NFL Opening Lines For Every Game Of The 2022 – 2023 Season

Written By Juan Carlos Blanco on May 18, 2022
NFL lines every game of the season each week

We are still a few months away from the start of the 2022 – 2023 NFL season but select lines have already been posted by legal online sportsbooks. As the dates of more and more games are learned following the league’s schedule release, more and more books will be posting odds for each contest. Below we will post lines for every single game of the 2022 – 2023 season, with point spreads for each game and a mini betting preview of each week.

Week 1

Here are NFL lines for the first week of the season.

DateOpening NFL Week 1 odds: SpreadOpening NFL Week 1 odds: MoneylineOpening NFL Week 1 odds: Over Under
Thursday, September 8Buffalo Bills +1 at LA Rams -1Buffalo Bills -110 vs. LA Rams -110Over Under 52
Sunday, September 11San Francisco 49ers -6.5 vs. Chicago Bears +6.5San Francisco 49ers -275 vs. Chicago Bears +220Over Under 42.5
Sunday, September 11Jacksonville Jaguars +4 vs. Washington Commanders -4Jacksonville Jaguars +160 vs. Washington Commanders -190Over Under 44.5
Sunday, September 11Pittsburgh Steelers +6.5 vs. Cincinnati Bengals -6.5Pittsburgh Steelers +200 vs. Cincinnati Bengals -250Over Under 45
Sunday, September 11New Orleans Saints -3.5 vs. Atlanta Falcons +3.5New Orleans Saints -180 vs. Atlanta Falcons +155Over Under 42
Sunday, September 11Cleveland Browns -3.5 vs. Carolina Panthers +3.5Cleveland Browns -180 vs. Carolina Panthers +155Over Under 42.5
Sunday, September 11Baltimore Ravens -4.5 vs. New York Jets +4.5Baltimore Ravens -195 vs. New York Jets +165Over Under 45
Sunday, September 11Philadelphia Eagles -4 vs. Detroit Lions +4Philadelphia Eagles -190 vs. Detroit Lions +160Over Under 46.5
Sunday, September 11New England Patriots +3 vs. Miami Dolphins -3New England Patriots +135 vs. Miami Dolphins -155Over Under 45
Sunday, September 11Indianapolis Colts -7.5 vs. Houston Texans +7.5Indianapolis Colts -380 vs. Houston Texans +290Over Under 44.5
Sunday, September 11New York Giants +6.5 vs. Tennessee Titans -6.5New York Giants +235 vs. Tennessee Titans -300Over Under 44
Sunday, September 11Green Bay Packers -1.5 vs. Minnesota Vikings +1.5Green Bay Packers -120 vs. Minnesota Vikings +100Over Under 49
Sunday, September 11Las Vegas Raiders +4 vs. LA Chargers -4Las Vegas Raiders +155 vs. LA Chargers -180Over Under 52
Sunday, September 11Kansas City Chiefs -3 vs. Arizona Cardinals +3Kansas City Chiefs -150 vs. Arizona Cardinals +130Over Under 53
Sunday, September 11Tampa Bay Buccaneers -2.5 vs. Dallas Cowboys +2.5Tampa Bay Buccaneers -135 vs. Dallas Cowboys +115Over Under 51.5
Monday, September 12Denver Broncos -4 vs. Seattle Seahawks +4Denver Broncos -190 vs. Seattle Seahawks +160Over Under 41

For a complete betting breakdown of NFL Week 1 odds head here.

Week 2

A look at NFL lines for the second week of the season. The odds displayed are from DraftKings Sportsbook.

DateOpening NFL Week 2 odds
Thursday, September 15LA Chargers +3 at Kansas City Chiefs -3
Sunday, September 18Washington Commanders +1 at Detroit Lions -1
Sunday, September 18Tampa Bay Buccaneers -3.5 at New Orleans Saints +3.5
Sunday, September 18New England Patriots -1 at Pittsburgh Steelers +1
Sunday, September 18Miami Dolphins +4 at Baltimore Ravens -4
Sunday, September 18Carolina Panthers +1 at New York Giants -1
Sunday, September 18Indianapolis Colts -4.5 at Jacksonville Jaguars +4.5
Sunday, September 18Seattle Seahawks +7.5 at San Francisco 49ers -7.5
Sunday, September 18Atlanta Falcons +13 at LA Rams -13
Sunday, September 18Cincinnati Bengals PK at Dallas Cowboys PK
Sunday, September 18Arizona Cardinals +3.5 at Las Vegas Raiders -3.5
Sunday, September 18Houston Texans +10 at Denver Broncos -10
Sunday, September 18Chicago Bears +8 at Green Bay Packers -8
Monday, September 19Tennessee Titans +7 at Buffalo Bills -7
Monday, September 19Minnesota Vikings +2.5 at Philadelphia Eagles -2.5

The Chargers finished their first season under Brandon Staley running on fumes and out of the postseason following a hot start, going 5-7 after winning four of their first five games. Los Angeles lost three of its last four, a sample that included a pair of overtime defeats. The Bolts return all of last season’s key components on the offensive end with the exception of tight end, where they actually got younger by swapping out Jared Cook for Gerald Everett. However, L.A. made some impressive additions to a defense that finished No. 23 in total yards per game allowed with the acquisitions of Khalil Mack, J.C. Jackson and Kyle Van Noy this offseason.

