Cavaliers vs. Knicks Prediction, Picks & Odds: NY to Continue Winning Ways

Author Juan Carlos Blanco | Published at November 11, 2026

See our Cavaliers vs. Knicks prediction, odds analysis, and picks for Nov. 11. — Nov 7, 2026; Cleveland, Ohio, USA; New York Knicks guard Jalen Brunson (11) reacts in the second quarter against the Cleveland Cavaliers at Rocket Arena. Mandatory Credit: David Richard-Imagn Images

Two teams currently headed in opposite directions, the Cavaliers and Knicks face off at Madison Square Garden on Wednesday night for their second meeting this season, after New York swept the Cavs in last postseason’s Eastern Conference Finals.

The Knicks have won four straight after a 0-3 start to their title-defense season, while the Cavs’ 3-1 start has slipped to 5-6 after four losses in their last five games.

Read on for our Cavaliers vs. Knicks prediction, picks, and odds analysis for tonight's clash between Eastern Conference rivals.

Cavaliers vs. Knicks Odds

Given each club’s recent form and the Knicks’ home-floor setting, New York has unsurprisingly been installed as a solid home favorite on FanDuel Sportsbook.

Also in tonight’s equation are the Knicks’ impressive 109-97 road win over Cleveland two games ago and the fact that four of New York’s six wins have come at MSG.

The game also carries what could be termed relatively modest offensive expectations. Not only did this season’s first head-to-head matchup yield only 206 total points, but the Knicks are also conceding an Eastern Conference-low 99.0 points per home game.

Spread: Cavaliers +4.5 (-118) / Knicks -4.5 (-104)
Moneyline: Cavaliers +144 / Knicks -172
Total (Over/Under): Over 221.5 (-110) / Under 221.5 (-110)

Consequently, NBA oddsmakers are projecting a competitive and fairly defense-centric game between two rivals who know each other very well. Each squad is also at what could be termed near full health in terms of front-line players, except for the Knicks’ Josh Hart, who remains questionable with an ankle injury and illness.

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Cleveland Cavaliers Betting Trends

The Cavaliers are 3-8 against the spread in 2026-27, including 1-4 on the road.
The Cavaliers are 0-2 ATS in games where they’ve had a rest advantage.
The Cavaliers are 3-5 ATS against Eastern Conference opponents.
The Cavaliers lost all four games to the Knicks in last postseason’s Eastern Conference Finals by double digits.

The Cavaliers have had some trouble separating in a couple of victories, and their last pair of losses, including the aforementioned one to the Knicks, have come by double digits.

Cleveland’s difficulties on the road are somewhat explainable, given that they’ve been very competitive against two high-quality opponents in the 76ers and the Thunder, while also taking a three-point loss to a solid team in the Hawks.

Meanwhile, their most recent victory — a 119-95 home thumping of a 76ers team at full health in an NBA Cup Group Play game Friday — offers reason for optimism heading into a matchup against a team they’ve lost six of their last seven games to.

New York Knicks Betting Trends

Four of the Knicks’ six wins this season have come at home by an average margin of 22.3 points, all coming in consecutive fashion leading into Wednesday’s game.
The Knicks are 3-3 against the spread at home, and the Over is just 1-5 in New York’s home games.
The Knicks were 2-1 straight up against the Cavaliers during the 2025-26 regular season while notching eight- and two-point wins, then posted a 19.3-point average margin of victory during the four-game ECF sweep.

The Knicks appear to have largely steadied themselves after dropping each of their first three games. Once New York started winning, it started winning big, posting double-digit victories in all but one of its six triumphs to date. Two of the last three victories the Knicks have notched have come by massive 30- and 32-point margins against the Bulls and Bucks, respectively.

While the caliber of competition goes up Wednesday, the Knicks’ recent history against Donovan Mitchell and Co., and the standout defense New York has largely played, gives the hosts plenty of momentum on paper heading into tonight’s clash.

Cavaliers vs. Knicks Prediction: Knicks -4.5 (-104)

While Jalen Brunson is still trying to consistently find his shot, the Knicks’ team defense has been mostly stellar and played a key role in getting the defending champs back on track after their sluggish start.

In addition to the Knicks surrendering an Eastern Conference-low 99.0 points per home game, New York also sports an Eastern Conference-best 0.987 defensive efficiency rating at home and surrenders Eastern Conference-low 40.4% shooting there as well.

In turn, the Cavaliers’ numbers pale in comparison.

Cleveland is giving up 117.4 points per road game, even as the Cavs are limiting opponents to stingy 44.8% shooting in that split. However, teams are teeing off on them from long range at home, as Cleveland is yielding an elevated 38.7% success rate from deep on the road. The Cavs are also allowing the league’s fourth-highest effective possession ratio overall (0.997), which helps explain some of their recent struggles after a strong start.

Given the disparity between the two teams’ overall resumes and defensive play — as well as the recent history of the series — our Cavaliers vs. Knicks prediction is that New York will cover the 4.5-point spread.

As of Wednesday morning, the public is also fully behind the Knicks continuing their winning ways. A whopping 89% and 84% of the bets are coming in on New York’s moneyline and the spread, respectively, and 84% of the money on the latter is also on the Knicks.

More Cavaliers vs. Knicks Picks, Props and Best Bets

Jalen Brunson Over 32.5 Points + Assists (-118, FanDuel) – Brunson is still trying to consistently find his shot, but he’s taking plenty of them (28.3 field-goal + free-throw attempts per game) and is averaging 33.7 points + assists across his last six contests while shooting 43.1% from three in that span. He also lit up Cleveland for 40 points + assists on the road two games ago, shooting 48.0% in that contest.
Donovan Mitchell Over 24.5 Points (-110, FanDuel) – Mitchell has mostly been himself during the Cavaliers’ struggles, averaging 29.0 points on 52.6% shooting in the three games before an 11-point clunker against the Hornets last time out. That includes a season-best 37-point outburst against the Knicks two games ago, and dating back to the beginning of last season, Mitchell is 6-2 to the Over on 24.5 points against the Knicks.