49ers vs. Steelers Preview: Best NFL Week 1 Betting Site Odds, Promos

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Written By Derek Wagner on September 8, 2023
49ers vs. steelers odds

The San Francisco 49ers (0-0) visit the Pittsburgh Steelers (0-0) at 1 p.m. ET on Sunday, Sept. 10. 49ers odds show San Fransico is a spread favorite and on the moneyline, with Steelers odds at as the best price for Pittsburgh to win across sports betting sites. The point total is set at . In this article, we break down everything you need to know before placing a bet on 49ers vs. Steelers odds.

49ers vs. Steelers Betting Odds

NFL Week 1 odds are explained below. Know what you’re betting before you bet it. You may click any of the odds in this post to navigate to the sportsbook to place a bet.


San Francisco 49ers


Pittsburgh Steelers


If the San Francisco 49ers win by 23 or more, a $16.00 bet on them will win you $10, for a total payout of $26.00. If the Pittsburgh Steelers win, tie, or lose by 22 or less, a $10 bet on them will win you $12.40, for a total payout of $22.40.


If the San Francisco 49ers win, a $700.00 bet on them will win you $10, for a total payout of $710.00. If the Pittsburgh Steelers win, a $10 bet on them will win you $150.00, for a total payout of $160.00. If final result is a tie, the bet results in a PUSH and your wager is refunded.

Total Score

If the final combined score is 38 or more, a $10 bet on OVER will win you $11.40, for a total payout of $21.40. If the final combined score is 37 or less, a $14.50 bet on UNDER will win you $10, for a total payout of $24.50.
Best Available Odds

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Odds updated September 10th, 2023, at 3:03 pm.

Odds and lines subject to change.

49ERS vs. STEELERS Props

Christian McCaffrey anytime TD

FanDuel first posted McCaffrey’s TD prop at +100 on Sunday, Sept. 3, and I figured those odds would change as the week progressed and bettors began hunting for props. The Steelers defense surrendered 13 touchdowns to running backs a season ago, six (most in the NFL) of which were through the air. With McCaffrey being the elite dual-threat-back he is, I like him to find the endzone at this price.

Best available odds for McCaffrey anytime touchdown:

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The forecast has the temperature settling in at 75 degrees and 6 mph winds at Acrisure Stadium before kickoff. The chance of rain is 44%.


NFL Teams finalize their injury reports two days before a game and denote whether a player is questionable, doubtful, or out. Practice participation is also logged during the week. Here is the 49ers injury report and the Steelers injury report for this week.

Starters On The Injury Report

During Monday’s practice, TE George Kittle was working off to the side with an undisclosed injury. This is the only starter for either team on the injury report on Monday.

49ers OFFENSE vs. steelers defense

The Steelers’ defense hopes to return to a top-10 unit this year with T.J. Watt back and healthy. They were in the league’s bottom half a year ago in Yards Per Play (YPP). Despite that, they were a top-10 unit against the run, only yielding 4.2 YPC last season. San Fran could struggle running the football as they have new starters on the right side of the offensive line, with Daniel Brunskill departing for Tennessee and Mike McGlinchey anchoring the offensive line for Denver.

For the secondary, Kyle Shanahan will undoubtedly try to pick on rookie cornerback Joey Porter Jr. Porter was known for his physicality at Penn State, but that could get him in trouble against a skills group that features Deebo Samuel and Brandon Aiyuk. For reference, Pittsburgh’s secondary graded out as bottom-12 in coverage (via PFF) last season.

Steelers offense vs. 49ers defense

Matt Canada‘s offense faces a stiff test in 49ers defense that boasted the best EPA per play a year ago. With that in mind, the Niners lost defensive coordinator Demeco Ryans and a few key pieces, most notably safety Jimmie Ward. Ward was instrumental for a Niners defense that logged the best turnover differential in the league last season at +13. They’re a prime regression candidate in that regard as Steve Wilks slots in as the new DC. During his most recent stops as defensive coordinator for the Cardinals and Browns, Wilks’ units finished bottom five and bottom seven in takeaways, respectively.


With a total set at a mere points, the betting market thinks this will be a low-scoring affair. This game features two of the more conservative coaches in the league, Shanahan and Tomlin. These squads were in the bottom quarter of the league in 4th down attempts a year ago. With this in mind, both coaches will likely aim to drain the clock in the second half. I lean towards the under if you’re deciding between the two.

If you’re into trends, unders went 10-7 in Steelers games a year ago.


Ultimately, I don’t think that Wilks can keep this Niners defense performing at the level they did a season ago. That, coupled with offensive line changes, has me skeptical of them early on. Instead of taking the Steelers , I teased them up to +8.5 and paired them with the Packers. I like Tomlin’s squad to keep it within one possession at home against an ultra-conservative coach in Shanahan. If you’re into trends, the Steelers are 15-4-3 ATS as home underdogs under Tomlin.

TheLines.com lead writer Eli Hershkovich also included the Steelers in his potential NFL Week 1 upsets.

Best of luck betting 49ers vs. Steelers odds.


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