We are still a few months away from the start of the 2022 – 2023 NFL season but select lines have already been posted by legal online sportsbooks. As the dates of more and more games are learned following the league’s schedule release, more and more books will be posting odds for each contest. Below we will post lines for every single game of the 2022 – 2023 season, with point spreads for each game and a mini betting preview of each week.
Week 1
Here are NFL lines for the first week of the season.
| Date | Opening NFL Week 1 odds: Spread | Opening NFL Week 1 odds: Moneyline | Opening NFL Week 1 odds: Over Under |
|---|---|---|---|
| Thursday, September 8 | Buffalo Bills +1 at LA Rams -1 | Buffalo Bills -110 vs. LA Rams -110 | Over Under 52 |
| Sunday, September 11 | San Francisco 49ers -6.5 vs. Chicago Bears +6.5 | San Francisco 49ers -275 vs. Chicago Bears +220 | Over Under 42.5 |
| Sunday, September 11 | Jacksonville Jaguars +4 vs. Washington Commanders -4 | Jacksonville Jaguars +160 vs. Washington Commanders -190 | Over Under 44.5 |
| Sunday, September 11 | Pittsburgh Steelers +6.5 vs. Cincinnati Bengals -6.5 | Pittsburgh Steelers +200 vs. Cincinnati Bengals -250 | Over Under 45 |
| Sunday, September 11 | New Orleans Saints -3.5 vs. Atlanta Falcons +3.5 | New Orleans Saints -180 vs. Atlanta Falcons +155 | Over Under 42 |
| Sunday, September 11 | Cleveland Browns -3.5 vs. Carolina Panthers +3.5 | Cleveland Browns -180 vs. Carolina Panthers +155 | Over Under 42.5 |
| Sunday, September 11 | Baltimore Ravens -4.5 vs. New York Jets +4.5 | Baltimore Ravens -195 vs. New York Jets +165 | Over Under 45 |
| Sunday, September 11 | Philadelphia Eagles -4 vs. Detroit Lions +4 | Philadelphia Eagles -190 vs. Detroit Lions +160 | Over Under 46.5 |
| Sunday, September 11 | New England Patriots +3 vs. Miami Dolphins -3 | New England Patriots +135 vs. Miami Dolphins -155 | Over Under 45 |
| Sunday, September 11 | Indianapolis Colts -7.5 vs. Houston Texans +7.5 | Indianapolis Colts -380 vs. Houston Texans +290 | Over Under 44.5 |
| Sunday, September 11 | New York Giants +6.5 vs. Tennessee Titans -6.5 | New York Giants +235 vs. Tennessee Titans -300 | Over Under 44 |
| Sunday, September 11 | Green Bay Packers -1.5 vs. Minnesota Vikings +1.5 | Green Bay Packers -120 vs. Minnesota Vikings +100 | Over Under 49 |
| Sunday, September 11 | Las Vegas Raiders +4 vs. LA Chargers -4 | Las Vegas Raiders +155 vs. LA Chargers -180 | Over Under 52 |
| Sunday, September 11 | Kansas City Chiefs -3 vs. Arizona Cardinals +3 | Kansas City Chiefs -150 vs. Arizona Cardinals +130 | Over Under 53 |
| Sunday, September 11 | Tampa Bay Buccaneers -2.5 vs. Dallas Cowboys +2.5 | Tampa Bay Buccaneers -135 vs. Dallas Cowboys +115 | Over Under 51.5 |
| Monday, September 12 | Denver Broncos -4 vs. Seattle Seahawks +4 | Denver Broncos -190 vs. Seattle Seahawks +160 | Over Under 41 |
For a complete betting breakdown of NFL Week 1 odds head here.
Week 2
A look at NFL lines for the second week of the season. The odds displayed are from DraftKings Sportsbook.
The Chargers finished their first season under Brandon Staley running on fumes and out of the postseason following a hot start, going 5-7 after winning four of their first five games. Los Angeles lost three of its last four, a sample that included a pair of overtime defeats. The Bolts return all of last season’s key components on the offensive end with the exception of tight end, where they actually got younger by swapping out Jared Cook for Gerald Everett. However, L.A. made some impressive additions to a defense that finished No. 23 in total yards per game allowed with the acquisitions of Khalil Mack, J.C. Jackson and Kyle Van Noy this offseason.
