NFL Opening Lines For Every Game Of The 2022 – 2023 Season

Written By Juan Carlos Blanco on August 17, 2022
NFL lines every game of the season each week

We are still a few weeks away from the start of the 2022 – 2023 pro football season but NFL odds for every week have already been posted by legal online sportsbooks. Below are lines for every single game of the 2022 – 2023 season, with point spreads for each game and a mini betting preview of each week.

Week 1

Here are NFL lines for the first week of the season.

DateOpening NFL Week 1 oddsNFL Week 1 Odds: August 17NFL Week 1 Odds: September 6NFL Week 1 Odds: September 9
Thursday, September 8Buffalo Bills +1 vs. LA Rams -1Buffalo Bills -2.5 vs. LA Rams +2.5Buffalo Bills -2.5 vs. LA Rams +2.5
Sunday, September 11San Francisco 49ers -6.5 vs. Chicago Bears +6.5San Francisco 49ers -7 vs. Chicago Bears +7San Francisco 49ers -7 vs. Chicago Bears +7San Francisco 49ers -7 vs. Chicago Bears +7
Sunday, September 11Jacksonville Jaguars +4 vs. Washington Commanders -4Jacksonville Jaguars +3.5 vs. Washington Commanders -3.5Jacksonville Jaguars +3 vs. Washington Commanders -3Jacksonville Jaguars +2.5 vs. Washington Commanders -2.5
Sunday, September 11Pittsburgh Steelers +6.5 vs. Cincinnati Bengals -6.5Pittsburgh Steelers +6.5 vs. Cincinnati Bengals -6.5Pittsburgh Steelers +6.5 vs. Cincinnati Bengals -6.5Pittsburgh Steelers +6.5 vs. Cincinnati Bengals -6.5
Sunday, September 11New Orleans Saints -3.5 vs. Atlanta Falcons +3.5New Orleans Saints -5 vs. Atlanta Falcons +5New Orleans Saints -5.5 vs. Atlanta Falcons +5.5New Orleans Saints -5.5 vs. Atlanta Falcons +5.5
Sunday, September 11Cleveland Browns -3.5 vs. Carolina Panthers +3.5Cleveland Browns +1 vs. Carolina Panthers -1Cleveland Browns +2.5 vs. Carolina Panthers -2.5Cleveland Browns vs. Carolina Panthers PK
Sunday, September 11Baltimore Ravens -4.5 vs. New York Jets +4.5Baltimore Ravens -7 vs. New York Jets +7Baltimore Ravens -7 vs. New York Jets +7Baltimore Ravens -6.5 vs. New York Jets +6.5
Sunday, September 11Philadelphia Eagles -4 vs. Detroit Lions +4Philadelphia Eagles -3.5 vs. Detroit Lions +3.5Philadelphia Eagles -4 vs,. Detroit Lions +4Philadelphia Eagles -4.5 vs. Detroit Lions +4.5
Sunday, September 11New England Patriots +3 vs. Miami Dolphins -3New England Patriots +3 vs. Miami Dolphins -3New England Patriots +3 vs. Miami Dolphins -3New England Patriots +3.5 vs. Miami Dolphins -3.5
Sunday, September 11Indianapolis Colts -7.5 vs. Houston Texans +7.5Indianapolis Colts -8 vs. Houston Texans +8Indianapolis Colts -8 vs. Houston Texans +8Indianapolis Colts -7 vs. Houston Texans +7
Sunday, September 11New York Giants +6.5 vs. Tennessee Titans -6.5New York Giants +6 vs. Tennessee Titans -6New York Giants +5.5 vs. Tennessee Titans -5.5New York Giants +5.5 vs. Tennessee Titans -5.5
Sunday, September 11Green Bay Packers -1.5 vs. Minnesota Vikings +1.5Green Bay Packers -2 vs. Minnesota Vikings +2Green Bay Packers -1.5 vs. Minnesota Vikings +1.5Green Bay Packers -1.5 vs. Minnesota Vikings +1.5
Sunday, September 11Las Vegas Raiders +4 vs. LA Chargers -4Las Vegas Raiders +3.5 vs. LA Chargers -3.5Las Vegas Raiders +3.5 vs. LA Chargers -3.5Las Vegas Raiders +3.5 vs. LA Chargers -3.5
Sunday, September 11Kansas City Chiefs -3 vs. Arizona Cardinals +3Kansas City Chiefs -3.5 vs. Arizona Cardinals +3.5Kansas City Chiefs -4.5 vs. Arizona Cardinals +4.5Kansas City Chiefs -6 vs. Arizona Cardinals +6
Sunday, September 11Tampa Bay Buccaneers -2.5 vs. Dallas Cowboys +2.5Tampa Bay Buccaneers -1.5 vs. Dallas Cowboys +1.5Tampa Bay Buccaneers -2 vs. Dallas Cowboys +2Tampa Bay Buccaneers -2.5 vs. Dallas Cowboys
Monday, September 12Denver Broncos -4 vs. Seattle Seahawks +4Denver Broncos -4.5 vs. Seattle Seahawks +4.5Denver Broncos -6.5 vs. Seattle Seahawks +6.5Denver Broncos -6.5 vs. Seattle Seahawks +6.5

For a complete betting breakdown of NFL Week 1 odds head here.

A Bills-Rams matchup to open the season on Thursday Night Football is about the very best the NFL could have conjured up from the defending champion Rams’ menu of opponents this season. The game currently features Los Angeles as a thin one-point home favorite and a 52-point projected total, figures that will certainly be subject to fluctuation as kickoff draws nearer.

