NFL Week 10 Odds: Point Spreads, Moneylines And Totals For Every Game

Written By Juan Carlos Blanco on November 12, 2022 - Last Updated on November 15, 2022
NFL Week 10 odds

The NFL has turned the page to the eleventh week of the football season. Go here for NFL Week 11 odds.

The NFL has never been more nip and tuck as this year’s standings and last Sunday’s results showed. Six games had a margin of victory of 7 points or less this past Sunday and there are only four teams that do not have three wins or more on the season. NFL Week 10 odds have been released by top sportsbooks and parity shows as narrow spreads are the norm. The Saints are +1 underdogs at the Steelers. Cleveland is +3.5 at the Dolphins -3.5. Denver is a +2.5 underdog at the Titans -2.5. And the Lions +2.5 are slight dogs at the Bears -2.5.

NFL Week 10 odds

View all of the NFL Week 10 odds below and click on the price you like to wager now. Pro football spreads, moneylines and totals from online sportsbooks are available to bet on here.

NFL Week 10 betting lines

Injury news and even a head coaching shake-up has impacted NFL Week 10 odds. Here are some of the betting line changes we see on Sunday morning. Initial spreads are the lookahead lines that were posted 10 days ago.

  • Broncos +2 at Titans -2 to Broncos +2.5 at Titans -2.5
  • Lions +1.5 at Bears -1.5 to Lions +2.5 at Bears -2.5
  • Browns +5.5 at Dolphins -5.5 to Browns +3.5 at Dolphins -3.5
  • Vikings +9.5 at Bills -9.5 to Vikings +6.5 at Bills -6.5
  • Colts +3.5 at Raiders -3.5 to Colts +4 at Raiders -4
  • Cowboys -3 at Packers +3 to Cowboys -4 at Packers +4
  • Chargers +3.5 at 49ers -3.5 to Chargers +7.5 at 49ers -7.5

Atlanta Falcons at Carolina Panthers +2.5

The Panthers looked like they were ready to mail in the rest of the season this past Sunday against the Bengals but Steve Wilks immediately got his team back on track with a 25-15 win over the Falcons. Atlanta closed as a -2.5 favorite. The game went under the total of 41.5 points.

Seattle Seahawks vs. Tampa Bay Buccaneers

The Seahawks continued their remarkable run Sunday against the Cardinals, sweeping the season series from their division rival with a 31-21 victory. The Buccaneers were able to snap a worrisome skid, albeit barely, with a last-second 16-13 win over the Rams.   

Seattle has been winning with a near-perfect mix of efficient work through the air from Geno Smith, effective work on the ground from rookie Kenneth Walker and a surprisingly improved defense, and all those components could once again be in position to thrive against the Buccaneers. Tampa Bay has been effective against the pass, but they’ve been atypically vulnerable to the run and are also struggling to put points on the board despite Mike Evans and Chris Godwin both being available to Tom Brady.

Brady has continued to put up big yardage totals – albeit with a typically heavy amount of pass attempts — but the Bucs can’t seem to finish drives off with touchdowns anywhere near a consistent-enough basis. Seattle’s defense is now allowing an NFL-low 272 total yards per game in the last three. Brady has also been under plenty of duress and Seattle has racked up 27 sacks in nine games, spelling another potentially long afternoon for the future Hall of Famer.

Despite the Buccaneers’ ongoing underwhelming body of work on offense and Seattle’s strong all-around play, Tampa Bay starts off the week as 2.5-point favorites on the neutral field. 

Minnesota Vikings at Buffalo Bills

The Vikings extended their winning streak to six games with a 20-17 victory on the road over the Commanders on Sunday. The Bills were upset by the Jets on the road by the same score, a game in which Josh Allen barely completed over 50.0 percent of his passes and suffered an elbow injury late.  

Minnesota was unable to get Dalvin Cook going on the ground against Washington, but head coach Kevin O’Connell continued to demonstrate his creativity by still affording his star back a chance to make an impact as a receiver with a critical touchdown reception. O’Connell wasted no time getting trade-deadline acquisition T.J. Hockenson involved in the passing game, with the athletic tight end leading the way with a team-high nine grabs Sunday. Kirk Cousins figures to need all the weapons he can muster against the Bills’ stingy defense, which still ranks No. 4 in total yards per game allowed (299.6) despite their Week 9 loss.