Meanwhile, the Chiefs’ regular-season trajectory was almost a diametric opposite of the Chargers, as they finished 9-1 after a concerning 3-4 start that included a 30-24 loss to Los Angeles at Arrowhead Stadium in Week 3. KC then walloped the Steelers in Ben Roethlisberger’s swan song in the wild-card round before pulling off an OT miracle against the Bills in the divisional round. However, the Bengals returned the favor the following week, qualifying for the Super Bowl on the backs of Patrick Mahomes and company with their own 27-24 OT win. The prevailing thought had been that a retool and reload for Andy Reid’s team would be in order this offseason, but instead, Kansas City surprisingly traded Tyreek Hill to the Dolphins and will attempt to replace him with the duo of JuJu Smith-Schuster and Marquez Valdes-Scantling, among others.

The two teams split the season series last season and how the KC offense will look without Hill will be one of the biggest questions heading into the season. Therefore, the narrow opening line of Chiefs -3 and low 50s projected total is understandable based on where things currently stand.

The Titans’12-5 record was good enough to take the AFC South by three games last season, but Mike Vrabel’s club became the eventual AFC champion Cincinnati Bengals’ second victim in their memorable postseason run with a 19-16 loss in the divisional round. Tennessee then surprisingly traded away its most explosive pass catcher just before the start of the NFL Draft when it moved A.J. Brown to the Eagles. That leaves the receiver they grabbed with one of the picks netted in that transaction, Arkansas product Treylon Burks, and veteran offseason acquisitions Robert Woods and Austin Hooper as the top targets for veteran Ryan Tannehill. Then, Derrick Henry should be back to 100 percent after a foot injury led to him missing the last nine games of the season before a return for the divisional-round loss.

The Bills had their own heartbreaking divisional-round defeat last January, with the Chiefs shocking Buffalo in a wild fourth quarter and overtime. The heartbreaking defeat naturally left Sean McDermott’s team hungry for retribution, and with such a talented roster already in place, Buffalo concentrated on making some select yet noteworthy additions in a bid to get over the top in 2022. Notably, the top two come from the defending champion Rams, as veteran guard Rodger Saffold and linebacker Von Miller both now wear blue and white. Meanwhile, crafty slot man Jamison Crowder shapes up as an even swap at minimum for the departed Cole Beasley, and Buffalo is also banking on a true breakout season from speedy Gabriel Davis after his memorable eight-catch, 201-yard, four-touchdown effort in the aforementioned divisional-round loss to the Chiefs.

With the trade of Tyreek Hill to the Dolphins, the Bills are odds-on favorites to win Super LVII, so their seven-point projected advantage for this opener at home, where they went 5-3-2 ATS last season and postseason, is also no surprise.

The Vikings begin a new era in 2022 after eight seasons under Mike Zimmer, as Kevin O’Connell, most recently offensive coordinator of the defending champion Rams, is now at the helm. The team ensured O’Connell wouldn’t be starting from scratch or with a retread at quarterback when it inked Kirk Cousins to a one-year $35 million extension. The team stood largely pat this offseason in terms of offensive personnel, although the presumed return to health of promising tight end Irv Smith after he missed all of 2021 with a meniscus injury should give the air attack a boost. Minnesota was more active in replenishing the other side of the ball, acquiring Za’Darius Smith and Jordan Hicks to revamp its linebacking corps and drafting highly regarded Lewis Cine at safety.

The Eagles made plenty of headlines with the acquisition of Brown from the Titans, a move that immediately props up what had been an alarmingly thin receiving corps. With Brown in the fold, DeVonta Smith and Dallas Goedert should certainly be the subject of less defensive attention, while free-agent signee Zach Pascal can slot into the No. 3 role he’s best suited for. If Miles Sanders can enjoy better health and better utilization in 2022, Philadelphia’s Jalen Hurts-led offense could certainly take a big step forward. The defense, which already finished No. 10 in yards per game allowed last season (329.9), could be even better with the additions of Haason Reddick and Kyzir White to the linebacker corps.

The Eagles, just 3-4-1 ATS last season at home, are 2.5-point favorites over a Vikings squad that went 5-4 against the number as a road team in 2021.

Week 3

Here are point spreads for the third week of the season.