Additionally, as is usually the case with opening weeks but even more so following such a wild offseason of personnel moves, there are plenty of intriguing matchups right out of the gate.

Among them are the projected debuts of Deshaun Watson in Cleveland after a missed 2021 season, Matt Ryan in Indianapolis after 14 seasons in Atlanta, Carson Wentz in his latest career reset in the nation’s capital and Davante Adams in the Silver and Black after a legendary run in Green Bay. Add in a Patrick Mahomes-Kyler Murray late-window battle Sunday afternoon that will serve as the Chiefs’ first game without the traded Tyreek Hill, and it’s a main slate that will be saturated with betting interest.

Then, the two primetime games are certainly fit for the league’s ribbon-cutting slate. Sunday night will see a rematch of last year’s season-opening clash between the Buccaneers and Cowboys that thrilled Thursday Night Football viewers, this time at AT & T Stadium in Arlington. Monday night, Russell Wilson will not only don a uniform other than the Seahawks’ for the first time, but he’ll be facing his old Seattle teammates right out of the gate at his previous Lumen Field digs in his Broncos regular-season debut.

Week 2

A look at NFL lines for the second week of the season. The odds displayed are from DraftKings Sportsbook.

DateOpening NFL Week 2 odds
Thursday, September 15LA Chargers +3 at Kansas City Chiefs -3
Sunday, September 18Washington Commanders +1 at Detroit Lions -1
Sunday, September 18Tampa Bay Buccaneers -3.5 at New Orleans Saints +3.5
Sunday, September 18New England Patriots -1 at Pittsburgh Steelers +1
Sunday, September 18Miami Dolphins +4 at Baltimore Ravens -4
Sunday, September 18Carolina Panthers +1 at New York Giants -1
Sunday, September 18Indianapolis Colts -4.5 at Jacksonville Jaguars +4.5
Sunday, September 18Seattle Seahawks +7.5 at San Francisco 49ers -7.5
Sunday, September 18Atlanta Falcons +13 at LA Rams -13
Sunday, September 18Cincinnati Bengals PK at Dallas Cowboys PK
Sunday, September 18Arizona Cardinals +3.5 at Las Vegas Raiders -3.5
Sunday, September 18Houston Texans +10 at Denver Broncos -10
Sunday, September 18Chicago Bears +8 at Green Bay Packers -8
Monday, September 19Tennessee Titans +7 at Buffalo Bills -7
Monday, September 19Minnesota Vikings +2.5 at Philadelphia Eagles -2.5

The Chargers finished their first season under Brandon Staley running on fumes and out of the postseason following a hot start, going 5-7 after winning four of their first five games. Los Angeles lost three of its last four, a sample that included a pair of overtime defeats. The Bolts return all of last season’s key components on the offensive end with the exception of tight end, where they actually got younger by swapping out Jared Cook for Gerald Everett. However, L.A. made some impressive additions to a defense that finished No. 23 in total yards per game allowed with the acquisitions of Khalil Mack, J.C. Jackson and Kyle Van Noy this offseason.

Meanwhile, the Chiefs’ regular-season trajectory was almost a diametric opposite of the Chargers, as they finished 9-1 after a concerning 3-4 start that included a 30-24 loss to Los Angeles at Arrowhead Stadium in Week 3. KC then walloped the Steelers in Ben Roethlisberger’s swan song in the wild-card round before pulling off an OT miracle against the Bills in the divisional round. However, the Bengals returned the favor the following week, qualifying for the Super Bowl on the backs of Patrick Mahomes and company with their own 27-24 OT win. The prevailing thought had been that a retool and reload for Andy Reid’s team would be in order this offseason, but instead, Kansas City surprisingly traded Tyreek Hill to the Dolphins and will attempt to replace him with the duo of JuJu Smith-Schuster and Marquez Valdes-Scantling, among others.

The two teams split the season series last season and how the KC offense will look without Hill will be one of the biggest questions heading into the season. Therefore, the narrow opening line of Chiefs -3 and low 50s projected total is understandable based on where things currently stand.

The Titans’12-5 record was good enough to take the AFC South by three games last season, but Mike Vrabel’s club became the eventual AFC champion Cincinnati Bengals’ second victim in their memorable postseason run with a 19-16 loss in the divisional round. Tennessee then surprisingly traded away its most explosive pass catcher just before the start of the NFL Draft when it moved A.J. Brown to the Eagles. That leaves the receiver they grabbed with one of the picks netted in that transaction, Arkansas product Treylon Burks, and veteran offseason acquisitions Robert Woods and Austin Hooper as the top targets for veteran Ryan Tannehill. Then, Derrick Henry should be back to 100 percent after a foot injury led to him missing the last nine games of the season before a return for the divisional-round loss.

The Bills had their own heartbreaking divisional-round defeat last January, with the Chiefs shocking Buffalo in a wild fourth quarter and overtime. The heartbreaking defeat naturally left Sean McDermott’s team hungry for retribution, and with such a talented roster already in place, Buffalo concentrated on making some select yet noteworthy additions in a bid to get over the top in 2022. Notably, the top two come from the defending champion Rams, as veteran guard Rodger Saffold and linebacker Von Miller both now wear blue and white. Meanwhile, crafty slot man Jamison Crowder shapes up as an even swap at minimum for the departed Cole Beasley, and Buffalo is also banking on a true breakout season from speedy Gabriel Davis after his memorable eight-catch, 201-yard, four-touchdown effort in the aforementioned divisional-round loss to the Chiefs.