Allen’s health will undoubtedly be a focus this week, as the star quarterback looked stagnant for a good portion of Sunday’s game. The Vikings defense can’t quite measure up to that of the Jets at the moment, but Minnesota did turn in an impressive performance on that front by allowing the Commanders only 263 yards of total offense. The caliber of competition is boosted significantly in this matchup, and the Vikes’ frequent troubles slowing down air attacks on the road (265.3 PYPG allowed) does bode well for Buffalo if Allen is healthy.

The Bills were as much as a -9.5 favorite over the Vikings when looking at lookahead NFL Week 10 odds but that number was all the way down to Buffalo -3.5 on Friday. Allen did not practice with the team on Thursday or Friday. If Allen can’t go Sunday then Case Keenum would get the start and this line could move through the key number of 3.

Detroit Lions at Chicago Bears

The Lions notched their second win Sunday and did so over a long-time thorn in their side, as Detroit shocked the Packers, 15-9. The Bears put on yet another surprising offensive display behind a record-setting rushing performance from Justin Fields, but they still fell just short of the Dolphins, 35-32.

The Lions’ offense remains a concern despite the win Sunday, as Detroit has clearly fallen off its early-season pace, particularly in the passing game. Jared Goff could nevertheless find success against a Bears defense that has been generous through the air over the last two games in particular against the Cowboys and Dolphins. Detroit doesn’t sport anywhere near the weapons of either squad, but Goff could have Josh Reynolds back at his disposal for this game after he missed Sunday with a back injury.

Fields’ recent form doesn’t bode well for a Lions defense that’s still giving up an NFL-high 417.3 total yards per game despite an impressive showing against the undermanned Packers in Week 9. Detroit has allowed an NFC-high 148.8 rushing yards per game, so this matchup could bode especially well for Chicago if it opts to deploy a heavy dose of its capable David Montgomery-Khalil Herbert duo, not to mention what Fields could do when he takes off with the ball. 

Given Chicago’s recent offensive surge and Detroit’s still-questionable defense and poor road play, the Bears are unsurprisingly 2.5-to-3-point home favorites when looking at NFL Week 10 odds.

Denver Broncos at Tennessee Titans

The Broncos were off in Week 9 following a narrow 21-17 win over the Jaguars in London in Week 8. The Titans nearly pulled off the remarkable feat of upsetting the Chiefs at Arrowhead Stadium without Ryan Tannehill, but Tennessee came up just short by a 20-17 score in overtime.

Russell Wilson showed some spark late in the comeback win against Jacksonville, and he finished that contest with 252 passing yards, his third-highest total of the season. However, the matchup against the Titans on their home field is hardly inviting, even with the extra time to gameplan. Tennessee is giving up just 227.7 passing yards per home game, nearly 77 full yards less per contest than they do on the road.

The Titans are naturally hoping to have Tannehill back from his ankle injury for this game, but that’s a complete unknown as the week starts. Malik Willis has been extremely limited in what he’s been allowed to do thus far in his two starts, and he looked worse the more the game went on Sunday night. Willis finished just 5-for-16 for 80 yards while taking three sacks, so if he’s called upon for another start, it’s likely head coach Mike Vrabel tries to lean on Derrick Henry even more than usual versus a Broncos defense that’s surrendered 139.7 rushing yards per game in the last three.

The Titans are unsurprisingly standard three-point home favorites as NFL Week 10 odds show, with the possibility of the number growing if Tannehill’s availability is confirmed.

Jacksonville Jaguars at Kansas City Chiefs

The Jaguars were able to snap a five-game losing streak with a come-from-behind 27-20 victory over the Raiders in Week 9. The Chiefs narrowly got by the Ryan Tannehill-less Titans by a 20-17 margin in overtime on Sunday night.

