NFL Opening Lines For Every Game Of The 2022 - 2023 Season

We are still a few weeks away from the start of the 2022 - 2023 pro football season but NFL odds for every week have already been posted by legal online sportsbooks. Below are lines for every single game of the 2022 - 2023 season, with point spreads for each game and a mini betting preview of each week.

Week 1

Here are NFL lines for the first week of the season.

For a complete betting breakdown of NFL Week 1 odds head here.

A Bills-Rams matchup to open the season on Thursday Night Football is about the very best the NFL could have conjured up from the defending champion Rams’ menu of opponents this season. The game currently features Los Angeles as a thin one-point home favorite and a 52-point projected total, figures that will certainly be subject to fluctuation as kickoff draws nearer.

Additionally, as is usually the case with opening weeks but even more so following such a wild offseason of personnel moves, there are plenty of intriguing matchups right out of the gate.

Among them are the projected debuts of Deshaun Watson in Cleveland after a missed 2021 season, Matt Ryan in Indianapolis after 14 seasons in Atlanta, Carson Wentz in his latest career reset in the nation’s capital and Davante Adams in the Silver and Black after a legendary run in Green Bay. Add in a Patrick Mahomes-Kyler Murray late-window battle Sunday afternoon that will serve as the Chiefs’ first game without the traded Tyreek Hill, and it’s a main slate that will be saturated with betting interest.

Then, the two primetime games are certainly fit for the league’s ribbon-cutting slate. Sunday night will see a rematch of last year’s season-opening clash between the Buccaneers and Cowboys that thrilled Thursday Night Football viewers, this time at AT & T Stadium in Arlington. Monday night, Russell Wilson will not only don a uniform other than the Seahawks’ for the first time, but he’ll be facing his old Seattle teammates right out of the gate at his previous Lumen Field digs in his Broncos regular-season debut.

Week 2

A look at NFL lines for the second week of the season. The odds displayed are from DraftKings Sportsbook.

The Chargers finished their first season under Brandon Staley running on fumes and out of the postseason following a hot start, going 5-7 after winning four of their first five games. Los Angeles lost three of its last four, a sample that included a pair of overtime defeats. The Bolts return all of last season’s key components on the offensive end with the exception of tight end, where they actually got younger by swapping out Jared Cook for Gerald Everett. However, L.A. made some impressive additions to a defense that finished No. 23 in total yards per game allowed with the acquisitions of Khalil Mack, J.C. Jackson and Kyle Van Noy this offseason.

Meanwhile, the Chiefs’ regular-season trajectory was almost a diametric opposite of the Chargers, as they finished 9-1 after a concerning 3-4 start that included a 30-24 loss to Los Angeles at Arrowhead Stadium in Week 3. KC then walloped the Steelers in Ben Roethlisberger’s swan song in the wild-card round before pulling off an OT miracle against the Bills in the divisional round. However, the Bengals returned the favor the following week, qualifying for the Super Bowl on the backs of Patrick Mahomes and company with their own 27-24 OT win. The prevailing thought had been that a retool and reload for Andy Reid’s team would be in order this offseason, but instead, Kansas City surprisingly traded Tyreek Hill to the Dolphins and will attempt to replace him with the duo of JuJu Smith-Schuster and Marquez Valdes-Scantling, among others.

The two teams split the season series last season and how the KC offense will look without Hill will be one of the biggest questions heading into the season. Therefore, the narrow opening line of Chiefs -3 and low 50s projected total is understandable based on where things currently stand.

The Titans’12-5 record was good enough to take the AFC South by three games last season, but Mike Vrabel’s club became the eventual AFC champion Cincinnati Bengals’ second victim in their memorable postseason run with a 19-16 loss in the divisional round. Tennessee then surprisingly traded away its most explosive pass catcher just before the start of the NFL Draft when it moved A.J. Brown to the Eagles. That leaves the receiver they grabbed with one of the picks netted in that transaction, Arkansas product Treylon Burks, and veteran offseason acquisitions Robert Woods and Austin Hooper as the top targets for veteran Ryan Tannehill. Then, Derrick Henry should be back to 100 percent after a foot injury led to him missing the last nine games of the season before a return for the divisional-round loss.

