NFL Week 12 Odds: Point Spreads, Moneylines And Totals For Every Game

Written By Juan Carlos Blanco on November 26, 2022
NFL Week 12 odds

Thanksgiving weekend signals the early stages of crunch time in each pro football season. NFL Week 12 odds have been posted by sportsbooks and there are some intriguing lines for this holiday football feast. Key Sunday games include the Bengals -2.5 at the Titans +2.5 and the Packers +6.5 at the Eagles -6.5. 

Below are live spreads as well as betting information on every game.

NFL Week 12 odds

View all of the NFL Week 12 odds below and click on the price you like to bet now. Pro football spreads, moneylines and totals from the best sportsbooks in the country are available to wager on here.

NFL Week 12 betting lines

Betting early on NFL Week 12 odds can have its advantages. Here are some spreads from Friday morning that jump out at first glance.

  • Bengals -2.5 at Titans +2.5
  • Falcons +4 at Commanders -4
  • Broncos -1 at Panthers +1
  • Rams +15.5 at Chiefs -15.5
  • Packers +6.5 at Eagles -6.5

These early lines give bettors an opportunity to contemplate spreads that may prove to be somewhat inefficient.

Tampa Bay Buccaneers at Cleveland Browns

The Buccaneers were off in Week 11 after notching a close win over the Seahawks in Germany in Week 10. The Browns fought hard as usual, but they still lost to the Bills by a 31-23 score on the neutral site of Ford Field. 

The Bucs showed some signs of climbing out of their offensive doldrums in the last two games before the bye, but certainly not enough to convince anyone they’re full speed ahead. Tampa Bay will have the rest advantage in this matchup and will have had further opportunity to work out the kinks, yet they’ll face a quality Browns secondary that’s only picked off three passes but surrendered just 214.8 passing yards per game. 

The Browns saw Nick Chubb shut down on the ground for the first time all season by Buffalo, but fortunately for the star running back, the Buccaneers’ defense hasn’t been anywhere as proficient against the run thus far as in recent seasons. Tampa Bay is allowing 116.6 rushing yards per game – up from 91.6 per contest a year ago – and head coach Kevin Stefanski will naturally lean on the run whenever game script allows. That said, the Jacoby Brissett-Amari Cooper has proven very proficient, but they’ll be challenged by a Bucs secondary giving up just 193.4 passing yards per contest. 

With the Browns playing competitively most weeks and the Bucs’ inconsistencies this season, Tampa Bay is just a field-goal favorite as the week begins. 

Cincinnati Bengals at Tennessee Titans

The Bengals got a bit of atonement against the Steelers in their Week 11 clash in Pittsburgh, avenging a Week 1 loss with a 37-23 victory. The Titans continued their quiet climb up the standings with a 27-17 road win over the Packers on Thursday night.  

Joe Burrow threw a career-high four touchdown passes versus Pittsburgh despite playing without Ja’Marr Chase (hip) yet again. The star wideout is slated to resume practicing this week and reportedly has a chance to return for this matchup, which would be a big help versus a secondary that’s been a lot stingier at home (232.8 PYPG) than on the road (289.5 PYPG). Joe Mixon’s availability will also be a big thing to monitor this week, as he exited Sunday’s contest with a concussion. 

The Titans have their passing game humming again with Ryan Tannehill under center, with the veteran QB throwing for 588 yards and a 4:1 TD:INT in his first two games back from an ankle injury. Derrick Henry is also putting forth his usual elite level of performance, already crossing the 1,000-yard mark on the ground and showing more as a receiver than in most seasons. The Bengals have been a much more vulnerable run defense on the road, where they’re surrendering 140 rushing yards per away contest.

In what could be one of the best games of the week, the Bengals opened the week as slim 1-to-1.5-point road favorites when looking at NFL Week 12 odds. That number could naturally shift one way or the other depending on Chase/Mixon news.

Houston Texans at Miami Dolphins

The Texans continued to spiral Sunday, dropping their fifth straight game and eight of the season with a 23-10 defeat at the hands of the Commanders. The Dolphins were off in Week 11 after heading into the bye with an impressive 39-17 home victory over the Browns. 

It’s fair to wonder if Davis Mills will be under center for Houston in this matchup, as Kyle Allen has starting experience and arguably couldn’t do much worse. Mills has thrown for under 200 yards in three of the past four games and has a 6:7 TD:INT over his last five contests overall. The Dolphins secondary hasn’t been very consistent overall, but it’s tightened up recently by yielding only 204 passing yards per road contest. The outlook might better for the linchpin of Houston’s offense, Dameon Pierce, as Miami is giving up 148.7 rushing yards per game in the last three contests. 