Meanwhile, the Chiefs’ regular-season trajectory was almost a diametric opposite of the Chargers, as they finished 9-1 after a concerning 3-4 start that included a 30-24 loss to Los Angeles at Arrowhead Stadium in Week 3. KC then walloped the Steelers in Ben Roethlisberger’s swan song in the wild-card round before pulling off an OT miracle against the Bills in the divisional round. However, the Bengals returned the favor the following week, qualifying for the Super Bowl on the backs of Patrick Mahomes and company with their own 27-24 OT win. The prevailing thought had been that a retool and reload for Andy Reid’s team would be in order this offseason, but instead, Kansas City surprisingly traded Tyreek Hill to the Dolphins and will attempt to replace him with the duo of JuJu Smith-Schuster and Marquez Valdes-Scantling, among others.
The two teams split the season series last season and how the KC offense will look without Hill will be one of the biggest questions heading into the season. Therefore, the narrow opening line of Chiefs -3 and low 50s projected total is understandable based on where things currently stand.
The Titans’12-5 record was good enough to take the AFC South by three games last season, but Mike Vrabel’s club became the eventual AFC champion Cincinnati Bengals’ second victim in their memorable postseason run with a 19-16 loss in the divisional round. Tennessee then surprisingly traded away its most explosive pass catcher just before the start of the NFL Draft when it moved A.J. Brown to the Eagles. That leaves the receiver they grabbed with one of the picks netted in that transaction, Arkansas product Treylon Burks, and veteran offseason acquisitions Robert Woods and Austin Hooper as the top targets for veteran Ryan Tannehill. Then, Derrick Henry should be back to 100 percent after a foot injury led to him missing the last nine games of the season before a return for the divisional-round loss.
The Bills had their own heartbreaking divisional-round defeat last January, with the Chiefs shocking Buffalo in a wild fourth quarter and overtime. The heartbreaking defeat naturally left Sean McDermott’s team hungry for retribution, and with such a talented roster already in place, Buffalo concentrated on making some select yet noteworthy additions in a bid to get over the top in 2022. Notably, the top two come from the defending champion Rams, as veteran guard Rodger Saffold and linebacker Von Miller both now wear blue and white. Meanwhile, crafty slot man Jamison Crowder shapes up as an even swap at minimum for the departed Cole Beasley, and Buffalo is also banking on a true breakout season from speedy Gabriel Davis after his memorable eight-catch, 201-yard, four-touchdown effort in the aforementioned divisional-round loss to the Chiefs.
With the trade of Tyreek Hill to the Dolphins, the Bills are odds-on favorites to win Super LVII, so their seven-point projected advantage for this opener at home, where they went 5-3-2 ATS last season and postseason, is also no surprise.
The Vikings begin a new era in 2022 after eight seasons under Mike Zimmer, as Kevin O’Connell, most recently offensive coordinator of the defending champion Rams, is now at the helm. The team ensured O’Connell wouldn’t be starting from scratch or with a retread at quarterback when it inked Kirk Cousins to a one-year $35 million extension. The team stood largely pat this offseason in terms of offensive personnel, although the presumed return to health of promising tight end Irv Smith after he missed all of 2021 with a meniscus injury should give the air attack a boost. Minnesota was more active in replenishing the other side of the ball, acquiring Za’Darius Smith and Jordan Hicks to revamp its linebacking corps and drafting highly regarded Lewis Cine at safety.
The Eagles made plenty of headlines with the acquisition of Brown from the Titans, a move that immediately props up what had been an alarmingly thin receiving corps. With Brown in the fold, DeVonta Smith and Dallas Goedert should certainly be the subject of less defensive attention, while free-agent signee Zach Pascal can slot into the No. 3 role he’s best suited for. If Miles Sanders can enjoy better health and better utilization in 2022, Philadelphia’s Jalen Hurts-led offense could certainly take a big step forward. The defense, which already finished No. 10 in yards per game allowed last season (329.9), could be even better with the additions of Haason Reddick and Kyzir White to the linebacker corps.
The Eagles, just 3-4-1 ATS last season at home, are 2.5-point favorites over a Vikings squad that went 5-4 against the number as a road team in 2021.
Week 3
Here are point spreads for the third week of the season.
Week 4
A glance at NFL lines for the fourth week of the campaign.
