March Madness Opening Odds 2022: Spreads, Over/Unders, Moneylines

Written By Brett Gibbons on March 13, 2022
March Madness opening odds

There’s no more anticipated time of year for fans of college basketball than the NCAA Tournament. This article will lay out 2022 March Madness opening odds, matchups, and locations. Check back in on Selection Sunday for the complete schedule and rundown.

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March Madness Opening Odds: West Region

(1) Gonzaga vs. (16) Georgia State

Spread

Gonzaga
Bet now
-27.5
Bet now
-23.5
Bet now
-26.5
Georgia State
Bet now
+27.5
Bet now
+23.5
Bet now
+26.5

When: Thursday, March 17

Where: Portland, Ore.

TV: TBD

(8) Boise State vs. (9) Memphis

Spread

Boise State
Bet now
-1.5
Bet now
-0.5
Bet now
+1.5
Memphis
Bet now
+1.5
Bet now
+0.5
Bet now
-1.5

When: Thursday, March 17

Where: Portland, Ore.

TV: TBD

(5) UConn vs. (12) New Mexico State

Spread

UConn
Bet now
-7
Bet now
-6.5
Bet now
-7.5
New Mexico State
Bet now
+7
Bet now
+6.5
Bet now
+7.5

When: Thursday, March 17

Where: Buffalo, N.Y.

TV: TBD

(4) Arkansas vs. (13) Vermont

Spread

Arkansas
Bet now
-5.5
Bet now
-5.5
Bet now
-5.5
Vermont
Bet now
+5.5
Bet now
+5.5
Bet now
+5.5

When: Thursday, March 17

Where: Buffalo, N.Y.

TV: TBD

(6) Alabama vs. (11) Rutgers/Notre Dame

Opening odds will be placed below once Alabama’s opponent is decided in the First Four.

When: Friday, March 18

Where: San Diego, Calif.

TV: TBD

(3) Texas Tech vs. (14) Montana State

Spread

Texas Tech
Bet now
-16.5
Bet now
-16
Bet now
Montana State
Bet now
+16.5
Bet now
+16
Bet now

When: Thursday, March 17

Where: San Diego, Calif.

TV: TBD

(7) Michigan State vs. (10) Davidson

Spread

Michigan State
Bet now
-1.5
Bet now
-1.5
Bet now
-1.5
Davidson
Bet now
+1.5
Bet now
+1.5
Bet now
+1.5

When: Friday, March 18

Where: Greenville, S.C.

TV: TBD

(2) Duke vs. (15) Cal State Fullerton

Spread

When: Friday, March 18

Where: Greenville, S.C.

TV: TBD

March Madness Opening Odds: East Region

(1) Baylor vs. (16) Norfolk State

Spread

Baylor
Bet now
-20.5
Bet now
-21.5
Bet now
-20.5
Norfolk State
Bet now
+20.5
Bet now
+21.5
Bet now
+20.5

When: Thursday, March 17

Where: Fort Worth, Texas

TV: TBD

(8) North Carolina vs. (9) Marquette

When: Thursday, March 17

Where: Fort Worth, Texas

TV: TBD

(5) Saint Mary’s vs. (12) Wyoming/Indiana

Opening odds will be placed below once Saint Mary’s opponent is decided in the First Four.

When: Thursday, March 17

Where: Portland, Ore.

TV: TBD

(4) UCLA vs. (13) Akron

Spread

Game
(Eastern Time)
(EST)
UCLA
Bet now
-15.5
Bet now
-15
Akron
Bet now
+15.5
Bet now
+15

When: Thursday, March 17

Where: Portland, Ore.

TV: TBD

(6) Texas vs. (11) Virginia Tech

Spread

When: Friday, March 18

Where: Milwaukee, Wis.

TV: TBD

(3) Purdue vs. (14) Yale

Spread

Purdue
Bet now
-17.5
Bet now
-16.5
Bet now
-16.5
Yale
Bet now
+17.5
Bet now
+16.5
Bet now
+16.5

When: Friday, March 18

Where: Milwaukee, Wis.

TV: TBD

(7) Murray State vs. (10) San Francisco

Spread

Murray State
Bet now
PK
Bet now
+1.5
Bet now
+1.5
San Francisco
Bet now
PK
Bet now
-1.5
Bet now
-1.5

When: Thursday, March 17

Where: Indianapolis, Ind.