DateOpening NFL Week 3 odds: Spread
Thursday, September 22Pittsburgh Steelers at Cleveland Browns - OTB
Sunday, September 25Baltimore Ravens pk at New England Patriots pk
Sunday, September 25New Orleans Saints -2 at Carolina Panthers +2
Sunday, September 25Philadelphia Eagles pk at Washington Commanders pk
Sunday, September 25Houston Texans +3 at Chicago Bears -3
Sunday, September 25Kansas City Chiefs -2.5 at Indianapolis Colts +2.5
Sunday, September 25Cincinnati Bengals -5 at New York Jets +5
Sunday, September 25Las Vegas Raiders +1 at Tennessee Titans -1
Sunday, September 25Buffalo Bills -3.5 at Miami Dolphins +3.5
Sunday, September 25Detroit Lions +5 at Minnesota Vikings -5
Sunday, September 25Jacksonville Jaguars +10.5 at Los Angeles Chargers -10.5
Sunday, September 25Green Bay Packers +3.5 at Tampa Bay Buccaneers -3.5
Sunday, September 25Atlanta Falcons +4 at Seattle Seahawks -4
Sunday, September 25Los Angeles Rams -2 at Arizona Cardinals +2
Sunday, September 25San Francisco 49ers +2.5 at Denver Broncos -2.5
Monday, September 26Dallas Cowboys at -3 New York Giants +3

Week 4

A glance at NFL lines for the fourth week of the campaign.

DateOpening NFL Week 4 odds: Spread
Thursday, September 29Miami Dolphins +4.5 at Cincinnati Bengals -4.5
Sunday, October 2Minnesota Vikings -1 at New Orleans Saints +1
Sunday, October 2Kansas City Chiefs +2.5 at Tampa Bay Buccaneers -2.5
Sunday, October 2New York Jets +3.5 at vs. Pittsburgh Steelers -3.5
Sunday, October 2Tennessee Titans +3 at Indianapolis Colts -3
Sunday, October 2Los Angeles Chargers -7.5 at Houston Texans +7.5
Sunday, October 2Jacksonville Jaguars +6 at Philadelphia Eagles -6
Sunday, October 2Chicago Bears +2.5 at New York Giants -2.5
Sunday, October 2Seattle Seahawks +1 at Detroit Lions -1
Sunday, October 2 Washington Commanders +5 at Dallas Cowboys -5
Sunday, October 2Buffalo Bills -1 at Baltimore Ravens +1
Sunday, October 2Arizona Cardinals -2.5 at Carolina Panthers +2.5
Sunday, October 2New England Patriots +5 at Green Bay Packers -5
Sunday, October 2Denver Broncos pk at Las Vegas Raiders pk
Monday, October 3Los Angeles Rams -1 at San Francisco 49ers +1

The Vikings will travel overseas for their fourth game under new head coach Kevin O’Connell to meet another NFC team that features a (semi) new face taking over for a franchise stalwart. New Orleans’ Sean Payton was one of two surprise coaching retirements this offseason, a development that ultimately resulted in defensive coordinator and former Raiders head coach Dennis Allen ascending to the top of the Saints staff.

Allen inherits a team that could be a lot more cohesive than a season ago, its first without Drew Brees since 2005. New Orleans was forced to go through a quarterback carousel of Jameis Winston, Taysom Hill, Trevor Siemian and even then-rookie Ian Book while also making do without star wideout Michael Thomas (ankle) for an entire season. That left the proverbial bullseye frequently on the back of Alvin Kamara, but the spotlight should shine a lot less brightly this season. Thomas is expected to be back to full strength, while first-round pick Chris Olave is projected to immediately slot into the No. 2 role. Allen will also still have plenty of sway over a defense that just added multi-time Pro Bowl safety Tyrann Mathieu following the draft.

Week 5

Here are NFL lines for the fifth week of the 2022 – 2023 season.

Date Opening NFL Week 5 odds: Spread
Thursday, October 6Indianapolis Colts +3 at Denver Broncos -3
Sunday, October 9 New York Giants +6.5 at Green Bay Packers -6.5
Sunday, October 9 Chicago Bears +4.5 at Minnesota Vikings -4.5
Sunday, October 9 Seattle Seahawks +4.5 at New Orleans Saints -4.5
Sunday, October 9 Pittsburgh Steelers +8 at Buffalo Bills -8
Sunday, October 9 Atlanta Falcons +10.5 at Tampa Bay Buccaneers
Sunday, October 9Houston Texans
+3 at Jacksonville Jaguars -3
Sunday, October 9 Detroit Lions +5 at New England Patriots -5 -5
Sunday, October 9Tennessee Titans pk at Washington Commanders pk
Sunday, October 9Miami Dolphins -2.5 at New York Jets +2.5
Sunday, October 9San Francisco 49ers -3 at Carolina Panthers +3
Sunday, October 9Philadelphia Eagles +2 at Arizona Cardinals -2
Sunday, October 9Dallas Cowboys +4.5 at Los Angeles Rams -4.5
Sunday, October 9Cincinnati Bengals +1 at Baltimore Ravens -1
Monday, October 10Las Vegas Raiders +4.5 at Kansas City Chiefs -4.5

