NFL Week 1 Game Preview: Buffalo Bills at Los Angeles Rams Odds

Written By FairwayJay on September 7, 2022 - Last Updated on September 8, 2022
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The Buffalo Bills visit the Los Angeles Rams at 8:20 p.m. ET on Thursday, Sept. 8. The primetime game to kick off the 2022 season shows the Bills as spread favorites and on the moneyline. The point total is set at . Read on for a full analysis of Rams – Bills odds.

In this article, we break down everything you need to know before placing a bet on the game, including team matchups, key metrics, weather, and the best available Week 1 odds. Click on the odds anywhere in this post to bet now.

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Bills vs. Rams Odds: Spread, Moneyline, Over/Under

When using the odds table, click the dropdown menu and select the type of bet you wish to make. 

Betting the point spread is when you wager on how many points a team will win or lose by. A plus sign in front of the spread is the underdog, and a minus sign is the favorite. The Bills would have to win by at least 3 points if you bet on Buffalo to cover the point spread (-2.5). A spread bet on the Rams would win if Los Angeles wins the game or loses by 1 or 2 points. 

Betting the moneyline is simply betting on which particular team will win a game.

The total is the number of combined points the two teams will score. Bettors can choose to bet the over or under on how many total points will be scored in the game. 

Bills vs. Rams Player Props

In the props tool search bar, type in a team or player and hit enter. You’ll see the various proposition bets offered by leading online sportsbooks. 

This is a valuable tool that allows bettors to compare odds and stats when considering a prop bet. 

Bills and Rams betting news & angles

The Bills had taken 78% of the spread money at DraftKings Sportsbook, as of Wednesday morning. DK dropped the Bills down to a -2 point favorite. In the over/under market, 58% of the bets and 61% of the handle were on the ‘Over’.

Los Angeles is 5-0 SU/ATS in Week 1 under head coach Sean McVay, and the Rams went 3-0 SU/ATS as an underdog last season (including playoffs)

Bills vs Rams injury report

 PositionInjuryMonTueWedGame Status
Van JeffersonWRKneeDNPDNP-
Tommy DoyleOTFootDNPDNPFPQuestionable
Isaiah McKenzieWRGroinFPFPFP
Quintin MorrisTEHamstringDNPDNPLPQuestionable
Jordan PoyerFSElbowFPFPFP
Tim SettleDTCalfFPFPFP
Stefon DiggsWRVet RestLP

Additional Bills injuries

CB Tre’Davious White (knee) is out (PUP), and will miss the first four games of the season.

Bills offense vs. Rams defense

Bills OStats (Rank)Rams D
29.8 (3)Points/Gm21.3 (9)
0.449 (1)Points/Play0.330 (7)
389.3 (5)Yards/Gm333.0 (13)
258.2 (7)Pass Yards/Gm238.0 (21)
131.2 (6)Rush Yards/Gm95.0 (5)
5.9 (7)Yards/Play5.2 (6)
6.8 (14)Yards/Pass6.4 (12)
4.8 (5)Yards/Rush3.9 (4)
47.33 (2)3rd Down %37.55 (7)
66.28 (1)Red Zone TD %53.13 (8)
1.2 (11)Turnovers/Gm1.4 (12)
3.89 (2)QB Sacked %7.39 (5)

Rams offense vs Bills defense

Rams OStats (Rank)Bills D
27.0 (6)Points/Gm18.3 (1)
0.427 (7)Points/Play0.303 (1)
373.2 (7)Yards/Gm289.2 (1)
277.5 (5)Pass Yards/Gm176.7 (1)
95.7 (27)Rush Yards/Gm112.5 (15)
5.9 (5)Yards/Play4.8 (1)
7.8 (2)Yards/Pass5.5 (1)
3.7 (29)Yards/Rush4.4 (16)
44.66 (6)3rd Down %33.61 (1)
59.09 (16)Red Zone TD %53.85 (10)
1.4 (21)Turnovers1.7 (4)
4.83 (6)QB Sacked %7.13 (9)

Bills vs. Rams betting insights

Why the Bills can cover the spread

With a top-3 scoring offense (28.4 PPG) from last season, and the No. 1 scoring defense (17.0 PPG), the Bills are the preseason Super Bowl favorites. Buffalo won five road games last season including at Miami, New Orleans, Kansas City and New England. Buffalo has also covered 13 of 21 non-conference games under head coach Sean McDermott.

