Celtics vs. 76ers vs. Prediction, Odds & Picks: Philly Takes Round 1

Author Jason Green | Published at November 10, 2026
Celtics vs. 76ers prediction for huge early season game. We have some of the best picks for this anticipated matchup.
Nov 2, 2026; Philadelphia, Pennsylvania, USA; Philadelphia 76ers guard Jaylen Brown (7) controls the ball against the Chicago Bulls during the second quarter at Xfinity Mobile Arena. Mandatory Credit: Bill Streicher-Imagn Images

The two leading teams in the Eastern Conference meet in Philly for what could be a drama-filled, nationally televised game, with the Philadelphia 76ers hosting the Boston Celtics. In this Celtics vs. 76ers prediction, we will lay it all on the table, from the game info and latest lines to betting trends, player props, and more.

The 76ers (9-2) lead the East, with the Celtics right behind them. This will be the first game between these division rivals since the blockbuster trade that sent Jaylen Brown to Philadelphia for Paul George and four draft picks, including two first-rounders, to Boston.

Celtics vs. 76ers Odds

Here are the odds for this Atlantic Division affair at DraftKings Sportsbook:

In this game, the 76ers are the favorite, and to win the bet and cover the spread, they must win by 2 or more points. For the Celtics to cover the spread, they must win outright or lose by fewer than 2 points.

Out point spread betting guide will show you all you need to know about the most popular NBA bet.

The Celtics have won three in a row, and in their last game they beat the Milwaukee Bucks 117-97. In the win, the team shot 47% from the field, and George and Jayson Tatum combined for 48 points.

Tatum ranks sixth in the NBA in scoring (27.1ppg), and George has played well in his first season in Boston, averaging 20.4 ppg, 5.2 rpg, and 4.1 assists per game.

The best NBA betting sites will offer many prop bets for every NBA game.

The 76ers got over their second loss of the season with a 127-21 win over the Chicago Bulls in their last game. While Philly shot a lower FG% (46% to 42%), they shot better from the 3-point range (41% to 27%) and had 11 more offensive boards (20-9). Every 76ers starter went for double figures, led by Jaylen Brown with 29 points; Tyrese Maxey had 27 points, and Joel Embiid had a double-double with 18 points and 10 rebounds.

The new superteam has gelled well early in the season. Maxey (26.9 ppg) and Brown (22.3 ppg) have led the way. Embiid has stayed healthy so far and is averaging 17.9 ppg and 9.7 rpg. LeBron James has not been the focal scorer but has played well, averaging 15.6 ppg, 7.1 rpg, and 6.7 assists per game.

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Key Stats

Celtics

76ers

Celtics vs. 76ers Injuries

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None

76ers

Celtics vs. 76ers Prediction: 76ers -1.5 (-104) 

The Celtics are the hotter team, but the 76ers are at home and want to send a message. The new superteam will do it on both ends of the floor, and they will put pressure on Boston.

Maxey, Brown, Embiid, and King James will come out, play well on their floor, and show they are the team to beat in the East. I do not see them blowing out the Celtics in any way, but with the extra buzz in the air, the stars for Philly will step up, which is why they are the team to cover the short spread in the much anticipated matchup.

The best US sportsbooks will offer many prop bets for all NBA games.

More Celtics vs. 76ers Picks, Props and Best Bets

Here are some solid prop bets for this big game:

Our prop betting guide gives you all the key info for that bet type.

Celtics vs. 76ers Broadcast Info