With the trade of Tyreek Hill to the Dolphins, the Bills are odds-on favorites to win Super LVII, so their seven-point projected advantage for this opener at home, where they went 5-3-2 ATS last season and postseason, is also no surprise.

The Vikings begin a new era in 2022 after eight seasons under Mike Zimmer, as Kevin O’Connell, most recently offensive coordinator of the defending champion Rams, is now at the helm. The team ensured O’Connell wouldn’t be starting from scratch or with a retread at quarterback when it inked Kirk Cousins to a one-year $35 million extension. The team stood largely pat this offseason in terms of offensive personnel, although the presumed return to health of promising tight end Irv Smith after he missed all of 2021 with a meniscus injury should give the air attack a boost. Minnesota was more active in replenishing the other side of the ball, acquiring Za’Darius Smith and Jordan Hicks to revamp its linebacking corps and drafting highly regarded Lewis Cine at safety.

The Eagles made plenty of headlines with the acquisition of Brown from the Titans, a move that immediately props up what had been an alarmingly thin receiving corps. With Brown in the fold, DeVonta Smith and Dallas Goedert should certainly be the subject of less defensive attention, while free-agent signee Zach Pascal can slot into the No. 3 role he’s best suited for. If Miles Sanders can enjoy better health and better utilization in 2022, Philadelphia’s Jalen Hurts-led offense could certainly take a big step forward. The defense, which already finished No. 10 in yards per game allowed last season (329.9), could be even better with the additions of Haason Reddick and Kyzir White to the linebacker corps.

The Eagles, just 3-4-1 ATS last season at home, are 2.5-point favorites over a Vikings squad that went 5-4 against the number as a road team in 2021.

Week 3

Here are point spreads for the third week of the season.

DateOpening NFL Week 3 odds: Spread
Thursday, September 22Pittsburgh Steelers at Cleveland Browns - OTB
Sunday, September 25Baltimore Ravens pk at New England Patriots pk
Sunday, September 25New Orleans Saints -2 at Carolina Panthers +2
Sunday, September 25Philadelphia Eagles pk at Washington Commanders pk
Sunday, September 25Houston Texans +3 at Chicago Bears -3
Sunday, September 25Kansas City Chiefs -2.5 at Indianapolis Colts +2.5
Sunday, September 25Cincinnati Bengals -5 at New York Jets +5
Sunday, September 25Las Vegas Raiders +1 at Tennessee Titans -1
Sunday, September 25Buffalo Bills -3.5 at Miami Dolphins +3.5
Sunday, September 25Detroit Lions +5 at Minnesota Vikings -5
Sunday, September 25Jacksonville Jaguars +10.5 at Los Angeles Chargers -10.5
Sunday, September 25Green Bay Packers +3.5 at Tampa Bay Buccaneers -3.5
Sunday, September 25Atlanta Falcons +4 at Seattle Seahawks -4
Sunday, September 25Los Angeles Rams -2 at Arizona Cardinals +2
Sunday, September 25San Francisco 49ers +2.5 at Denver Broncos -2.5
Monday, September 26Dallas Cowboys at -3 New York Giants +3

An array of interesting conference battles highlight the Sunday portion of the slate, as there are Chiefs-Colts, Bills-Dolphins, Ravens-Patriots, Raiders-Titans, Rams-Cardinals and Packers-Buccaneers battles on tap. Then, the Sunday night interconference meeting between the 49ers and Broncos will see Wilson taking on his first marquee opponent at home after his Empower Field debut in Week 2 versus the Texans, a game Denver is currently a 2.5-point favorite in.

Week 4

A glance at NFL lines for the fourth week of the campaign.

DateOpening NFL Week 4 odds: Spread
Thursday, September 29Miami Dolphins +4.5 at Cincinnati Bengals -4.5
Sunday, October 2Minnesota Vikings -1 at New Orleans Saints +1
Sunday, October 2Kansas City Chiefs +2.5 at Tampa Bay Buccaneers -2.5
Sunday, October 2New York Jets +3.5 at vs. Pittsburgh Steelers -3.5
Sunday, October 2Tennessee Titans +3 at Indianapolis Colts -3
Sunday, October 2Los Angeles Chargers -7.5 at Houston Texans +7.5
Sunday, October 2Jacksonville Jaguars +6 at Philadelphia Eagles -6
Sunday, October 2Chicago Bears +2.5 at New York Giants -2.5
Sunday, October 2Seattle Seahawks +1 at Detroit Lions -1
Sunday, October 2 Washington Commanders +5 at Dallas Cowboys -5
Sunday, October 2Buffalo Bills -1 at Baltimore Ravens +1
Sunday, October 2Arizona Cardinals -2.5 at Carolina Panthers +2.5
Sunday, October 2New England Patriots +5 at Green Bay Packers -5
Sunday, October 2Denver Broncos pk at Las Vegas Raiders pk
Monday, October 3Los Angeles Rams -1 at San Francisco 49ers +1

The slate opens with a Dolphins-Bengals showdown in Cincinnati that will pit what should be two high-powered passing games against each other. The 2022 debut of the NFL’s International Series then kicks off Sunday’s ledger, as the Vikings and Saints tangle in London. Bills-Ravens and Titans-Colts tilts shape up as the highlights of the early window, and the later part of the day is loaded with a trifecta consisting of Patriots-Packers, Broncos-Raiders and Chiefs-Buccaneers (primetime) showdowns. The week concludes with the Rams and 49ers doing battle on Monday Night Football, their first ’22 encounter following January’s epic NFC Championship Game, with the Rams notably narrow one-point road favorites at this stage of the postseason.

