NFL Week 10 Odds: Spreads, Moneylines, Totals For Every Game

Written By Juan Carlos Blanco on November 13, 2021 - Last Updated on November 16, 2021

Check out NFL Week 11 lines here.

The NFL is more unpredictable than ever as last weekend set a new parity bar. Jacksonville’s 9-6 upset of the Bills undoubtedly sits atop the list of surprises, but the Broncos nearly shutting out the Cowboys before two late garbage-time Dallas touchdowns and the Browns thumping the Bengals by 25 points on the road certainly qualify as runner-up candidates. We now turn the pro football page and look at NFL Week 10 odds. The slate kicked off Thursday with the Dolphins upsetting the Ravens. Other notable matchups on the docket Sunday include Falcons versus Cowboys, Browns versus Patriots, Saints versus Titans and Vikings versus Chargers. There is also a Packers versus Seahawks showdown in Green Bay that could mark the returns of both Aaron Rodgers and Russell Wilson to action and a Chiefs versus Raiders divisional battle in desert.

NFL Week 10 odds

Below are updated NFL Week 10 odds available to wager on. Click on the pro football betting prices you like with point spreads, moneylines and totals available.

How the lines are changing

Here is a look at how NFL Week 10 odds are changing in the days leading up to kickoff. Here, first, are the lookahead lines followed up updated lines.

  • Baltimore Ravens (-6.5) vs. Miami Dolphins (+6.5)
  • Tampa Bay Buccaneers (-7.5) vs. Washington Football Team (+7.5)
  • Cleveland Browns (+3) vs. New England Patriots (-3)
  • Buffalo Bills (-13.5) vs. New York Jets (+13.5)
  • Atlanta Falcons (+9.5) vs. Dallas Cowboys (-9.5)
  • Jacksonville Jaguars (+10.5) vs. Indianapolis Colts (-10.5)
  • Detroit Lions (+9.5) vs. Pittsburgh Steelers (-9.5)
  • New Orleans Saints (+2.5) vs. Tennessee Titans (-2.5)
  • Minnesota Vikings (+3) vs. LA Chargers (-3)
  • Philadelphia Eagles (+1.5) vs. Denver Broncos (-1.5)
  • Kansas City Chiefs (-3) vs. Las Vegas Raiders (+3)
  • LA Rams (-3) vs. San Francisco 49ers (+3)

Here are updated NFL Week 10 odds:

  • Baltimore Ravens (-7.5) at Miami Dolphins (+7.5)
  • Atlanta Falcons (+8) at Dallas Cowboys (-8)
  • New Orleans Saints (+3) at Tennessee Titans (-3)
  • Jacksonville Jaguars (+10) at Indianapolis Colts (-10)
  • Cleveland Browns (+2) at New England (-2)
  • Buffalo Bills (-13) at New York Jets (+13)
  • Detroit Lions (+5.5) at Pittsburgh Steelers (-5.5)
  • Tampa Bay Buccaneers (-9.5) at Washington Football Team (+9.5)
  • Carolina Panthers (+8.5) at Arizona Cardinals (-8.5)
  • Minnesota Vikings (+3.5) at LA Chargers (-3.5)
  • Philadelphia Eagles (+1) at Denver Broncos (-1)
  • Seattle Seahawks (+3) at Green Bay Packers (-3)
  • Kansas City Chiefs (-2.5) at Las Vegas Raiders (+2.5)
  • LA Rams (-3.5) at San Francisco 49ers (+3.5)

Thursday, Nov. 11

Baltimore Ravens at Miami Dolphins – 8:20 p.m. ET

The Ravens authored a stirring victory on Sunday at home against the Vikings, overcoming a two-touchdown deficit in the second half to eventually escape with a 34-31 overtime win. The Dolphins prevailed on their home field themselves, but it could hardly be considered inspiring – they managed to get past the one-win Texans by a 17-9 score while committing five turnovers.

Lamar Jackson put on an MVP-caliber performance against Minnesota by racking up 386 total yards (266 passing, 120 rushing) and three touchdown passes. The veteran backfield duo of Devonta Freeman and Le’Veon Bell also turned back the clock by combining for 127 rushing yards and a touchdown on the ground (Bell) and through the air (Freeman). The Dolphins will be hard-pressed to plug all those holes on defense, considering Miami is allowing the third-most total yards per game (391.9).

