Week 1 NFL Betting Upset Predictions To Consider For Longshot Parlays & Pick ‘Em Pools

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Written By Eli Hershkovich | Last Updated
Week 1 NFL Power Rankings

With NFL Week 1 odds almost underway, we’ve seen plenty of underdogs and trendy upset predictions garner interest. Therefore, their odds have dipped at a multitude of NFL betting sites. For those intrigued by the potential payout longshots in parlays (and same game parlays) provide, here is a trio of plus-money teams to consider. Keep in mind that this two- or three-team parlay doesn’t represent a personal wager on my betting card. Be on the lookout for my best bets column by following TheLines on Twitter.

Click any of the odds below to place a bet at the best sports betting sites. These prices are the best available in your state.

san francisco 49ers at pittsburgh steelers

Although 49ers odds received a (non-odds) boost Wednesday, thanks to All-Pro edge rusher Nick Bosa ending his holdout while becoming the highest-paid defensive player in league history, there’s reason to believe in Steelers odds. Their best price point avaialble for an outright victory is . For one, Pittsburgh’s blitz-heavy defense has a mismatch against San Francisco’s shaky offensive line.

Mike Tomlin’s defensive front generated the third-lowest pressure rate across the NFL in 2022, yet sack artist T.J. Watt suffered a Week 1 pec injury that caused him to miss seven games. The Steelers dropped six of them. Opposite of Watt will be left tackle Trent Williams, who turned 35 years old in July and hasn’t played a full season since 2013. Per PFF, San Francisco’s three projected interior offensive linemen (Aaron Banks, Jon Feliciano, and Spencer Burford) failed to grade in the 40th percentile at their respective positions last year. If Pittsburgh wins the battle in the trenches, it certainly stands a chance.

jacksonville jaguars at indianapolis colts

This NFL betting underdog at odds is much stinkier, especially with stud tailback Jonathan Taylor on the PUP list. That said, this line was in the 3.5-point range before Taylor’s absence was announced. The betting market seemingly capped it at before it began to reverse course as the week progressed. Is Taylor really worth a point to the spread — and change on the moneyline? Probably not.

For bettors who are willing to stomach a wager on rookie signal caller Anthony Richardson, one of three fresh-faced QBs making their pro debut Sunday, there may be some value on the board. If you’re interested in attaching either Bryce Young or C.J. Stroud onto your parlay, their ML odds are against the Falcons and at the Ravens, respectively. If you’re into trends, keep in mind that rookie QBs are 11-9-1 ATS in Week 1 since 2010. Hence, the results probably aren’t as bad as you’d initially expect.

las vegas raiders at denver broncos

The last time Jimmy Garoppolo and Russell Wilson met, Denver edged out an ugly 11-10 win in prime time last year. But these long-time rivals among NFC West odds are meeting again in the AFC West. Considering Wilson ranked No. 26 among qualified QBs in EPA per dropback, seeing Broncos odds as a short favorite may come as a surprise. If the Garoppolo-McDaniels law firm avoids a negative game script against Denver’s vaunted secondary, Raiders odds at will be in the mix for a divisional upset.

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