Week 5

Here are NFL lines for the fifth week of the 2022 – 2023 season.

Date Opening NFL Week 5 odds: Spread
Thursday, October 6Indianapolis Colts +3 at Denver Broncos -3
Sunday, October 9 New York Giants +6.5 at Green Bay Packers -6.5
Sunday, October 9 Chicago Bears +4.5 at Minnesota Vikings -4.5
Sunday, October 9 Seattle Seahawks +4.5 at New Orleans Saints -4.5
Sunday, October 9 Pittsburgh Steelers +8 at Buffalo Bills -8
Sunday, October 9 Atlanta Falcons +10.5 at Tampa Bay Buccaneers
Sunday, October 9Houston Texans
+3 at Jacksonville Jaguars -3
Sunday, October 9 Detroit Lions +5 at New England Patriots -5 -5
Sunday, October 9Tennessee Titans pk at Washington Commanders pk
Sunday, October 9Miami Dolphins -2.5 at New York Jets +2.5
Sunday, October 9San Francisco 49ers -3 at Carolina Panthers +3
Sunday, October 9Philadelphia Eagles +2 at Arizona Cardinals -2
Sunday, October 9Dallas Cowboys +4.5 at Los Angeles Rams -4.5
Sunday, October 9Cincinnati Bengals +1 at Baltimore Ravens -1
Monday, October 10Las Vegas Raiders +4.5 at Kansas City Chiefs -4.5

A Ryan-Wilson TNF face-off in what will be Denver’s third straight home game kicks off the week, followed by another intriguing marquee QB battle when Justin Herbert and the Chargers travel to take on Watson and the Browns in the Dawg Pound. There’s more of the same in the late window and the primetime slots, as Eagles-Cardinals, Cowboys-Rams, Bengals-Ravens (SNF) and Raiders-Chiefs (MNF) matchups are also on the schedule.

Week 6

Here we take stock of pro football lines for the sixth week of the season.

DateOpening NFL Week 6 odds
Thursday, October 13Washington Commanders pk at Chicago Bears pk
Sunday, October 16Tampa Bay Buccaneers -3.5 at Pittsburgh Steelers +3.5
Sunday, October 16Minnesota Vikings +3 at Miami Dolphins -3
Sunday, October 16Baltimore Ravens -3.5 at New York Giants +3.5
Sunday, October 16Cincinnati Bengals -1 at New Orleans Saints +1
Sunday, October 16San Francisco 49ers -5.5 at Atlanta Falcons +5.5
Sunday, October 16Jacksonville Jaguars +7 at Indianapolis Colts -7
Sunday, October 16New York Jets +7.5 at Green Bay Packers -7.5
Sunday, October 16Arizona Cardinals -2.5 at Seattle Seahawks +2.5
Sunday, October 16Carolina Panthers +9 at Los Angeles Rams -9
Sunday, October 16Buffalo Bills -1.5 at Kansas City Chiefs +1.5
Sunday, October 16Dallas Cowboys pk at Philadelphia Eagles pk
Monday, October 17Denver Broncos +3 at Los Angeles Chargers -3

In the first week with teams on bye, Bill Belichick gets a crack at trying to slow down Watson as the Patriots and Browns face off in the early window in Cleveland, while the Bengals pay a visit to the new-look, Dennis Allen-led Saints in a noteworthy interconference meeting. However, for a second straight week, the action truly heats up in the latter portion of the slate. Not only do the Bills and Chiefs meet at Arrowhead in a rematch of January’s instant classic of an AFC Divisional Round matchup – a game Buffalo is currently favored by 1.5 points in — but Cowboys-Eagles and Broncos-Chargers constitute the primetime games that close out the ledger.

Week 7

A look at lines for the seventh week of the campaign.

DateOpening NFL Week 7 odds
Thursday, October 20New Orleans Saints +3 at Arizona Cardinals -3
Sunday, October 23New York Giants +1.5 at Jacksonville Jaguars -1.5
Sunday, October 23Indianapolis Colts pk at Tennessee Titans pk
Sunday, October 23Green Bay Packers -3 at Washington Commanders +3
Sunday, October 23Detroit Lions +6.5 at Dallas Cowboys -6.5
Sunday, October 23Tampa Bay Buccaneers -5 at Carolina Panthers +5
Sunday, October 23Atlanta Falcons +10 at Cincinnati Bengals -10
Sunday, October 23New York Jets +7.5 at Denver Broncos -7.5
Sunday, October 23Houston Texans +8 at Las Vegas Raiders -8
Sunday, October 23Seattle Seahawks +8.5 at Los Angeles Chargers -8.5
Sunday, October 23Kansas City Chiefs -1 at San Francisco 49ers +1
Sunday, October 23Pittsburgh Steelers +3.5 at Miami Dolphins -3.5
Monday, October 24Chicago Bears +5 at New England Patriots -5

The Browns visit the Ravens in the early window of this slate, while Colts-Titans and Packers-Commanders battles are also featured bouts in the early window. With the likes of the Bills, Rams, Vikings and Eagles, there aren’t as many noteworthy games in the latter portion of the ledger as in prior weeks to this point. However, a Chiefs-49ers interconference battle certainly qualifies as an exception, the Steelers-Dolphins matchup in Miami, which could potentially feature Kenny Pickett at quarterback for Pittsburgh, arguably does as well.