The Giants will be heading into the fifth game of the Brian Daboll Era by the time this overseas trip rolls around. New York was in need of a major makeover after two years of Joe Judge, the second culminating in a 4-13 mark. Daniel Jones enters a pivotal year, as his fifth-year option for 2023 wasn’t picked up this offseason. The hope is that Daboll’s influence, which certainly had a seismically important impact on the development of Josh Allen the last four seasons in Buffalo, makes all the difference for Jones, who’s already had to endure multiple coaching and coordinator changes during his first three years in the league. He’s projected to work with mostly the same skill-position group from a year ago, although better health for Kenny Golladay, Sterling Shepard, Kadarius Toney and Darius Slayton would go a long way toward making the former Duke signal-caller’s life easier.

It’s been a tumultuous offseason in Title Town USA, one that began with some mystery surrounding Aaron Rodgers’ plans for 2022. No sooner was that settled via Rodgers’ announcement he’d return to Green Bay for a 15th season than the team traded Davante Adams to the Raiders in the first of what’s turned out to be a season of significant change in the receiver landscape around the league. Rodgers is now without his favorite target, and the Packers’ attempts to address the significant vacuum Adams’ departure created appear underwhelming on paper. Injury-prone Sammy Watkins may not be suited to anything better than a No. 3 role at this point in his career, while rookie second-round pick Christian Watson is almost certainly going to need most of the season to truly acclimate to the NFL after playing his college ball at North Dakota State.

The Packers open as big favorites, but that number could easily change if these two teams actually appear to be about even on offense over the first four games of the season.

Week 6

Here we take stock of pro football lines for the sixth week of the season.

DateOpening NFL Week 6 odds
Thursday, October 13Washington Commanders pk at Chicago Bears pk
Sunday, October 16Tampa Bay Buccaneers -3.5 at Pittsburgh Steelers +3.5
Sunday, October 16Minnesota Vikings +3 at Miami Dolphins -3
Sunday, October 16Baltimore Ravens -3.5 at New York Giants +3.5
Sunday, October 16Cincinnati Bengals -1 at New Orleans Saints +1
Sunday, October 16San Francisco 49ers -5.5 at Atlanta Falcons +5.5
Sunday, October 16Jacksonville Jaguars +7 at Indianapolis Colts -7
Sunday, October 16New York Jets +7.5 at Green Bay Packers -7.5
Sunday, October 16Arizona Cardinals -2.5 at Seattle Seahawks +2.5
Sunday, October 16Carolina Panthers +9 at Los Angeles Rams -9
Sunday, October 16Buffalo Bills -1.5 at Kansas City Chiefs +1.5
Sunday, October 16Dallas Cowboys pk at Philadelphia Eagles pk
Monday, October 17Denver Broncos +3 at Los Angeles Chargers -3

Week 7

A look at lines for the seventh week of the campaign.

DateOpening NFL Week 7 odds
Thursday, October 20New Orleans Saints +3 at Arizona Cardinals -3
Sunday, October 23New York Giants +1.5 at Jacksonville Jaguars -1.5
Sunday, October 23Indianapolis Colts pk at Tennessee Titans pk
Sunday, October 23Green Bay Packers -3 at Washington Commanders +3
Sunday, October 23Detroit Lions +6.5 at Dallas Cowboys -6.5
Sunday, October 23Tampa Bay Buccaneers -5 at Carolina Panthers +5
Sunday, October 23Atlanta Falcons +10 at Cincinnati Bengals -10
Sunday, October 23New York Jets +7.5 at Denver Broncos -7.5
Sunday, October 23Houston Texans +8 at Las Vegas Raiders -8
Sunday, October 23Seattle Seahawks +8.5 at Los Angeles Chargers -8.5
Sunday, October 23Kansas City Chiefs -1 at San Francisco 49ers +1
Sunday, October 23Pittsburgh Steelers +3.5 at Miami Dolphins -3.5
Monday, October 24Chicago Bears +5 at New England Patriots -5

Week 8

Here are spreads for the eighth weekend of the pro football season.

