NFL Week 15 Rundown: Lines, Spreads, Over/Unders, Injury News

Written By Brett Gibbons on December 19, 2021 - Last Updated on December 20, 2021
NFL Week 15

Week 15 was the week that COVID hijacked. A flush of COVID-positive tests with the Browns, Rams, and Washington forced multiple reschedules and– when it was all said and done– 125+ players were placed on the COVID/reserve list in just three days. Regardless, there’s football to be played and just four more weeks of regular season NFL football remain.

Here at TheLines, we’ll keep you up-to-date with all the player movement, game postponements, injury news, and everything you need to know for NFL Week 15.

Celebrate– bye weeks are a thing of the past!

New England Patriots (9-4) at Indianapolis Colts (7-6)

Kickoff: Saturday, December 18, 8:20 p.m. ET
TV Channel: NFL Network
Look-ahead line: NE -1
Current Line: IND (), O/U ()

New England vs. Indianapolis key injuries

  • Colts vs Patriots Week 15 Injury Report

Colts vs. Patriots: Week 15 NFL Betting Preview

New England vs. Indianapolis betting news & angles

Carolina Panthers (5-8) at Buffalo Bills (7-6)

Time of game: 1:00 p.m. ET
TV Channel: FOX
Look-ahead line: BUF -9.5
Current Line: BUF (), O/U ()

Carolina vs. Buffalo key injuries

  • Bills vs Panthers Week 15 Injury Report

Bills vs. Panthers: Week 15 NFL Betting Preview

Carolina vs. Buffalo betting news & angles

Arizona Cardinals (10-3) at Detroit Lions (1-11-1)

Time of game: 1:00 p.m. ET
TV Channel: FOX
Look-ahead line: ARI -12.5
Current Line: ARI (), O/U ()

Arizona vs. Detroit key injuries

  • Cardinals vs Lions Week 15 Injury Report

Cardinals vs. Lions: Week 15 NFL Betting Preview

Arizona vs. Detroit betting news & angles

Houston Texans (2-11) at Jacksonville Jaguars (2-11)

Time of game: 1:00 p.m. ET
TV Channel: CBS
Look-ahead line: JAX -3.5
Current Line: JAX (), O/U ()

Houston vs. Jacksonville key injuries

  • Jaguars vs Texans Week 15 Injury Report

Jaguars vs. Texans: Week 15 NFL Betting Preview

Houston vs. Jacksonville betting news & angles

New York Jets (3-10) at Miami Dolphins (6-7)

Time of game: 1:00 p.m. ET
TV Channel: CBS
Look-ahead line: MIA -7
Current Line: MIA (), O/U ()

N.Y. Jets vs. Miami key injuries

  • Dolphins vs Jets Week 15 Injury Report

Dolphins vs. Jets: Week 15 NFL Betting Preview

N.Y. Jets vs. Miami betting news & angles

Dallas Cowboys (9-4) at New York Giants (4-9)

Time of game: 1:00 p.m. ET
TV Channel: FOX
Look-ahead line: DAL -10 (+100)
Current Line: DAL (), O/U ()

Dallas vs. N.Y. Giants key injuries

  • Cowboys vs Giants Week 15 Injury Report

Cowboys vs. Giants: Week 15 NFL Betting Preview

Dallas vs. N.Y. Giants betting news & angles

Tennessee Titans (9-4) at Pittsburgh Steelers (6-6-1)

Time of game: 1:00 p.m. ET
TV Channel: CBS
Look-ahead line: TEN -2.5
Current Line: PIT (), O/U ()

Tennessee vs. Pittsburgh key injuries:

  • Titans vs Steelers Week 15 Injury Report

Steelers vs. Titans: Week 15 NFL Betting Preview

Tennessee vs. Pittsburgh betting news & angles

Cincinnati Bengals (7-6) at Denver Broncos (7-6)

