NFL Week 1 Odds: Pro Football Point Spreads, Moneylines, Over Unders

Written By Matt Burke on May 20, 2022
NFL Week 1 odds

The first week of the NFL season is always special as fans and bettors get their first real glimpse of all 32 teams. Legal online sportsbooks have posted NFL Week 1 odds to view and bet on. The pro football lines include the marquee first game of the season on Thursday night, September 8, which will feature the defending champion LA Rams playing host to the Buffalo Bills at SoFi Stadium in Los Angeles.

NFL Week 1 odds

Check out NFL Week 1 odds below. View and wager on point spreads, moneylines and totals for each pro football game on the docket. Compare the opening lines for Week 1 with the current odds as well.

Some non-Week 1 games have already been posted by online sportsbook apps as well, which you can check out below.

DateSpreadMoneylineOver Under
Thursday, September 15LA Chargers +3, Kansas City Chiefs -3LA Chargers +140, Kansas City Chiefs -160Over Under 52.5
Monday, September 19Tennessee Titans +7, Buffalo Bills -7Tennessee Titans +280, Buffalo Bills -365OTB
Monday, September 19Minnesota Vikings +2.5, Philadelphia Eagles -2.5Minnesota Vikings +115, Philadelphia Eagles -135OTB
Sunday, October 2Minnesota Vikings -1, New Orleans Saints +1Minnesota Vikings -115, New Orleans Saints -105Over Under 46.5
Sunday, October 2Kansas City Chiefs +2.5, Tampa Bay Buccaneers -2.5Kansas City Chiefs +115, Tampa Bay Buccaneers -135OTB
Sunday, October 9New York Giants +6.5, Green Bay Packers -6.5New York Giants +225, Green Bay Packers -280Over Under 45.5
Sunday, October 30Denver Broncos -6.5, Jacksonville Jaguars +6.5Denver Broncos -280, Jacksonville Jaguars +225Over Under 47
Sunday, November 13Seattle Seahawks +9.5, Tampa Bay Buccaneers -9.5Seattle Seahawks +340, Tampa Bay Buccaneers -450Over Under 46.5
Sunday, November 13Dallas Cowboys +4, Green Bay Packers -4Dallas Cowboys +160, Green Bay Packers -190OTB
Monday, November 21San Francisco 49ers -2.5, Arizona Cardinals +2.5San Francisco 49ers -135, Arizona Cardinals +115Over Under 48
Sunday, December 25Denver Broncos +2.5, LA Rams -2.5Denver Broncos +130, LA Rams -150OTB
  • Sept. 15: Chargers +3 vs. Chiefs -3
  • Sept. 19: Titans +7 vs. Bills -7
  • Sept. 19: Vikings +2.5 vs. Eagles -2.5
  • Oct. 2: Vikings -1 vs. Saints +1
  • Oct. 9: Giants +6.5 vs. Packers -6.5
  • Oct. 30: Broncos -6.5 vs. Jaguars +6.5
  • Nov. 13: Seahawks +9 vs. Buccaneers -9
  • Nov. 13: Cowboys +4 vs. Packers -4
  • Nov. 21: 49ers -2.5 vs. Cardinals +2.5
  • Dec. 25: Broncos +2.5 vs. Rams -2.5

Thursday, Sept. 8

Buffalo Bills at LA Rams – 8:20 p.m. ET

Matthew Stafford and friends are still riding high after their monumental victory over the Cincinnati Bengals in last season’s Super Bowl. The new challenge for the Rams is to try and become the first repeat NFL champion since the New England Patriots accomplished the feat nearly 18 years ago.

The Rams opened as a -1 favorite over the Bills, who are expected to once again be a legitimate Super Bowl contender.

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Sunday, Sept. 11

The first full football Sunday of the season will take place on Sept. 11. It will be highlighted by a rematch of last year’s NFL season opener as the Buccaneers will face off against the Cowboys. In contrast to last year, however, this game will be played at AT&T Stadium.

Monday, Sept. 12

The first Monday night contest of the season is a doozy as new Broncos quarterback Russell Wilson will take on his former team, the Seahawks, in Seattle. Denver opened as a -4 favorite.

How lines for NFL Week 1 are changing

Here we will look at how NFL Week 1 lines change from when they were first posted, throughout the summer months, and just prior to the first full football weekend. Spreads, moneylines and totals have been released.

DateOpening NFL Week 1 odds: SpreadOpening NFL Week 1 odds: MoneylineOpening NFL Week 1 odds: Over Under
Thursday, September 8Buffalo Bills +1 at LA Rams -1Buffalo Bills -110 vs. LA Rams -110Over Under 52
Sunday, September 11San Francisco 49ers -6.5 vs. Chicago Bears +6.5San Francisco 49ers -275 vs. Chicago Bears +220Over Under 42.5
Sunday, September 11Jacksonville Jaguars +4 vs. Washington Commanders -4Jacksonville Jaguars +160 vs. Washington Commanders -190Over Under 44.5
Sunday, September 11Pittsburgh Steelers +6.5 vs. Cincinnati Bengals -6.5Pittsburgh Steelers +200 vs. Cincinnati Bengals -250Over Under 45
Sunday, September 11New Orleans Saints -3.5 vs. Atlanta Falcons +3.5New Orleans Saints -180 vs. Atlanta Falcons +155Over Under 42
Sunday, September 11Cleveland Browns -3.5 vs. Carolina Panthers +3.5Cleveland Browns -180 vs. Carolina Panthers +155Over Under 42.5
Sunday, September 11Baltimore Ravens -4.5 vs. New York Jets +4.5Baltimore Ravens -195 vs. New York Jets +165Over Under 45
Sunday, September 11Philadelphia Eagles -4 vs. Detroit Lions +4Philadelphia Eagles -190 vs. Detroit Lions +160Over Under 46.5
Sunday, September 11New England Patriots +3 vs. Miami Dolphins -3New England Patriots +135 vs. Miami Dolphins -155Over Under 45
Sunday, September 11Indianapolis Colts -7.5 vs. Houston Texans +7.5Indianapolis Colts -380 vs. Houston Texans +290Over Under 44.5
Sunday, September 11New York Giants +6.5 vs. Tennessee Titans -6.5New York Giants +235 vs. Tennessee Titans -300Over Under 44
Sunday, September 11Green Bay Packers -1.5 vs. Minnesota Vikings +1.5Green Bay Packers -120 vs. Minnesota Vikings +100Over Under 49
Sunday, September 11Las Vegas Raiders +4 vs. LA Chargers -4Las Vegas Raiders +155 vs. LA Chargers -180Over Under 52
Sunday, September 11Kansas City Chiefs -3 vs. Arizona Cardinals +3Kansas City Chiefs -150 vs. Arizona Cardinals +130Over Under 53
Sunday, September 11Tampa Bay Buccaneers -2.5 vs. Dallas Cowboys +2.5Tampa Bay Buccaneers -135 vs. Dallas Cowboys +115Over Under 51.5
Monday, September 12Denver Broncos -4 vs. Seattle Seahawks +4Denver Broncos -190 vs. Seattle Seahawks +160Over Under 41
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Matt Burke

Matt Burke is the Sports Editor and Head of Evergreen/SEO Content at He is the Founder and former Editor-in-Chief of MetroBet, a digital and print sports betting platform, and was the Executive Sports Editor at Metro US Newspapers (New York, Philadelphia, Boston) from 2014-2020. Matt has covered Super Bowls and Final Fours, and his work has appeared for Sports Illustrated, CBS Sports, the Eagle Tribune, Gloucester Daily Times and Newburyport Daily News. Matt is a graduate of the University of Connecticut.

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