| Date | Opening NFL Week 4 odds: Spread |
|---|---|
| Thursday, September 29 | Miami Dolphins +4.5 at Cincinnati Bengals -4.5 |
| Sunday, October 2 | Minnesota Vikings -1 at New Orleans Saints +1 |
| Sunday, October 2 | Kansas City Chiefs +2.5 at Tampa Bay Buccaneers -2.5 |
| Sunday, October 2 | New York Jets +3.5 at vs. Pittsburgh Steelers -3.5 |
| Sunday, October 2 | Tennessee Titans +3 at Indianapolis Colts -3 |
| Sunday, October 2 | Los Angeles Chargers -7.5 at Houston Texans +7.5 |
| Sunday, October 2 | Jacksonville Jaguars +6 at Philadelphia Eagles -6 |
| Sunday, October 2 | Chicago Bears +2.5 at New York Giants -2.5 |
| Sunday, October 2 | Seattle Seahawks +1 at Detroit Lions -1 |
| Sunday, October 2 | Washington Commanders +5 at Dallas Cowboys -5 |
| Sunday, October 2 | Buffalo Bills -1 at Baltimore Ravens +1 |
| Sunday, October 2 | Arizona Cardinals -2.5 at Carolina Panthers +2.5 |
| Sunday, October 2 | New England Patriots +5 at Green Bay Packers -5 |
| Sunday, October 2 | Denver Broncos pk at Las Vegas Raiders pk |
| Monday, October 3 | Los Angeles Rams -1 at San Francisco 49ers +1 |
The Vikings will travel overseas for their fourth game under new head coach Kevin O’Connell to meet another NFC team that features a (semi) new face taking over for a franchise stalwart. New Orleans’ Sean Payton was one of two surprise coaching retirements this offseason, a development that ultimately resulted in defensive coordinator and former Raiders head coach Dennis Allen ascending to the top of the Saints staff.
Allen inherits a team that could be a lot more cohesive than a season ago, its first without Drew Brees since 2005. New Orleans was forced to go through a quarterback carousel of Jameis Winston, Taysom Hill, Trevor Siemian and even then-rookie Ian Book while also making do without star wideout Michael Thomas (ankle) for an entire season. That left the proverbial bullseye frequently on the back of Alvin Kamara, but the spotlight should shine a lot less brightly this season. Thomas is expected to be back to full strength, while first-round pick Chris Olave is projected to immediately slot into the No. 2 role. Allen will also still have plenty of sway over a defense that just added multi-time Pro Bowl safety Tyrann Mathieu following the draft.
Week 5
Here are NFL lines for the fifth week of the 2022 – 2023 season.
| Date | Opening NFL Week 5 odds: Spread |
|---|---|
| Thursday, October 6 | Indianapolis Colts +3 at Denver Broncos -3 |
| Sunday, October 9 | New York Giants +6.5 at Green Bay Packers -6.5 |
| Sunday, October 9 | Chicago Bears +4.5 at Minnesota Vikings -4.5 |
| Sunday, October 9 | Seattle Seahawks +4.5 at New Orleans Saints -4.5 |
| Sunday, October 9 | Pittsburgh Steelers +8 at Buffalo Bills -8 |
| Sunday, October 9 | Atlanta Falcons +10.5 at Tampa Bay Buccaneers |
| Sunday, October 9 | Houston Texans +3 at Jacksonville Jaguars -3 |
| Sunday, October 9 | Detroit Lions +5 at New England Patriots -5 -5 |
| Sunday, October 9 | Tennessee Titans pk at Washington Commanders pk |
| Sunday, October 9 | Miami Dolphins -2.5 at New York Jets +2.5 |
| Sunday, October 9 | San Francisco 49ers -3 at Carolina Panthers +3 |
| Sunday, October 9 | Philadelphia Eagles +2 at Arizona Cardinals -2 |
| Sunday, October 9 | Dallas Cowboys +4.5 at Los Angeles Rams -4.5 |
| Sunday, October 9 | Cincinnati Bengals +1 at Baltimore Ravens -1 |
| Monday, October 10 | Las Vegas Raiders +4.5 at Kansas City Chiefs -4.5 |
The Giants will be heading into the fifth game of the Brian Daboll Era by the time this overseas trip rolls around. New York was in need of a major makeover after two years of Joe Judge, the second culminating in a 4-13 mark. Daniel Jones enters a pivotal year, as his fifth-year option for 2023 wasn’t picked up this offseason. The hope is that Daboll’s influence, which certainly had a seismically important impact on the development of Josh Allen the last four seasons in Buffalo, makes all the difference for Jones, who’s already had to endure multiple coaching and coordinator changes during his first three years in the league. He’s projected to work with mostly the same skill-position group from a year ago, although better health for Kenny Golladay, Sterling Shepard, Kadarius Toney and Darius Slayton would go a long way toward making the former Duke signal-caller’s life easier.
It’s been a tumultuous offseason in Title Town USA, one that began with some mystery surrounding Aaron Rodgers’ plans for 2022. No sooner was that settled via Rodgers’ announcement he’d return to Green Bay for a 15th season than the team traded Davante Adams to the Raiders in the first of what’s turned out to be a season of significant change in the receiver landscape around the league. Rodgers is now without his favorite target, and the Packers’ attempts to address the significant vacuum Adams’ departure created appear underwhelming on paper. Injury-prone Sammy Watkins may not be suited to anything better than a No. 3 role at this point in his career, while rookie second-round pick Christian Watson is almost certainly going to need most of the season to truly acclimate to the NFL after playing his college ball at North Dakota State.
