NFL Week 11 Betting Preview: San Francisco 49ers Vs. Arizona Cardinals

Written By Mo Nuwwarah on November 21, 2022
49ers Cardinals odds

The San Francisco 49ers face the Arizona Cardinals in Mexico City at 8:15 p.m. ET on Monday, Nov. 21. Primary markets for the game show the 49ers as spread favorites and on the moneyline. 49ers Cardinals odds feature a total set at .

In this article, we break down everything you need to know before placing a bet on the game, including team matchups, key metrics, weather and the best available NFL Week 11 odds. Click on the odds anywhere in this post to bet now.

49ers Vs. Cardinals Odds: Spread, Moneyline, Over/Under

When using the odds table, click the dropdown menu and select the type of bet you wish to make. 

Betting the point spread is when you wager on how many points a team will win or lose by. A plus sign in front of the spread denotes the underdog, and a minus sign denotes the favorite.

In this case, the 49ers would have to win by at least nine points if you bet them to cover the point spread (-8) — an eight-point win would return your money. A spread bet on the Cardinals would win if they win the game or lose by fewer than eight — again, an eight-point loss returns your money. 

Betting the moneyline is simply betting on which particular team will win a game.

The betting total is the number of combined points the two teams will score. Bettors can choose to bet the over or under on how many total points will be scored in the game. 

  • Join our NFL Discord channel to receive an immediate notification when any of our staff members places a bet. Sign up under the #roles server and join our growing community of more than 3,000 sports fans.

49ers Vs. Cardinals Player Props

In the props tool search bar, type in a team or player and hit enter. You’ll see the various proposition bets offered by leading online sportsbooks. 

This is a valuable tool that allows bettors to compare odds and stats when considering a prop bet. Unlike bigger markets like moneylines and spreads that often reach a consensus number, shopping for prop bet lines can often reveal sizable differences in the numbers.

49ers Vs. Cardinals Betting News & Angles

Use this rolling, updating list of news bites about each team to help your handicapping for 49ers – Cardinals odds.

49ers Vs. Cardinals Injury Report

San Francisco Injuries

PlayerPos.InjuryStatusAvg. Snap Count
Danny GrayWRAnkleQuestionable6.6

Arizona Injuries

PlayerPos.InjuryStatusAvg. Snap Count
Kyler MurrayQBHamstringQuestionable72.2
Marquise BrownWRFootQuestionable71.3
Byron MurphyCBBackQuestionable68.2
Colt McCoyQBLegQuestionable66.0
Zach ErtzTELegOut57.8
Matt PraterKHipQuestionable6.0

49ers Offense Vs. Cardinals Defense

49ers OffenseStats (Rank)Cardinals Defense
22 (18)Points/Gm25.8 (30)
0.36 (16)Points/Play0.410 (28)
360 (9)Yards/Gm357.6 (22)
236.3 (10)Pass Yards/Gm247.1 (23)
123.7 (14)Rush Yards/Gm110.5 (9)
5.6 (6)Yards/Play5.7 (21)
7.6 (4)Yards/Pass6.8 (20)
4.4 (20)Yards/Rush4.4 (12)
45.61% (5)3rd Down %43.97% (26)
54.84% (17)Red Zone %67.5% (28)
1.4 (23)Turnovers/Game1.4 (11)
6.06% (12)Sack Rate4.99% (26)

Cardinals Offense Vs. 49ers Defense

Cardinals OffenseStats (Rank)49ers Defense
23 (13)Points/Gm18.1 (4)
0.334 (21)Points/Play0.304 (9)
333.7 (19)Yards/Gm280.6 (1)
220.6 (18)Pass Yards/Gm197.9 (8)
113.1 (19)Rush Yards/Gm82.7 (1)
4.9 (29)Yards/Play4.7 (3)
5.5 (32)Yards/Pass6.1 (8)
4.4 (21)Yards/Rush3.4 (1)
34.78% (27)3rd Down %40.98% (17)
60% (11)Red Zone %61.9% (24)
0.9 (4)Turnovers/Game1.1 (19)
6.31% (16)Sack Rate9.06% (3)

49ers Vs. Cardinals Betting Insights

Why The 49ers Can Cover The Spread

This defense is looking healthy and dominant once again. Since the destruction at the hands of the Chiefs, they’ve shut down the Rams and Chargers, admittedly two low-powered offenses at the moment. But the Cardinals have not exactly looked like the 1999 Rams, so they figure to get the clamps treatment also. Whether a less than 100% Kyler Murray or Colt McCoy, this figures to be another fairly easy assignment for this unit, and if the Cardinals can’t surpass 14 points — a distinct possibility — then the Niners can cover even this large number.