Miami’s passing attack can look close to unstoppable at times, with the Tua-Tyreek-Waddle trio hitting on all cylinders in several games already. Houston’s biggest Achilles heel has been stopping the run, however, and with Jeff Wilson and Raheem Mostert already looking like an even better 1-2 punch than they formed on occasion in San Francisco, they could get a healthy dose of work Sunday. The Texans are still giving up an NFL-high amount of rushing yards (178.9 per game) and have been adequate preventing big plays through the air, so Miami could surprise a bit by turning to the ground attack often. 

Given the state of both teams, the Dolphins were unsurprisingly the slate’s second-biggest NFL Week 12 odds favorite with as much as a 12.5-point projected advantage to open the week. 

Chicago Bears at New York Jets

The Bears fell short in a wire-to-wire battle against the Falcons on Sunday and saw Justin Fields sustain a shoulder injury that has him listed day-to-day as the week starts. The Jets suffered yet another frustrating loss at the hands of the Patriots, losing 10-3 on a punt return touchdown with five seconds left.  

If Fields is unavailable for this matchup, it will naturally be a monumental loss for a Chicago offense that’s thrived on his elite rushing ability the threat it presents to defenses. Fields’ backup is Trevor Siemian, who’s been serviceable in past starting opportunities, but the Bears would have to shift to more of a passing-based attack with him under center. Despite plenty of speed at receiver, the shift in philosophy would be especially hard to pull off against a typically elite Jets pass defense.

New York has not shortage of offensive questions of its own, as Zach Wilson threw for only 77 yards. Head coach Robert Saleh was noncommittal about his starter for this matchup when asked Monday, and with both Joe Flacco and Mike White to turn to as options, there could certainly be at least a one-week change afoot. The matchup against the Bears should allow whoever is under center to enjoy some balance, however, as Chicago is allowing an NFC-high 166.8 rushing yards per road contest.

With Fields’ status up in the air and New York’s elite defense, the Jets are 5.5-point home favorites to start the week.

Atlanta Falcons at Washington Commanders

The Falcons remained in contention in an uncertain NFC South on Sunday with a 27-24 home victory. The Commanders continued to thrive under Taylor Heinicke, knocking off the Texans by a 23-10 score in a win that earned Heinicke the starting job moving forward.

The Falcons are now 5-6 following Sunday’s victory and half-game behind the Bucs for the NFC South lead. However, this matchup shapes up as somewhat incompatible for Atlanta’s strength, as Washington has been very good at slowing down the ground game head coach Arthur Smith clearly favors. The Commanders are surrendering only 78.8 rushing yards per home game, and what’s more, Washington has conceded an NFC-low 57 rushing yards per contest over the last three and could have Chase Young (knee) available to make his season debut. 

Heinicke certainly hasn’t put up any spectacular numbers during his time in the starting job, but Washington is now 4-1 with him at the helm. Heinicke has the benefit of what seems to be an improving running game helmed by Brian Robinson and Antonio Gibson at his disposal as well, and the Falcons may be ripe for a heavy dose of the impressive duo considering they’ve given up a whopping 161 rushing yards per contest in the last three.

Washington is a 3.5-to-4-point home favorite as the week starts, although given the proximity in talent level between the two teams, this line could be ripe for some narrowing.

Denver Broncos at Carolina Panthers

The Broncos suffered another frustrating loss in Week 11, dropping a 22-16 decision in overtime to the Raiders. The Panthers couldn’t get any offense from Baker Mayfield’s spot start, as they mustered all of three points in a road loss to the Ravens. 

Russell Wilson posted his highest completion rate of the season (77.4%) in Sunday’s loss, with the fact he was facing one of the weakest pressure defenses in the NFL undoubtedly playing a big part. The matchup against the Panthers isn’t that much more daunting, considering they have only 22 sacks in 11 games. Wilson could also potentially get Jerry Jeudy (ankle) back for this game, which would naturally be a boon for his prospects.

On the Panthers’ side, the quarterback situation will be one to monitor during the week, as PJ Walker could potentially return from his ankle injury, or Sam Darnold could be at least given an opportunity to split some time with either Walker or Mayfield according to latest comments from interim coach Steve Wilks. The matchup doesn’t shape up as appealing in that regard for any of the trio, as the Broncos are only allowing 186.4 passing yards per away contest. It’s a bit more palatable for D’Onta Foreman, with Denver conceding 123 rushing yards per road game.

With both teams’ offenses floundering and uncertainty surrounding Carolina’s quarterback situation, Denver is just around a 2.5-point road favorite when looking at NFL Week 12 odds.