Why The Rams can cover the spread

Only one time has a Super Bowl champion been a home underdog in Week 1, and that 2016 Broncos team won outright. The Rams won the toughest division in football last season on their way to winning the Super Bowl. Los Angeles is also 5-0 SU/ATS in Week 1 under head coach Sean McVay, and the Rams went 3-0 SU/ATS as an underdog last season (including playoffs). The Rams’ key performers and players return and the defense can create pressure on Bills QB Josh Allen as they ranked third in the NFL with 50 sacks last season while picking off 19 passes.

Reasons to bet the over

The Bills offense led the league in yards per point (13.1) last season while the Rams were No. 7 (13.7). Both teams averaged 5.9 yards per play to tie for third. Big game quarterbacks deliver, and Josh Allen was elite late last season and sensational in the playoffs. He passed for more than 5,000 yards in 19 games with 45 TD passes and ran for nearly 900 yards and 7 touchdowns. Stafford won the Super Bowl and passed for more than 6,000 yards in 21 games with 50 TD passes. Add in All-Pro WR Stefon Diggs and AP Offensive Player of the Year Cooper Kupp, and how do you slow them down? The pace projection is fast and number of plays is expected to be high.  

Reasons to bet the under

The Bills defense allowed a league-low 289 yards per game last season. Matthew Stafford did not play in the Rams preseason games and did not throw at all during the offseason due to lingering soreness in his right elbow. He’s dealing with some tendinitis, and the 34-year-old QB has been involved in some team drills during training camp. Stafford participated in some joint practices against the Cincinnati Bengals last week. Speculative bettors could believe Stafford may not be as sharp in the opener without full speed reps. 

Bills vs. Rams matchups to watch for

Highlight three key matchups that could impact player props and highlight the best available odds using MetaBet dynamic text.

Matthew Stafford vs Bills secondary

Buffalo had the NFL’s No. 1 passing defense last year. But the Bills will be without star CB Tre’Davious White (PUP). Stafford’s passing yards prop has dropped 9 yards from last week at Caesars Sportsbook.

Stafford’s passing yards:  

Rams Receivers vs Bills secondary

The focus will be on last year’s AP Offensive Player of the Year Cooper Kupp. His receiving yards prop is at FanDuel Sportsbook. But new Rams WR Allen Robinson has seen his receiving yards prop move up from 55 to .

Rams new offensive coordinator vs Bills defense

The Rams added Liam Coen as their offensive coordinator to replace Kevin O’Connell, who took the Minnesota Vikings head coaching job. In a projected faster-paced game, the Rams two running backs should both see plenty of action with Cam Akers and Darrell Henderson combining for at least 25 carries against a Bills defense that was average (115.4 YPG) against the run last season and faces a far more explosive offense in the Rams.   

Final thoughts

The Bills have taken money after opening as a slight underdog and now a -2.5 favorite in Bills Rams odds. BetMGM reports that this is the most bet game thus far heading into Week 1. The Bills have taken the most bets and money as the sportsbooks biggest liability with 90% of the spread money on Buffalo. The line is not likely to hit 3 with buy-back risk on the Rams.  

The total is 51.5 at DraftKings Sportsbook, 52 at Caesars and 52.5 at FanDuel and BetMGM. The total is likely to rise a bit more with a Prime Time shootout expected. Both offenses have added proven performers to top-scoring offenses a season ago, and can spread the ball and field against defenses with some depth issues, especially in the secondary for the Bills.

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FairwayJay is a leading national sports and gaming analyst and is recognized as one of the sports industry's most insightful professionals. Jay has pursued his passions and maintained a pulse on the sports, gaming and poker industries while living in Las Vegas for nearly two decades. He's been a regular featured guest on sports and gaming radio shows, podcasts and produces sports betting and related industry articles and content for various sites and sources.

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