2024 March Madness Betting Odds: NCAA Tournament Second Round Spreads, Moneylines, Totals

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Written By Eli Hershkovich | Last Updated March 24, 2024

With half of second-round March Madness odds settled, online sportsbooks have released markets for eight more games on Sunday. This single-elimination tournament continues through the Final Four on April 6 and the national championship game on April 8. Click on the tables below to bet second-round odds now. North Carolina sports betting is also officially underway. Tar Heel State residents can snag up to $2,950 in bonus bets for NCAA tournament odds.

east region second-round odds

No. 1 UConn vs. No. 9 Northwestern

Expect the defending champs to struggle with 16th-seeded Stetson? Think again. Meanwhile, the Wildcats needed overtime to knock off FAU — last year’s Cinderella story.

Advanced metrics sites, like our partner Haslametrics, project a 10-point margin, yet I wouldn’t advise fading the Huskies. Northwestern doesn’t have the bodies to compete with UConn on the glass, especially if center Matthew Nicholson remains out with a foot injury. On the other hand, the Huskies’ best spread odds are .

No. 5 San Diego State vs. No. 13 Yale

The Aztecs survived an upset by 12th-seeded UAB, but Auburn wasn’t as fortunate. The Bulldogs cashed at +600 moneyline odds, tallying the second-biggest upset in this year’s NCAA tournament. Haslametrics gives Yale a fighter’s chance to marginally hang within the spread, projecting a 68.3-62.9 victory for the Aztecs.

West REGION second-round ODDS

No. 3 Baylor vs. No. 6 Clemson

While the Bears easily disposed of 14th-seeded Colgate on Friday, their center Yves Missi reaggravated a back injury. Baylor coach Scott Drew downplayed it postgame, but whether Missi will have a minutes restriction is unknown.

The Tigers delivered the same blow to their first-round opponent, blitzing 11th-seeded New Mexico by double figures after they closed as the underdog. Their five-out offense, guided by the frontcourt of PJ Hall and Ian Schieffelin, makes for a potential mismatch versus Drew’s zone defense. If you buy into Clemson’s upside, its best spread odds are .

Haslametrics has the Bears only favored by three points, to boot.

No. 4 Alabama vs. No. 12 Grand Canyon

If you’re looking for uptempo action, this contest should have droves of just that. Both teams won their first-round affair comfortably, and the Crimson Tide were even up by 31 points at one juncture.

The Antelopes’ athleticism could create havoc for Alabama’s exploitable defense, especially if they can consistently pick on Mark Sears & Co. in transition. The Tide ranked in the 35th percentile of opponents’ fast-break points per game in SEC play. Haslametrics is estimating a final score of 83.2-77.9, siding with Grand Canyon’s second-round odds of , as of this publishing.

South region second-round odds

No. 1 Houston vs. No. 9 Texas A&M

In the Cougars’ first game since Iowa State ripped them apart in the Big 12 tournament championship, they took out their anger on 16th-seeded Longwood, generating a 40-point win. Houston’s next opponent is a much stiffer test, facing an Aggies unit that nearly overcame a 21-point win against them in December.

Texas A&M is a completely different group with Manny Obaseki in the starting lineup, too. During this seven-game span, it’s 6-1 straight up while the junior forward averages 16.7 points per game. Nevertheless, Haslametrics projects a 70.8-60.5 victory for the Cougars.

No. 2 Marquette vs. No. 10 Colorado

You’d be remiss to call the Buffaloes under-seeded, but the spread of Golden Eagles reflects Colorado’s pure talent level. Even though Tad Boyle’s defense was leaky in Friday’s walk-off victory over Florida, it boasts a top-100 rebounding clip at both ends. That could be a significant variable against an undersized Marquette team that lacks the prototypical center — size-wise.

Haslametrics projects the score to wind up 74.8-72.6, slightly favoring the Buffs’ spread odds of .

No. 4 Duke vs. No. 13 James Madison

The Blue Devils topped 13th-seeded Vermont despite Kyle Filipowski‘s three-point scoring output. They may have their hands full versus the Dukes’ pressure-driven defense that forced the Badgers into 19 turnovers, resulting in 27 points off takeaways. That was equivalent to Wisconsin’s highest turnover rate since the 2019 Big Ten Tournament.

Haslametrics’ forecast differs from the line, estimating a 77.8-71.2 Duke win that favors JMU spread odds.

midwest region

No. 1 Purdue vs. No. 8 Utah State

After becoming the second team to falter against a No. 16 seed last season, the Boilermakers covered as 26.5-point favorites against Grambling State. Next up, they take on an ultra-experienced Aggies bunch, driven by the 6-foot-8 do-it-all big Great Osobor. The matchup between Osobor and Zach Edey, the likely two-time Wooden Award winner, is one to monitor.

However, Haslametrics doesn’t expect a competitive contest, forecasting an 82.3-69.1 victory for Purdue.

Where Can You Bet On College Basketball Player Props?

Arizona, Colorado, Iowa, Ohio, Pennsylvania, Tennessee, Virginia, and West Virginia all forbid wagering on college basketball player props.

The remaining states with online sportsbooks, such as North Carolina, authorize betting on college basketball player prop odds, including in-state teams.