The Bills had their own heartbreaking divisional-round defeat last January, with the Chiefs shocking Buffalo in a wild fourth quarter and overtime. The heartbreaking defeat naturally left Sean McDermott’s team hungry for retribution, and with such a talented roster already in place, Buffalo concentrated on making some select yet noteworthy additions in a bid to get over the top in 2022. Notably, the top two come from the defending champion Rams, as veteran guard Rodger Saffold and linebacker Von Miller both now wear blue and white. Meanwhile, crafty slot man Jamison Crowder shapes up as an even swap at minimum for the departed Cole Beasley, and Buffalo is also banking on a true breakout season from speedy Gabriel Davis after his memorable eight-catch, 201-yard, four-touchdown effort in the aforementioned divisional-round loss to the Chiefs.

With the trade of Tyreek Hill to the Dolphins, the Bills are odds-on favorites to win Super LVII, so their seven-point projected advantage for this opener at home, where they went 5-3-2 ATS last season and postseason, is also no surprise.

The Vikings begin a new era in 2022 after eight seasons under Mike Zimmer, as Kevin O’Connell, most recently offensive coordinator of the defending champion Rams, is now at the helm. The team ensured O’Connell wouldn’t be starting from scratch or with a retread at quarterback when it inked Kirk Cousins to a one-year $35 million extension. The team stood largely pat this offseason in terms of offensive personnel, although the presumed return to health of promising tight end Irv Smith after he missed all of 2021 with a meniscus injury should give the air attack a boost. Minnesota was more active in replenishing the other side of the ball, acquiring Za’Darius Smith and Jordan Hicks to revamp its linebacking corps and drafting highly regarded Lewis Cine at safety.

The Eagles made plenty of headlines with the acquisition of Brown from the Titans, a move that immediately props up what had been an alarmingly thin receiving corps. With Brown in the fold, DeVonta Smith and Dallas Goedert should certainly be the subject of less defensive attention, while free-agent signee Zach Pascal can slot into the No. 3 role he’s best suited for. If Miles Sanders can enjoy better health and better utilization in 2022, Philadelphia’s Jalen Hurts-led offense could certainly take a big step forward. The defense, which already finished No. 10 in yards per game allowed last season (329.9), could be even better with the additions of Haason Reddick and Kyzir White to the linebacker corps.

The Eagles, just 3-4-1 ATS last season at home, are 2.5-point favorites over a Vikings squad that went 5-4 against the number as a road team in 2021.

Week 3

Here are point spreads for the third week of the season.

An array of interesting conference battles highlight the Sunday portion of the slate, as there are Chiefs-Colts, Bills-Dolphins, Ravens-Patriots, Raiders-Titans, Rams-Cardinals and Packers-Buccaneers battles on tap. Then, the Sunday night interconference meeting between the 49ers and Broncos will see Wilson taking on his first marquee opponent at home after his Empower Field debut in Week 2 versus the Texans, a game Denver is currently a 2.5-point favorite in.

Week 4

A glance at NFL lines for the fourth week of the campaign.

The slate opens with a Dolphins-Bengals showdown in Cincinnati that will pit what should be two high-powered passing games against each other. The 2022 debut of the NFL’s International Series then kicks off Sunday’s ledger, as the Vikings and Saints tangle in London. Bills-Ravens and Titans-Colts tilts shape up as the highlights of the early window, and the later part of the day is loaded with a trifecta consisting of Patriots-Packers, Broncos-Raiders and Chiefs-Buccaneers (primetime) showdowns. The week concludes with the Rams and 49ers doing battle on Monday Night Football, their first ’22 encounter following January’s epic NFC Championship Game, with the Rams notably narrow one-point road favorites at this stage of the postseason.

Week 5

Here are NFL lines for the fifth week of the 2022 - 2023 season.

A Ryan-Wilson TNF face-off in what will be Denver’s third straight home game kicks off the week, followed by another intriguing marquee QB battle when Justin Herbert and the Chargers travel to take on Watson and the Browns in the Dawg Pound. There’s more of the same in the late window and the primetime slots, as Eagles-Cardinals, Cowboys-Rams, Bengals-Ravens (SNF) and Raiders-Chiefs (MNF) matchups are also on the schedule.

Week 6

Here we take stock of pro football lines for the sixth week of the season.

In the first week with teams on bye, Bill Belichick gets a crack at trying to slow down Watson as the Patriots and Browns face off in the early window in Cleveland, while the Bengals pay a visit to the new-look, Dennis Allen-led Saints in a noteworthy interconference meeting. However, for a second straight week, the action truly heats up in the latter portion of the slate. Not only do the Bills and Chiefs meet at Arrowhead in a rematch of January’s instant classic of an AFC Divisional Round matchup – a game Buffalo is currently favored by 1.5 points in -- but Cowboys-Eagles and Broncos-Chargers constitute the primetime games that close out the ledger.