The big story for Brian Flores’ squad on this past Sunday was the fact Tua Tagovailoa wasn’t deemed healthy enough to start due to a fractured finger. Tua was in uniform and served as Jacoby Brissett’s emergency backup, and it remains to be seen which of the two players will be under center against Baltimore. Brissett performed reasonably well against Houston but still threw two interceptions, and the competition is clearly much stiffer Thursday. The Ravens have had some issues on defense, but Baltimore has actually been better on the road, giving up just 19.0 points per game as compared to 27.6 conceded per home contest.

Given the current state of both clubs, it’s no surprise Baltimore is a robust road favorite that already saw its projected advantage grow by a full point when compared to the look-ahead line.

Sunday, Nov. 14

Atlanta Falcons at Dallas Cowboys () – 1 p.m. ET

The Falcons got to 4-4 Sunday with a big divisional win, toppling the Saints on the road by a 27-25 score despite a strong performance from New Orleans’ Trevor Siemian. The Cowboys came out surprisingly flat in Dak Prescott’s return from a one-game absence, leading to a 30-16 drubbing at the hands of the Broncos that wasn’t even as close as the final score indicates.

Atlanta’s path to its .500 record is in part a testament to the team’s ability to overcome adversity, considering the Falcons are currently playing without top receiver Calvin Ridley. Offseason arrival Cordarrelle Patterson is being utilized expertly by new head coach Arthur Smith in his scheme, and Matt Ryan, who boasts the second-highest completion percentage of his career (69.4) and a 15:6 TD:INT, seems to be getting increasingly comfortable despite working with just an average group of wideouts. The Cowboys defense could present another opportunity for a big day, as Dallas is now allowing 270.5 passing yards per contest.

Dallas could well look back at Sunday’s debacle against Denver at season’s end and conclude it was nothing more than an outlier performance over a long season, but the Cowboys were outcoached and outschemed on both sides of the ball. Coach Mike McCarthy kept Prescott in the game for the entirety of the contest and that ultimately yielded two garbage-time touchdowns, but they’ll have to figure out how to get the offensive engine revving much sooner than the fourth quarter against Atlanta. The Falcons sport a tough road defense, ranking in the top half of the league with 341.2 total yards per contest allowed and giving up a stingy 97.4 rushing yards per game in that split.

Despite Week 9 outcomes, this spread is surprisingly large in favor of the hosts and is as high as 10 point sin some sportsbooks as the week begins.

New Orleans Saints at Tennessee Titans () – 1 p.m. ET

Update: Saints star RB Alvin Kamara (knee) will not play Sunday.

The Saints had a heartbreaker of a home loss to the Falcons in Week 9, dropping a 27-25 decision on a Younghoe Koo game-winning 29-yard field goal. The Titans knocked off yet another elite opponent, and on the road to boot, as they went into Los Angeles in their first game without Derrick Henry and notched a 28-16 victory.

New Orleans did have something pretty important to hang its hat from Sunday’s defeat, that being the play of Trevor Siemian. Coach Sean Payton’s decision to afford the journeyman the start despite Taysom Hill being available proved to be a prudent one, as Siemian threw for 249 yards and two touchdowns without an interception. Mark Ingram was also further reintegrated back into the offense and teamed with Alvin Kamara to produce 93 rushing yards, so New Orleans’ offense appears capable of some solid balance moving forward.

The Titans were able to succeed to an extent with a tandem backfield in their own right Sunday night, as the newly arrived Adrian Peterson, D’Onta Foreman and Jeremy McNichols were able to piece together 74 rushing yards and a touchdown (Peterson’s). However, while that sufficed against the Rams, it could be much tougher to achieve balance against a Saints defense that’s allowing an NFL-low 73.8 rushing yards per contest. Ryan Tannehill does at least have both A.J. Brown and Julio Jones available, something that’s been far from guaranteed this season.

Despite the team’s respective Week 9 outcomes, the narrow look-ahead line of Titans -2.5 did not move in the immediate aftermath.

Jacksonville Jaguars at Indianapolis Colts () – 1 p.m. ET

The Jaguars pulled off the upset of the season to date in Week 9, managing to keep Josh Allen and his teammates out of the end zone in a 9-6 win. The Colts took the field Thursday night and engaged in an unexpected shootout with the Jets that Indianapolis prevailed in by a 45-30 margin.