Week 8

Here are spreads for the eighth weekend of the pro football season.

DateOpening NFL Week 8 odds
Thursday, October 27Baltimore Ravens +3.5 at Tampa Bay Buccaneers -3.5
Sunday, October 30Denver Broncos -6.5 at vs. Jacksonville Jaguars +6.5
Sunday, October 30Pittsburgh Steelers +3 at Philadelphia Eagles -3
Sunday, October 30Chicago Bears +7 at Dallas Cowboys -7
Sunday, October 30Miami Dolphins -3 at Detroit Lions +3
Sunday, October 30Arizona Cardinals +1 at Minnesota Vikings -1
Sunday, October 30Carolina Panthers pk at Atlanta Falcons pk
Sunday, October 30Las Vegas Raiders -1 at New Orleans Saints +1
Sunday, October 30New England Patriots -1.5 at New York Jets +1.5
Sunday, October 30Tennessee Titans -4.5 at Houston Texans +4.5
Sunday, October 30San Francisco 49ers +4.5 at Los Angeles Rams -4.5
Sunday, October 30New York Giants +2.5 at Seattle Seahawks -2.5
Sunday, October 30Green Bay Packers +4 at Buffalo Bills -4

The NFL sends October off in style, starting right from the first game of the week. The Ravens and Buccaneers serve up a Thursday night treat in Tampa, while the Cardinals-Vikings, Raiders-Saints, 49ers-Rams and SNF Packers-Bills matchups also hold plenty of interest. Additionally, Wentz makes his return to Indianapolis for what he hopes will be a bit of redemption after the unceremonious end to his Colts tenure, and the week concludes with a Bengals-Browns battle in Cleveland on Monday Night Football.

Week 9

A look at NFL lines for the ninth weekend of the season.

DateOpening NFL Week 9 odds
Thursday, November 3Philadelphia Eagles -4.5 at Houston Texans +4.5
Sunday, November 6Minnesota Vikings pk at Washington Commanders pk
Sunday, November 6Las Vegas Raiders -3 at Jacksonville Jaguars +3
Sunday, November 6Miami Dolphins -3 at Chicago Bears +3
Sunday, November 6Buffalo Bills -6.5 at New York Jets +6.5
Sunday, November 6Los Angeles Chargers -6.5 at Atlanta Falcons +6.5
Sunday, November 6Indianapolis Colts pk at New England Patriots pk
Sunday, November 6Carolina Panthers +8.5 at Cincinnati Bengals -8.5
Sunday, November 6Green Bay Packers -5 at Detroit Lions +5
Sunday, November 6Seattle Seahawks +5.5 at Arizona Cardinals -5.5
Sunday, November 6Los Angeles Rams +1.5 at Tampa Bay Buccaneers -1.5
Sunday, November 6Tennessee Titans +5 at Kansas City Chiefs -5
Monday, November 7Baltimore Ravens -1 at New Orleans Saints +1

Some heavy hitters are on bye this week, a list that includes the Browns, Cowboys, Broncos and 49ers. However, Colts-Patriots, Vikings-Commanders and Rams-Buccaneers battles pop from the Sunday main slate. A Titans-Chiefs encounter on Sunday Night Football is highly interesting as well, considering recent history between the teams, while a Ravens-Saints clash in the NOLA on Monday Night Football could also turn out to be a wire-to-wire battle if New Orleans is off to a strong start with the likes of Jameis Winston, Alvin Kamara, Michael Thomas and Chris Olave leading the way.

Week 10

Here are spreads for the 10th weekend of the season.

DateOpening NFL Week 10 odds
Friday, November 11Atlanta Falcons +3 at Carolina Panthers -3
Sunday, November 13Seattle Seahawks +9.5 at Tampa Bay Buccaneers -9.5
Sunday, November 13Dallas Cowboys +4 at vs. Green Bay Packers -4
Sunday, November 13Detroit Lions +1.5 at Chicago Bears -1.5
Sunday, November 13New Orleans Saints +1.5 at Pittsburgh Steelers -1.5
Sunday, November 13Denver Broncos pk at Tennessee Titans pk
Sunday, November 13Minnesota Vikings +7.5 at Buffalo Bills -7.5
Sunday, November 13Jacksonville Jaguars +10 at Kansas City Chiefs -10
Sunday, November 13Houston Texans +3 at New York Giants -3
Sunday, November 13Indianapolis Colts +2 at Las Vegas Raiders -2
Sunday, November 13Arizona Cardinals +6 at Los Angeles Rams -6
Sunday, November 13Los Angeles Chargers pk at San Francisco 49ers pk
Monday, November 14Washington Commanders +3.5 at Philadelphia Eagles -3.5

Tom Brady and the Buccaneers have the distinction of kicking off the Sunday portion of the slate in Munich against the Seahawks, the first NFL regular-season game ever played in Germany. The day continues with Vikings-Bills, Browns-Dolphins and Broncos-Titans games standing out in the early window, followed by a loaded three-game late-afternoon menu that consists of Colts-Raiders, Cowboys-Packers and Cardinals-Rams matchups. The day then concludes with another main-event-worthy tussle, as the Chargers make the short trip to face the 49ers.

Week 11

A look at NFL lines for the 11th weekend of the campaign.

