Second Round Odds: March Madness College Basketball Lines, Spreads

Written By Brett Gibbons on March 18, 2022 - Last Updated on March 20, 2022
Round of 32 odds

The NCAA Tournament is underway and the madness has just begun. What surprises does the second round have in store? Follow this article for live, updated second-round odds as the matchups are decided. Keep up-to-date with TheLines for complete March Madness coverage, analysis, and the latest odds.

We also have the Round of 32 TV schedule. Check back here for odds and matchups as they are determined.

BetMGM March Madness Special Offer! Bet $10 on a moneyline and win $200 if either team makes a 3-pointer!

West Region Second Round Odds

(1) Gonzaga vs. (9) Memphis

When: Saturday, March 19

Where: Portland, Ore.

(12) New Mexico State vs. (4) Arkansas

When: Saturday, March 19

Where: Buffalo, N.Y.

(11) Notre Dame vs. (3) Texas Tech

When: Sunday, March 20

Where: San Diego, Calif.

(7) Michigan State vs. (2) Duke

When: Sunday, March 20

Where: Greenville, S.C.

Free Pick’Em Contests! Compete for prizes every day by entering our free betting games. NFL, MLB, golf and more!

East Region Second Round Odds

(1) Baylor vs. (8) North Carolina

When: Saturday, March 19

Where: Fort Worth, Texas

(5) Saint Mary’s vs. (4) UCLA

When: Saturday, March 19

Where: Portland, Ore.

(6) Texas vs. (3) Purdue

When: Sunday, March 20

Where: Milwaukee, Wis.

(7) Murray State vs. (15) Saint Peter’s

When: Saturday, March 19

Where: Indianapolis, Ind.

South Region Second Round Odds

(1) Arizona vs. (9) TCU

When: Sunday, March 20

Where: San Diego, Calif.

(5) Houston vs. (4) Illinois

When: Sunday, March 20

Where: Pittsburgh, Pa.

(11) Michigan vs. (3) Tennessee

When: Saturday, March 19

Where: Indianapolis, Ind.

(7) Ohio State vs. (2) Villanova

When: Sunday, March 20

Where: Pittsburgh, Pa.

Midwest Region Second Round Odds

(1) Kansas vs. (9) Creighton

When: Saturday, March 19

Where: Fort Worth, Texas

(12) Richmond vs. (4) Providence

When: Saturday, March 19

Where: Buffalo, N.Y.

(11) Iowa State vs. (3) Wisconsin

When: Sunday, March 20

Where: Milwaukee, Wis.

(10) Miami vs. (2) Auburn

When: Sunday, March 20

Where: Greenville, S.C.

Brett Gibbons Avatar
Written by
Brett Gibbons

Brett is an avid sports traveler and former Division-I football recruiter for Bowling Green and Texas State. He’s a graduate of BGSU and works as an auditor for Google content curation products. He’s also contributed to Sports Illustrated and Fansided during his young writing career.

View all posts by Brett Gibbons