The monumental Week 9 win is a testament to the Jaguars’ defense, as Jacksonville actually only produced all of 218 total yards at a microscopic 3.8 yards per play. Trevor Lawrence also suffered an injury scare when he appeared to get his ankle twisted after one of his pass attempt, but he returned to the game in short order. One of the key injury-related questions that will linger for Urban Meyer’s squad this week pertains to James Robinson, who missed Sunday’s victory with a heel injury.

Carson Wentz was operating without T.Y. Hilton again in Week 9 against New York but still threw for 272 yards and three touchdowns. However, the big story was once again Jonathan Taylor, who continued a spectacular run of production with a 172-yard, two-touchdown effort on the ground highlighted by a 78-yard run. Jacksonville is considerably improved against the run this season and is allowing 96.0 rushing yards per road game; therefore, this will likely be a much more stringent test for the star second-year back than it was during his rookie 2020 campaign, when he tore through the Jags for 275 yards and two touchdowns at 7.1 yards per carry over two games.

The Colts remain hefty home favorites as the week begins despite Jacksonville’s notable feat Sunday.

Cleveland Browns at New England Patriots () – 1 p.m. ET

Update: Nick Chubb (COVID-19) will not play Sunday against New England. Starting at running back for Cleveland will be D’Ernest Johnson.

The Browns, on the eve of finally putting an end to the tumultuous Odell Beckham era in Cleveland, came out looking like a mentally unburdened squad and impressively throttled the division-rival Bengals by a 41-16 score. The Patriots went into Carolina and notched a notable victory of their own with a 24-6 win that improved their road mark to 4-0.

Baker Mayfield leveraged the downfield talents of Donovan Peoples-Jones effectively without Beckham available, hitting the second-year wideout for a 60-yard touchdown. However, the triumph was a true team effort, as Denzel Ward also had a 99-yard pick-six, while Nick Chubb totaled 137 rushing yards, a big chunk if it coming on a 70-yard touchdown run. Running game and defense will undoubtedly be a pivotal part of the gameplan again versus Bill Belichick’s savvy defense, which has picked off a league-high 13 passes.

New England also followed a run-heavy, defensive-minded approach against the Panthers, and with the increasingly ineffective Sam Darnold under center for Carolina, that was more than enough. The Patriots’ Mac Jones did even less than Mayfield had to do in Cleveland’s win, with the rookie throwing for just 139 yards with a touchdown, an INT and a lost fumble. His play will undoubtedly have to come up a notch or two against the Browns defense, which has been about as thorny a matchup for opposing quarterbacks as New England’s has.

Oddsmakers envisioned this as a close game pre-Week 9 when they assigned a look-ahead line of Patriots -3, and the public has ensured a notable reduction by as much as two points in Sunday’s aftermath.

Buffalo Bills () at New York Jets – 1 p.m. ET

The Bills helped facilitate arguably the most shocking outcome of the first half of the season Sunday, getting stymied offensively for all four quarters by the lowly Jaguars on their way to a9-6 loss. The Jets showed some fight on a short week in a Thursday night loss to the Colts, racking up a season-high amount of points despite playing most of the game with third-string quarterback Josh Johnson in a 45-30 defeat.

The worst thing that could have happened to the Jets may well have been the Bills’ shocking upset defeat at Jacksonville’s hands. It’s likely a safe bet that if Buffalo would have been tempted to take its division rival lightly, it won’t be after Sunday’s result. It was an inexplicably poor day for the Bills’ vaunted passing game in particular, considering the Jaguars’ extensive issues against the pass. The Jets are at least much more attackable all the way around than the Jaguars, as New York is ranked in the bottom half of the league in both passing yards per game (274.9) and rushing yards per game (133.2) allowed.

One of the prevalent questions for the Jets this week will be the health of their quarterbacks. Zach Wilson is still unlikely to return from his knee injury for this contest as per coach Robert Saleh’s remarks Monday, but Mike White, who helped author what was the season’s biggest upset before Sunday when he led New York to a Week 8 win over the Bengals, could be ready to return from the forearm injury that knocked him out of Thursday’s contest against the Colts. Whichever of the three possible candidates (including Johnson) gets the call will hope to have top wideout Corey Davis back from his hip injury after a two-game absence.

