Detroit Pistons vs. Cleveland Cavaliers Odds, Picks & Predictions - Game 4

Written By Chris Kubala | Published at May 11, 2026
May 7, 2026; Detroit, Michigan, USA; Cleveland Cavaliers guard James Harden (1) dribbles in the first half against the Detroit Pistons during game two of the second round of the 2026 NBA Playoffs at Little Caesars Arena. Mandatory Credit: Rick Osentoski-Imagn Images

The second round of the NBA playoffs continue with an Eastern Conference battle as the top-seeded Detroit Pistons take on the fourth-seeded Cleveland Cavaliers Monday night. It’s Game 4 of the best-of-seven series and we have you covered with our Pistons vs. Cavaliers prediction.

In the opening game of the series Tuesday night, Detroit picked up a 111-101 home victory to draw first blood. The Pistons covered the line as a 3.5-point favorite. In addition, the Pistons earned a 107-97 win at home in Game 2 Thursday night. They covered the line as a 3.5-point favorite in that contest. Meanwhile, Cleveland got on the board with a 116-109 win in Game 3 at home, covering the line as a 5.5-point favorite.

In the all-time playoff meetings between the teams, the Cavaliers own a 16-8 edge in head-to-head victories. Cleveland has won three of the four previous postseason series between the teams. Let’s break down this Pistons vs. Cavaliers matchup.

Pistons Seeking to Rebound After Game 3 Defeat

Detroit took the first two games of the series but couldn’t carry that momentum on the road in Game 3. The Pistons look to rebound after seeing their five-game win streak snapped as they take the floor here. In Game 3, Detroit led by seven early, trailed by two after the opening quarter, by 16 at the half and by as many as 17 in the game. The Pistons rallied to tie the game at 100 with 4:57 remaining. However, unlike Games 1 and 2, it was Detroit stumbling down the stretch, sending them to defeat. Cade Cunningham led the Pistons with 27 points, 10 rebounds and 10 assists in the loss. He did turn the ball over eight times, which proved critical.

In the postseason, the Pistons are 10th in the league in scoring offense as they average 104.4 points a game. Detroit is 4th in rebounding with an average of 45.6 boards per contest. They are 11th in assists by dishing out 21.6 dimes a night. The Pistons are 2nd in the league in scoring defense as they give up an average of 99.8 points per contest. Cade Cunningham leads the way offensively for the Pistons with 30.2 points, 5.6 rebounds and 7.7 assists per game. Tobias Harris contributes 21.3 points plus 7.7 rebounds a night as a secondary scoring option.

Detroit is 9th in the league in field goal percentage as they shoot 44.5% from the floor. The Pistons are 14th in the league in threes per game as they hit 10.1 triples per contest. They are 6th in three-point percentage as they connect on 35.2% of their attempts from beyond the arc. However, Detroit is average at the charity stripe, ranking 8th by shooting 76.3% at the line.

Key Injury Report for Pistons:

Cavaliers Trying to Square the Series

Cleveland avenged a pair of fourth quarter wilting performances to earn the win in Game 3 Saturday to get on the board in the series. The Cavaliers improved to 5-0 at home in the postseason and try to even the series with a win here. In Game 3, Cleveland shook off trailing by seven early in the game but took a 16-point advantage at the half. The Cavaliers didn’t maintain that edge, finding themselves even with 4:57 to go. Cleveland responded with eight of the next 11 points and picked up the victory. Donovan Mitchell led the Cavaliers with 35 points and 10 rebounds in the win.

The Cavaliers come into this one ranked 5th in the league in scoring offense as they put up an average of 109.7 points per game this postseason. Cleveland is 6th in rebounding as they grab 42.3 boards per contest and stand 12th in assists by handing out 21.5 dimes a contest this postseason. The Cavaliers are 9th in the league in scoring defense as they allow an average of 109.8 points per game this season. Donovan Mitchell leads the way in the scoring department for Cleveland as he puts up 25.1 points plus 5.4 rebounds a night on the year. James Harden (19.5 points, 5.3 rebounds, six assists) and Evan Mobley (16.3 points, 7.8 rebounds) are solid secondary options.

Cleveland is 4th in the league in field goal percentage as they shoot 47.2% from the floor as a team in the playoffs. The Cavaliers are 5th by knocking down an average of 12.6 three-pointers a night while they are 11th by connecting on 33.6% of their attempts from beyond the arc. Meanwhile, Cleveland is below average at the charity stripe as they rank 11th by shooting 73.7% from the line as a team.

Key Injury Report for Cavaliers:

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Pistons vs. Cavaliers Prediction

Detroit took the first two games in this series but those games came at home. Cleveland is unbeaten at home in the playoffs (5-0) compared to their 0-5 mark as the visiting team. The Cavaliers showed grit as they didn’t fold after letting their lead slip away. Detroit still has the upper hand but they are a young team that lacks the killer instinct a team needs in the playoffs. That comes with time and experience in big games. Cleveland has covered the line in each of their home games in the postseason. Therefore, look for the Cavaliers to square things up with a win here.

Our Prediction: Cavaliers -3.5 (BetMGM, -110)

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