The Packers open as big favorites, but that number could easily change if these two teams actually appear to be about even on offense over the first four games of the season.
Week 6
Here we take stock of pro football lines for the sixth week of the season.
| Date | Opening NFL Week 6 odds |
|---|---|
| Thursday, October 13 | Washington Commanders pk at Chicago Bears pk |
| Sunday, October 16 | Tampa Bay Buccaneers -3.5 at Pittsburgh Steelers +3.5 |
| Sunday, October 16 | Minnesota Vikings +3 at Miami Dolphins -3 |
| Sunday, October 16 | Baltimore Ravens -3.5 at New York Giants +3.5 |
| Sunday, October 16 | Cincinnati Bengals -1 at New Orleans Saints +1 |
| Sunday, October 16 | San Francisco 49ers -5.5 at Atlanta Falcons +5.5 |
| Sunday, October 16 | Jacksonville Jaguars +7 at Indianapolis Colts -7 |
| Sunday, October 16 | New York Jets +7.5 at Green Bay Packers -7.5 |
| Sunday, October 16 | Arizona Cardinals -2.5 at Seattle Seahawks +2.5 |
| Sunday, October 16 | Carolina Panthers +9 at Los Angeles Rams -9 |
| Sunday, October 16 | Buffalo Bills -1.5 at Kansas City Chiefs +1.5 |
| Sunday, October 16 | Dallas Cowboys pk at Philadelphia Eagles pk |
| Monday, October 17 | Denver Broncos +3 at Los Angeles Chargers -3 |
Week 7
A look at lines for the seventh week of the campaign.
| Date | Opening NFL Week 7 odds |
|---|---|
| Thursday, October 20 | New Orleans Saints +3 at Arizona Cardinals -3 |
| Sunday, October 23 | New York Giants +1.5 at Jacksonville Jaguars -1.5 |
| Sunday, October 23 | Indianapolis Colts pk at Tennessee Titans pk |
| Sunday, October 23 | Green Bay Packers -3 at Washington Commanders +3 |
| Sunday, October 23 | Detroit Lions +6.5 at Dallas Cowboys -6.5 |
| Sunday, October 23 | Tampa Bay Buccaneers -5 at Carolina Panthers +5 |
| Sunday, October 23 | Atlanta Falcons +10 at Cincinnati Bengals -10 |
| Sunday, October 23 | New York Jets +7.5 at Denver Broncos -7.5 |
| Sunday, October 23 | Houston Texans +8 at Las Vegas Raiders -8 |
| Sunday, October 23 | Seattle Seahawks +8.5 at Los Angeles Chargers -8.5 |
| Sunday, October 23 | Kansas City Chiefs -1 at San Francisco 49ers +1 |
| Sunday, October 23 | Pittsburgh Steelers +3.5 at Miami Dolphins -3.5 |
| Monday, October 24 | Chicago Bears +5 at New England Patriots -5 |
Week 8
Here are spreads for the eighth weekend of the pro football season.
| Date | Opening NFL Week 8 odds |
|---|---|
| Thursday, October 27 | Baltimore Ravens +3.5 at Tampa Bay Buccaneers -3.5 |
| Sunday, October 30 | Denver Broncos -6.5 at vs. Jacksonville Jaguars +6.5 |
| Sunday, October 30 | Pittsburgh Steelers +3 at Philadelphia Eagles -3 |
| Sunday, October 30 | Chicago Bears +7 at Dallas Cowboys -7 |
| Sunday, October 30 | Miami Dolphins -3 at Detroit Lions +3 |
| Sunday, October 30 | Arizona Cardinals +1 at Minnesota Vikings -1 |
| Sunday, October 30 | Carolina Panthers pk at Atlanta Falcons pk |
| Sunday, October 30 | Las Vegas Raiders -1 at New Orleans Saints +1 |
| Sunday, October 30 | New England Patriots -1.5 at New York Jets +1.5 |
| Sunday, October 30 | Tennessee Titans -4.5 at Houston Texans +4.5 |
| Sunday, October 30 | San Francisco 49ers +4.5 at Los Angeles Rams -4.5 |
| Sunday, October 30 | New York Giants +2.5 at Seattle Seahawks -2.5 |
| Sunday, October 30 | Green Bay Packers +4 at Buffalo Bills -4 |
The Broncos will be one of the most closely watched teams this season as they begin an exciting new era on offense under Russell Wilson. The acquisition of the long-time Seahawk was the headliner in one of the biggest trades in an offseason full of them when he was moved to Denver on March 16th for multiple players and picks. Wilson walks into a talented offense for which he could well prove to be the missing piece, as Javonte Williams, Melvin Gordon, Jerry Jeudy, Courtland Sutton and the promising Albert Okwuegbunam are already in place. Additionally, the Broncos get back KJ Hamler, a talented slot wideout who missed the last 14 games of 2021 with a torn ACL. On defense, the addition of Randy Gregory to a talented front seven that’s back up by a potential shutdown secondary could take the unit to the next level.