Time of game: 4:05 p.m. ET
TV Channel: CBS
Look-ahead line: CIN -3
Current Line: DEN (), O/U ()

Cincinnati vs. Denver key injuries

  • Broncos vs Bengals Week 15 Injury Report

Broncos vs. Bengals: Week 15 NFL Betting Preview

Cincinnati vs. Denver betting news & angles

Atlanta Falcons (6-7) at San Francisco 49ers (7-6)

Time of game: 4:05 p.m. ET
TV Channel: CBS
Look-ahead line: SF -7.5
Current Line: SF (), O/U ()

Atlanta vs. San Francisco key injuries

  • 49ers vs Falcons Week 15 Injury Report

49ers vs. Falcons: Week 15 NFL Betting Preview

Atlanta vs. San Francisco betting news & angles

Green Bay Packers (10-3) at Baltimore Ravens (8-5)

Time of game: 4:25 p.m. ET
TV Channel: FOX
Look-ahead line: GB -2
Current Line: GB (), O/U ()

Green Bay vs. Baltimore key injuries

  • Packers vs Ravens Week 15 Injury Report

Packers vs. Ravens: Week 15 NFL Betting Preview

Green Bay vs. Baltimore betting news & angles

New Orleans Saints (6-7) at Tampa Bay Buccaneers (10-3)

Time of game: 8:20 p.m. ET
TV Channel: NBC
Look-ahead line: TB -11.5
Current Line: TB (), O/U ()

New Orleans vs. Tampa Bay key injuries

  • Buccaneers vs Saints Week 15 Injury Report

Buccaneers vs. Saints: Week 15 NFL Betting Preview

New Orleans vs. Tampa Bay betting news & angles

Las Vegas Raiders (6-7) at Cleveland Browns (7-6)

Time of game: 5:00 p.m. ET
TV Channel: NFL Network
Look-ahead line: CLE -5.5
Current Line: LVR (), O/U ()

Las Vegas vs. Cleveland key injuries

  • Raiders vs Browns Week 15 Injury Report

Raiders vs. Browns: Week 15 NFL Betting Preview

Las Vegas vs. Cleveland betting news & angles

Minnesota Vikings (6-7) at Chicago Bears (4-9)

Time of game: 8:15 p.m. ET
TV Channel: ESPN
Look-ahead line: MIN -4
Current NFL Week 15 Odds: MIN (), O/U ()

Minnesota vs. Chicago injuries

  • Vikings vs Bears Week 15 Injury Report

Vikings vs. Bears: Week 15 NFL Betting Preview

Minnesota vs. Chicago betting news & angles

Seattle Seahawks (5-8) at Los Angeles Rams (9-4)

Time of game: Tuesday, December 21, 7:00 p.m. ET
TV Channel: FOX
Look-ahead line: LAR -7
Current Line: LAR (), O/U ()

Seattle vs. L.A. key injuries

  • Rams vs Seahawks Week 15 Injury Report

Rams vs. Seahawks: Week 15 NFL Betting Preview

Seattle vs. L.A. Rams betting news & angles

Washington Football Team (6-7) at Philadelphia Eagles (6-7)

Time of game: Tuesday, December 21, 7:00 p.m. ET
TV Channel: FOX
Look-ahead line: PHI -2.5
Current Line: PHI (), O/U ()

Washington vs. Philadelphia key injuries

  • Eagles vs Washington Week 15 Injury Report

Eagles vs. Washington: Week 15 NFL Betting Preview

Washington vs. Philadelphia betting news & angles

Keep up-to-date with theLines for NFL Week 15 odds and NFL previews all season long.

Brett Gibbons Avatar
Written by
Brett Gibbons

Brett is an avid sports traveler and former Division-I football recruiter for Bowling Green and Texas State. He’s a graduate of BGSU and works as an auditor for Google content curation products. He’s also contributed to Sports Illustrated and Fansided during his young writing career.

View all posts by Brett Gibbons