Baltimore Ravens at Jacksonville Jaguars

The Ravens struggled badly on offense most of the day, but they managed to tough out a 13-3 win against the Panthers on Sunday. The Jaguars were off in Week 11 after falling to the Chiefs, 27-17, in a road showdown in Week 10.   

Lamar Jackson battled a late-week illness that may have affected his play Sunday, but Baltimore at least got the victory and saw Mark Andrews return from a one-game absence to record six grabs. Demarcus Robinson also thrived as the lead receiver with a nine-catch, 128-yard tally, and the entire air attack could benefit from a Jags defense that’s surrendered some big plays through the air. Gus Edwards (hamstring/knee) may also be available to return, which would naturally round out Baltimore’s attack nicely versus Jacksonville’s inconsistent run D.

The Jags will have had the benefit of extra prep time for this game, and the Trevor Lawrence-Christian Kirk connection was certainly playing well going into the bye. However, the passing attack, which hasn’t been the most consistent part of the Jacksonville’s squad by any stretch, faces a Ravens secondary that’s getting better against the pass as the season unfolds. Baltimore is giving up only 223 passing yards per contest in the last three, a notable improvement over its 249.8 season figure.

Despite the four-win difference between the teams, the Ravens are actually just four-point road favorites when looking at NFL Week 12 odds.

Los Angeles Chargers at Arizona Cardinals

The Chargers suffered another frustrating loss to the Chiefs on Sunday night, taking a 30-27 home loss and once again losing Mike Williams to injury. The Cardinals will take the field Monday night in Mexico City against the 49ers without Kyle Murray (hamstring) sitting for a second straight game.  

Justin Herbert had Keenan Allen and Williams back together on the field for what must have seemed like a fleeting moment Sunday night, and while the latter’s aggravation of his ankle issue is being downplayed by head coach Brandon Staley as the week begins, it remains to seen if he’ll be available for this matchup against a Cardinals secondary that’s been much more generous at home than on the road. 

The Cardinals will have to roll with Colt McCoy again Monday night, and they’ll also be hoping DeAndre Hopkins doesn’t aggravate the hamstring injury that had him sporting a questionable designation going into the contest. One hopeful piece of news for Arizona’s offense is the potential return of Marquise Brown from his foot fracture for this game. Brown was able to practice leading into Monday’s game and could well be active by the time this game rolls around.

Ahead of the Monday night clash and with Murray’s status in the air, the Cards are 3.5-point home underdogs.

Las Vegas Raiders at Seattle Seahawks

The Raiders have beaten the Broncos for two of their three wins this season, with their latest success against their long-time rivals coming in a 22-16 overtime victory. The Seahawks were off in Week 11 after dropping a 21-16 decision to the Buccaneers in Germany.

Las Vegas’ win still leaves Josh McDaniels’ squad at just 3-7 and still sporting an inconsistent passing attack outside of Davante Adams. Derek Carr is still struggling with accuracy in McDaniels’ system, and with Hunter Renfrow and Darren Waller both on IR, there’s also precious little depth behind Adams. The Seahawks secondary also presents a tough matchup, having given up just 181.7 passing yards per contest in the last three.

Geno Smith has played so well, there’s plenty of contract extension talk already in the air for a player that was believed to be relegated to journeyman status for what remained of his career coming into this season. The bye week also gave DK Metcalf some valuable rest after getting banged up in recent weeks, and the matchup against the Raiders defense is attractive all the way around — Las Vegas is allowing the sixth-most total yards per game (370.5). 

The Seahawks are 3.5-point home favorites in NFL Week 12 odds.

Los Angeles Rams at Kansas City Chiefs

The Rams saw Matthew Stafford suffer another head injury in Sunday’s matchup against the Saints, which culminated in yet another loss for the defending champs. The Chiefs got past the Chargers on Sunday night on the road in the textbook trademark fashion – a game-winning TD reception from Travis Kelce in the closing seconds.    

Stafford was still being evaluated for a potential concussion as of Monday afternoon, so his status for this game is firmly in the air to say the least. John Wolford also missed Sunday’s game with a neck injury, and if both he and Stafford were unavailable, L.A. may be forced to turn to Bryce Perkins, who filled in serviceably Sunday after Stafford exited. With Cooper Kupp (ankle) on IR as well, the offense looks nothing like last year’s Super Bowl-winning edition to say the least, likely leaving them ill-equipped to capitalize on a Chiefs defense that can have its share of breakdowns against both the run and pass.