The Jaguars suffered through a mostly ignominious 2021 season that began with no shortage of hype and promise. However, just about every hope the Jacksonville faithful had about a new beginning for the franchise began crumbling in preseason when rookie first-round pick Travis Etienne suffered a Lisfranc injury that sidelined him for the season. Meyer eventually was fired after leading the Jags to a 2-11 mark through the first 13 games, while first overall pick Trevor Lawrence endured a difficult rookie season that included a 12:17 TD:INT, 59.6 percent completion rate and 32 sacks. The Clemson product will now work under the tutelage of Doug Pederson and has gained Christian Kirk and Evan Engram as new targets, but it remains to be seen how big a leap he’ll be able to make in his second year after having to learn a new offense for the second time in as many offseasons.
The Broncos could be even bigger favorites by the time this game rolls around if the improvement Wilson is expected to bring is as significant as projected and the Jaguars struggle to get their bearings early.
Week 9
A look at NFL lines for the ninth weekend of the season.
| Date | Opening NFL Week 9 odds |
|---|---|
| Thursday, November 3 | Philadelphia Eagles -4.5 at Houston Texans +4.5 |
| Sunday, November 6 | Minnesota Vikings pk at Washington Commanders pk |
| Sunday, November 6 | Las Vegas Raiders -3 at Jacksonville Jaguars +3 |
| Sunday, November 6 | Miami Dolphins -3 at Chicago Bears +3 |
| Sunday, November 6 | Buffalo Bills -6.5 at New York Jets +6.5 |
| Sunday, November 6 | Los Angeles Chargers -6.5 at Atlanta Falcons +6.5 |
| Sunday, November 6 | Indianapolis Colts pk at New England Patriots pk |
| Sunday, November 6 | Carolina Panthers +8.5 at Cincinnati Bengals -8.5 |
| Sunday, November 6 | Green Bay Packers -5 at Detroit Lions +5 |
| Sunday, November 6 | Seattle Seahawks +5.5 at Arizona Cardinals -5.5 |
| Sunday, November 6 | Los Angeles Rams +1.5 at Tampa Bay Buccaneers -1.5 |
| Sunday, November 6 | Tennessee Titans +5 at Kansas City Chiefs -5 |
| Monday, November 7 | Baltimore Ravens -1 at New Orleans Saints +1 |
Week 10
Here are spreads for the 10th weekend of the season.
| Date | Opening NFL Week 10 odds |
|---|---|
| Friday, November 11 | Atlanta Falcons +3 at Carolina Panthers -3 |
| Sunday, November 13 | Seattle Seahawks +9.5 at Tampa Bay Buccaneers -9.5 |
| Sunday, November 13 | Dallas Cowboys +4 at vs. Green Bay Packers -4 |
| Sunday, November 13 | Detroit Lions +1.5 at Chicago Bears -1.5 |
| Sunday, November 13 | New Orleans Saints +1.5 at Pittsburgh Steelers -1.5 |
| Sunday, November 13 | Denver Broncos pk at Tennessee Titans pk |
| Sunday, November 13 | Minnesota Vikings +7.5 at Buffalo Bills -7.5 |
| Sunday, November 13 | Jacksonville Jaguars +10 at Kansas City Chiefs -10 |
| Sunday, November 13 | Houston Texans +3 at New York Giants -3 |
| Sunday, November 13 | Indianapolis Colts +2 at Las Vegas Raiders -2 |
| Sunday, November 13 | Arizona Cardinals +6 at Los Angeles Rams -6 |
| Sunday, November 13 | Los Angeles Chargers pk at San Francisco 49ers pk |
| Monday, November 14 | Washington Commanders +3.5 at Philadelphia Eagles -3.5 |
The Seahawks moved on from franchise legend and nine-time Pro Bowler Russell Wilson this offseason, and by the time this game rolls around, they’ll presumably be deep into Drew Lock’s or Geno Smith’s starting tenure. Seattle’s offense could well prove positively pedestrian under either player or even Jacob Eason, even with Tyler Lockett and DK Metcalf still heading up the wideout corps, Rashaad Penny, second-round pick Kenneth Walker and potentially Chris Carson in the backfield and talented and perhaps misused-to-date tight end Noah Fant. Neither Lock nor Smith have done anything in their careers suggesting they’re the long-term answer at quarterback, and they certainly could drag down even a talented group of skill-position players with them on many weeks.
