Cleveland Cavaliers vs. Detroit Pistons Odds, Picks & Predictions - Game 5

Written By Chris Kubala | Published at May 13, 2026
May 5, 2026; Detroit, Michigan, USA; Detroit Pistons center Jalen Duren (0) dunks in the second half against the Cleveland Cavaliers during game one of the second round of the 2026 NBA Playoffs at Little Caesars Arena. Mandatory Credit: Rick Osentoski-Imagn Images

The second round of the NBA playoffs continue with an Eastern Conference battle as the fourth-seeded Cleveland Cavaliers take on the top-seeded Detroit Pistons Wednesday night. It’s Game 5 of the best-of-seven series and we have you covered with our Cavaliers vs. Pistons prediction.

In the opening game of the series Tuesday night, Detroit picked up a 111-101 home victory to draw first blood. The Pistons covered the line as a 3.5-point favorite. In addition, the Pistons earned a 107-97 win at home in Game 2 Thursday night. They covered the line as a 3.5-point favorite in that contest. Cleveland got on the board with a 116-109 win in Game 3 at home, covering the line as a 5.5-point favorite. The Cavaliers squared the series with a 112-103 home win in Game 4 Monday night. They covered the line as a 3.5-point favorite.

In the all-time playoff meetings between the teams, the Cavaliers own a 17-8 edge in head-to-head victories. Cleveland has won three of the four previous postseason series between the teams. Let’s break down this Pistons vs. Cavaliers matchup.

Cavaliers Still Searching for First Road Win of Postseason

Cleveland won their second straight game and ran their home mark to 6-0 as they took Game 4 Monday night. Meanwhile, the Cavaliers are 0-5 as the visiting team, as they find themselves here. In Game 4, Cleveland trailed by three after the opening quarter and by four at the half before getting in gear. The Cavaliers scored the first 22 points of the second half to take control of the game. Cleveland outscored Detroit 38-21 in the third quarter. They never let the Pistons closer than eight the rest of the way for the win. Donovan Mitchell led the Cavaliers with 43 points in the win.

The Cavaliers come into this one ranked 5th in the league in scoring offense as they put up an average of 109.2 points per game this postseason. Cleveland is 7th in rebounding as they grab 41.5 boards per contest and stand 12th in assists by handing out 21.6 dimes a contest this postseason. The Cavaliers are 9th in the league in scoring defense as they allow an average of 109.8 points per game this season. Donovan Mitchell leads the way in the scoring department for Cleveland as he puts up 26.7 points plus 5.4 rebounds a night on the year. James Harden (19.9 points, 4.8 rebounds, 6.5 assists) and Evan Mobley (16.4 points, 7.8 rebounds) are solid secondary options.

Cleveland is 5th in the league in field goal percentage as they shoot 46.9% from the floor as a team in the playoffs. The Cavaliers are 5th by knocking down an average of 12.7 three-pointers a night while they are 11th by connecting on 33.7% of their attempts from beyond the arc. Cleveland is below average at the charity stripe as they rank 10th by shooting 75.4% from the line as a team.

Key Injury Report for Cavaliers:

Pistons Seeking to Regain Momentum

Detroit led 2-0 in this series but returns home losers of two straight contests. The Pistons try to regain momentum as they take the floor here in a pivotal Game 5. In Game 4, Detroit led by three after the opening quarter, by as many as seven in the first half and by four at intermission. The Pistons fell apart in the third quarter, trailing by 13 at the end of the stanza. Detroit got no closer than eight the rest of the way to wind up with the loss. Caris LeVert led the Pistons with 24 points off the bench in a losing effort.

In the postseason, the Pistons are 10th in the league in scoring offense as they average 104.3 points a game. Detroit is 5th in rebounding with an average of 44.6 boards per contest. They are 11th in assists by dishing out 21.7 dimes a night. The Pistons are 1st in the league in scoring defense as they give up an average of 100.9 points per contest. Cade Cunningham leads the way offensively for the Pistons with 29.2 points, 5.4 rebounds and 7.5 assists per game. Tobias Harris contributes 20.8 points plus 7.7 rebounds a night as a secondary scoring option.

Detroit is 7th in the league in field goal percentage as they shoot 45.1% from the floor. The Pistons are 14th in the league in threes per game as they hit 10.1 triples per contest. They are 5th in three-point percentage as they knock down 35.8% of their attempts from beyond the arc. Detroit is below average at the charity stripe, ranking 9th by shooting 76.2% at the line.

Key Injury Report for Pistons:

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Cavaliers vs. Pistons Prediction

Cleveland is a stellar 6-0 at home in the playoffs but they are 0-5 on the road. In addition, the Cavaliers are 0-5 ATS as the visiting team in the playoffs entering this game. Mitchell exploded in the second half of Game 4, putting up 39 points, helping Cleveland rally to even the series. Detroit rebounded after dropping Games 3 and 4 in Orlando during the first round by winning the next three contests. The Pistons took care of business at home in the first two games of the set. Until Cleveland proves they can win as the visiting team, fade them accordingly.  Therefore, give the points and take the Pistons here.

Our Prediction: Pistons -3.5 (DraftKings, -112)

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