Mahomes managed without JuJu Smith-Schuster (concussion) and Mecole Hardman (IR-abdomen) on Sunday night, turning to Kelce, Justin Watson and Skyy Moore to make up for the lost production. Rookie running back Isiah Pacheco also went off for 107 rushing yards, making the loss of Clyde Edwards-Helaire to a high ankle sprain much more tolerable. The Chiefs appear to have more than enough to take advantage of a Rams defense that seems to be wilting under the weight of its ineffective offense, even giving up three touchdowns to Andy Dalton in Week 11. 

With the Rams in such disarray and the Chiefs likely to get Smith-Schuster back, KC’s status as the biggest NFL Week 12 odds favorite is up to -15.5 in some spots.

New Orleans Saints at San Francisco 49ers

The Saints’ Andy Dalton validated head coach Dennis Allen’s decision to stick with him Sunday, as the veteran threw three touchdowns in a 27-20 win over the Rams. The Niners face the short-handed Cardinals on Monday night in Mexico City.

New Orleans has to be encouraged by Dalton’s showing, which included an impressive connection with veteran Jarvis Landry. Not having Michael Thomas (IR-toe) naturally hurts, but Dalton has learned to navigate the star wideout’s absence by focusing on Chris Olave, Juwan Johnson and perhaps Landry moving forward as well. Alvin Kamara is also on hand in his usual versatile role, although the entire group will be challenged by the 49ers’ elite all-around defense, one that could especially cause plenty of trouble on the pass-rush front against the mostly immobile veteran QB.

The Niners will be looking to further refine their usage of the dynamic backfield combo of Eli Mitchell and Christian McCaffrey in Monday night’s game. While the visitors will have a rest edge in this matchup, San Francisco’s vast array of weapons should allow head coach Kyle Shanahan to keep all his key assets mostly fresh.

Ahead of MNF, the Niners are up to 8.5-point home favorites in Week 12 odds.

Green Bay Packers at Philadelphia Eagles

The Packers opened the Week 11 slate with another tough loss at Lambeau, dropping a 27-17 decision to the Titans. The Eagles had to tough it out, but they got past the Colts on the road, 17-16. 

Aaron Rodgers and Christian Watson continued their impressive chemistry with two more touchdown connections against Tennessee, but there were still nowhere near enough points scored by night’s end. Unfortunately for the struggling Pack, the matchup is about as difficult in Week 12, although Aaron Jones could have a bit more success on the ground versus an Eagles team that continued to display some vulnerability on that front Sunday versus Jonathan Taylor despite the recent additions of Linval Joseph and Ndamukong Suh. 

Philly found the Colts defense a tough puzzle to crack most of the afternoon Sunday, with even the vaunted passing game encountering some rough sledding. Just as is the case for the Packers’ offense, the going may not get much easier for this primetime clash. Green Bay is giving up only 192.5 passing yards per contest and has picked off eight passes. As such, a pivot to more Miles Sanders might be in order – the Pack gives up 135.8 rushing yards per contest overall.

The Eagles are unsurprisingly 6.5-to-7-point home favorites in NFL Week 12 odds.

Pittsburgh Steelers at Indianapolis Colts

The Steelers fought valiantly but fell short to the Bengals in Week 11, dropping a 37-30 decision. The Colts turned in another spirited performance in their second game under Jeff Saturday before falling to the visiting Eagles, 17-16. 

Kenny Pickett continued to show improving rapport with fellow young stars George Pickens and Pat Freiermuth, who he connected with on 12 occasions overall Sunday. Najee Harris also now has 189 combined rushing yards over the last two games, by far his best stretch of the season. He’ll need to likely shoulder a 2021-type workload in this game, as Jaylen Warren suffered a hamstring injury in Sunday’s loss. The matchup against the Colts does lend itself much more to the ground game – Indy is giving up 133 rush yards per home game.

Saturday’s decision to turn back to Matt Ryan has produced pretty solid results so far, and the veteran quarterback and his pass catchers could really find some success in this matchup. Pittsburgh was taken to task by Joe Burrow and Tee Higgins on Sunday, with the Bengals QB throwing a career-high four TDs. The Steelers have now surrendered a co-NFL-high 21 touchdown passes and have only mustered 19 sacks, although they have snagged 12 interceptions. Taylor will naturally still play a big role as well, and Pittsburgh checks in surrendering much more ground production on the road (129.2 RYPG) than at home (77.6 RYPG).

The Colts were standard three-point home favorites in NFL Week 12 odds as of Monday afternoon.  

How the point spreads are changing

Here we take stock of how NFL Week 12 odds are changing. More point spreads will be added to this table in the days leading up to kickoff of each game.

