March Madness Final Four Opening Odds: NCAA Tournament Betting
Next weekend, we move to the national semifinals of the 2025 NCAA men’s basketball tournament, better known as the odds for the Final Four. The favorites continue to dominate, going 12-0 since the Sweet 16. In fact, this marks the second Final Four since the 1985 expansion to feature all No. 1 seeds. The other time was in 2008, with Kansas, Memphis, UCLA, and UNC. The site? San Antonio.
Find the opening prices for the Final Four among Madness Madness odds. We recommend checking out the best sportsbook promos for more offers. If you’re in Illinois, sign up for the bet365 Illinois bonus code. This operator is now in the Prairie State!
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Florida vs. Auburn odds: spread, moneyline, total
Saturday, April 5, 6:09 p.m. ET
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Florida
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In their lone regular-season meeting, the Gators entered Neville Arena and blitzed the Tigers as 11-point underdogs. More impressively, they did so without guard Alijah Martin (hip). Todd Golden’s squad mitigated Martin’s absence by shooting 39.4% from three-point territory.
All eyes will zone in on star forward Johni Broome, who briefly exited Auburn’s Elite Eight win over Michigan State with a right elbow injury. The Wooden Award contender will have five days to rest before squaring off against his SEC rival.
Last April, I bet on Auburn’s national title futures. As the week progresses, I’ll decide whether to hedge by wagering on Florida.
Meanwhile, this total is the highest in a Final Four or national championship game since Maryland vs. Kansas in 2002.
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duke vs. houston odds: spread, moneyline, total
Saturday, April 5, 8:49 p.m. ET
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In a rematch of last year’s Sweet 16 tilt, the Cougars will seek revenge after falling to the Blue Devils without their former star guard, Jamal Shead (ankle), for much of the game. As expected, Duke is favored this time at the best March Madness betting sites.
Houston’s top-ranked, ultra-aggressive defense undoubtedly impacted Tennessee’s 5-of-29 three-point shooting (17.2%) on Sunday, but Duke is a different animal. In the NCAA tournament, the Blue Devils have shot 47.3% from behind the arc. They’re paced by veteran guard Tyrese Proctor, knocking down 64.3% of his triples during the Big Dance.
Whether Duke continues its torrid efficiency from behind the arc will undoubtedly decide the victor and the total.
final four odds: national championship futures
watcH: final four betting preview
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