NFL Week 10 Rundown: Expert Picks, Lines, Spreads, Over/Unders

Written By Brett Gibbons on November 14, 2021
NFL Week 10 Odds

NFL Week 10 offers a stacked slate of games. Notable storylines on the week include the return of both Aaron Rodgers and Russell Wilson in Green Bay to face each other. Top games of the week include the Saints at Titans, Browns at Patriots, and Chiefs at Raiders. Find the NFL Week 10 odds, injuries, and how you can watch the games below.

Teams on bye this week include the Chicago Bears, Cincinnati Bengals, New York Giants, and Houston Texans.

Atlanta Falcons (4-4) at Dallas Cowboys (6-2)

Kickoff: 1:00 p.m. ET
TV Channel: FOX
Look-ahead line: DAL -9.5
Current Line: DAL (), O/U ()

Atlanta at Dallas key injuries

Falcons vs. Cowboys betting news & angles

Jacksonville Jaguars (2-6) at Indianapolis Colts (4-5)

Time of game: 1:00 p.m. ET
TV Channel: CBS
Look-ahead line: IND -10.5
Current Line: IND (), O/U ()

Jacksonville at Indianapolis key injuries

Colts vs. Jaguars betting news & angles

Cleveland Browns (5-4) at New England Patriots (5-4)

Time of game: 1:00 p.m. ET
TV Channel: CBS
Look-ahead line: NE -3
Current Line: NE (), O/U ()

Cleveland vs. New England key injuries

Browns vs. Patriots betting news & angles

Buffalo Bills (5-3) at New York Jets (2-6)

Time of game: 1:00 p.m. ET
TV Channel: CBS
Look-ahead line: BUF -13.5
Current Line: BUF (), O/U ()

Buffalo at New York Jets key injuries

Jets vs. Bills betting news & angles

Detroit Lions (0-8) at Pittsburgh Steelers (5-3)

Time of game: 1:00 p.m. ET
TV Channel: FOX
Look-ahead line: PIT -8.5
Current Line: PIT (), O/U ()

Detroit at Pittsburgh key injuries

Jaguars vs. Bills betting news & angles

New Orleans Saints (5-3) at Tennessee Titans (7-2)

Time of game: 1:00 p.m. ET
TV Channel: CBS
Look-ahead line: TEN -2.5
Current Line: TEN (), O/U ()

New Orleans at Tennessee key injuries

Saints vs. Titans betting news & angles

Tampa Bay Buccaneers (6-2) at Washington Football Team (2-6)

Time of game: 1:00 p.m. ET
TV Channel: FOX
Look-ahead line: TB -8
Current Line: TB (), O/U ()

Tampa Bay at Washington key injuries:

Washington vs. Buccaneers betting news & angles

Carolina Panthers (4-5) at Arizona Cardinals (8-1)

Time of game: 4:05 p.m. ET
TV Channel: FOX
Look-ahead line: NL
Current Line: ARI (), O/U ()

Carolina at Arizona key injuries

Panthers vs. Cardinals betting news & angles

Minnesota Vikings (3-5) at Los Angeles Chargers (5-3)

Time of game: 4:05 p.m. ET
TV Channel: FOX
Look-ahead line: LAC -2.5
Current Line: LAC (), O/U ()

Minnesota vs. L.A. Chargers key injuries

Vikings vs. Chargers betting news & angles

Philadelphia Eagles (3-6) at Denver Broncos (5-4)

Time of game: 4:25 p.m. ET
TV Channel: CBS
Look-ahead line: DEN -1.5
Current Line: DEN (), O/U ()

Philadelphia at Denver key injuries

Eagles vs. Broncos betting news & angles

Seattle Seahawks (3-5) at Green Bay Packers (7-2)

Time of game: 4:25 p.m. ET
TV Channel: CBS
Look-ahead line: NL
Current Line: GB (), O/U ()

Seattle at Green Bay key injuries

Seahawks vs. Packers betting news & angles

Kansas City Chiefs (5-4) at Las Vegas Raiders (5-3)

Time of game: 8:20 p.m. ET
TV Channel: NBC
Look-ahead line: KC -3
Current Line: KC (), O/U ()

Kansas City at Las Vegas key injuries

Raiders vs. Chiefs betting news & angles

Los Angeles Rams (7-2) at San Francisco 49ers (3-5)

Time of game: 8:15 p.m. ET
TV Channel: ESPN
Look-ahead line: LAR -3
Current NFL Week 10 Odds: LAR (), O/U ()

L.A. Rams at San Francisco injuries

49ers vs. Rams betting news & angles

Keep up-to-date with theLines for NFL Week 10 odds and NFL previews all season long.

Brett Gibbons Avatar
Written by
Brett Gibbons

Brett is an avid sports traveler and former Division-I football recruiter for Bowling Green and Texas State. He’s a graduate of BGSU and works as an auditor for Google content curation products. He’s also contributed to Sports Illustrated and Fansided during his young writing career.

View all posts by Brett Gibbons