There’s been no shortage of news surrounding the Buccaneers this offseason, considering the 41-day retirement of Tom Brady and the sudden departure from the head coaching ranks of Bruce Arians. After the smoke cleared, both men remain with the organization, albeit with Arians now in the front office. General manager Jason Licht once again did a bang-up job holding on to key offensive pieces, inking Chris Godwin and Leonard Fournette to contracts this offseason. He also found the room to do some prudent free-agent spending in the form of Russell Gage and Logan Ryan, the type of veteran signings that can often serve as the final piece of the puzzle for Super Bowl contenders.
The Buccaneers’ heavy favorite status is naturally based on preseason projections at this point, but it could well hold just as true by the time this game rolls around.
Week 11
A look at NFL lines for the 11th weekend of the campaign.
| Date | Opening NFL Week 11 odds |
|---|---|
| Thursday, November 17 | Tennessee Titans +4.5 at Green Bay Packers -4.5 |
| Sunday, November 20 | Chicago Bears PK at Atlanta Falcons PK |
| Sunday, November 20 | Washington Commanders -3 at Houston Texans +3 |
| Sunday, November 20 | Carolina Panthers +7 at Baltimore Ravens -7 |
| Sunday, November 20 | New York Jets +6 at New England Patriots -6 |
| Sunday, November 20 | LA Rams -3 at New Orleans Saints +3 |
| Sunday, November 20 | Philadelphia Eagles +3 at Indianapolis Colts -3 |
| Sunday, November 20 | Detroit Lions +1.5 at New York Giants -1.5 |
| Sunday, November 20 | Las Vegas Raiders +3 at Denver Broncos -3 |
| Sunday, November 20 | Dallas Cowboys PK at Minnesota Vikings PK |
| Sunday, November 20 | Kansas City Chiefs +1.5 at LA Chargers -1.5 |
| Sunday, November 20 | Cincinnati Bengals -2.5 at Pittsburgh Steelers +2.5 |
| Monday, November 21 | San Francisco 49ers -2.5 at Arizona Cardinals +2.5 |
Will Trey Lance be under center for the 49ers by the time this game rolls around? That’s one of the key questions for San Francisco as it enters 2022 trying to take the final step to return to the Super Bowl after falling just narrowly short of the Big Game last January. Jimmy Garoppolo got the Niners to within four points of overcoming the eventual SB champion Rams in the NFC Championship Game, but he’s been the subject of trade rumors from virtually the moment that game ended. Then, standout wide receiver Deebo Samuel is requesting to become the latest big-name player at his position to be traded this offseason, so whether he’s still in a San Francisco uniform by the time this game rolls around remains to be seen.
The Cardinals have had their fair share of offseason personnel-related drama, and it’s been almost exclusively centered on star quarterback Kyler Murray. The two-time Pro Bowler wants a long-term deal before the start of the ’22 season, but with Arizona already picking up his fifth-year option for 2023, it would seem highly likely Murray is under center for this game barring injury. He should be working with both offseason acquisition Marquise Brown and DeAndre Hopkins by the time this game comes to pass, as the latter will have finished the six-game PED suspension he’ll serve to open the season.
The Cardinals swept the season series in 2021, but the Niners got much further and may indeed still retain favorites status by the time this game kicks off.
Week 12
Here are NFL lines for the 12th weekend of the pro football season.
| Date | Opening NFL Week 12 odds |
|---|---|
| Thursday, November 24 | Buffalo Bills -8 at Detroit Lions +8 |
| Thursday, November 24 | New York Giants +7 at Dallas Cowboys -7 |
| Thursday, November 24 | New England Patriots +1.5 at Minnesota Vikings -1.5 |
| Sunday, November 27 | Denver Broncos -4 at Carolina Panthers +4 |
| Sunday, November 27 | Cincinnati Bengals PK at Tennessee Titans PK |
| Sunday, November 27 | Baltimore Ravens -4 at Jacksonville Jaguars +4 |
| Sunday, November 27 | Atlanta Falcons +5 at Washington Commanders -5 |
| Sunday, November 27 | Houston Texans +7 at Miami Dolphins -7 |
| Sunday, November 27 | Chicago Bears +2 at New York Jets -2 |
| Sunday, November 27 | LA Chargers -1.5 at Arizona Cardinals +1.5 |
| Sunday, November 27 | Las Vegas Raiders -2 at Seattle Seahawks +2 |
| Sunday, November 27 | New Orleans Saints +4 at San Francisco 49ers -4 |
| Sunday, November 27 | LA Rams +2.5 at Kansas City Chiefs -2.5 |
| Sunday, November 27 | Green Bay Packers PK at Philadelphia Eagles PK |
| Monday, November 28 | Pittsburgh Steelers +4.5 at Indianapolis Colts -4.5 |
Week 13
A glance at spreads for the 13th week of the season.
