College Football Picks and Parlays for Week 7: Big Teams and Big Players Go Big

Written By Jason Green | Published at October 16, 2026

Major conference games are on Saturday, so let’s get into our best college football picks and parlays for Week 7.

College Football Picks and Parlays

Perhaps the biggest game in Week 7 is fifth-ranked Indiana (6-0) hosting fourth-ranked Ohio State (5-1).

BetMGM Sportsbook has Ohio State as a 3.5-point favorite, with the total set at 50.5.

Ohio State to cover 3.5-point spread: Since losing to Texas, the Buckeyes have mauled their last four opponents. They have one of the nation's best passing offenses, and calling them balanced would be an understatement, as they rank seventh in both points per game and opponents’ PPG. Indiana is undefeated, but they haven't faced a ranked team, and two of their last three games have been close. OSU will take advantage of a Hoosiers pass defense ranked only 68th in the nation and win and cover, avenging last season’s loss.
Over 50.5 points: Last season when these teams met, the total went Under, but I am leaning towards the Over this time around. The Buckeyes have the fifth-ranked passing attack and will face an IU pass defense that ranks only 68th. They will move the ball through the air and score big. While the Hoosiers are run-first, they have a solid QB in Josh Hoover and an offense that ranks 14th in the nation in scoring. OSU will get it done through the air, and IU will have to do the same to keep up, so this will be a higher-scoring affair.

The odds for this parlay are +273, so a $100 bet would pay $373, for a $273 profit.

NCAAF Parlay: Ohio State to cover at -3.5 and Over 50.5 points: (+273, BetMGM)

Check out our parlay betting guide for all the key info for the bet type.

BYU (5-0) is the eighth-ranked team in the nation and hosts second-ranked Notre Dame (6-0).

DraftKings Sportsbook has Notre Dame as a big 10.5-point favorite with a total of 46.5.

Notre Dame to cover the 10.5-point spread: BYU is 5-0 and in the top 10, but are they that good? They haven't faced a ranked opponent, and their last two Big 10 games were against teams that aren't over .500; they won by 7 and 14 points. Notre Dame also hasn't played a ranked team, but they did face a solid 4-1 Wisconsin team and scored 58 points in their last game. The Fighting Irish rank fourth in both points per game and opponents’ PPG, and they will take it to the Cougars, win, and cover the double-digit spread.
Under 46.5: Pretty low total but with good reason. BYU has a solid defense, and on offense they mostly run. Notre Dame is more balanced but is stronger in the run game. Look for a lot of running plays that will eat up the clock, and Notre Dame will not score big against a BYU team ranked tied for eighth and giving up an average of 13.4 ppg. The Irish will also play strong defense against a Cougars team that has scored only 41 points in its last two games.

The odds for this parlay are +268, so a $100 bet would pay $368, for a $268 profit.

NCAAF Parlay: Notre Dame to cover at -10.5 and Under 46.5 points: (+268, DraftKings)

Both Alabama (5-1) and Missouri (5-1) are ranked and face ranked teams on the road this Saturday.

Alabama to win and cover 7.5-point spread: Alabama is coming off their first loss of the season, where they lost to second-ranked Georgia by three points. Tennessee is the 14th-ranked team in the nation with their only loss to Texas. They are solid, but not as great as Bama. In the 'Volunteers' last two wins, both were close and came against teams that are 1-5 combined in SEC play. The Crimson Tide will roll in this one, and I would have taken them even if they were double-digit favorites.
Missouri to cover 5.5-point spread: Missouri is the 13th-ranked team in the nation and on the road and underdogs this Saturday facing ninth-ranked Ole Miss. The Tigers don't have a dynamic offense, but they have a solid ground game that will get the job done against an Ole Miss run defense ranked only 104th in the nation. Missouri crushed Florida in the game before their last one, and the Bulldogs' only loss this season was a 52-28 loss to Florida.

The odds for this parlay are +261, so a $100 bet would pay $361, for a $261 profit.

NCAAF Parlay: Both Alabama and Missouri to cover: (+261, DraftKings)

Here is a three-leg parlay with player props from FanDuel.

Jamal Roberts Over 110 rushing yards (-146): Missouri RB Roberts ranks second in the nation in rushing yards and has rushed for over 200 yards in each of the last two games. He will go big again as Mizzou faces Ole Miss, which ranks 104th in the nation in run defense.
Julian Sayin Over 250 passing yards (-140): Ohio State QB Sayin has the fourth-most passing yards in the nation and has passed for over 250 yards in three of five games this season. He will do it again on Saturday against an Indiana pass defense ranked 68th in the nation that has given up more than 250 passing yards in each of its last two games.
Malachi Toney 90+ Yards (-178): The Miami WR has the eighth most receiving yards in the nation and has over 90 receiving yards in four of five games this season. On Saturday, he will face a Florida State pass defense ranked only 115th in the nation.

The odds for this parlay are +351, so a $100 bet would pay $351, for a $251 profit.

NCAAF Parlay: Jamal Roberts Over 110 rushing yards, Julian Sayin Over 250 passing yards, and Malachi Toney 90+ receiving yards: (+351, FanDuel)

The top US sportsbooks will have competitive odds for every NCAAF D1 matchup as well as many betting markets for the bigger games.