NFL Week 1 Updated Odds: Spreads, Totals, Moneylines, Injuries

Written By Brett Gibbons on September 11, 2022
NFL Week 1

After a long offseason, we’ve finally made it to NFL Week 1. The weekend is jampacked with big games, highlighted by the Kansas City Chiefs at Arizona Cardinals and Tampa Bay Buccaneers at Dallas Cowboys. There’s also a trio of quarterbacks facing their former teams: the Panthers’ Baker Mayfield hosts the Browns, Jets veteran Joe Flacco faces the Ravens, and Broncos’ Russell Wilson makes his homecoming against the Seahawks.

NFL Week 1 odds

Live NFL News Updates & Betting Angles

Check back all weekend long as TheLines team provides live NFL news and betting analysis for every team as it happens.

Week 1 Player Props

Check out our prop search took below to compare the best player props at every legal US sportsbook. Search for any player on the Week 1 slate and click on the odds you like to be directed to the sportsbook and place your bet!

Best odds for NFL week 1

New Orleans Saints at Atlanta Falcons

Kickoff: 1:00 p.m.
TV Channel: FOX
Look-ahead line: NO -3.5
Current Line: NO (), O/U ()

Cleveland Browns at Carolina Panthers

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: CLE -3.5
Current Line: CAR (), O/U ()

San Francisco 49ers at Chicago Bears

Time of game: 1:00 p.m.
TV Channel: FOX
Look-ahead line: SF -6.5
Current Line: SF (), O/U ()

Pittsburgh Steelers at Cincinnati Bengals

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: CIN -6.5
Current Line: CIN (), O/U ()

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Philadelphia Eagles at Detroit Lions

Time of game: 1:00 p.m.
TV Channel: FOX
Look-ahead line: PHI -4
Current Line: PHI (), O/U ()

Indianapolis Colts at Houston Texans

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: IND -7.5
Current Line: IND (), O/U ()

Baltimore Ravens at New York Jets

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: BAL -4.5
Current Line: BAL (), O/U ()

New England Patriots at Miami Dolphins

Time of game: 1:00 p.m.
TV Channel: CBS
Look-ahead line: MIA -3
Current Line: MIA (), O/U ()

Jacksonville Jaguars at Washington Commanders

Time of game: 1:00 p.m.
TV Channel: FOX
Look-ahead line: WAS -4
Current Line: WAS (), O/U ()

Kansas City Chiefs at Arizona Cardinals

Time of game: 4:25 p.m.
TV Channel: CBS
Look-ahead line: KC -3
Current Line: KC (), O/U ()

Las Vegas Raiders at Los Angeles Chargers

Time of game: 4:25 p.m.
TV Channel: CBS
Look-ahead line: LAC -4
Current Line: LAC (), O/U ()

Green Bay Packers at Minnesota Vikings

Time of game: 4:25 p.m.
TV Channel: FOX
Look-ahead line: GB -1.5
Current Line: GB (), O/U ()

New York Giants at Tennessee Titans

Time of game: 4:25 p.m.
TV Channel: FOX
Look-ahead line: TEN -6.5
Current Line: TEN (), O/U ()

Tampa Bay Buccaneers at Dallas Cowboys

Time of game: 8:20 p.m.
TV Channel: NBC
Look-ahead line: TB -2.5
Current Line: TB (), O/U ()

Denver Broncos at Seattle Seahawks

Time of game: 8:15 p.m.
TV Channel: ESPN
Look-ahead line: DEN -4
Current Line: DEN (), O/U ()

NFL Week 1 Picks and Best Bets

Matt Brown, Stephen Andress and Adam Candee break down the entire Week 1 betting slate and offer their predictions and best bets for every game. Watch below!

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Written by
Brett Gibbons

Brett is an avid sports traveler and former Division-I football recruiter for Bowling Green and Texas State. He’s a graduate of BGSU and works as an auditor for Google content curation products. He’s also contributed to Sports Illustrated and Fansided during his young writing career.

View all posts by Brett Gibbons