DateNFL Week 12 Odds: November 20NFL Week 12 Odds: November 21NFL Week 12 Odds: November 26
Thursday, November 24Bills -10 at Lions +10Bills -9.5 at Lions +9.5Bills -9.5 at Lions +9.5
Thursday, November 24Giants +8 at Cowboys -8Giants +8.5 at Cowboys -8.5Giants +10 at Cowboys -10
Thursday, November 24Patriots +3 at Vikings -3Patriots +3 at Vikings -3Patriots +2.5 at Vikings -2.5
Sunday, November 27Bengals -1.5 at Titans +1.5 Bengals -1 at Titans +1Bengals -2.5 at Titans +2.5
Sunday, November 27Buccaneers -3 at Browns +3Buccaneers -3.5 at Browns +3.5Buccaneers -3.5 at Browns +3.5
Sunday, November 27Falcons +3 at Commanders -3Falcons +3 at Commanders -3Falcons +3.5 at Commanders -3.5
Sunday, November 27Bears +5.5 at Jets -5.5Bears +5.5 at Jets -5.5Bears +6 at Jets -6
Sunday, November 27Ravens -4.5 at Jaguars +4.5Ravens -4 at Jaguars +4Ravens -3.5 at Jaguars +3.5
Sunday, November 27Texans +12 at Dolphins -12Texans +12 at Dolphins -12Texans +14 at Dolphins -14
Sunday, November 27Broncos -2.5 at Panthers +2.5Broncos -2.5 at Panthers +2.5Broncos -1 at Panthers +1
Sunday, November 27Chargers -3 at Cardinals +3Chargers -3 at Cardinals +3Chargers -2.5 at Cardinals +2.5
Sunday, November 27Raiders +3.5 at Seahawks -3.5Raiders +4 at Seahawks -4Raiders +3.5 at Seahawks -3.5
Sunday, November 27Saints +8.5 at 49ers -8.5Saints +8 at 49ers -8Saints +9.5 at 49ers -9.5
Sunday, November 27Rams +14 at Chiefs -14Rams +14 at Chiefs -14Rams +15.5 at Chiefs -15.5
Sunday, November 27Packers +6.5 at Eagles -6.5Packers +6.5 at Eagles -6.5Packers +6.5 at Eagles -6.5
Monday, November 28Steelers +2.5 at Colts -2.5Steelers +3 at Colts -3Steelers +2.5 at Colts -2.5

Lines shown below are from Wednesday, November 16.

DateNFL Week 12 Odds: SpreadsNFL Week 12 Odds: MoneylinesNFL Week 12 Odds: Totals
Thursday, November 24Bills -10 at Lions +10Bills -460 at Lions +37051.5
Thursday, November 24Giants +7 at Cowboys -7Giants +240 at Cowboys -28543
Thursday, November 24Patriots +3.5 at Vikings -3.5Patriots +155 at Vikings -18043.5
Sunday, November 27Ravens -4 at Jaguars +4Ravens -205 at Jaguars +17546.5
Sunday, November 27Bears +3.5 at Jets -3.5Bears +165 at Jets -19547
Sunday, November 27Falcons +3 at Commanders -3Falcons +150 at Commanders -17542
Sunday, November 27Buccaneers -3 at Browns +3Buccaneers -170 at Browns +14545
Sunday, November 27Broncos -2.5 at Panthers +2.5Broncos -145 at Panthers +12536.5
Sunday, November 27Texans +9.5 at Dolphins -9.5Texans +340 at Dolphins -42545
Sunday, November 27Bengals -2 at Titans +2Bengals -125 at Titans +10543
Sunday, November 27Chargers -2.5 at Cardinals +2.5Chargers -135 at Cardinals +11547.5
Sunday, November 27Raiders +3.5 at Seahawks -3.5Raiders +140 at Seahawks -16547.5
Sunday, November 27Rams +10 at Chiefs -10Rams +360 at Chiefs -45045.5
Sunday, November 27Saints +8.5 at 49ers -8.5Saints +320 at 49ers -39041.5
Sunday, November 27Packers +6.5 at Eagles -6.5Packers +230 at Eagles -27545
Monday, November 28Steelers +3 at Colts -3Steelers +140 at Colts -16539.5
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Written by
Juan Carlos Blanco

Juan Carlos Blanco has served as a freelance writer for a wide variety of online publications and websites, with an intensive focus on fantasy sports. Juan has provided analysis and comprehensive coverage of the MLB, NBA, NFL, CFL, AAF and AFL while also reporting on news and developments in the daily fantasy sports and online gaming industries.

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