DateOpening NFL Week 8 odds
Thursday, October 27Baltimore Ravens +3.5 at Tampa Bay Buccaneers -3.5
Sunday, October 30Denver Broncos -6.5 at vs. Jacksonville Jaguars +6.5
Sunday, October 30Pittsburgh Steelers +3 at Philadelphia Eagles -3
Sunday, October 30Chicago Bears +7 at Dallas Cowboys -7
Sunday, October 30Miami Dolphins -3 at Detroit Lions +3
Sunday, October 30Arizona Cardinals +1 at Minnesota Vikings -1
Sunday, October 30Carolina Panthers pk at Atlanta Falcons pk
Sunday, October 30Las Vegas Raiders -1 at New Orleans Saints +1
Sunday, October 30New England Patriots -1.5 at New York Jets +1.5
Sunday, October 30Tennessee Titans -4.5 at Houston Texans +4.5
Sunday, October 30San Francisco 49ers +4.5 at Los Angeles Rams -4.5
Sunday, October 30New York Giants +2.5 at Seattle Seahawks -2.5
Sunday, October 30Green Bay Packers +4 at Buffalo Bills -4

The Broncos will be one of the most closely watched teams this season as they begin an exciting new era on offense under Russell Wilson. The acquisition of the long-time Seahawk was the headliner in one of the biggest trades in an offseason full of them when he was moved to Denver on March 16th for multiple players and picks. Wilson walks into a talented offense for which he could well prove to be the missing piece, as Javonte Williams, Melvin Gordon, Jerry Jeudy, Courtland Sutton and the promising Albert Okwuegbunam are already in place. Additionally, the Broncos get back KJ Hamler, a talented slot wideout who missed the last 14 games of 2021 with a torn ACL. On defense, the addition of Randy Gregory to a talented front seven that’s back up by a potential shutdown secondary could take the unit to the next level.

The Jaguars suffered through a mostly ignominious 2021 season that began with no shortage of hype and promise. However, just about every hope the Jacksonville faithful had about a new beginning for the franchise began crumbling in preseason when rookie first-round pick Travis Etienne suffered a Lisfranc injury that sidelined him for the season. Meyer eventually was fired after leading the Jags to a 2-11 mark through the first 13 games, while first overall pick Trevor Lawrence endured a difficult rookie season that included a 12:17 TD:INT, 59.6 percent completion rate and 32 sacks. The Clemson product will now work under the tutelage of Doug Pederson and has gained Christian Kirk and Evan Engram as new targets, but it remains to be seen how big a leap he’ll be able to make in his second year after having to learn a new offense for the second time in as many offseasons.

The Broncos could be even bigger favorites by the time this game rolls around if the improvement Wilson is expected to bring is as significant as projected and the Jaguars struggle to get their bearings early.

Week 9

A look at NFL lines for the ninth weekend of the season.

DateOpening NFL Week 9 odds
Thursday, November 3Philadelphia Eagles -4.5 at Houston Texans +4.5
Sunday, November 6Minnesota Vikings pk at Washington Commanders pk
Sunday, November 6Las Vegas Raiders -3 at Jacksonville Jaguars +3
Sunday, November 6Miami Dolphins -3 at Chicago Bears +3
Sunday, November 6Buffalo Bills -6.5 at New York Jets +6.5
Sunday, November 6Los Angeles Chargers -6.5 at Atlanta Falcons +6.5
Sunday, November 6Indianapolis Colts pk at New England Patriots pk
Sunday, November 6Carolina Panthers +8.5 at Cincinnati Bengals -8.5
Sunday, November 6Green Bay Packers -5 at Detroit Lions +5
Sunday, November 6Seattle Seahawks +5.5 at Arizona Cardinals -5.5
Sunday, November 6Los Angeles Rams +1.5 at Tampa Bay Buccaneers -1.5
Sunday, November 6Tennessee Titans +5 at Kansas City Chiefs -5
Monday, November 7Baltimore Ravens -1 at New Orleans Saints +1

Week 10

Here are spreads for the 10th weekend of the season.

DateOpening NFL Week 10 odds
Friday, November 11Atlanta Falcons +3 at Carolina Panthers -3
Sunday, November 13Seattle Seahawks +9.5 at Tampa Bay Buccaneers -9.5
Sunday, November 13Dallas Cowboys +4 at vs. Green Bay Packers -4
Sunday, November 13Detroit Lions +1.5 at Chicago Bears -1.5
Sunday, November 13New Orleans Saints +1.5 at Pittsburgh Steelers -1.5
Sunday, November 13Denver Broncos pk at Tennessee Titans pk
Sunday, November 13Minnesota Vikings +7.5 at Buffalo Bills -7.5
Sunday, November 13Jacksonville Jaguars +10 at Kansas City Chiefs -10
Sunday, November 13Houston Texans +3 at New York Giants -3
Sunday, November 13Indianapolis Colts +2 at Las Vegas Raiders -2
Sunday, November 13Arizona Cardinals +6 at Los Angeles Rams -6
Sunday, November 13Los Angeles Chargers pk at San Francisco 49ers pk
Monday, November 14Washington Commanders +3.5 at Philadelphia Eagles -3.5

The Seahawks moved on from franchise legend and nine-time Pro Bowler Russell Wilson this offseason, and by the time this game rolls around, they’ll presumably be deep into Drew Lock’s or Geno Smith’s starting tenure. Seattle’s offense could well prove positively pedestrian under either player or even Jacob Eason, even with Tyler Lockett and DK Metcalf still heading up the wideout corps, Rashaad Penny, second-round pick Kenneth Walker and potentially Chris Carson in the backfield and talented and perhaps misused-to-date tight end Noah Fant. Neither Lock nor Smith have done anything in their careers suggesting they’re the long-term answer at quarterback, and they certainly could drag down even a talented group of skill-position players with them on many weeks.