Jacksonville still doesn’t look anywhere near trustworthy on a week-to-week basis, and in this matchup, they won’t have the benefit of facing another inconsistent team like the Raiders. The Jags’ most reliable week-to-week offensive piece at the moment is undoubtedly “redshirt rookie” Travis Etienne, who put together his third straight 100-yard effort Sunday. The Chiefs do have some drastic home/road splits on run defense, shaping up as much more generous at home with 131.8 rushing yards per game allowed.

Patrick Mahomes threw for nearly 500 yards in Sunday night’s game despite KC managing only 20 points in four-plus quarters, a rare display of inefficiency for the Chiefs overall. However, Titans coach Mike Vrabel is a master opponent-specific game-planner, and the matchup therefore could be a lot less thorny against Jacksonville. The Jags have been a much more generous road defense (373.6 YPG allowed, compared to 305.8 at home), so it could be another banner statistical day for the hosts.

Despite KC’s struggles against Tennessee, the Chiefs are still robust 9.5-point home favorites.

Cleveland Browns at Miami Dolphins

The Browns were off in Week 9 after throttling the Bengals on Monday night in Week 8, 32-13. The Dolphins were able to keep their offense humming against the Bears and needed every point in a 35-32 road win on Sunday.   

The Browns do have the benefit of plenty of film on how best to attack Miami’s increasingly vulnerable defense, and the matchup would be all that more tantalizing were Deshaun Watson already under center. As it is, Jacoby Brissett has had his moments and displayed plenty of chemistry with Amari Cooper in particular. The Nick Chubb-Kareem Hunt duo also remains intact after the trade deadline, and although Miami shut down the conventional ground attack well against the Bears, the Fins are still surrendering 143 rushing yards per contest in the last three.

Tua Tagovailoa and the Tyreek Hill-Jaylen Waddle duo have proven nearly unstoppable at times, while the Browns secondary has been vulnerable at times with Denzel Ward missing the last three games with a concussion. Ward did return to practice Monday, however, and Cleveland has also been a much more effective road pass defense with an NFL-low 144 passing yards per road game and 51.6 percent completion rate allowed in that split. Given those numbers, there may be a bit more reliance on a ground game that now has Jeff Wilson in addition to Raheem Mostert, with the former enjoying an impressive team debut Sunday (72 total yards, receiving TD). 

Despite Miami’s impressive form on offense, the well-rested Browns are relatively modest four-point road underdogs as we look at NFL Week 10 odds.

Houston Texans at New York Giants

The Texans gave the Eagles more of a fight than expected to start off Week 9 on Thursday night, but Houston still fell by a 29-17 scored. The Giants were off in Week 9 after seeing a four-game winning streak snapped by the Seahawks, 27-13.

The Texans’ offense continues to run primarily through rookie running back Dameon Pierce, who continues to handle a significant week-to-week workload irrespective of game script. Pierce’s matchup is actually a favorable one, as stopping the run has been the Giants’ defense Achilles heel in many games. New York is surrendering only 173.5 passing yards per home game and is giving up an NFL-low 55.3 percent completion rate in that split, but the G-Men yield the third-most rushing yards per home contest (170.5). 

New York’s offense has also been heavily focused on its star running back this season, with good reason. Saquon Barkley has bounced back to early-career form and has managed to remain healthy, and this is a matchup that just seems to beg for heavy usage on his part. Houston, as has been the case for several seasons, struggles considerably against the run, allowing an NFL-high 182.5 rushing yards per road game, along with 5.9 yards per carry in that split. 

With Brian Daboll and his staff having the benefit of a bye week to prepare for this matchup and New York’s typically strong play at home, NFL Week 10 odds show the G-Men as 6.5-point home favorites.

New Orleans Saints at Pittsburgh Steelers

The Saints came out of their bye week worse for the wear as they were hammered by the Ravens, 27-13. The Steelers were off in Week 9 after taking a 35-13 pummeling from the Eagles in Week 8.  

The Saints are expecting Michael Thomas to miss the rest of the season with his toe injury, but Jarvis Landry should have a good chance to return for this matchup. The matchup against the Steelers defense has been more palatable this season than in recent years, but Pittsburgh expects to have T.J. Watt back from his pectoral injury after he returned to practice.

