Philadelphia 76ers vs. New York Knicks Odds, Picks & Predictions - Game 2

Written By Chris Kubala | Published at May 6, 2026
May 4, 2026; New York, New York, USA; New York Knicks center Karl-Anthony Towns (32) controls the ball against Philadelphia 76ers center Joel Embiid (21) during the first quarter of game one of the eastern conference semifinal round of the 2026 NBA Playoffs at Madison Square Garden. Mandatory Credit: Brad Penner-Imagn Images

The second round of the NBA playoffs continue in earnest with an Eastern Conference battle as the seventh-seeded Philadelphia 76ers take on the third-seeded New York Knicks in Game 2 of their best of seven series Wednesday night and we have you covered with our 76ers vs. Knicks prediction. In Game 1 of the series, the Knicks rolled to a 137-98 triumph to draw first blood in the series Monday night. They easily covered the line as a 7.5-point favorite.

In the all-time playoff series between the teams, Philadelphia has won five of the nine previous series. The 76ers own a 23-17 advantage in head-to-head playoff victories. Let’s break down this 76ers vs. Knicks matchup.

76ers Shooting to Bounce Back After Blowout

Philadelphia went the distance against Boston in the opening round. The lack of rest got the better of them as they took a beating in the opening game of the series Monday night. In Game 1, Philadelphia trailed 7-2 out of the gate before going on an 11-3 run to take a 13-10 lead midway through the first quarter. That was the high water mark for the 76ers, who trailed by eight after the opening quarter, by 21 at the half and by as many as 40 in the loss. Paul George led Philadelphia with 17 points in the loss.

In the playoffs, the 76ers are 10th in the league in scoring offense with 103 points per game. The 76ers are 14th in rebounding as they collect 39.5 rebounds per contest. They are 14th in assists by dishing out an average of 20.9 dimes a night. Philadelphia is 1th in the league in scoring defense as they allow an average of 110.4 points a contest. Tyrese Maxey is a solid option for the 76ers as he puts up 25.1 points and siix assists per game this postseason. Joel Embiid (25.2 points, eight rebounds, 5.8 assists) and Paul George (17.4 points) are good secondary scoring options.

Philadelphia is 9th in the league in field goal percentage as they shoot 44.2% from the floor as a team. The 76ers are 8th in threes per game as they drain 11.5 triples a contest. They are 6th in three-point shooting by connecting on 35.4% of their attempts from beyond the arc. Philadelphia stands 3rd in the league in free throw shooting as they convert 80.9% of their attempts at the stripe.

Key Injury Report for 76ers:

Knicks Look to Take 2-0 Series Advantage

New York didn’t miss a beat after drubbing Atlanta in Game 6 as they thrashed Philadelphia in the opener. The Knicks now seek a 2-0 series edge before switching venues for Games 3 and 4 as they take the floor here. On Monday night, New York led by eight after the opening quarter and pulled away from there. The Knicks led by 21 at the half, by 29 after three quarters and by as many as 40 in the game. New York shot a scorching 63.1% from the floor in the victory. Jalen Brunson led the Knicks with 35 points in the victory as one of four players in double figures.

In the postseason, the Knicks are 2nd in the league in scoring offense with 120.6 points per contest entering this game. New York is 4th in the league in rebounding as they collect 44.9 rebounds per game. They are 3rd in the league in assists by dishing out 25.6 dimes per contest. The Knicks are 3rd in the league in scoring defense by allowing 100 points per contest. Jalen Brunson (27.6 points, 5.7 assists) is the team’s leading scorer. OG Anunoby (21 points, 7.9 rebounds) and Karl-Anthony Towns (18.4 points, 10.6 rebounds, six assists) provide a good secondary punch for the Knicks in the playoffs.

New York is 1st in the league in field goal percentage as they shoot 51.8% from the floor as a team. The Knicks are 4th in the league in threes per game as they knock down 12.9 triples a night. They are 1st in three-point shooting by hitting 40.2% of their attempts from beyond the arc. New York is solid at the charity stripe, ranking 5th in the league by cashing in 76.8% of their attempts.

Key Injury Report for Knicks:

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76ers vs. Knicks Prediction

Game 1 of this series was a blowout as Nick Nurse pulled his starters with five minutes to go in the third quarter. The 76ers don’t have a very deep rotation, as we touched on in our preview for Game 1. We pointed out in that one that four starters logged at least 39 minutes in Game 7 against the Celtics. The Knicks took advantage of the fatigue factor and blitzed Philadelphia into submission. New York leads the league in postseason field goal percentage and they can utilize their depth. Playing at home, give the advantage to the Knicks here as they take a 2-0 advantage.

Our Prediction: Knicks -7.5 (FanDuel, -115)

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