| Date | Opening NFL Week 13 odds |
|---|---|
| Thursday, December 1 | Buffalo Bills -3 at New England Patriots +3 |
| Sunday, December 4 | Green Bay Packers -4 at Chicago Bears +4 |
| Sunday, December 4 | Jacksonville Jaguars +2 at Detroit Lions -2 |
| Sunday, December 4 | Washington Commanders PK at New York Giants PK |
| Sunday, December 4 | Tennessee Titans +1 at Philadelphia Eagles -1 |
| Sunday, December 4 | Denver Broncos +1.5 at Baltimore Ravens -1.5 |
| Sunday, December 4 | New York Jets +4.5 at Minnesota Vikings -4.5 |
| Sunday, December 4 | Pittsburgh Steelers -2.5 at Atlanta Falcons +2.5 |
| Sunday, December 4 | Seattle Seahawks +9.5 at LA Rams -9.5 |
| Sunday, December 4 | Miami Dolphins +3.5 at San Francisco 49ers -3.5 |
| Sunday, December 4 | Kansas City Chiefs PK at Cincinnati Bengals PK |
| Sunday, December 4 | LA Chargers PK at Las Vegas Raiders |
| Sunday, December 4 | Indianapolis Colts +2.5 at Dallas Cowboys -2.5 |
| Monday, December 5 | New Orleans Saints +6.5 at Tampa Bay Buccaneers -6.5 |
Week 14
Taking stock of NFL lines for the 14th weekend of the season.
| Date | Opening NFL Week 14 odds |
|---|---|
| Thursday, December 8 | Las Vegas Raiders +4 at LA Rams -4 |
| Sunday, December 11 | Jacksonville Jaguars +6.5 at Tennessee Titans -6.5 |
| Sunday, December 11 | New York Jets +9.5 at Buffalo Bills -9.5 |
| Sunday, December 11 | Houston Texans +8 at Dallas Cowboys -8 |
| Sunday, December 11 | Philadelphia Eagles -1.5 at New York Giants +1.5 |
| Sunday, December 11 | Minnesota Vikings -2 at Detroit Lions +2 |
| Sunday, December 11 | Baltimore Ravens -2 at Pittsburgh Steelers +2 |
| Sunday, December 11 | Miami Dolphins +5.5 at LA Chargers -5.5 |
| Sunday, December 11 | Carolina Panthers +2.5 at Seattle Seahawks -2.5 |
| Sunday, December 11 | Tampa Bay Buccaneers PK at San Francisco 49ers PK |
| Sunday, December 11 | Kansas City Chiefs PK at Denver Broncos PK |
| Monday, December 12 | New England Patriots +2.5 at Arizona Cardinals -2.5 |
Week 15
Here are lines for NFL games for the 15th weekend of the campaign.
| Date | Opening NFL Week 15 odds |
|---|---|
| Thursday, December 15 | San Francisco 49ers -3 at Seattle Seahawks +3 |
| Sunday, December 18 | Philadelphia Eagles -2.5 at Chicago Bears +2.5 |
| Sunday, December 18 | Kansas City Chiefs -10 at Houston Texans +10 |
| Sunday, December 18 | Detroit Lions +2.5 at New York Jets -2.5 |
| Sunday, December 18 | Dallas Cowboys -3.5 at Jacksonville Jaguars +3.5 |
| Sunday, December 18 | Pittsburgh Steelers -1 at Carolina Panthers +1 |
| Sunday, December 18 | New York Giants +3.5 at Washington Commanders -3.5 |
| Sunday, December 18 | Miami Dolphins +6 at Buffalo Bills -6 |
| Sunday, December 18 | Indianapolis Colts PK at Minnesota Vikings PK |
| Sunday, December 18 | Atlanta Falcons +5 at New Orleans Saints -5 |
| Sunday, December 18 | Arizona Cardinals +4 at Denver Broncos -4 |
| Sunday, December 18 | Cincinnati Bengals +3 at Tampa Bay Buccaneers -3 |
| Sunday, December 18 | Tennessee Titans +5 at LA Chargers -5 |
| Sunday, December 18 | New England Patriots +3 at Las Vegas Raiders -3 |
| Monday, December 19 | LA Rams PK at Green Bay Packers PK |
Week 16
The holidays have arrived as we look at NFL lines for the 16th weekend of the season.