With the betting public likely treating Buffalo’s hiccup as an outlier, the Bills remain very heavy road favorites, essentially unchanged from the look-ahead line.

Detroit Lions at Pittsburgh Steelers () – 1 p.m. ET

Update 11/14: Steelers QB Ben Roethlisberger will miss Sunday’s game after being placed on the reserve/COVID-19 list. Mason Rudolph will start under center for Pittsburgh.

The Lions were off in Week 9 following a disheartening 44-6 rout at the hands of the Eagles in Week 8. The Steelers suit up Monday night to take on the Chicago Bears, with Pittsburgh looking to notch its fourth straight win.

Coach Dan Campbell has started to field some questions about his quarterback situation after Jared Goff turned in a lackluster performance against Philadelphia and took some boos from the home crowd in the process. Goff is averaging a modest 6.5 yards per attempt that’s his lowest since the rookie 2016 campaign he spent in offensive purgatory under Jeff Fisher, and his 8:6 TD:INT is positively pedestrian. In fairness, however, he’s working with what’s likely the weakest receiving corps in the NFL and has also taken 23 sacks. The matchup against the Steelers defense isn’t exactly heartening, considering Pittsburgh’s well-earned reputation for relentless pursuit of the quarterback.

Irrespective of Monday night’s outcome, the Steelers will be looking to attack Detroit through both the ground and air, considering the Lions’ defense’s all-around poor play. Ben Roethlisberger is keeping the ball much closer to the line of scrimmage overall than during his younger years (6.6 yards per attempt), but the Lions have allowed an NFL-high 12.9 yards per completion. The going could be good for star rookie Najee Harris as well, as Detroit gives up the fourth-most rushing yards per game (134.5).

Ahead of the Steelers’ Monday night battle against Chicago, they’re heavy home favorites, with that number perhaps subject to at least modest movement depending on the outcome of that contest.

Tampa Bay Buccaneers () at Washington Football Team – 1 p.m. ET

The Bucs were off in Week 9 after suffering their second loss of the season in Week 8 to the Saints. Washington was also on bye in Week 9 after getting toppled by the Broncos, 17-10.

Tampa Bay’s loss to New Orleans wasn’t necessarily a shock, considering the Saints defense has mostly had Tom Brady’s number since he joined the Bucs at the start of last season. The defending champs have had a chance to reset, but they’re not guaranteed to have either Antonio Brown (ankle) or Rob Gronkowski (back) for this contest. The news wasn’t bright on either to start the week, with Brown still donning a walking boot and coach Bruce Arians also saying Gronk was iffy for Week 10.

Naturally, at 2-6, Washington won’t have much sympathy. The Football Team has dropped four straight and is still likely to have Taylor Heinicke under center for this contest. After a fast start, Heinicke has come back to earth, posting a 59.6 percent completion rate and a 3:6 TD:INT during the aforementioned losing streak. The Bucs are the type of defense that can certainly capitalize on an inconsistent and relatively inexperienced quarterback, especially with an extra week to game plan.

The Bucs are unsurprisingly big road favorites and are very likely to remain at their current number or higher even if Brown and Gronkowski are eventually announced as unavailable. (11/14 Update: Both players are out)

Carolina Panthers at Arizona Cardinals () – 4:05 p.m. ET

The Panthers sunk further into their abyss in Week 9 with a 24-6 loss to the Patriots that saw Sam Darnold throw three more interceptions and potentially jeopardize his starting job. The Cardinals took a page from the short-handed Green Bay Packers team that handed them their first loss in Week 8 when they went into San Francisco without Kyle Murray or DeAndre Hopkins and notched a two-touchdown win over the 49ers.

Carolina did get Christian McCaffrey off injured reserve Sunday, and in the star back’s first game since Week 3, he collected 106 total yards from scrimmage. However, the fact he was also the team’s leading receiver with just four receptions for 54 yards underscores how ineffective the passing game was yet again. Matters don’t portend to get much better whether it’s Darnold or P.J. Walker under center in this Week 10 matchup, as the Cardinals are allowing an NFC-low 182.5 passing yards per home contest and have also collected 25 sacks through nine games.

