NFL Week 1 Odds: Pro Football Point Spreads, Moneylines, Over Unders, & Props

Written By Juan Carlos Blanco on September 11, 2022 - Last Updated on September 13, 2022

The first week of the 2022 NFL season is in the books. If you are looking for NFL Week 2 lines go here. There you will find odds from all of the top legal online sportsbooks in the US.

View and bet on NFL Week 1 odds below. The first week of the NFL season is always special as fans and bettors get their first real glimpse of all 32 teams. The pro football lines include a Sunday slate that will see Baker Mayfield take on his former team and we’ll get our first glimpse of the loaded AFC West as the Raiders take on the Chargers. Monday Night Football will close the week with another highly anticipated game as new Broncos quarterback Russell Wilson will return to Seattle to face his former team.

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NFL Week 1 odds

Check out NFL Week 1 odds below. View and wager on point spreads, moneylines and totals for each pro football game on the docket. Compare the opening lines for Week 1 with the current odds as well.

Week 1 player props

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Week 1 betting breakdowns

The 2022 NFL regular season opened on Thursday with the reigning champion LA Rams getting blasted by the preseason Super Bowl favorite Bills.

Buffalo Bills (-2) at LA Rams (+2)

The Bills showcased their high-flying offense Thursday, easily covering the -2 closing line. Buffalo blasted the Rams, 31-10, as Under bettors cashed tickets on a 51.5 total.

The first full football Sunday of the season will take place on Sept. 11. It will be highlighted by a rematch of last year’s NFL season opener as the Buccaneers will face off against the Cowboys. The early window will see Baker Mayfield square off against his former team in the Browns and there is a key AFC East clash with the Patriots battling the Dolphins in Miami.

Cleveland Browns () at Carolina Panthers ()

The Browns will likely roll with Jacoby Brissett under center against the Panthers with Deshaun Watson suspended for the first 11 games on the season. Cleveland had been favored at most books until the Watson ruling was handed down. Now the Panthers are narrow favorites at most sportsbooks.

Revenge will be on the mind of Mayfield as he looks to resurrect his career in Carolina.

Baltimore Ravens () at New York Jets ()

Last year’s Ravens squad seemed cursed as they suffered major injuries at the running back position before the season even began. Running back J.K. Dobbins should be ready for this Week 1 affair against the Jets and Lamar Jackson is getting a decent amount of MVP buzz.

Head coach Robert Saleh is entering a crucial second season as the head man with the Jets. He will have to try and win with Joe Flacco under center in Week 1.

New England Patriots () at Miami Dolphins ()

It’s always tough to gauge how a team will respond to a first-year head coach. New Dolphins coach Mike McDaniel has the luxury of coaching a team with plenty of talent, most notably WR Tyreek Hill, but it remains to be seen if McDaniel is cut out for being the boss on South Beach.

In McDaniels’ favor is that Miami has historically been relative kryptonite to Bill Belichick whenever the Pats play at Hard Rock Stadium. Belichick’s Patriots have won in Miami just once in their last five tries.

Philadelphia Eagles () at Detroit Lions ()

The Lions were far from a pushover last season as they were competitive in most games while going 11-6 against the spread. Jared Goff will also be getting some help offensively as the Lions signed WR DJ Chark in the off-season.

The Eagles also filled a glaring need this past spring, inking elite pass rusher Haason Reddick to a 3-year, $45 million deal. That was in addition to the trades they swung for WR A.J. Brown and CB Chauncey Gardner-Johnson.

Jacksonville Jaguars () at Washington Commanders ()

Doug Pederson worked wonders for Nick Foles in Philadelphia and once upon a time had Carson Wentz in the MVP conversation. Pederson will now try his hand at making former top overall pick Trevor Lawrence an elite QB. NFL schedule makers are no fools, and this otherwise mundane match-up has some spice as Pederson will go head-to-head against Wentz.