DateOpening NFL Week 11 odds
Thursday, November 17Tennessee Titans +4.5 at Green Bay Packers -4.5
Sunday, November 20Chicago Bears PK at Atlanta Falcons PK
Sunday, November 20Washington Commanders -3 at Houston Texans +3
Sunday, November 20Carolina Panthers +7 at Baltimore Ravens -7
Sunday, November 20New York Jets +6 at New England Patriots -6
Sunday, November 20LA Rams -3 at New Orleans Saints +3
Sunday, November 20Philadelphia Eagles +3 at Indianapolis Colts -3
Sunday, November 20Detroit Lions +1.5 at New York Giants -1.5
Sunday, November 20Las Vegas Raiders +3 at Denver Broncos -3
Sunday, November 20Dallas Cowboys PK at Minnesota Vikings PK
Sunday, November 20Kansas City Chiefs +1.5 at LA Chargers -1.5
Sunday, November 20Cincinnati Bengals -2.5 at Pittsburgh Steelers +2.5
Monday, November 21San Francisco 49ers -2.5 at Arizona Cardinals +2.5

As the stretch run begins in earnest, the Titans and Packers kick it off on Thursday Night Football at Lambeau. Browns-Bills, Eagles-Colts and Rams-Saints duels then highlight the early portion of Sunday’s slate, and the last five games of the ledger round out what should be highly appealing pre-Thanksgiving appetizer. Raiders-Broncos, Chiefs-Chargers and Cowboys-Vikings clashes are rock-solid late-window games, and the Bengals-Steelers and 49ers-Cardinals primetime affairs are the icing on the cake.

Week 12

Here are NFL lines for the 12th weekend of the pro football season.

DateOpening NFL Week 12 odds
Thursday, November 24Buffalo Bills -8 at Detroit Lions +8
Thursday, November 24New York Giants +7 at Dallas Cowboys -7
Thursday, November 24New England Patriots +1.5 at Minnesota Vikings -1.5
Sunday, November 27Denver Broncos -4 at Carolina Panthers +4
Sunday, November 27Cincinnati Bengals PK at Tennessee Titans PK
Sunday, November 27Baltimore Ravens -4 at Jacksonville Jaguars +4
Sunday, November 27Atlanta Falcons +5 at Washington Commanders -5
Sunday, November 27Houston Texans +7 at Miami Dolphins -7
Sunday, November 27Chicago Bears +2 at New York Jets -2
Sunday, November 27LA Chargers -1.5 at Arizona Cardinals +1.5
Sunday, November 27Las Vegas Raiders -2 at Seattle Seahawks +2
Sunday, November 27New Orleans Saints +4 at San Francisco 49ers -4
Sunday, November 27LA Rams +2.5 at Kansas City Chiefs -2.5
Sunday, November 27Green Bay Packers PK at Philadelphia Eagles PK
Monday, November 28Pittsburgh Steelers +4.5 at Indianapolis Colts -4.5

The annual three-game Thanksgiving slate opens up with a Bills-Lions interconference tussle, one in which what should be an improved Detroit team that fought hard all last season tries to establish some significant credibility with a national TV audience. A traditional NFC East rivalry game between the Giants and Cowboys follows, and the primetime Patriots-Vikings faceoff certainly carries plenty of intrigue as well. The Turkey Day triple feature is a rock-solid primer for the rest of the slate, which features a Buccaneers-Browns battle in Cleveland, a Bengals-Titans AFC Divisional Round Game rematch in Tennessee, a Chargers-Chiefs matchup featuring a marquee quarterback showdown and a Rams-Chiefs encounter at Arrowhead that marks the first meeting between the teams since a 54-51 Rams win in 2018.

Week 13

A glance at spreads for the 13th week of the season.

DateOpening NFL Week 13 odds
Thursday, December 1Buffalo Bills -3 at New England Patriots +3
Sunday, December 4Green Bay Packers -4 at Chicago Bears +4
Sunday, December 4Jacksonville Jaguars +2 at Detroit Lions -2
Sunday, December 4Washington Commanders PK at New York Giants PK
Sunday, December 4Tennessee Titans +1 at Philadelphia Eagles -1
Sunday, December 4Denver Broncos +1.5 at Baltimore Ravens -1.5
Sunday, December 4New York Jets +4.5 at Minnesota Vikings -4.5
Sunday, December 4Pittsburgh Steelers -2.5 at Atlanta Falcons +2.5
Sunday, December 4Seattle Seahawks +9.5 at LA Rams -9.5
Sunday, December 4Miami Dolphins +3.5 at San Francisco 49ers -3.5
Sunday, December 4Kansas City Chiefs PK at Cincinnati Bengals PK
Sunday, December 4LA Chargers PK at Las Vegas Raiders
Sunday, December 4Indianapolis Colts +2.5 at Dallas Cowboys -2.5
Monday, December 5New Orleans Saints +6.5 at Tampa Bay Buccaneers -6.5

The Bills and Patriots commemorate the flipping of the calendar to December with what could be a classic late-season AFC East slugfest on Thursday night. Russell Wilson and Lamar Jackson then steal the spotlight in the early portion of the Sunday ledger as the Broncos visit the Ravens, with a Ryan Tannehill-Jalen Hurts battle in Philadelphia serving as a highly appealing undercard bout. The schedule really heats up as the day gets later, however; the second window of games includes Dolphins-49ers, Chiefs-Bengals and Chargers-Raiders battles. An action-packed week that should have a healthy dose of postseason implications then closes out with a Colts-Cowboys interconference showdown on Sunday Night Football and a Saints-Buccaneers MNF clash that sees Brady go up against a Dennis Allen-coordinated defense that’s given him plenty of trouble since his arrival in Tampa Bay.

