March Madness Betting Odds: Sweet 16 Spreads, Moneylines, Totals

We’re almost reaching the start of the Sweet 16 round of 2025 March Madness. Despite fewer games that will draw action on college basketball betting sites, we’ll still provide a complete picture of NCAA Tournament lines, winner odds, and bets against the spread.

The single-elimination tournament runs through the Final Four in San Antonio on April 5 and the national championship game on April 7.

Find the best odds for the NCAA men’s basketball tournament’s Sweet 16 round after sportsbooks release them. Click on the tables below to bet on the Madness now.

SOUTH Region SWEET 16 Odds

Opening Odds

Game	Favorite	Underdog	Over/Under
(1) Auburn vs. (5) Michigan	Auburn -7.5 (-110)	Michigan +7.5 (-110)	150.5
(2) Michigan State vs. (6) Ole Miss	Michigan State -3.5 (-105)	Ole Miss +3.5 (-115)	143.5

South Region Betting Odds

No. 1 Auburn vs. No. 5 Michigan

Not expected to be a national contender in 2025 after back-to-back missed tournaments and the firing of Juwan Howard, Michigan has put things together under Dusty May. The Wolverines trounced Texas A&M in the second half, winning by 16, and they’ll now face an Auburn team that has cooled off considerably from its national No. 1 ranking.

Wooden Award candidate Johni Broome from Auburn had an uncharacteristically poor game against Creighton. He shot just 4-for-13, struggling against Creighton’s size. Michigan has a pair of 7-footers in Danny Wolf and Vladislav Goldin, though the former frequently operates on the outside. Broome will have to make a better effort for the Tigers to continue marching forward.

No. 2 Michigan State vs. No. 6 Ole Miss

This is a fascinating matchup, as each team has weaknesses that align with the opposing team’s strengths.

Michigan State is elite on the glass, ranking in the top 20 in both offensive and defensive rebounding rates. The Rebels are poor on both counts and must take care not to be overpowered inside.

Meanwhile, Ole Miss excels in the turnover battle. They never give up the ball (they have the third-lowest adjusted turnover rate) and turn opponents over frequently. Michigan State barely has a net positive differential there.

Watch for the 3-point battle to swing things as well. Ole Miss has shot the lights out thus far (19-for-39 from deep). Michigan State has Torvik’s top-rated 3-point defense.

EAST Region SWEET 16 Odds

Opening Odds

Game	Favorite	Underdog	Over/Under
(1) Duke vs. (4) Arizona	Duke -8.5 (-120)	Arizona +8.5 (-102)	153.5
(2) Alabama vs. (6) BYU	Alabama-4.5 (-114)	BYU +4.5 (-106)	175.5

East Region Betting Odds

No. 1 Duke vs. No. 4 Arizona

Cooper Flagg didn’t look appreciably slowed by injury in posting an 18-9-6 line as Duke routed the upset-minded Baylor Bears. Tyrese Proctor has put on an incredible shooting display as well. He caught fire in the ACC final against Louisville and hasn’t stopped scorching the nets to an eye-popping 19-for-30 across three games.

The Blue Devils continue to look invincible, hence the hefty spread against a more than respectable Arizona squad that had no trouble erasing an early 15-point deficit against Oregon.

No. 2 Alabama vs. No. 6 BYU

BYU showed the market’s faith in them was justified, holding off a furious Wisconsin rally to advance. Alabama righted the ship after a shaking opening game against Robert Morris, easily beating St. Mary’s.

Both teams love to fire away from deep, and both teams shoot the ball well. This could be a classic game of make-or-miss from the 3-point line, and the over/under reflects the chances of another barnburner. Alabama challenges teams with its breakneck pace (No. 1), so BYU will have to keep the turnovers in check after giving it away 11 times versus Wisconsin.