There’s been no shortage of news surrounding the Buccaneers this offseason, considering the 41-day retirement of Tom Brady and the sudden departure from the head coaching ranks of Bruce Arians. After the smoke cleared, both men remain with the organization, albeit with Arians now in the front office. General manager Jason Licht once again did a bang-up job holding on to key offensive pieces, inking Chris Godwin and Leonard Fournette to contracts this offseason. He also found the room to do some prudent free-agent spending in the form of Russell Gage and Logan Ryan, the type of veteran signings that can often serve as the final piece of the puzzle for Super Bowl contenders.

The Buccaneers’ heavy favorite status is naturally based on preseason projections at this point, but it could well hold just as true by the time this game rolls around.

Claim Your $1,050 Bonus at DraftKings Sportsbook
1
Up to $1,050 FREE
New User Bonus. T&Cs Apply.
NBA Playoffs Promo: Bet $5 Win $150
PLUS $50 Free On Deposit
PLUS Up to $1,000 Deposit Bonus
To Claim: Click Play Now

Week 11

A look at NFL lines for the 11th weekend of the campaign.

DateOpening NFL Week 11 odds
Thursday, November 17Tennessee Titans +4.5 at Green Bay Packers -4.5
Sunday, November 20Chicago Bears PK at Atlanta Falcons PK
Sunday, November 20Washington Commanders -3 at Houston Texans +3
Sunday, November 20Carolina Panthers +7 at Baltimore Ravens -7
Sunday, November 20New York Jets +6 at New England Patriots -6
Sunday, November 20LA Rams -3 at New Orleans Saints +3
Sunday, November 20Philadelphia Eagles +3 at Indianapolis Colts -3
Sunday, November 20Detroit Lions +1.5 at New York Giants -1.5
Sunday, November 20Las Vegas Raiders +3 at Denver Broncos -3
Sunday, November 20Dallas Cowboys PK at Minnesota Vikings PK
Sunday, November 20Kansas City Chiefs +1.5 at LA Chargers -1.5
Sunday, November 20Cincinnati Bengals -2.5 at Pittsburgh Steelers +2.5
Monday, November 21San Francisco 49ers -2.5 at Arizona Cardinals +2.5

Will Trey Lance be under center for the 49ers by the time this game rolls around? That’s one of the key questions for San Francisco as it enters 2022 trying to take the final step to return to the Super Bowl after falling just narrowly short of the Big Game last January. Jimmy Garoppolo got the Niners to within four points of overcoming the eventual SB champion Rams in the NFC Championship Game, but he’s been the subject of trade rumors from virtually the moment that game ended. Then, standout wide receiver Deebo Samuel is requesting to become the latest big-name player at his position to be traded this offseason, so whether he’s still in a San Francisco uniform by the time this game rolls around remains to be seen.

The Cardinals have had their fair share of offseason personnel-related drama, and it’s been almost exclusively centered on star quarterback Kyler Murray. The two-time Pro Bowler wants a long-term deal before the start of the ’22 season, but with Arizona already picking up his fifth-year option for 2023, it would seem highly likely Murray is under center for this game barring injury. He should be working with both offseason acquisition Marquise Brown and DeAndre Hopkins by the time this game comes to pass, as the latter will have finished the six-game PED suspension he’ll serve to open the season.

The Cardinals swept the season series in 2021, but the Niners got much further and may indeed still retain favorites status by the time this game kicks off.

Week 12

Here are NFL lines for the 12th weekend of the pro football season.

DateOpening NFL Week 12 odds
Thursday, November 24Buffalo Bills -8 at Detroit Lions +8
Thursday, November 24New York Giants +7 at Dallas Cowboys -7
Thursday, November 24New England Patriots +1.5 at Minnesota Vikings -1.5
Sunday, November 27Denver Broncos -4 at Carolina Panthers +4
Sunday, November 27Cincinnati Bengals PK at Tennessee Titans PK
Sunday, November 27Baltimore Ravens -4 at Jacksonville Jaguars +4
Sunday, November 27Atlanta Falcons +5 at Washington Commanders -5
Sunday, November 27Houston Texans +7 at Miami Dolphins -7
Sunday, November 27Chicago Bears +2 at New York Jets -2
Sunday, November 27LA Chargers -1.5 at Arizona Cardinals +1.5
Sunday, November 27Las Vegas Raiders -2 at Seattle Seahawks +2
Sunday, November 27New Orleans Saints +4 at San Francisco 49ers -4
Sunday, November 27LA Rams +2.5 at Kansas City Chiefs -2.5
Sunday, November 27Green Bay Packers PK at Philadelphia Eagles PK
Monday, November 28Pittsburgh Steelers +4.5 at Indianapolis Colts -4.5

Week 13

A glance at spreads for the 13th week of the season.