Week 14

Taking stock of NFL lines for the 14th weekend of the season.

DateOpening NFL Week 14 odds
Thursday, December 8Las Vegas Raiders +4 at LA Rams -4
Sunday, December 11Jacksonville Jaguars +6.5 at Tennessee Titans -6.5
Sunday, December 11New York Jets +9.5 at Buffalo Bills -9.5
Sunday, December 11Houston Texans +8 at Dallas Cowboys -8
Sunday, December 11Philadelphia Eagles -1.5 at New York Giants +1.5
Sunday, December 11Minnesota Vikings -2 at Detroit Lions +2
Sunday, December 11Baltimore Ravens -2 at Pittsburgh Steelers +2
Sunday, December 11Miami Dolphins +5.5 at LA Chargers -5.5
Sunday, December 11Carolina Panthers +2.5 at Seattle Seahawks -2.5
Sunday, December 11Tampa Bay Buccaneers PK at San Francisco 49ers PK
Sunday, December 11Kansas City Chiefs PK at Denver Broncos PK
Monday, December 12New England Patriots +2.5 at Arizona Cardinals -2.5

A total of six teams are on bye in the final off week of the season, but there’s still plenty to keep an eye on in Week 14. The run of notable TNF games continues with the Raiders and Rams tangling in Los Angeles. Then, Browns-Bengals and Eagles-Giants divisional matchups in Sunday’s early window could certainly play a big part in the playoff hopes/positioning of all four teams. The late window and pair of primetime contests continue to feature plenty of relevant matchups as well, with the Dolphins visiting the Chargers, the Buccaneers dropping in on the 49ers, the Chiefs tangling with the Broncos on Sunday night, and the Patriots making a trek to the desert to face the Cardinals in a MNF showdown.

Week 15

Here are lines for NFL games for the 15th weekend of the campaign.

DateOpening NFL Week 15 odds
Thursday, December 15San Francisco 49ers -3 at Seattle Seahawks +3
Sunday, December 18Philadelphia Eagles -2.5 at Chicago Bears +2.5
Sunday, December 18Kansas City Chiefs -10 at Houston Texans +10
Sunday, December 18Detroit Lions +2.5 at New York Jets -2.5
Sunday, December 18Dallas Cowboys -3.5 at Jacksonville Jaguars +3.5
Sunday, December 18Pittsburgh Steelers -1 at Carolina Panthers +1
Sunday, December 18New York Giants +3.5 at Washington Commanders -3.5
Sunday, December 18Miami Dolphins +6 at Buffalo Bills -6
Sunday, December 18Indianapolis Colts PK at Minnesota Vikings PK
Sunday, December 18Atlanta Falcons +5 at New Orleans Saints -5
Sunday, December 18Arizona Cardinals +4 at Denver Broncos -4
Sunday, December 18Cincinnati Bengals +3 at Tampa Bay Buccaneers -3
Sunday, December 18Tennessee Titans +5 at LA Chargers -5
Sunday, December 18New England Patriots +3 at Las Vegas Raiders -3
Monday, December 19LA Rams PK at Green Bay Packers PK

The NFL still hasn’t locked in the day and time slot for five games, three which will be played on Saturday. This week also marks the return to a full ledger following the conclusion of bye weeks, which makes for a busy weekend. There’s a pair of especially intriguing divisional battles on tap in Dolphins-Bills and Ravens-Browns, while a Colts-Vikings interconference affair also holds plenty of interest. Additionally, what’s been established as the late-window and primetime schedule is excellent – Cardinals-Broncos, Titans-Chargers and Bengals-Buccaneers battles make for an elite late-afternoon trio of contests, while the Patriots-Raiders and Rams-Packers primetime duels, the latter game notably a Pick ‘Em at this juncture of the offseason, ensure a momentous finish to the week.

Week 16

The holidays have arrived as we look at NFL lines for the 16th weekend of the season.

DateOpening NFL Week 16 odds
Thursday, December 22Jacksonville Jaguars +2.5 at New York Jets -2.5
Saturday, December 24Houston Texans +8 at Tennessee Titans -8
Saturday, December 24New York Giants +5 at Minnesota Vikings -5
Saturday, December 24Cincinnati Bengals -1 vs. New England Patriots +1
Saturday, December 24Detroit Lions +2.5 at Carolina Panthers -2.5
Saturday, December 24Seattle Seahawks +10.5 at Kansas City Chiefs -10.5
Saturday, December 24Atlanta Falcons +7.5 at Baltimore Ravens -7.5
Saturday, December 24Buffalo Bills -7 at Chicago Bears +7
Saturday, December 24Washington Commanders +6 at San Francisco 49ers -6
Saturday, December 24Philadelphia Eagles +3.5 at Dallas Cowboys -3.5
Saturday, December 24Las Vegas Raiders -1.5 at Pittsburgh Steelers +1.5
Sunday, December 25Green Bay Packers -1 at Miami Dolphins +1
Sunday, December 25Denver Broncos +3.5 at LA Rams -3.5
Sunday, December 25Tampa Bay Buccaneers -2.5 at Arizona Cardinals +2.5
Monday, December 26LA Chargers -1 at Indianapolis Colts +1

This Christmas and the NFL heavily intersect once again this season, as Christmas Eve’s Saturday date means the largest portion of the slate unfolds that day. The Saints-Browns, Bengals-Patriots and Eagles-Cowboys tussles shape up as the most interesting games in the afternoon portion of the schedule, while the Raiders and Steelers cap off matters at Heinz Field in a rare Saturday night battle. Then, the present under tree for NFL fans on Sunday is a trio of marquee matchups – Packers-Dolphins, Broncos-Rams and Buccaneers-Cardinals, the latter marking the first-ever meeting between Brady and Murray. As good as that trifecta projects to be, it doesn’t represent the end of noteworthy Week 16 games – the Chargers visit the Colts on Monday Night Football to close out the holiday festivities.