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Midwest Region SWEET 16 Odds

Opening Odds

Game	Favorite	Underdog	Over/Under
(1) Houston vs. (4) Purdue	Houston -8.5 (+100)	Purdue +8.5 (-120)	132.5
(2) Tennessee vs. (3) Kentucky	Tennessee -4.5 (-110)	Kentucky +4.5 (-110)	145.5

Midwest Region Betting Odds

No. 1 Houston vs. No. 4 Purdue

Opponents paraded to the paint and scored with little trouble against Purdue this season. According to Haslametrics, they rank 26th-worst in opponent FG% from close range, and Torvik has them 341st in adjusted 2-point defense. However, they’ve been surprisingly fine on that end thus far, allowing about 44% shooting on 2s to their first two opponents.

Was that a product of facing a couple of mid-majors, or has Purdue turned a corner?

Bettors may not find out yet, as Houston employs an offensive style heavy on mid-range shots. It’s something to keep in mind, considering Purdue’s first two defensive performances have been out of character.

Gonzaga scored efficiently against the Cougars’ top-rated unit (50% FGs). Kelvin Sampson’s group will look to step it up against the Braden Smith-Trey Kaufman-Renn combo.

No. 2 Tennessee vs. No. 3 Kentucky

Tennesee did not suffer many losses in a 29-7 season despite facing the toughest conference in the country. However, one team they couldn’t quite seem to solve was the Wildcats. Kentucky topped the Volunteers twice, including a five-point win in Knoxville.

Poor shooting doomed the Vols in both games. They also took an unfathomable 45 3s in the home loss, indicative of a failure to get the offense working inside.

Kentucky will look to get out and run, while Tennessee tries to slow the pace to a crawl (338th in adjusted tempo).

West Region SWEET 16 Odds

Opening Odds

Game	Favorite	Underdog	Over/Under
(3)Texas Tech vs. (10) Arkansas	Texas Tech -5.5 (-110)	Arkansas +5.5 (-110)	146.5
(1) Florida vs. (4) Maryland	Florida -6.5 (-115)	Maryland +6.5 (-105)	154.5

West Region Betting Odds

No. 1 Florida vs. No. 4 Maryland

Both of these teams played coin flips in the second round against much lower-seeded opponents. Florida barely nipped two-time defending champions UConn despite being nearly double-digit favorites. The Terrapins needed a hotly debated buzzer beater to get by Colorado State.

Maryland rode its starters very hard in the CSU win, getting just 21 minutes out of the backups. Thomas Haugh and Denzel Aberdeen are giving Florida productive minutes off the bench, so the Gators should have an edge there. If this is a higher-scoring game as the over/under suggests, then the Terps may wear down in the second half.

No. 3 Texas Tech vs. No. 10 Arkansas

The closest thing to a Cinderella in what’s been a rather chalky tournament thus far, Arkansas upended St. John’s by holding them to an astonishing 28% shooting. Arkansas is KenPom’s lowest-rated team left at 36th, a full 12 spots behind BYU.

Texas Tech’s Darrion Williams quieted concerns about his health with a monster 28-6-5 game on 11-for-18 shooting against Drake.

If the Raiders’ offense is rolling again behind Williams and bruiser J.T. Toppin (11-for-13 against Drake), then another 2-for-19 shooting day from beyond the arc by Arkansas simply won’t cut it. That’s been a weak point all season, as the Razorbacks are converting just 32.4% of their deep attempts.

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Where Can You Bet On College Basketball Player Props?

Among CBB online betting regulations, Arizona, Colorado, Florida, Illinois, Indiana, Iowa, Louisiana, Maryland, Massachusetts, New York, Ohio, Pennsylvania, Tennessee, Virginia, and West Virginia prohibit gambling on college basketball player props.

Connecticut, Illinois, Maine, New York, Tennessee, and Virginia don’t allow betting on in-state schools (some exceptions for playing in the tournament) and/or in-state player props. The remaining states with legal online sportsbooks, such as new bet365 state Tennessee, authorize wagering on college basketball player prop odds, including in-state teams.

Oregon does not allow online wagering on college sports. Sorry, Ducks flock.

watcH: sweet 16 betting preview

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