Week 7

A look at lines for the seventh week of the campaign.

The Browns visit the Ravens in the early window of this slate, while Colts-Titans and Packers-Commanders battles are also featured bouts in the early window. With the likes of the Bills, Rams, Vikings and Eagles, there aren’t as many noteworthy games in the latter portion of the ledger as in prior weeks to this point. However, a Chiefs-49ers interconference battle certainly qualifies as an exception, the Steelers-Dolphins matchup in Miami, which could potentially feature Kenny Pickett at quarterback for Pittsburgh, arguably does as well.

Week 8

Here are spreads for the eighth weekend of the pro football season.

The NFL sends October off in style, starting right from the first game of the week. The Ravens and Buccaneers serve up a Thursday night treat in Tampa, while the Cardinals-Vikings, Raiders-Saints, 49ers-Rams and SNF Packers-Bills matchups also hold plenty of interest. Additionally, Wentz makes his return to Indianapolis for what he hopes will be a bit of redemption after the unceremonious end to his Colts tenure, and the week concludes with a Bengals-Browns battle in Cleveland on Monday Night Football.

Week 9

A look at NFL lines for the ninth weekend of the season.

Some heavy hitters are on bye this week, a list that includes the Browns, Cowboys, Broncos and 49ers. However, Colts-Patriots, Vikings-Commanders and Rams-Buccaneers battles pop from the Sunday main slate. A Titans-Chiefs encounter on Sunday Night Football is highly interesting as well, considering recent history between the teams, while a Ravens-Saints clash in the NOLA on Monday Night Football could also turn out to be a wire-to-wire battle if New Orleans is off to a strong start with the likes of Jameis Winston, Alvin Kamara, Michael Thomas and Chris Olave leading the way.

Week 10

Here are spreads for the 10th weekend of the season.

Tom Brady and the Buccaneers have the distinction of kicking off the Sunday portion of the slate in Munich against the Seahawks, the first NFL regular-season game ever played in Germany. The day continues with Vikings-Bills, Browns-Dolphins and Broncos-Titans games standing out in the early window, followed by a loaded three-game late-afternoon menu that consists of Colts-Raiders, Cowboys-Packers and Cardinals-Rams matchups. The day then concludes with another main-event-worthy tussle, as the Chargers make the short trip to face the 49ers.

Week 11

A look at NFL lines for the 11th weekend of the campaign.

As the stretch run begins in earnest, the Titans and Packers kick it off on Thursday Night Football at Lambeau. Browns-Bills, Eagles-Colts and Rams-Saints duels then highlight the early portion of Sunday’s slate, and the last five games of the ledger round out what should be highly appealing pre-Thanksgiving appetizer. Raiders-Broncos, Chiefs-Chargers and Cowboys-Vikings clashes are rock-solid late-window games, and the Bengals-Steelers and 49ers-Cardinals primetime affairs are the icing on the cake.

Week 12

Here are NFL lines for the 12th weekend of the pro football season.

The annual three-game Thanksgiving slate opens up with a Bills-Lions interconference tussle, one in which what should be an improved Detroit team that fought hard all last season tries to establish some significant credibility with a national TV audience. A traditional NFC East rivalry game between the Giants and Cowboys follows, and the primetime Patriots-Vikings faceoff certainly carries plenty of intrigue as well. The Turkey Day triple feature is a rock-solid primer for the rest of the slate, which features a Buccaneers-Browns battle in Cleveland, a Bengals-Titans AFC Divisional Round Game rematch in Tennessee, a Chargers-Chiefs matchup featuring a marquee quarterback showdown and a Rams-Chiefs encounter at Arrowhead that marks the first meeting between the teams since a 54-51 Rams win in 2018.

Week 13

A glance at spreads for the 13th week of the season.