Week 17

The calendar turns to 2023 as we look at lines for the penultimate weekend of the regular season.

DateOpening NFL Week 17 odds
Thursday, December 29Dallas Cowboys +1.5 at Tennessee Titans -1.5
Sunday, January 1Indianapolis Colts -3 vs. New York Giants +3
Sunday, January 1Carolina Panthers +9 at Tampa Bay Buccaneers -9
Sunday, January 1New Orleans Saints +3 at Philadelphia Eagles -3
Sunday, January 1Chicago Bears +1.5 at Detroit Lions -1.5
Sunday, January 1Miami Dolphins +1.5 at New England Patriots -1.5
Sunday, January 1Arizona Cardinals -3.5 at Atlanta Falcons +3.5
Sunday, January 1Denver Broncos +4.5 at Kansas City Chiefs -4.5
Sunday, January 1Pittsburgh Steelers +5.5 at Baltimore Ravens -5.5
Sunday, January 1Jacksonville Jaguars PK at Houston Texans PK
Sunday, January 1New York Jets +1.5 at Seattle Seahawks -1.5
Sunday, January 1Minnesota Vikings +5.5 at Green Bay Packers -5.5
Sunday, January 1San Francisco 49ers +1.5 at Las Vegas Raiders -1.5
Sunday, January 1LA Rams +1.5 at LA Chargers -1.5
Monday, January 2Buffalo Bills PK at Cincinnati Bengals PK

A thrill-packed holiday season NFL style continues amidst the plethora of college bowl games also unfolding, as the Cowboys make a rare trek to Tennessee in what should be a key interconference clash on the final TNF game of the season. Then, the league kicks off 2023 in remarkable fashion Sunday as the postseason picture becomes increasingly clearer. The Broncos-Chiefs and Dolphins-Patriots early-afternoon divisional battles could be especially critical for each team, as could a Vikings-Packers NFC North faceoff in the second window of games. Meanwhile, 49ers-Raiders and Rams-Chargers interconference matchups, the latter a Sunday night affair, make for an excellent way to finish off the day. And, the slate is topped off by a Bills-Bengals MNF season finale that could well be an AFC Championship Game preview, one that’s currently listed as a Pick ‘Em.

Week 18

Teams will be scrambling for a spot in the NFL Playoffs as we look at opening spreads for the final weekend.

DateOpening NFL Week 18 odds
Sunday, January 8Baltimore Ravens +3 at Cincinnati Bengals -3
Sunday, January 8New England Patriots +7 at Buffalo Bills -7
Sunday, January 8Minnesota Vikings -1.5 at Chicago Bears +1.5
Sunday, January 8Detroit Lions +8 at Green Bay Packers -8
Sunday, January 8New York Giants +5 at Philadelphia Eagles -5
Sunday, January 8Houston Texans +8.5 at Indianapolis Colts -8.5
Sunday, January 8New York Jets +5.5 at Miami Dolphins -5.5
Sunday, January 8Tennessee Titans -3 at Jacksonville Jaguars +3
Sunday, January 8LA Rams -5.5 at Seattle Seahawks +5.5
Sunday, January 8Kansas City Chiefs -2 vs. Las Vegas Raiders +2
Sunday, January 8Dallas Cowboys -1 vs. Washington Commanders +1
Sunday, January 8Arizona Cardinals +3 vs. San Francisco 49ers -3
Sunday, January 8Carolina Panthers +4.5 vs. New Orleans Saints -4.5
Sunday, January 8Tampa Bay Buccaneers -7.5 vs. Atlanta Falcons +7.5
Sunday, January 8LA Chargers PK vs. Denver Broncos PK

As customary, the final week of the regular season will be exclusively constituted by divisional games as final division/postseason positioning is settled. Two of the 16 games on the slate will ultimately be played on Saturday, and another will serve as the curtain closer of the 2022 regular season on Sunday night. Some of the most critical games based on preseason outlooks could well be Patriots-Bills, Ravens-Bengals, Chargers-Broncos, Chiefs-Raiders and Cardinals-49ers — all those contests having a reasonably good chance of serving as games that decide the winner of those respective divisions. Notably, it’s also a slate that can’t really be prognosticated very far in advance, considering the significant uncertainty regarding motivation for each team and the corresponding personnel usage that could bring about.

Juan Carlos Blanco Avatar
Written by
Juan Carlos Blanco

Juan Carlos Blanco has served as a freelance writer for a wide variety of online publications and websites, with an intensive focus on fantasy sports. Juan has provided analysis and comprehensive coverage of the MLB, NBA, NFL, CFL, AAF and AFL while also reporting on news and developments in the daily fantasy sports and online gaming industries.

View all posts by Juan Carlos Blanco