Chicago White Sox vs. Boston Red Sox Odds, Picks & Predictions

Written By Chris Kubala | Published at August 6, 2026
Jul 22, 2026; Boston, Massachusetts, USA; Boston Red Sox first baseman Willson Contreras (40) hits a double against the Baltimore Orioles during the fourth inning at Fenway Park. Mandatory Credit: Brian Fluharty-Imagn Images

It’s the conclusion of a series on the diamond between a pair of American League squads battling for playoff positioning as the Chicago White Sox play the final game of a three-game set with the Boston Red Sox Thursday night and we have you covered with our White Sox vs. Red Sox prediction.

These teams opened their series Tuesday night with Boston battering their way to a 14-2 triumph. As a result, they drew first blood in the series. Which team picks up the win in the finale of the series here on getaway day? This article was originally published prior to the conclusion of the middle game of the series at Fenway Park Wednesday night.

Chicago Trying to Extend AL Central Advantage

White Sox Last Game

Chicago won four of their previous five before getting shellacked in the opening game of this set Tuesday night. The White Sox entered Wednesday with a 59-53 record on the year. They owned a three-game edge on the Guardians for the top spot in the AL Central race. On Tuesday night. Chicago finished with six hits as no player had more than one in the contest. The White Sox were just one of nine with runners in scoring position and left seven men on base in the loss. Davis Martin (9-6) took the loss as he allowed nine runs on 10 hits with two walks and one strikeout over five innings of work before departing.

White Sox Probable Starter

Luis Castillo projects to make his White Sox debut after being acquired from Seattle earlier this week. It marks his 21st appearance and 18th start of the season overall, his first with Chicago. Castillo is 3-9 with a 5.06 ERA, a 1.395 WHIP, 32 walks and 86 strikeouts over 99.2 innings of work on the year. He didn’t factor in the decision in his last start, which came with the Mariners against the Dodgers on the road July 28. In that outing, Castillo threw five innings, allowing five runs on 11 hits with two walks and two strikeouts. He didn’t factor in the decision as the Mariners earned a 7-6 victory.

In his last three starts, Castillo is 0-2 with a 6.35 ERA, a 1.706 WHIP, five walks and nine strikeouts over 17 innings of work. Castillo makes his seventh career appearance, sixth start, against the Red Sox in this contest. He is 2-3 with a 5.34 ERA, a 1.219 WHIP, 10 walks and 34 strikeouts over 32 innings of work against them. Castillo is 2-1 with a 4.24 ERA, a 1.118 WHIP, six walks and 20 strikeouts over 17 innings of work in three career starts at Fenway Park.

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Red Sox Trying to Chase Down AL East Lead

Red Sox Last Game

Boston ran their win streak to six games and improved to 15-3 since the All-Star break by clobbering the White Sox Tuesday night. That win in the opening game of the set improved the Red Sox to 61-51 on the year and stood third in the AL East, 5.5 games behind Tampa Bay. They owned the second wild card in the American League and stood six games clear of the Twins and Rangers to remain in the playoff field. On Tuesday, Boston rapped out 15 hits with seven different players recording a pair. Wilyer Abreu (his 18th and 19th) homered twice while Jarren Duran (his 15th) and Chad Durbin (his 11th) also went deep in the win. Patrick Sandoval (1-0) earned the win as he threw five innings, allowing two runs on six hits with four walks and five strikeouts, before departing.

Red Sox Probable Starter

Ranger Suarez gets the ball for the Red Sox as he makes his 20th start of the season in this contest. He is 4-3 with a 3.15 ERA, a 1.16 WHIP, 28 walks and 105 strikeouts over 100 innings of work this season. Suarez didn’t factor in the decision in his last start, which came Friday against the Dodgers on the road. He threw 4.2 innings, allowing three runs on four hits with two walks and two strikeouts, in a game the Red Sox eventually won 9-4.

In his last three starts, Suarez has no record with a 4.76 ERA, a 1.41 WHIP, two walks and 13 strikeouts over 11.1 innings of work. Suarez didn’t factor in the decision in his lone career outing against the White Sox. That outing came in relief with the Phillies on August 4, 2019 at Citizens Bank Park. He threw a 1-2-3 inning, striking out one, in a 10-5 Phillies defeat. Suarez makes his 12th career appearance, 10th start, at Fenway Park in this contest. He is 1-2 with one save, a 3.26 ERA, a 1.168 WHIP, 15 walks and 52 strikeouts over 49.2 innings of work in those outings.

White Sox vs. Red Sox Prediction

Red Sox ML (-178, FanDuel)

Both teams are in playoff position entering this contest but we’re backing Boston here. The Red Sox have been sizzling since the start of July. Boston entered Wednesday 23-3 in their last 26 games dating back to July 2. Suarez, who hasn’t been as good as we saw in Philadelphia this season, is still better than Castillo. While the addition of Castillo gives the White Sox a veteran arm for the stretch run, he still has to find a way to return to form. Boston had five straight wins between the teams entering Wednesday night. In addition, the White Sox are 25-32 on the road this year. The Red Sox take care of business here and stay hot with a win here.

Over 9 (-110, FanDuel)

Boston entered Wednesday having seen the under post a 61-48-3 mark on the year. However, the Red Sox bats woke up at the All-Star break. After averaging 4.10 runs per game in the first half of the season, Boston averages 5.72 runs a game since the break. Chicago has gone over the number in 64 of their 112 games this year. The White Sox are eighth in the majors in runs per game this season. Castillo owns an ERA over five and it could be worse as nine of the 65 runs he’s allowed are unearned. In addition, he’s served up 16 homers on the year. Current Red Sox hitters own a .304 average (24 of 79) against Castillo with a dozen extra base hits. Boston piles up runs and the White Sox help out, pushing this over the number.

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