The Cardinals will naturally hope to have both of their aforementioned stars back on the field for this game, but at least they know veteran Colt McCoy, who threw for 249 yards and a touchdown in Sunday’s win, is a capable steward of the offense. It bears noting McCoy was working not only without Hopkins, but sans No. 2 wideout A.J. Green (COVID-19 protocols) as well. Moreover, Chase Edmonds exited early with what was eventually diagnosed as a high-ankle sprain and is expected to miss multiple games. (Update: Edmonds is now on injured reserve)

Even with the uncertainty surrounding several key Cardinals, Arizona is a hefty home favorite over the spiraling Panthers.

Minnesota Vikings at Los Angeles Chargers () – 4:05 p.m. ET

The Vikings fell short again in Week 9, dropping another narrow decision in overtime to the Baltimore Ravens after leading by two touchdowns in the second half. The Chargers were able to snap a two-game skid with a 27-24 win over the Philadelphia Eagles on the road behind a masterful performance from Justin Herbert.

Minnesota often displays plenty of positive signs, but more often than not, the Vikings can’t seem to put it all together for four quarters. Mike Zimmer’s squad has suffered its five losses by margins of three, one, seven, four and three points. The good news for Week 10 is that they’ll be facing a team with its fair share of inconsistencies in the Chargers, which are only 2-2 at home, have trouble slowing down the run, and have both won and lost several close games.

The Chargers can take solace in Herbert’s strong resurgence in Week 9 following a pair of sub-par games and the play of the offense as a whole. The defense struggled with the mobility of Jalen Hurts, but that won’t be anywhere near as much of an issue against Kirk Cousins. The Bolts have actually been excellent against the pass all season and allow the third-fewest passing yards per game (197.0), but as alluded to earlier, there could be plenty of opportunity for Dalvin Cook, considering L.A. is giving up an NFL-high 161.6 rushing yards per contest.

Oddsmakers don’t put too much faith in the Chargers at home, even with L.A. having two more wins than Minnesota, as they’re narrow favorites.

Philadelphia Eagles at Denver Broncos () – 4:25 p.m. ET

The Eagles played well on offense but couldn’t quite keep up on defense in Week 9, ultimately falling to the Chargers by a 27-24 score. The Broncos went into Dallas and played a complete game, jumping out to a shocking 30-0 lead before Dallas notched a couple of garbage-time scores.

Jalen Hurts put the ball up only 17 times and coach Nick Sirianni showed a firm commitment to the run (while on injured reserve, Miles Sanders surely stews) by having his running backs carry a total of 29 times. When factoring in Hurts’ 62 rushing yards, Philly racked up 176 overall at 4.5 yards per carry. The Broncos have allowed just 98.3 rushing yards per contest, however, so it may very well be difficult to repeat the feat in Week 10 and could put plenty of pressure on Hurts to navigate what could be a dangerous secondary.

Teddy Bridgewater put together another rock-solid performance against Dallas and is now completing a career-high 70.2 percent of his passes while generating a 14:5 TD:INT. After collecting 249 yards Sunday, he now faces an Eagles secondary that just surrendered well over 300 to Justin Herbert and that’s given up an average of 283.3 over its last three games. The good news for Denver is that its running game is also in good shape and poised to offer Bridgewater plenty of support. Melvin Gordon and Javonte Williams combined for 191 rushing yards and a touchdown (Gordon’s) against Dallas and now get a crack at a Philly defense giving up 119.7 per contest on the ground, the league’s 13th-highest figure.

The public is buying the Broncos plenty after Sunday, pushing the look-ahead line of -1.5 to -3 as the week begins.

Seattle Seahawks at Green Bay Packers () – 4:25 p.m. ET

(Sunday, 11/14 Update: Both Russell Wilson and Aaron Rodgers are activated from their respective reserve lists and will start Sunday’s game against one another. The Packers remain 3.5-point favorites after the news)

This always shaped up as an intriguing matchup, but given the circumstances at play with both quarterbacks, there’s a whole new level of uncertainty surrounding the interconference clash. The Seahawks look like they have a shot to get Russell Wilson back from the serious finger injury that landed him on IR, as he returned to practice Monday and apparently threw the ball very well according to head coach Pete Carroll. The Packers have a bit more uncertainty with Aaron Rodgers, as it’s unclear whether he’ll be cleared to come off the reserve/COVID-19 list in time of this contest, considering Saturday is the first day he’ll be eligible.