The Steelers will hope the bye week gave Kenny Pickett a chance to take a bit of a breather after his first four starts of his career. Counting his second-half debut against the Jets last month, Pickett already has 165 pass attempts under his belt, yet he’s been thrown to the wolves schedule-wise a bit by having to face New York, the Bills, the Bucs and the Eagles in four of his first five appearances. This matchup doesn’t necessarily shape up as much more appealing, however, especially if Marshon Lattimore is finally able to make it back from his abdominal injury that will cost him another contest Monday night.

New Orleans’ ugly performance on Monday night did little to impact this spread. NFL Week 10 odds show the Saints as -2.5 favorites.

Indianapolis Colts at Las Vegas Raiders

The Colts not only took a 26-3 drubbing from the Patriots on Sunday, but their rapidly spiraling season claimed another victim Monday when head coach Frank Reich was fired and franchise legend Jeff Saturday was installed in his place. The Raiders have plenty of problems of their own, with Las Vegas blowing a 20-7 lead to drop a 27-20 decision.

The Colts will be the week’s biggest enigma while being led into battle on the road by a first-time NFL head coach, and presumably, a second-year quarterback in Sam Ehlinger who seemed to take a major step back against the Patriots. Indy also will hope to have Jonathan Taylor (ankle) back in the fold after two straight absences. Ehlinger could certainly use him to help keep the defense honest, although the Raiders have been far from dominant while allowing 372 total yards per home game, the league’s sixth-highest figure in that split.

Las Vegas’ offense is often a mystery itself with the transition to Josh McDaniels’ system a tricky one for Derek Carr thus far. There are times, such as in the first half Sunday, where the veteran signal-caller looks fully comfortable in the scheme, but others where his play turns increasingly ragged. Carr sports his lowest completion percentage (62.3) since 2017, while his 6.9 yards per attempt are also his worst figure since that season. The Colts’ defense has been impressive despite the struggles on the other side, yielding the fifth-fewest total yards per game (292.4) on the road.

In a matchup of two teams in clear upheaval, oddsmakers have decided the Raiders still have far more together than the Colts, making Vegas 6-to-6.5-point home favorites for the time being. 

Dallas Cowboys at Green Bay Packers

The Cowboys were off in Week 9 after delivering a 49-29 throttling to the Bears in Week 8. The Packers’ alarming slump continued and the team’s offense suffered even more attrition during a 15-9 loss to the Lions on Sunday.  

The Cowboys may have Ezekiel Elliott back from his knee issues for this game, although the veteran running back conceded Monday that he’ll likely have to go back to wearing a brace when he resumes football activities. That could mean another week of Tony Pollard as the lead back against a Green Bay defense that’s been vulnerable on the ground at times but did a good job against old teammate Jamaal Williams on Sunday. Meanwhile, the outlook for Dak Prescott and the air attack is an interesting one against a Packers defense surrendering an inconceivably low 83.7 passing yards per home game after having faced the relatively non-threatening (from a passing perspective) quartet of Justin Fields, Mac Jones/Bailey Zappe and Zach Wilson at Lambeau thus far.  

Aaron Rodgers is undoubtedly at his wit’s end at this point, but there’s no calvary that’s coming to rescue Green Bay’s sluggish air attack. In fact, the short-handed receiving corps is now missing impressive rookie Romeo Doubs with a high ankle sprain for the next few games, while Randall Cobb (ankle) remains on injured reserve and Christian Watson is dealing with a chest issue. The matchup against Dallas’ defense is already daunting enough, especially with the Cowboys coming off a bye – they’ve compiled an NFL-high 33 sacks despite having played just eight games and have surrendered only eight TD passes against seven INTs. 

In a testament to the state of both squads, the Packers are actually 5-to-5.5-point underdogs at Lambeau Field with a healthy Aaron Rodgers.

Arizona Cardinals at LA Rams

The Cardinals were stymied by the Seahawks for the second time this season Sunday, taking a 31-21 loss at the hands of their NFC West rival. The Rams’ rocky title-defense season experienced another downswing when they fell to the Buccaneers, 16-13, courtesy of Tampa Bay’s last-minute touchdown. 

