NFL Point Spreads: The 5 Largest Of The 2021-22 Season

Written By Brett Gibbons on July 21, 2021
NFL Point Spreads Biggest ever

BetMGM has released odds on every NFL game for the 2021-22 season (save for Week 18), including point spreads and totals. Despite many of these games being weeks and months away from being played, the disparities between the teams can get pretty steep. Below, we’ll take a look at the five largest point spreads for the upcoming NFL season.

All odds in this article were taken from BetMGM and are accurate as of July 21. When placing bets on NFL point spreads, be sure to shop around at different sportsbooks to compare the numbers and ensure you’re getting the best value.

ALSO READ: Betting lines for every 2021-22 NFL regular season game

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Five largest point spreads of the 2021-22 NFL Season

5. Week 14: Las Vegas Raiders at Kansas City Chiefs (-10.5)

It wouldn’t be a complete list of projected blowouts without mentioning the Kansas City Chiefs at least once. Since Patrick Mahomes overtook the starting duties for the Chiefs, Kansas City is 5-1 against the Raiders and four of the five instances saw at least one team score 35 points.

Las Vegas stunned K.C. early last season and kept their second matchup within a single score. However, the Chiefs have won the last six matchups by an average of 14 points. The Raiders had one of the most widely criticized offseasons of 2021 and are projected by many to take a step backwards. Oddsmakers see Mahomes and the Chiefs’ offense being able to pile on the points in this one.

4. Week 7: Houston Texans at Arizona Cardinals (-10.5)

This matchup begins a trend across the rest of this list. The Houston Texans had one of the most disastrous offseasons in recent NFL history and are now projected to have a brutal 2021-22 season. The Cardinals, despite being labeled as disappointing, can score in bunches – something the Texans may struggle with this year.

Arizona posted 30 or more points seven times last season and retained most of the offense; they also gained All-Pro center Rodney Hudson, adding to the talent pool. Should Kyler Murray orchestrate the Cardinals offense like they did a season ago, Houston will struggle to keep up.

3. Week 6: Houston Texans at Indianapolis Colts (-11.5)

The Colts are favorites in the AFC South at many books and are huge favorites in this home game against the Texans. With a 48-point over/under set, oddsmakers project a 30-18 final score (rounded for fractions). The Colts’ weekly projections will be heavily reliant on how Carson Wentz fits with the team, but this point spread should be fairly constant.

Running back Jonathan Taylor should be projected for a field day this week against a Texans’ defense that ranked last in most major rushing defense categories a season ago. Without any real improvements on the defensive side of the ball this off-season, Houston will be bleeding yards on the ground again in 2021.

2. Week 7: Detroit Lions at Los Angeles Rams (-12)

Matthew Stafford’s first game against his former team is projected to be a runaway for the Rams. Even without Cam Akers carrying the ball, L.A. has an explosive passing offense on the shoulders of receivers Robert Woods and Cooper Kupp. The Lions ranked last in coverage by PFF in 2020 and lost both of their top corners (Desmond Trufant, Justin Coleman).

Detroit also finished with a bottom-third pass rush, according to PFF, a season ago and did not make any noteworthy upgrades to the defensive line this offseason. Their weaknesses are easily exploited by a Rams offensive system that relies on scheming their players open. Despite a middle-of-the-road 46-point over/under currently set, Los Angeles should be able to find the end zone often this week.

1. Week 17: Houston Texans at San Francisco 49ers (-13.5)

It won’t come as a surprise that the Texans lead the list as recipients of the biggest projected blowout this coming season. What may be surprising is that it’s projected to be at the hands of the 49ers, who are coming off a 4-12 season. San Francisco returns most of their missing starters this year and many see them as taking the biggest step forward (or rather, return to form).

This game has a 46-point over/under set, with an implied score of 30-16 (rounded for fractions). While 13.5 might not be a startling number for college football bettors, this number is astronomical in the NFL. The 49ers are bigger and more athletic than the Texans at every position. By Week 17, the QB situation should be ironed out for San Francisco and it seems no matter the starter, this game is expected to be out of reach for Houston.

It may also be worth mentioning of the tanking possibility of the Texans by this point in the season.

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Brett Gibbons

Brett is an avid sports traveler and former Division-I football recruiter for Bowling Green and Texas State. He’s a graduate of BGSU and works as an auditor for Google content curation products. He’s also contributed to Sports Illustrated and Fansided during his young writing career.

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