The Bills and Patriots commemorate the flipping of the calendar to December with what could be a classic late-season AFC East slugfest on Thursday night. Russell Wilson and Lamar Jackson then steal the spotlight in the early portion of the Sunday ledger as the Broncos visit the Ravens, with a Ryan Tannehill-Jalen Hurts battle in Philadelphia serving as a highly appealing undercard bout. The schedule really heats up as the day gets later, however; the second window of games includes Dolphins-49ers, Chiefs-Bengals and Chargers-Raiders battles. An action-packed week that should have a healthy dose of postseason implications then closes out with a Colts-Cowboys interconference showdown on Sunday Night Football and a Saints-Buccaneers MNF clash that sees Brady go up against a Dennis Allen-coordinated defense that’s given him plenty of trouble since his arrival in Tampa Bay.

Week 14

Taking stock of NFL lines for the 14th weekend of the season.

A total of six teams are on bye in the final off week of the season, but there’s still plenty to keep an eye on in Week 14. The run of notable TNF games continues with the Raiders and Rams tangling in Los Angeles. Then, Browns-Bengals and Eagles-Giants divisional matchups in Sunday’s early window could certainly play a big part in the playoff hopes/positioning of all four teams. The late window and pair of primetime contests continue to feature plenty of relevant matchups as well, with the Dolphins visiting the Chargers, the Buccaneers dropping in on the 49ers, the Chiefs tangling with the Broncos on Sunday night, and the Patriots making a trek to the desert to face the Cardinals in a MNF showdown.

Week 15

Here are lines for NFL games for the 15th weekend of the campaign.

The NFL still hasn’t locked in the day and time slot for five games, three which will be played on Saturday. This week also marks the return to a full ledger following the conclusion of bye weeks, which makes for a busy weekend. There’s a pair of especially intriguing divisional battles on tap in Dolphins-Bills and Ravens-Browns, while a Colts-Vikings interconference affair also holds plenty of interest. Additionally, what’s been established as the late-window and primetime schedule is excellent – Cardinals-Broncos, Titans-Chargers and Bengals-Buccaneers battles make for an elite late-afternoon trio of contests, while the Patriots-Raiders and Rams-Packers primetime duels, the latter game notably a Pick ‘Em at this juncture of the offseason, ensure a momentous finish to the week.

Week 16

The holidays have arrived as we look at NFL lines for the 16th weekend of the season.

This Christmas and the NFL heavily intersect once again this season, as Christmas Eve’s Saturday date means the largest portion of the slate unfolds that day. The Saints-Browns, Bengals-Patriots and Eagles-Cowboys tussles shape up as the most interesting games in the afternoon portion of the schedule, while the Raiders and Steelers cap off matters at Heinz Field in a rare Saturday night battle. Then, the present under tree for NFL fans on Sunday is a trio of marquee matchups – Packers-Dolphins, Broncos-Rams and Buccaneers-Cardinals, the latter marking the first-ever meeting between Brady and Murray. As good as that trifecta projects to be, it doesn’t represent the end of noteworthy Week 16 games – the Chargers visit the Colts on Monday Night Football to close out the holiday festivities.

Week 17

The calendar turns to 2023 as we look at lines for the penultimate weekend of the regular season.

A thrill-packed holiday season NFL style continues amidst the plethora of college bowl games also unfolding, as the Cowboys make a rare trek to Tennessee in what should be a key interconference clash on the final TNF game of the season. Then, the league kicks off 2023 in remarkable fashion Sunday as the postseason picture becomes increasingly clearer. The Broncos-Chiefs and Dolphins-Patriots early-afternoon divisional battles could be especially critical for each team, as could a Vikings-Packers NFC North faceoff in the second window of games. Meanwhile, 49ers-Raiders and Rams-Chargers interconference matchups, the latter a Sunday night affair, make for an excellent way to finish off the day. And, the slate is topped off by a Bills-Bengals MNF season finale that could well be an AFC Championship Game preview, one that’s currently listed as a Pick ‘Em.

Week 18

Teams will be scrambling for a spot in the NFL Playoffs as we look at opening spreads for the final weekend.

As customary, the final week of the regular season will be exclusively constituted by divisional games as final division/postseason positioning is settled. Two of the 16 games on the slate will ultimately be played on Saturday, and another will serve as the curtain closer of the 2022 regular season on Sunday night. Some of the most critical games based on preseason outlooks could well be Patriots-Bills, Ravens-Bengals, Chargers-Broncos, Chiefs-Raiders and Cardinals-49ers -- all those contests having a reasonably good chance of serving as games that decide the winner of those respective divisions. Notably, it’s also a slate that can’t really be prognosticated very far in advance, considering the significant uncertainty regarding motivation for each team and the corresponding personnel usage that could bring about.