MNF Week 5 NFL Parlay Picks: How to Maximize Bets in Chiefs vs Jaguars Matchup
Written By Nick Crain | Last Updated at October 8, 2025
Monday Night Football delivers an exciting Week 5 matchup, as the Jacksonville Jaguars host the Kansas City Chiefs. This is a contest that gives bettors even more chances to build creative multi-leg wagers, especially parlay picks.
From correlated rushing props to team totals and player performance combos, there’s plenty of value across both games for multi-leg bets. There are offensive weapons all over both teams, with a variety of fascinating players that factor into tonight’s plays.
With that in mind, here are the three best MNF parlay picks for Week 5 and where the lines provide an edge for the best odds tonight.
The Thornton Game
- Leg 1: Tyquan Thornton Anytime TD Scorer
- Leg 2: Tyquan Thornton o14.5 Receiving Yards
📊 Parlay Odds: +916 (via BetMGM) ⭐
Through four games this season, Thornton has logged 182 yards on 10 catches, good for 18.2 yards per reception. As such, he should only need a catch or two in order to hit his over on yards.
Furthermore, he has caught three touchdowns, which is good for most on the Chiefs. Tonight is a big spot for him to continue his impressive early-season run and establish himself as a key offensive piece, even as Kansas City gets healthier.
QBs on the Run
- Leg 1: Patrick Mahomes o21.5 Rushing Yards
- Leg 2: Trevor Lawrence o9.5 Rushing Yards
📊 Parlay Odds: +257 (via Caesars Sportsbook) ⭐
With 130 yards rushing on the season, Mahomes, interestingly enough, leads the Chiefs in ground yardage through four games. If he keeps up this rate tonight, exceeding 21.5 yards will be no problem.
Lawrence isn't as much of a threat as a rusher, only rushing for 32 yards on the season, but he can when needed. The Chiefs' defense has allowed big QB rushes at various points in the season, and with Lawrence's line only being 9.5 yards, it just takes one big run to cash.
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- Leg 1: Kansas City Chiefs -3.5
- Leg 2: Combined Score o45.5 Points
📊 Parlay Odds: +264 (via bet365) ⭐
After a slow start to the season, Kansas City is getting key players back each week and continues to look stronger. Despite the Jags being at home and having a better record to this point, the Chiefs are more experienced and are the favorite for a reason -- with a cover of only 3.5 being an attractive bet.
This game also has the makings of a shootout, with playmakers on both teams' offenses. Both in the backfield and out wide, the Chiefs and Jaguars have players who can score with one single touch, along with defenses that are prone to allowing points in chunks.
Parlays always come with added risk, but the structure of this week’s board makes several angles appealing. These MNF Week 5 parlay bets provide strong paths to a payout. Be sure to shop for the best MNF parlay odds before locking in your plays, but these are among the best parlay bets NFL Week 5 has to offer.
Featured Image Mandatory Credit: Denny Medley-Imagn Images
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