belichick gives Jarrett Stidham the reins of the offense over the last two games, but the best statistical matchup could be against a Bills defense giving up 121.4 rushing yards per contest.

Despite the Patriots’ status as hosts, New England is listed as a home underdog.

Sunday, 12/27 Update: Even with the Bills already having clinched the division, they’ve become only bigger favorites as the week has gone on, with this line having some of the more notable movement of the week (outside of the Browns’ COVID-inspired change).

Week 16 lookahead lines vs. current spread

Here is a comparison of NFL Week 16 odds with the lookahead line and the current spread.

GameLookahead lineCurrent spreadMoneyline
Minnesota at New OrleansSaints -6.5Saints -6.5Saints -306, Vikings +262
Tampa Bay at DetroitBuccaneers -9.5Buccaneers -12Buccaneers -586, Lions +452
San Francisco at ArizonaCardinals -2.5Cardinals -6Cardinals -260, 49ers +215
Miami at Las VegasRaiders -1.5Dolphins -2Dolphins -123, Raiders +111
Atlanta at Kansas CityChiefs -10.5Chiefs -10.5Chiefs -550, Falcons +410
Chicago at JacksonvilleBears -5Bears -7.5Bears -430, Jaguars +340
Cincinnati at HoustonTexans -8.5Texans -7.5Texans -360, Bengals +290
Cleveland at New York JetsBrowns -11Browns -6.5Browns -300, Jets +245
Indianapolis at PittsburghSteelers -2Steelers -1.5Steelers -120, Colts +102
New York Giants at BaltimoreRavens -9.5Ravens -9.5Ravens -460, Giants +360
Carolina at WashingtonWashington -2Washington -1Washington -110, Panthers -106
Denver at LA ChargersChargers -2.5Chargers -3Chargers -154, Broncos +130
LA Rams at SeattleSeahawks -1Seahawks -1Seahawks -122, Rams +104
Philadelphia at DallasEagles -1Eagles -3Eagles -164, Cowboys +138
Tennessee at Green BayPackers -4Packers -3Packers -164, Titans +138
Buffalo at New EnglandBills -4.5Bills -7Bills -320, Patriots +260
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Juan Carlos Blanco

Juan Carlos Blanco has served as a freelance writer for a wide variety of online publications and websites, with an intensive focus on fantasy sports. Juan has provided analysis and comprehensive coverage of the MLB, NBA, NFL, CFL, AAF and AFL while also reporting on news and developments in the daily fantasy sports and online gaming industries.

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