Seattle was on bye in Week 9, while the Packers were forced to play with second-year signal-caller Jordan Love in Kansas City. All told, Love handled the big-game atmosphere well, but he ultimately couldn’t finish off enough drives and Green Bay fell by a 13-7 score. The good news was that Davante Adams and Allen Lazard returned from their respective COVID absences, while Marquez Valdes-Scantling came off IR after overcoming an early-season hamstring injury. That leaves either Love or Rodgers with a full wideout arsenal to go into this battle with.

This line will continue to be one of the most interesting to monitor this week as news unfolds. For the moment, the Packers are relatively modest home favorites but that figure could very well be subject to change.

Kansas City Chiefs () at Las Vegas Raiders – 8:20pm ET

The Chiefs managed to skate by again with another mediocre offensive performance in Week 9, escaping with a 13-7 home victory over the Packers despite Jordan Love being the one under center. The Raiders came off another tumultuous week and got handled by the Giants on the road coming out of their bye, 23-16.

Patrick Mahomes and his guys on that side of the ball still don’t look right, but they’ll naturally have to work through whatever issues they’re going through as not one of Kansas City’s front-line skill players is going to be subject to a benching. Mahomes finally broke a seven-game streak of throwing at least one interception Sunday yet completed a season-low 54.1 percent of his throws. He’ll look to improve on last year’s performances against Las Vegas, where he completed just 63.6 percent of his attempts over two games.

The Raiders are down one speed receiver but gained another in veteran DeSean Jackson, who signed with the team Monday. How quickly he gets up to speed with Derek Carr and Las Vegas’ system remains to be seen, but it looks like there’s a definite need for him after Bryan Edwards came up empty in his first audition as the Raiders’ main downfield threat against the G-Men. The Chiefs defense has been essentially challenged to slow down anyone all season, so Vegas could rediscover its mojo on offense in this matchup.

In a testament to the difficulty of division matchups and the luster the Chiefs have lost with recent play, KC is a narrow road favorite going into the week.

Monday, Nov. 15

Los Angeles Rams () at San Francisco 49ers –  8:15 p.m. ET

(Sunday, 11/14 Update: Robert Woods was lost for the season for a torn ACL in Friday’s practice, but the Rams’ signing of Odell Beckham, Jr. earlier in the week gives them the reinforcement they need to make up for the loss. Beckham will play Monday night and the Rams have settled in as 3.5-point favorites, slightly up from the 3-point initial line but down from the 4.5-5 they’d gotten to before Woods’ injury)

The Rams stumbled badly at home Sunday night against the Titans, which toppled them by a 28-16 score that belies the level to which they frustrated the high-octane Los Angeles offense. The 49ers dropped to 0-4 on their home field of Levi Stadium with an embarrassing 31-17 loss to a Cardinals team without Kyler Murray, DeAndre Hopkins and A.J. Green.

Matthew Stafford, Robert Woods and Cooper Kupp all finished with perfectly acceptable numbers in Sunday night’s loss, but those numbers were largely built in a futile attempt to crawl out of a 21-3 first-half hole. The Rams will look to get back on track against a 49ers team they lost two on both occasions last season, albeit with a different quarterback. L.A. is an impressive 4-0 on the road, supporting the notion of a bounce-back effort.

The 49ers are getting some good play from Jimmy Garoppolo on a statistical level, but San Fran continues to struggle with consistency on defense. The Niners did get George Kittle back from injured reserve Sunday and the talented tight end immediately got back into the swing of things with a 6-101-1 line. Brandon Aiyuk also seems to be coming around, but San Francisco will need a complete effort on both sides of the ball to get past the Rams.

Despite both teams suffering Week 9 losses, the Rams’ look-ahead projected advantage has grown considerably from its initial -3 figure.

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Juan Carlos Blanco

Juan Carlos Blanco has served as a freelance writer for a wide variety of online publications and websites, with an intensive focus on fantasy sports. Juan has provided analysis and comprehensive coverage of the MLB, NBA, NFL, CFL, AAF and AFL while also reporting on news and developments in the daily fantasy sports and online gaming industries.

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