Why The Cardinals Can Cover The Spread

There’s always an uncertainty hanging over any game on foreign soil. How will players handle the travel, and specifically, the altitude at Mexico City? Furthermore, as bad as this Cardinals offense has been, the possibility remains they could break out a bit here. That’s because regardless of the QB, that player might have the best complement of weapons the team has had available all year. RB James Conner looks healthy again, and more importantly, the WR combo of Marquise Brown and Deandre Hopkins has a chance to step on the field together for the first time all year.

Reasons To Bet The Over

The aforementioned WR situation of the Cardinals, for one thing. The coverage of the 49ers has been solid, but that’s certainly where you want to attack them, as solid is a step down from their incredible run defense. If the Cardinals can move the ball through the air because they have three solid WRs — Brown, Hopkins and Rondale Moore — then the 49ers will be forced to get a little more aggressive themselves. They should be able to put up some points against this weak Cardinals D that ranks 21st in DVOA.

Reasons To Bet The Under

Can the Cardinals move the ball? If the 49ers are the only ones scoring, that usually means the game is going under here. This Cardinals offense, while potentially getting healthier, has basically been a disaster all season. If the 49ers go up 17-3 and revert to clock-killing mode on the ground, with a bad — but not turnover-prone — passing offense on the other side, then this game probably won’t even see 35 points scored.

49ers Vs. Cardinals Matchups To Watch For

George Kittle Vs. Cardinals Coverage

While speed at LB wouldn’t appear to be an issue for a team running Isaiah Simmons and Zaven Collins out there, the Cardinals have been weak covering opposing TEs so far. Only the Seahawks have allowed more fantasy production to the TE position. Kittle has had a relatively quiet year, taking a back seat to the likes of Deebo Samuel and even Brandon Aiyuk, but this could be a breakout opportunity for him.

Cardinals Offense Vs. Injuries

Who will be available on the Cardinals offense? We know Kyler Murray and Hollywood Brown are toss-ups, and Zach Ertz will be out after a season-ending injury. But the offensive line has been in rough shape injury-wise after having just about the entire unit questionable or worse last week. Given the 49ers bring an elite rate of pressure, having a bunch of backup linemen in could very well doom this Cardinals offense, so watch the report there and see who suits up. Over/yes sack props could be in play here for the Niners.

Jimmy Garoppolo Vs. Cardinals Pass Rush

If the Cardinals are to have a chance in this game, they likely need to get pressure on Jimmy Garoppolo. According to PFF, his passer rating falls a massive 37 points when pressured. Arizona doesn’t have the coverage skills to make up for a weak pass rush here, especially against these 49ers weapons. The Niners have had solid protection all year, and the Cardinals rank bottom eight in adjusted sack rate, so this looks like an uphill climb.

Final thoughts

The 49ers look like the stronger, healthier team. They should win this game, but a few variables could make things interesting. One is obviously the travel to Mexico City and playing at a high altitude, higher than even these teams would experience in Mile High. Another is the health of the Cardinals offense and especially Kyler Murray. How effective will he be even if he plays? And what will the receiving weapons look like? A 49ers teaser looks like a relatively safe if you’re worried about these things, but keep in mind, you’ll be taking a bad number if Murray eventually gets ruled in and the line drops to something like 49ers -6.5.

Best of luck betting on 49ers Cardinals odds.

Best Promos To Use on 49ers Cardinals Odds

UP TO $1,050 FREE
New User Bonus. T&Cs Apply.
DraftKings Promo: Bet $5 Win $150
PLUS $50 Free On Deposit
PLUS Up to $1,000 Deposit Bonus
To Claim: Click Bet Now
UP TO $1,250
On Caesars
Up to $1,250 On Caesars
+ get 1,000 Caesars Reward Credits 
+ also get 1,000 Tier Credits 
Redeem for free bets, hotel stays, & more!
Use Promo Code: LEGALFULL
No Sweat First Bet
Up to $1,000 No Sweat First Bet
Available on iOS, Android & Desktop
To Claim: Click Bet Now
Risk Free Bet
Exclusive Offer:
$100 Risk Free Bet
Use Promo Code: BETBONUS
Mo Nuwwarah Avatar
Written by
Mo Nuwwarah

Mo Nuwwarah got his start in gambling early, making his first sports bet on his beloved Fab Five against the UNC Tar Heels in the 1993 NCAA tournament. He lost $5 to his dad and got back into sports betting years later during a 15-year run in the poker industry. A 2011 journalism graduate from Nebraska-Omaha, he combines those skills with his love of sports and statistics to help bettors make more informed decisions with a focus on pro football, baseball and basketball.

View all posts by Mo Nuwwarah