The first week of the NFL season is always special as fans and bettors get their first real glimpse of all 32 teams. Legal online sportsbooks have posted NFL Week 1 odds to view and bet on. The pro football lines include the marquee first game of the season on Thursday night, September 8, which will feature the defending champion LA Rams playing host to the Buffalo Bills at SoFi Stadium in Los Angeles.
NFL Week 1 odds
Check out NFL Week 1 odds below. View and wager on point spreads, moneylines and totals for each pro football game on the docket. Compare the opening lines for Week 1 with the current odds as well.
Some non-Week 1 games have already been posted by online sportsbook apps as well, which you can check out below.
|Thursday, September 15||LA Chargers +3, Kansas City Chiefs -3||LA Chargers +140, Kansas City Chiefs -160||Over Under 52.5|
|Monday, September 19||Tennessee Titans +7, Buffalo Bills -7||Tennessee Titans +280, Buffalo Bills -365||OTB|
|Monday, September 19||Minnesota Vikings +2.5, Philadelphia Eagles -2.5||Minnesota Vikings +115, Philadelphia Eagles -135||OTB|
|Sunday, October 2||Minnesota Vikings -1, New Orleans Saints +1||Minnesota Vikings -115, New Orleans Saints -105||Over Under 46.5|
|Sunday, October 2||Kansas City Chiefs +2.5, Tampa Bay Buccaneers -2.5||Kansas City Chiefs +115, Tampa Bay Buccaneers -135||OTB|
|Sunday, October 9||New York Giants +6.5, Green Bay Packers -6.5||New York Giants +225, Green Bay Packers -280||Over Under 45.5|
|Sunday, October 30||Denver Broncos -6.5, Jacksonville Jaguars +6.5||Denver Broncos -280, Jacksonville Jaguars +225||Over Under 47|
|Sunday, November 13||Seattle Seahawks +9.5, Tampa Bay Buccaneers -9.5||Seattle Seahawks +340, Tampa Bay Buccaneers -450||Over Under 46.5|
|Sunday, November 13||Dallas Cowboys +4, Green Bay Packers -4||Dallas Cowboys +160, Green Bay Packers -190||OTB|
|Monday, November 21||San Francisco 49ers -2.5, Arizona Cardinals +2.5||San Francisco 49ers -135, Arizona Cardinals +115||Over Under 48|
|Sunday, December 25||Denver Broncos +2.5, LA Rams -2.5||Denver Broncos +130, LA Rams -150||OTB|
- Sept. 15: Chargers +3 vs. Chiefs -3
- Sept. 19: Titans +7 vs. Bills -7
- Sept. 19: Vikings +2.5 vs. Eagles -2.5
- Oct. 2: Vikings -1 vs. Saints +1
- Oct. 9: Giants +6.5 vs. Packers -6.5
- Oct. 30: Broncos -6.5 vs. Jaguars +6.5
- Nov. 13: Seahawks +9 vs. Buccaneers -9
- Nov. 13: Cowboys +4 vs. Packers -4
- Nov. 21: 49ers -2.5 vs. Cardinals +2.5
- Dec. 25: Broncos +2.5 vs. Rams -2.5
Thursday, Sept. 8
Buffalo Bills at LA Rams – 8:20 p.m. ET
Matthew Stafford and friends are still riding high after their monumental victory over the Cincinnati Bengals in last season’s Super Bowl. The new challenge for the Rams is to try and become the first repeat NFL champion since the New England Patriots accomplished the feat nearly 18 years ago.
The Rams opened as a -1 favorite over the Bills, who are expected to once again be a legitimate Super Bowl contender.
Sunday, Sept. 11
The first full football Sunday of the season will take place on Sept. 11. It will be highlighted by a rematch of last year’s NFL season opener as the Buccaneers will face off against the Cowboys. In contrast to last year, however, this game will be played at AT&T Stadium.
Monday, Sept. 12
The first Monday night contest of the season is a doozy as new Broncos quarterback Russell Wilson will take on his former team, the Seahawks, in Seattle. Denver opened as a -4 favorite.
How lines for NFL Week 1 are changing
Here we will look at how NFL Week 1 lines change from when they were first posted, throughout the summer months, and just prior to the first full football weekend. Spreads, moneylines and totals have been released.
|Date||Opening NFL Week 1 odds: Spread||Opening NFL Week 1 odds: Moneyline||Opening NFL Week 1 odds: Over Under|
|Thursday, September 8||Buffalo Bills +1 at LA Rams -1||Buffalo Bills -110 vs. LA Rams -110||Over Under 52|
|Sunday, September 11||San Francisco 49ers -6.5 vs. Chicago Bears +6.5||San Francisco 49ers -275 vs. Chicago Bears +220||Over Under 42.5|
|Sunday, September 11||Jacksonville Jaguars +4 vs. Washington Commanders -4||Jacksonville Jaguars +160 vs. Washington Commanders -190||Over Under 44.5|
|Sunday, September 11||Pittsburgh Steelers +6.5 vs. Cincinnati Bengals -6.5||Pittsburgh Steelers +200 vs. Cincinnati Bengals -250||Over Under 45|
|Sunday, September 11||New Orleans Saints -3.5 vs. Atlanta Falcons +3.5||New Orleans Saints -180 vs. Atlanta Falcons +155||Over Under 42|
|Sunday, September 11||Cleveland Browns -3.5 vs. Carolina Panthers +3.5||Cleveland Browns -180 vs. Carolina Panthers +155||Over Under 42.5|
|Sunday, September 11||Baltimore Ravens -4.5 vs. New York Jets +4.5||Baltimore Ravens -195 vs. New York Jets +165||Over Under 45|
|Sunday, September 11||Philadelphia Eagles -4 vs. Detroit Lions +4||Philadelphia Eagles -190 vs. Detroit Lions +160||Over Under 46.5|
|Sunday, September 11||New England Patriots +3 vs. Miami Dolphins -3||New England Patriots +135 vs. Miami Dolphins -155||Over Under 45|
|Sunday, September 11||Indianapolis Colts -7.5 vs. Houston Texans +7.5||Indianapolis Colts -380 vs. Houston Texans +290||Over Under 44.5|
|Sunday, September 11||New York Giants +6.5 vs. Tennessee Titans -6.5||New York Giants +235 vs. Tennessee Titans -300||Over Under 44|
|Sunday, September 11||Green Bay Packers -1.5 vs. Minnesota Vikings +1.5||Green Bay Packers -120 vs. Minnesota Vikings +100||Over Under 49|
|Sunday, September 11||Las Vegas Raiders +4 vs. LA Chargers -4||Las Vegas Raiders +155 vs. LA Chargers -180||Over Under 52|
|Sunday, September 11||Kansas City Chiefs -3 vs. Arizona Cardinals +3||Kansas City Chiefs -150 vs. Arizona Cardinals +130||Over Under 53|
|Sunday, September 11||Tampa Bay Buccaneers -2.5 vs. Dallas Cowboys +2.5||Tampa Bay Buccaneers -135 vs. Dallas Cowboys +115||Over Under 51.5|
|Monday, September 12||Denver Broncos -4 vs. Seattle Seahawks +4||Denver Broncos -190 vs. Seattle Seahawks +160||Over Under 41|