DateOpening NFL Week 13 odds
Thursday, December 1Buffalo Bills -3 at New England Patriots +3
Sunday, December 4Green Bay Packers -4 at Chicago Bears +4
Sunday, December 4Jacksonville Jaguars +2 at Detroit Lions -2
Sunday, December 4Washington Commanders PK at New York Giants PK
Sunday, December 4Tennessee Titans +1 at Philadelphia Eagles -1
Sunday, December 4Denver Broncos +1.5 at Baltimore Ravens -1.5
Sunday, December 4New York Jets +4.5 at Minnesota Vikings -4.5
Sunday, December 4Pittsburgh Steelers -2.5 at Atlanta Falcons +2.5
Sunday, December 4Seattle Seahawks +9.5 at LA Rams -9.5
Sunday, December 4Miami Dolphins +3.5 at San Francisco 49ers -3.5
Sunday, December 4Kansas City Chiefs PK at Cincinnati Bengals PK
Sunday, December 4LA Chargers PK at Las Vegas Raiders
Sunday, December 4Indianapolis Colts +2.5 at Dallas Cowboys -2.5
Monday, December 5New Orleans Saints +6.5 at Tampa Bay Buccaneers -6.5

Week 14

Taking stock of NFL lines for the 14th weekend of the season.

DateOpening NFL Week 14 odds
Thursday, December 8Las Vegas Raiders +4 at LA Rams -4
Sunday, December 11Jacksonville Jaguars +6.5 at Tennessee Titans -6.5
Sunday, December 11New York Jets +9.5 at Buffalo Bills -9.5
Sunday, December 11Houston Texans +8 at Dallas Cowboys -8
Sunday, December 11Philadelphia Eagles -1.5 at New York Giants +1.5
Sunday, December 11Minnesota Vikings -2 at Detroit Lions +2
Sunday, December 11Baltimore Ravens -2 at Pittsburgh Steelers +2
Sunday, December 11Miami Dolphins +5.5 at LA Chargers -5.5
Sunday, December 11Carolina Panthers +2.5 at Seattle Seahawks -2.5
Sunday, December 11Tampa Bay Buccaneers PK at San Francisco 49ers PK
Sunday, December 11Kansas City Chiefs PK at Denver Broncos PK
Monday, December 12New England Patriots +2.5 at Arizona Cardinals -2.5

Week 15

Here are lines for NFL games for the 15th weekend of the campaign.

DateOpening NFL Week 15 odds
Thursday, December 15San Francisco 49ers -3 at Seattle Seahawks +3
Sunday, December 18Philadelphia Eagles -2.5 at Chicago Bears +2.5
Sunday, December 18Kansas City Chiefs -10 at Houston Texans +10
Sunday, December 18Detroit Lions +2.5 at New York Jets -2.5
Sunday, December 18Dallas Cowboys -3.5 at Jacksonville Jaguars +3.5
Sunday, December 18Pittsburgh Steelers -1 at Carolina Panthers +1
Sunday, December 18New York Giants +3.5 at Washington Commanders -3.5
Sunday, December 18Miami Dolphins +6 at Buffalo Bills -6
Sunday, December 18Indianapolis Colts PK at Minnesota Vikings PK
Sunday, December 18Atlanta Falcons +5 at New Orleans Saints -5
Sunday, December 18Arizona Cardinals +4 at Denver Broncos -4
Sunday, December 18Cincinnati Bengals +3 at Tampa Bay Buccaneers -3
Sunday, December 18Tennessee Titans +5 at LA Chargers -5
Sunday, December 18New England Patriots +3 at Las Vegas Raiders -3
Monday, December 19LA Rams PK at Green Bay Packers PK

Week 16

The holidays have arrived as we look at NFL lines for the 16th weekend of the season.