The Washington defense will have to deal with what could be a surprisingly strong Jags offense. Jacksonville added WR Christian Kirk, WR Zay Jones and Pro Bowl G Brandon Scherff. They also get 2021 first round pick Travis Etienne back from injury.

Indianapolis Colts () at Houston Texans ()

The Colts are -130 to win the AFC South this season despite their meltdown late last season. Indianapolis GM Chris Ballard acted with conviction by trading away Carson Wentz and trading for Matt Ryan. Ryan’s MVP-calibre years are likely behind him at 37-years-old but a steady, veteran hand under center should help remedy the Colts. Indy made the playoffs with an 11-5 record the season before last with old man Philip Rivers under center. There’s no reason to believe Ryan can’t get the Colts back to double-digit wins.

Ryan’s first test as a Colt will come on the road against the Texans. Houston is around a +8 underdog at most books. New Texans coach Love Smith hasn’t been a head man in the league since 2015 with the Buccaneers, a stint that saw him go just 8-24 in two seasons. The Texans’ defense should be improved with No. 3 overall pick Derek Stingley Jr. highlighting the group.

San Francisco 49ers () at Chicago Bears ()

Kyle Shanahan is going for broke in 2022 as he elevated Trey Lance to become the 49ers’ starting QB. Lance has already given the San Francisco offense a different feel in training camp as the team is taking many more shots down the field – something that didn’t happen often with Jimmy Garoppolo under center. Lance will face a Bears team in Week 1 that gave up the third fewest passing yards per game in the NFL last season.

The Bears will also feature something of a new look this season as former Colts defensive coordinator Matt Eberflus takes over as head coach. Bears QB Justin Fields will to improve following an often rocky rookie campaign. Calling the plays for Fields will be former Packers quarterbacks coach Luke Getsy. The 38-year-old Getsy is a first-time play-caller in the NFL.

Sunday, 9/11 Update: The 49ers’ George Kittle is inactive due to a groin injury, but the 49ers remain solid favorites against what might be the most talent-deficient team in the league.

Pittsburgh Steelers () at Cincinnati Bengals ()

The AFC North once again figures to be one of the more competitive divisions in all of football. Pittsburgh and Cincinnati will kick things off at 1 p.m. on the first Sunday of the season, with the Bengals as -6.5 home favorites. The total is 44 points with the Steelers set to start Mitchell Trubisky at quarterback. Trubisky won the opening day job over rookie Kenny Pickett.

The Bengals certainly know who their franchise QB is for the foreseeable future as Joe Burrow led the team to a surprise berth in this past season’s Super Bowl. Burrow, however, had his appendix removed in late July and missed much of the preseason. The major concern for the Bengals the past few years centers around keeping Burrow upright. Cincy’s front office did invest in the team’s offensive line this past spring, bringing in La’el Collins, Ted Karras and Alex Cappa.

New Orleans Saints () at Atlanta Falcons ()

The Falcons begin a new era after trading Matt Ryan to the Colts this offseason, with veteran journeyman Marcus Mariota set to serve as a placeholder for rookie third round pick Desmond Ridder. Despite the downgrade under center, there’s optimism in Atlanta about how first round wideout Drake London can combine with dynamic tight end Kyle Pitts and do-it-all running back Cordarrelle Patterson.

The Saints turn a page in their franchise history as well, with Dennis Allen taking over the head coaching duties from Sean Payton. Offensive coordinator Pete Carmichael will now be the top voice guiding quarterback Jameis Winston, who’s hoping to build on an last year’s encouraging eight-game sample as New Orleans’ starting quarterback. The returning Michael Thomas (ankle) and first-round pick Chris Olave should help Winston.

The Saints unsurprisingly get the nod as road favorites in this spot after each team notched a win in the other’s home turf last season.