The Cardinals couldn’t get DeAndre Hopkins anywhere near as involved Sunday as he’d been the last two games, and the result was a stagnant offense for long stretches once again. Kyler Murray also was under 200 yards for the second time this season, and although he seems to have developed some great chemistry with Rondale Moore as a secondary option the last few games, he has another tough divisional assignment on his plate in the Rams despite having thrown for 314 yards against L.A. back in a 20-12 loss in Week 3.

The Rams have their own troubles on offense, as Matthew Stafford was under 200 yards himself Sunday against Tampa Bay and took another four sacks. The veteran signal-caller can still connect with Cooper Kupp consistently – doing so on eight occasions for 127 yards and a touchdown Sunday – but the rest of the receiving corps has had trouble achieving week-to-week consistency. Arizona does have a relatively modest 16 sacks in nine games, so there’s a chance Stafford has a bit of a reprieve in terms of pressure in this matchup. 

With both teams struggling, the Rams are standard three-point home favorites as the week begins.

LA Chargers at San Francisco 49ers

The Chargers were able to sneak past the Falcons on the road without their top two receivers in Week 9, notching a 20-17 road win. The 49ers were off in Week 9 after recording a big 31-14 win over the Rams on the road in Week 8. 

Justin Herbert will hope to have Keenan Allen back for this game after he apparently tweaked his hamstring during L.A.’s Week 8 bye. Mike Williams’ chances of suiting up are much more remote according to reports, with his ankle injury still expected to keep him out a couple more games at minimum. Even at full strength, this would be an utterly forgettable matchup for the Bolts – the Niners defense is allowing an NFL-low 285.9 total yards per game along with a minuscule 4.8 yards per play.

San Francisco’s week off came at a particularly timely juncture, as it may have given Deebo Samuel enough time to recover from the hamstring injury that cost him Week 8. Adding the versatile weapon back into the mix will have nightmarish consequences for opposing defenses, as trade acquisition Christian McCaffrey already looked completely comfortable in the win over the Rams while racking up 149 total yards and two total TDs against the Rams.

With the Allen’s status highly uncertain and Williams still projected to be out, the rested Niners are seven-point home favorites to start the week, with this number having plenty of potential to increase in coming days.

Washington Commanders at Philadelphia Eagles

The Commanders were on the other side of the coin Sunday against the Vikings, falling by a 20-17 score after notching three straight wins by a combined eight points. The Eagles kept their record unblemished with a tougher-than-expected 29-17 victory against the Texans on Thursday night to open the Week 9 slate.   

Some of Taylor Heinicke’s shortcomings began to shine through in Sunday’s loss to the Vikings, with his fourth-quarter interception particularly critical in the loss. With Washington still having trouble carving out running room as well for either Brian Robinson or Antonio Gibson, this is a particularly worrisome matchup overall. Philly has shown some vulnerability to the run at times, but they could well opt to stack the box a bit against the inconsistent Heinicke and exert some of the pressure that’s already led to 26 sacks and 12 interceptions. 

There simply aren’t many holes to poke in Philly, with the Eagles’ undefeated mark an accurate representation of their dominance on both sides of the ball. The extra rest they’ll have in this spot after having played Thursday night should only make them more dangerous, and although Washington could certainly make life hard on Miles Sanders, the Commanders’ propensity for allowing chunk plays through the air (11.3 yards per completion, third highest in the league) could be a recipe for disaster against the AJ Brown-DeVonta Smith duo.

The Eagles opened the week as 10.5-to-11-point home favorites as we look at NFL Week 10 odds. It is a number that could very well expand as the week continues.

How spreads are changing

Here we will take stock of how NFL Week 10 odds are changing. More point spreads will be added to this table in the days leading up to kickoff of each contest.