DateOpening NFL Week 16 odds
Thursday, December 22Jacksonville Jaguars +2.5 at New York Jets -2.5
Saturday, December 24Houston Texans +8 at Tennessee Titans -8
Saturday, December 24New York Giants +5 at Minnesota Vikings -5
Saturday, December 24Cincinnati Bengals -1 vs. New England Patriots +1
Saturday, December 24Detroit Lions +2.5 at Carolina Panthers -2.5
Saturday, December 24Seattle Seahawks +10.5 at Kansas City Chiefs -10.5
Saturday, December 24Atlanta Falcons +7.5 at Baltimore Ravens -7.5
Saturday, December 24Buffalo Bills -7 at Chicago Bears +7
Saturday, December 24Washington Commanders +6 at San Francisco 49ers -6
Saturday, December 24Philadelphia Eagles +3.5 at Dallas Cowboys -3.5
Saturday, December 24Las Vegas Raiders -1.5 at Pittsburgh Steelers +1.5
Sunday, December 25Green Bay Packers -1 at Miami Dolphins +1
Sunday, December 25Denver Broncos +3.5 at LA Rams -3.5
Sunday, December 25Tampa Bay Buccaneers -2.5 at Arizona Cardinals +2.5
Monday, December 26LA Chargers -1 at Indianapolis Colts +1

This showdown between Russell Wilson and a team he knows extremely well from his NFC West days – and which also happens to be the defending Super Bowl champion – rightfully garners the holiday spotlight. Wilson has compiled 4,304 yards and a 26:13 TD:INT against the Rams in 20 career games, but he’s only 3-8, including one playoff game, against Los Angeles since Sean McVay took the head coaching reins in 2017.

There should definitely be a good read on how well the nine-time Pro Bowler has acclimated to his new Denver teammates by this point in the season. Meanwhile, the Rams title-defense campaign will be nearing its end stages and there should be a good feel for how close the ’22 edition of Sean McVay’s squad is to the prior year’s. L.A. will once again feature Matthew Stafford under center, but the pass-catching corps will have a different look with Robert Woods now in Tennessee, Odell Beckham, who suffered an ACL tear in the Super Bowl win over the Bengals, perhaps not on the roster, and new No. 2 wideout Allen Robinson hoping to reignite his career in McVay’s offense.

Week 17

The calendar turns to 2023 as we look at lines for the penultimate weekend of the regular season.

DateOpening NFL Week 17 odds
Thursday, December 29Dallas Cowboys +1.5 at Tennessee Titans -1.5
Sunday, January 1Indianapolis Colts -3 vs. New York Giants +3
Sunday, January 1Carolina Panthers +9 at Tampa Bay Buccaneers -9
Sunday, January 1New Orleans Saints +3 at Philadelphia Eagles -3
Sunday, January 1Chicago Bears +1.5 at Detroit Lions -1.5
Sunday, January 1Miami Dolphins +1.5 at New England Patriots -1.5
Sunday, January 1Arizona Cardinals -3.5 at Atlanta Falcons +3.5
Sunday, January 1Denver Broncos +4.5 at Kansas City Chiefs -4.5
Sunday, January 1Pittsburgh Steelers +5.5 at Baltimore Ravens -5.5
Sunday, January 1Jacksonville Jaguars PK at Houston Texans PK
Sunday, January 1New York Jets +1.5 at Seattle Seahawks -1.5
Sunday, January 1Minnesota Vikings +5.5 at Green Bay Packers -5.5
Sunday, January 1San Francisco 49ers +1.5 at Las Vegas Raiders -1.5
Sunday, January 1LA Rams +1.5 at LA Chargers -1.5
Monday, January 2Buffalo Bills PK at Cincinnati Bengals PK

Week 18

Teams will be scrambling for a spot in the NFL Playoffs as we look at opening spreads for the final weekend.

DateOpening NFL Week 18 odds
Sunday, January 8Baltimore Ravens +3 at Cincinnati Bengals -3
Sunday, January 8New England Patriots +7 at Buffalo Bills -7
Sunday, January 8Minnesota Vikings -1.5 at Chicago Bears +1.5
Sunday, January 8Detroit Lions +8 at Green Bay Packers -8
Sunday, January 8New York Giants +5 at Philadelphia Eagles -5
Sunday, January 8Houston Texans +8.5 at Indianapolis Colts -8.5
Sunday, January 8New York Jets +5.5 at Miami Dolphins -5.5
Sunday, January 8Tennessee Titans -3 at Jacksonville Jaguars +3
Sunday, January 8LA Rams -5.5 at Seattle Seahawks +5.5
Sunday, January 8Kansas City Chiefs -2 vs. Las Vegas Raiders +2
Sunday, January 8Dallas Cowboys -1 vs. Washington Commanders +1
Sunday, January 8Arizona Cardinals +3 vs. San Francisco 49ers -3
Sunday, January 8Carolina Panthers +4.5 vs. New Orleans Saints -4.5
Sunday, January 8Tampa Bay Buccaneers -7.5 vs. Atlanta Falcons +7.5
Sunday, January 8LA Chargers PK vs. Denver Broncos PK
Juan Carlos Blanco Avatar
Written by
Juan Carlos Blanco

Juan Carlos Blanco has served as a freelance writer for a wide variety of online publications and websites, with an intensive focus on fantasy sports. Juan has provided analysis and comprehensive coverage of the MLB, NBA, NFL, CFL, AAF and AFL while also reporting on news and developments in the daily fantasy sports and online gaming industries.

View all posts by Juan Carlos Blanco