New York Giants () at Tennessee Titans ()

Big Blue is starting over yet again at the top with Brian Daboll, most recently renowned for guiding the Bills’ super-charged offense. The hiring of the offensive guru is, in theory, supposed to be a boon for the development of Daniel Jones, who will be playing out the last year of his rookie contract in 2022. A reportedly fully healthy Saquon Barkley should also help New York’s chances, as should first round pick Kayvon Thibodeaux, who’ll be leaned on to boost a pass rush that accounted for a modest 34 sacks a year ago.

Tennessee is aiming to atone for last January’s highly disappointing postseason, one that saw the Titans earn the No. 1 seed in the AFC only to promptly suffer a 19-16 home loss in the divisional round to the Bengals. The offseason brought one particularly major change for Mike Vrabel’s club, as A.J. Brown was traded to the Eagles and Trayvon Burks was drafted in the first round as his replacement. Derrick Henry is back to health after a foot injury limited him to eight regular season games in 2021. Veteran Ryan Tannehill will once again lead the offense, but rookie Malik Willis is already in the fold as the heir apparent under center.

Tennessee’s opening line status as near-touchdown favorite was unsurprising as the Giants were 3-6 ATS on the road last season. The spread was Titans -5.5 at DraftKings Sportsbook the day after Tennessee star linebacker Harold Landry suffered a torn ACL at practice.

Green Bay Packers () at Minnesota Vikings ()

Another team set to sail into unchartered waters in their Week 1 contest is the Packers, which traded away star wideout Davante Adams to the Raiders this offseason and therefore will see future Hall of Famer Aaron Rodgers work with a somewhat makeshift group of receivers to open the season. Other key offensive pieces such as the backfield tandem of Aaron Jones and A.J. Dillon remain, as well as a defense that finished ranked No. 8 with 321.7 total yards per game allowed.

The Vikings have a sense of a reset themselves, with former Rams offensive coordinator Kevin O’Connell taking the reins from Mike Zimmer, who was dismissed after eight seasons as head coach. Minnesota otherwise has its key core back on offense and ready to absorb O’Connell’s and his staff’s teachings as the Super Bowl-winning assistant-turned-head-coach aims to maximize the impressive collection of talent his new team boasts at quarterback, running back and receiver in particular.

The two teams split the 2021 season series and the Vikings’ victory came at home, and with some key changes for both teams this offseason, the Pack is currently a narrow road favorite in a game with a line that could shift around some closer to kickoff.

Kansas City Chiefs () at Arizona Cardinals ()

Both teams will enter this game missing some key firepower at wideout from last season, but for markedly different reasons. The Chiefs may have made the most surprising trade of a very eventful offseason when they sent Tyreek Hill to the Dolphins, and the million-dollar question of whether their attempt to replace his production with Marquez Valdes-Scantling and JuJu Smith-Schuster will be successful begins to be answered with this Week 1 showdown.

On the other side, the Cardinals will be down DeAndre Hopkins as he begins his six-game PED suspension to start the season. Arizona did acquire a pretty nifty contingency plan in Marquise Brown via trade from the Ravens just before Day 1 of the draft in April, and he’ll be relied on to display instant renewed chemistry with former college teammate Kyler Murray, who snagged his much-sought-after extension on his rookie contract this offseason.

While this game may not have the luster it otherwise would have carried had Hill and Hopkins been playing in it, it should still be one of the marquee matchups of the season-opening slate. The Chiefs, which were 4-4 ATS as a road favorite last season, have a projected advantage of about a field goal for the time being, while the projected total of 52.5-to-53.5 points is unsurprisingly one of the highest of Week 1.

Las Vegas Raiders () at LA Chargers ()

The Raiders open the season with no shortage of hype after the aforementioned trade for Adams, which they naturally believe could be the piece that puts them over the top in what projects to be a hellacious AFC West and conference in general. The remaining key components from last year’s playoff team – Derek Carr, Josh Jacobs, Hunter Renfrow and Darren Waller among them – are all back in the fold as well, and Vegas will undoubtedly key on setting the right tone early against a division rival that’s received as much press as they have this offseason.