This showdown between Russell Wilson and a team he knows extremely well from his NFC West days – and which also happens to be the defending Super Bowl champion – rightfully garners the holiday spotlight. Wilson has compiled 4,304 yards and a 26:13 TD:INT against the Rams in 20 career games, but he’s only 3-8, including one playoff game, against Los Angeles since Sean McVay took the head coaching reins in 2017.
There should definitely be a good read on how well the nine-time Pro Bowler has acclimated to his new Denver teammates by this point in the season. Meanwhile, the Rams title-defense campaign will be nearing its end stages and there should be a good feel for how close the ’22 edition of Sean McVay’s squad is to the prior year’s. L.A. will once again feature Matthew Stafford under center, but the pass-catching corps will have a different look with Robert Woods now in Tennessee, Odell Beckham, who suffered an ACL tear in the Super Bowl win over the Bengals, perhaps not on the roster, and new No. 2 wideout Allen Robinson hoping to reignite his career in McVay’s offense.
Week 17
The calendar turns to 2023 as we look at lines for the penultimate weekend of the regular season.
| Date | Opening NFL Week 17 odds |
|---|---|
| Thursday, December 29 | Dallas Cowboys +1.5 at Tennessee Titans -1.5 |
| Sunday, January 1 | Indianapolis Colts -3 vs. New York Giants +3 |
| Sunday, January 1 | Carolina Panthers +9 at Tampa Bay Buccaneers -9 |
| Sunday, January 1 | New Orleans Saints +3 at Philadelphia Eagles -3 |
| Sunday, January 1 | Chicago Bears +1.5 at Detroit Lions -1.5 |
| Sunday, January 1 | Miami Dolphins +1.5 at New England Patriots -1.5 |
| Sunday, January 1 | Arizona Cardinals -3.5 at Atlanta Falcons +3.5 |
| Sunday, January 1 | Denver Broncos +4.5 at Kansas City Chiefs -4.5 |
| Sunday, January 1 | Pittsburgh Steelers +5.5 at Baltimore Ravens -5.5 |
| Sunday, January 1 | Jacksonville Jaguars PK at Houston Texans PK |
| Sunday, January 1 | New York Jets +1.5 at Seattle Seahawks -1.5 |
| Sunday, January 1 | Minnesota Vikings +5.5 at Green Bay Packers -5.5 |
| Sunday, January 1 | San Francisco 49ers +1.5 at Las Vegas Raiders -1.5 |
| Sunday, January 1 | LA Rams +1.5 at LA Chargers -1.5 |
| Monday, January 2 | Buffalo Bills PK at Cincinnati Bengals PK |
Week 18
Teams will be scrambling for a spot in the NFL Playoffs as we look at opening spreads for the final weekend.
| Date | Opening NFL Week 18 odds |
|---|---|
| Sunday, January 8 | Baltimore Ravens +3 at Cincinnati Bengals -3 |
| Sunday, January 8 | New England Patriots +7 at Buffalo Bills -7 |
| Sunday, January 8 | Minnesota Vikings -1.5 at Chicago Bears +1.5 |
| Sunday, January 8 | Detroit Lions +8 at Green Bay Packers -8 |
| Sunday, January 8 | New York Giants +5 at Philadelphia Eagles -5 |
| Sunday, January 8 | Houston Texans +8.5 at Indianapolis Colts -8.5 |
| Sunday, January 8 | New York Jets +5.5 at Miami Dolphins -5.5 |
| Sunday, January 8 | Tennessee Titans -3 at Jacksonville Jaguars +3 |
| Sunday, January 8 | LA Rams -5.5 at Seattle Seahawks +5.5 |
| Sunday, January 8 | Kansas City Chiefs -2 vs. Las Vegas Raiders +2 |
| Sunday, January 8 | Dallas Cowboys -1 vs. Washington Commanders +1 |
| Sunday, January 8 | Arizona Cardinals +3 vs. San Francisco 49ers -3 |
| Sunday, January 8 | Carolina Panthers +4.5 vs. New Orleans Saints -4.5 |
| Sunday, January 8 | Tampa Bay Buccaneers -7.5 vs. Atlanta Falcons +7.5 |
| Sunday, January 8 | LA Chargers PK vs. Denver Broncos PK |