DateNFL Week 10 Odds: November 7NFL Week 10 Odds: November 9NFL Week 10 Odds: November 11NFL Week 10 Odds: November 13
Thursday, November 10Falcons -3 at Panthers +3Falcons -3 at Panthers +3Falcons -2.5 at Panthers +2.5Falcons -2.5 at Panthers +2.5
Sunday, November 13Seahawks +2.5 at Buccaneers -2.5Seahawks +3 at Buccaneers -3Seahawks +2.5 at Buccaneers -2.5Seahawks +2.5 at Buccaneers -2.5
Sunday, November 13Vikings +7.5 at Bills -7.5Vikings +4.5 at Bills -4.5Vikings +3.5 at Bills -3.5Vikings +7 at Bills -7
Sunday, November 13Broncos +3 at Titans -3Broncos +2.5 at Titans -2.5Broncos +3 at Titans -3Broncos +2 at Titans -2
Sunday, November 13Texans +6.5 at Giants -6.5Texans +5 at Giants -5Texans +4.5 at Giants -4.5Texans +5 at Giants -5
Sunday, November 13Browns +4 at Dolphins -4Browns +3.5 at Dolphins -3.5Browns +3.5 at Dolphins -3.5Browns +3.5 at Dolphins -3.5
Sunday, November 13Jaguars +9.5 at Chiefs -9.5Jaguars +9.5 at Chiefs -9.5Jaguars +9 at Chiefs -9Jaguars +9.5 at Chiefs -9.5
Sunday, November 13Lions +2.5 at Bears -2.5Lions +3 at Bears -3Lions +2.5 at Bears -2.5Lions +2.5 at Bears -2.5
Sunday, November 13Saints -2.5 at Steelers +2.5Saints -2.5 at Steelers +2.5Saints -1.5 at Steelers +1.5Saints +1 at Steelers -1
Sunday, November 13Colts +6.5 at Raiders -6.5Colts +6 at Raiders -6Colts +4.5 at Raiders -4.5Colts +4 at Raiders -4
Sunday, November 13Cowboys -5 at Packers +5Cowboys -5 at Packers +5Cowboys -4.5 at Packers +4.5Cowboys -3.5 at Packers +3.5
Sunday, November 13Cardinals +3 at Rams -3Cardinals +3 at Rams -3Cardinals +1.5 at Rams -1.5Cardinals +3 at Rams -3
Sunday, November 13Chargers +7 at 49ers -7Chargers +7 at 49ers -7Chargers +7 at 49ers -7Chargers +7.5 at 49ers -7.5
Monday, November 14Commanders +11 at Eagles -11Commanders +10.5 at Eagles -10.5Commanders +11 at Eagles -11Commanders +11 at Eagles -11

Initial point spreads are from Wednesday, November 2.

DateNFL Odds: November 2 spreadsNFL Odds: November 2 moneylinesNFL Odds: November 2 over unders
Thursday, November 10Falcons -1.5 at Panthers +1.5Falcons -125 at Panthers +10540.5
Sunday, November 13Seahawks +2.5 at Buccaneers -2.5Seahawks +120 at Buccaneers -14046.5
Sunday, November 13Texans +6 at Giants -6Texans +210 at Giants -25038
Sunday, November 13Broncos +2 at Titans -2Broncos +110 at Titans -13040
Sunday, November 13Jaguars +9.5 at Chiefs -9.5Jaguars +340 at Chiefs -42549
Sunday, November 13Lions +1.5 at Bears -1.5Lions +105 at Bears -12545.5
Sunday, November 13Browns +5.5 at Dolphins -5.5Browns +195 at Dolphins -23046.5
Sunday, November 13Saints -2.5 at Steelers +2.5Saints -145 at Steelers +12541.5
Sunday, November 13Vikings +9.5 at Bills -9.5Vikings +340 at Bills -42549.5
Sunday, November 13Colts +3.5 at Raiders -3.5 Colts +155 at Raiders -18043
Sunday, November 13Cowboys -3 at Packers +3Cowboys -150 at Packers +13044.5
Sunday, November 13Cardinals +3 at Rams -3Cardinals +145 at Rams -170 45
Sunday, November 13Chargers +3.5 at 49ers -3.5Chargers +160 at 49ers -19047.5
Monday, November 14Commanders +10.5 at Eagles -10.5Commanders +380 at Eagles -47545
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Juan Carlos Blanco

Juan Carlos Blanco has served as a freelance writer for a wide variety of online publications and websites, with an intensive focus on fantasy sports. Juan has provided analysis and comprehensive coverage of the MLB, NBA, NFL, CFL, AAF and AFL while also reporting on news and developments in the daily fantasy sports and online gaming industries.

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