Louisville Vs. Duke: College Football Betting Lines, Odds and Trends – November 18, 2021

Written By Staff on November 16, 2021

The Duke Blue Devils (3-7, 0-6 ACC) will look to end a six-game skid when they take the field against the Louisville Cardinals (5-5, 3-4 ACC). The Blue Devils, +725 on the moneyline to win, host the Cardinals, listed at -20.5 on the spread, on November 18, 2021 at 7:30 PM ET on ESPN. The total for the contest is set at 60 points.

In this article you’ll find everything you need to know to place a bet on the game, including statistical trends, key metrics and more, as well as updated odds.

This article references odds updated as of November 18, 2021 at 7:01 PM ET. Find all the current odds for this game in the table below and click here to claim your free sports bet (up to $1,001) at Caesars!

Louisville Vs. Duke Betting Odds

For college football picks and predictions this week, check out our best bets article at PlayPicks.

Louisville Offense Vs. Duke Defense

Cardinals Offense Stats (Rank) Blue Devils Defense
30.0 (55) Points/Gm 36.8 (121)
425.1 (42) Yards/Gm 499.9 (130)
223.8 (65) Pass Yards/Gm 304.8 (129)
201.3 (22) Rush Yards/Gm 195.1 (115)
7.8 (55) Yards/Pass 9.3 (123)
5.0 (26) Yards/Rush 4.9 (104)
37.6% (82) 3rd Down % 47.6% (122)
7 (23) Turnovers 10 (47)
4 (22) Sacks 5 (99)

Duke Offense Vs. Louisville Defense

Duke Offense Stats (Rank) Louisville Defense
24.2 (97) Points/Gm 25.0 (62)
434.6 (37) Yards/Gm 384.7 (75)
242.3 (56) Pass Yards/Gm 251.7 (108)
192.3 (34) Rush Yards/Gm 133.0 (45)
7.5 (67) Yards/Pass 7.1 (50)
4.2 (70) Yards/Rush 4.0 (55)
42.9% (44) 3rd Down % 35.5% (33)
12 (89) Turnovers 9 (65)
5 (30) Sacks 15 (6)

When Louisville Has The Ball

  • The Blue Devils defense gives up 195.1 yards per game on the ground (115th in college football). The Cardinals will be looking to exploit that fact with the No. 22 rushing offense (201.3 per game).
  • Duke’s defense ranks 130th in yards allowed per game (499.9), while Louisville’s offense is 42nd in college football at 425.1 yards per game.
  • The Blue Devils allow 4.9 yards per rushing attempt (104th in the FBS). The Cardinals are 26th in rushing, averaging 5.0 per carry.
  • Louisville has allowed four sacks (22nd-fewest in college football), while Duke’s defense has five (29th-fewest).

When Duke Has The Ball

  • The Blue Devils average 242.3 passing yards per game (56th in the FBS) compared to the 251.7 per game the Cardinals give up (108th in college football).
  • Duke has the 37th-ranked offense in the FBS in yards per game (434.6). They will be up against a Louisville defense ranked 75th, giving up 384.7 yards per game.
  • The Blue Devils’ offense ranks 97th in the FBS at 24.2 points per game. They will be up against the Cardinals’ defense which gives up 25.0 per game (62nd in college football).
  • Duke’s pass protection has resulted in five sacks given up, 30th-fewest in college football. Louisville’s defense has racked up 15 (sixth-most).
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Louisville Betting Trends And Insights

  • Louisville is 5-5-0 ATS this season.
  • The Cardinals have been favored by 20.5 points or more this season once, and failed to cover the spread.
  • Louisville’s games have gone over the point total three out of 10 times this season.
  • Louisville and its opponents have scored more than 60 points in four of 10 games this season.
  • The Cardinals have won three of the four games they were the moneyline favorite this season (75%).

Duke Betting Trends And Insights

  • Duke has won four games against the spread this season, while failing to cover six times.
  • The Blue Devils have been an underdog by 20.5 points or more this year once, and failed to cover the spread.
  • In Duke’s 10 chances this season, the combined scoring has gone over the point total five times.
  • Duke has combined with its opponent to score more than 60 points in four of 10 games this season.
  • The Blue Devils have been underdogs in seven games this season and won one (14.3%) of those contests.

Louisville Players To Watch

  • Malik Cunningham has thrown for 2,168 yards while completing 61.1% of his passes (165-of-270), with 13 touchdowns and five interceptions this year (216.8 yards per game). He’s also carried the ball 139 times for 709 yards and 16 touchdowns, averaging 70.9 yards per game.
  • Jalen Mitchell has 633 yards on 136 carries (63.3 ypg), with four rushing touchdowns.
  • This season Jordan Watkins has 31 catches and leads the team with 479 yards (47.9 per game) while hauling in three touchdowns.
  • Tyler Harrell has hauled in 13 catches for 407 yards (50.9 yards per game) and four touchdowns.
  • Marshon Ford has racked up 402 yards on 37 receptions with one touchdown, averaging 40.2 yards per game.

Duke Players To Watch

  • This year, Gunnar Holmberg has collected 2,034 passing yards (226.0 yards per game) while going 178-for-257 (69.3% completion percentage) and throwing seven touchdowns and six interceptions. He has tacked on 163 rushing yards on 80 carries with six touchdowns, averaging 18.1 yards per game.
  • Mataeo Durant has rushed for a team-leading 1,087 yards on 221 carries (108.7 yards per game) while scoring nine touchdowns. He also averages 22.5 receiving yards per game, grabbing 23 passes for 225 yards and two touchdowns.
  • Jordan Moore has 221 yards on 43 carries (24.6 ypg), with three rushing touchdowns.
  • Jake Bobo has 62 catches and paces his team with 667 receiving yards (66.7 ypg) while scoring one touchdown.
  • Jalon Calhoun has chipped in with 630 yards (on 45 catches) and three touchdowns.

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