TV: TBD

(2) Kentucky vs. (15) Saint Peter’s

Spread

Game
(Eastern Time)
(EST)
Kentucky
Bet now
-17
Bet now
-17.5
Saint Peter's
Bet now
+17
Bet now
+17.5

When: Thursday, March 17

Where: Indianapolis, Ind.

TV: TBD

March Madness Opening Odds: South Region

(1) Arizona vs. (16) Wright State/Bryant

Opening odds will be placed below once Arizona’s opponent is decided in the First Four.

When: Friday, March 18

Where: San Diego, Calif.

TV: TBD

(8) Seton Hall vs. (9) TCU

When: Friday, March 18

Where: San Diego, Calif.

TV: TBD

(5) Houston vs. (12) UAB

When: Friday, March 18

Where: Pittsburgh, Pa.

TV: TBD

(4) Illinois vs. (13) Chattanooga

Spread

Illinois
Bet now
-7.5
Bet now
-9
Bet now
-7.5
Chattanooga
Bet now
+7.5
Bet now
+9
Bet now
+7.5

When: Friday, March 18

Where: Pittsburgh, Pa.

TV: TBD

(6) Colorado State vs. (11) Michigan

Spread

Colorado State
Bet now
PK
Bet now
-1.5
Bet now
-2.5
Michigan
Bet now
PK
Bet now
+1.5
Bet now
+2.5

When: Thursday, March 17

Where: Indianapolis, Ind.

TV: TBD

(3) Tennessee vs. (14) Longwood

Spread

Tennessee
Bet now
-17
Bet now
-16
Bet now
-16.5
Longwood
Bet now
+17
Bet now
+16
Bet now
+16.5

When: Thursday, March 17

Where: Indianapolis, Ind.

TV: TBD

(7) Ohio State vs. (10) Loyola-Chicago

Spread

Ohio State
Bet now
+1.5
Bet now
+0.5
Bet now
+1.5
Loyola Chicago
Bet now
-1.5
Bet now
-0.5
Bet now
-1.5

When: Friday, March 18

Where: Pittsburgh, Pa.

TV: TBD

(2) Villanova vs. (15) Delaware

Spread

Villanova
Bet now
-17
Bet now
-16.5
Bet now
-17.5
Delaware
Bet now
+17
Bet now
+16.5
Bet now
+17.5

When: Friday, March 18

Where: Pittsburgh, Pa.

TV: TBD

March Madness Opening Odds: Midwest Region

(1) Kansas vs. (16) Texas Southern/Texas A&M Corpus Christi

Opening odds will be placed below once Kansas’ opponent is decided in the First Four.

When: Thursday, March 17

Where: Fort Worth, Texas

TV: TBD

(8) San Diego State vs. (9) Creighton

Spread

San Diego State
Bet now
-2.5
Bet now
-2
Bet now
-2.5
Creighton
Bet now
+2.5
Bet now
+2
Bet now
+2.5

When: Thursday, March 17

Where: Fort Worth, Texas

TV: TBD

(5) Iowa vs. (12) Richmond

Spread

When: Thursday, March 17

Where: Buffalo, N.Y.

TV: TBD

(4) Providence vs. (13) South Dakota State

Spread

Providence
Bet now
-1.5
Bet now
-3
Bet now
-2.5
South Dakota State
Bet now
+1.5
Bet now
+3.5
Bet now
+2.5

When: Thursday, March 17

Where: Buffalo, N.Y.

TV: TBD

(6) LSU vs. (11) Iowa State

Spread

When: Friday, March 18

Where: Milwaukee, Wis.

TV: TBD

(3) Wisconsin vs. (14) Colgate

Spread

When: Friday, March 18

Where: Milwaukee, Wis.

TV: TBD

(7) USC vs. (10) Miami FL

When: Friday, March 18

Where: Greenville, S.C.

TV: TBD

(2) Auburn vs. (15) Jacksonville State

When: Friday, March 18

Where: Greenville, S.C.

TV: TBD

Brett Gibbons Avatar
Written by
Brett Gibbons

Brett is an avid sports traveler and former Division-I football recruiter for Bowling Green and Texas State. He’s a graduate of BGSU and works as an auditor for Google content curation products. He’s also contributed to Sports Illustrated and Fansided during his young writing career.

View all posts by Brett Gibbons