The Bolts are being heralded as one of the favorites to come out of the AFC if the Bills falter, considering the body of work Justin Herbert has put together in his first two seasons and the fact he gets back the likes of Austin Ekeler, Keenan Allen and Mike Williams as key skill-position assets. Meanwhile, the defense saw a major talent infusion led by the likes of cornerback J.C. Jackson and linebackers Khalil Mack and Kyle Van Noy.

The Raiders won the Week 18 meeting between these clubs in overtime last January, but they understandably head into the season-opening showdown as underdogs of just over a field goal.

Tampa Bay Buccaneers () at Dallas Cowboys ()

There’s a potential storm brewing in Tampa Bay as the regular season draws closer, beyond just the usual Florida summer afternoon deluge. Tom Brady is on a personal leave from the team as the second preseason game approaches, and the latest word from head coach Todd Bowles on a potential return date is decidedly non-committal in nature. If Brady remains away from the team through the Buccaneers’ preseason finale, his availability for Week 1 at minimum will be fair to question. If all returns to normal and he’s indeed under center for this rematch of last year’s TNF opener, Brady will presumably be working with a wideout corps that’s still likely to be without Chris Godwin (knee) but will have Mike Evans and newcomer Russell Gage leading the way.

The Cowboys always have plenty of anticipation surrounding them, and this year is certainly no different. A potential make-or-break season for head coach Mike McCarthy is on tap, and he’ll kick it off with a revamped receiving corps that’s going to be significantly short-handed to start the campaign. Michael Gallup is still expected to be sidelined while in the final stages of his recovery from last January’s torn ACL, while free-agent addition James Washington will miss the first several games of the season with a broken foot suffered in camp.

This line will certainly be one to watch as kickoff nears, but for now, oddsmakers appear to be hedging with a narrow 1.5-point projected advantage for Tampa Bay pending potential further Brady developments.

The first Monday night contest of the season is a doozy as new Broncos quarterback Russell Wilson will take on his former team, the Seahawks, in Seattle.

Denver Broncos () at Seattle Seahawks ()

It will be no picnic for Geno Smith in his first start as Seahawks QB as he faces a Broncos defense that allowed the third-fewest points in the league (18.9) last year. The main story in this one, of course, is Wilson – who knows better than anyone about winning and winning big at Lumen Field. Wilson will have plenty of targets at his disposal including Jerry Jeudy, Courtland Sutton and KJ Hamler. Running back Javonte Williams is also poised for a monster sophomore season.

Denver opened as a -4 favorite and that line now sits at Broncos -6.5 at most spots.

How the NFL Week 1 lines are changing

View how the point spreads for the first week of the season are changing in the days leading up to the kickoffs of each game.

DateOpening NFL Week 1 oddsNFL Week 1 Odds: August 17NFL Week 1 Odds: September 6NFL Week 1 Odds: September 9
Thursday, September 8Buffalo Bills +1 vs. LA Rams -1Buffalo Bills -2.5 vs. LA Rams +2.5Buffalo Bills -2.5 vs. LA Rams +2.5
Sunday, September 11San Francisco 49ers -6.5 vs. Chicago Bears +6.5San Francisco 49ers -7 vs. Chicago Bears +7San Francisco 49ers -7 vs. Chicago Bears +7San Francisco 49ers -7 vs. Chicago Bears +7
Sunday, September 11Jacksonville Jaguars +4 vs. Washington Commanders -4Jacksonville Jaguars +3.5 vs. Washington Commanders -3.5Jacksonville Jaguars +3 vs. Washington Commanders -3Jacksonville Jaguars +2.5 vs. Washington Commanders -2.5
Sunday, September 11Pittsburgh Steelers +6.5 vs. Cincinnati Bengals -6.5Pittsburgh Steelers +6.5 vs. Cincinnati Bengals -6.5Pittsburgh Steelers +6.5 vs. Cincinnati Bengals -6.5Pittsburgh Steelers +6.5 vs. Cincinnati Bengals -6.5
Sunday, September 11New Orleans Saints -3.5 vs. Atlanta Falcons +3.5New Orleans Saints -5 vs. Atlanta Falcons +5New Orleans Saints -5.5 vs. Atlanta Falcons +5.5New Orleans Saints -5.5 vs. Atlanta Falcons +5.5
Sunday, September 11Cleveland Browns -3.5 vs. Carolina Panthers +3.5Cleveland Browns +1 vs. Carolina Panthers -1Cleveland Browns +2.5 vs. Carolina Panthers -2.5Cleveland Browns vs. Carolina Panthers PK
Sunday, September 11Baltimore Ravens -4.5 vs. New York Jets +4.5Baltimore Ravens -7 vs. New York Jets +7Baltimore Ravens -7 vs. New York Jets +7Baltimore Ravens -6.5 vs. New York Jets +6.5
Sunday, September 11Philadelphia Eagles -4 vs. Detroit Lions +4Philadelphia Eagles -3.5 vs. Detroit Lions +3.5Philadelphia Eagles -4 vs,. Detroit Lions +4Philadelphia Eagles -4.5 vs. Detroit Lions +4.5
Sunday, September 11New England Patriots +3 vs. Miami Dolphins -3New England Patriots +3 vs. Miami Dolphins -3New England Patriots +3 vs. Miami Dolphins -3New England Patriots +3.5 vs. Miami Dolphins -3.5
Sunday, September 11Indianapolis Colts -7.5 vs. Houston Texans +7.5Indianapolis Colts -8 vs. Houston Texans +8Indianapolis Colts -8 vs. Houston Texans +8Indianapolis Colts -7 vs. Houston Texans +7
Sunday, September 11New York Giants +6.5 vs. Tennessee Titans -6.5New York Giants +6 vs. Tennessee Titans -6New York Giants +5.5 vs. Tennessee Titans -5.5New York Giants +5.5 vs. Tennessee Titans -5.5
Sunday, September 11Green Bay Packers -1.5 vs. Minnesota Vikings +1.5Green Bay Packers -2 vs. Minnesota Vikings +2Green Bay Packers -1.5 vs. Minnesota Vikings +1.5Green Bay Packers -1.5 vs. Minnesota Vikings +1.5
Sunday, September 11Las Vegas Raiders +4 vs. LA Chargers -4Las Vegas Raiders +3.5 vs. LA Chargers -3.5Las Vegas Raiders +3.5 vs. LA Chargers -3.5Las Vegas Raiders +3.5 vs. LA Chargers -3.5
Sunday, September 11Kansas City Chiefs -3 vs. Arizona Cardinals +3Kansas City Chiefs -3.5 vs. Arizona Cardinals +3.5Kansas City Chiefs -4.5 vs. Arizona Cardinals +4.5Kansas City Chiefs -6 vs. Arizona Cardinals +6
Sunday, September 11Tampa Bay Buccaneers -2.5 vs. Dallas Cowboys +2.5Tampa Bay Buccaneers -1.5 vs. Dallas Cowboys +1.5Tampa Bay Buccaneers -2 vs. Dallas Cowboys +2Tampa Bay Buccaneers -2.5 vs. Dallas Cowboys
Monday, September 12Denver Broncos -4 vs. Seattle Seahawks +4Denver Broncos -4.5 vs. Seattle Seahawks +4.5Denver Broncos -6.5 vs. Seattle Seahawks +6.5Denver Broncos -6.5 vs. Seattle Seahawks +6.5
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Juan Carlos Blanco

Juan Carlos Blanco has served as a freelance writer for a wide variety of online publications and websites, with an intensive focus on fantasy sports. Juan has provided analysis and comprehensive coverage of the MLB, NBA, NFL, CFL, AAF and AFL while also reporting on news and developments in the daily fantasy sports and online gaming industries.

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