NFL Week 12 Look-Ahead Lines: 49ers vs. Seahawks Part Of Thanksgiving Tripleheader

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Written By Mo Nuwwarah | Last Updated
NFL Week 12 look ahead lines

NFL Week 12 look-ahead lines are out. Several key divisional battles dot the slate, but perhaps the most interesting is that in the NFC West, where the Seahawks look to shuck the shackles that the 49ers have clamped on them in recent years. Winning at home is probably a must if they hope to compete for the NFC West, and this game will determine first place regardless of Week 11 results.

Every week, usually on Friday, will post look-ahead lines for the following week’s games, pulled from NFL betting sites. These sportsbook odds give an early snapshot of the current market opinions of teams absent the week-to-week bias that can take hold following weekend results. Please scroll to the bottom of the page for info on how to use them.

NFL Week 12 Look-Ahead Lines

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Week 12 NFL NFL Primetime Games

Thanksgiving Thursday Night Football Odds

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The 49ers looked like a Super Bowl odds juggernaut again in Week 10, thrashing the Jaguars on the road. They have an even easier assignment in Week 11 and should look good once again hosting Tampa Bay, so market confidence in this team figures to remain quite high.

But is it enough to get Seahawks odds anywhere near the key number of +7? They do play a Rams team that has given them major issues recently. However, with this number sitting in a bit of a dead zone, it seems unlikely anything of particular note comes into play.

Oft-injured key 49ers pieces like Deebo Samuel, Trent Williams, and Christian McCaffrey are the ones to watch. San Francisco will remain a solid favorite as long as they remain off the injury report. The 49ers haven’t lost to Seattle since Russell Wilson was on the team, with an average margin of victory of 15.3.

Black Friday NFL Odds

The NFL has opted to experiment with an extra island game on this year’s holiday schedule, and the Jets and Dolphins drew the short week.

Will the Jets show they can score offensive touchdowns? If Zach Wilson once again looks inept against an injury-riddled Buffalo defense in Week 11, then Dolphins odds may hit -7 here. They figure to look good again this week, with market expectation of a blowout victory over Las Vegas. The look-ahead may offer the only chance to get Miami south of the key number.

Sunday Night Football Odds

After looking like world-beaters for several weeks running, the Ravens crashed back to earth in an ugly fall-from-ahead loss to the Browns. Since they have a high-profile island game against a fellow contender in Cincinnati, all eyes will be on Baltimore this week. However, this number still reflects a really strong, possibly peak market on Ravens odds.

Taking Chargers odds above the key number looks potentially enticing, but keep in mind they have a bit of a trappy spot in Week 11 heading to Green Bay, in between two games with top contenders. Additionally, Keenan Allen has popped up on the injury report this week. The highly productive but often banged-up wideout holds massive importance in this passing game, given the other injuries suffered by the wide receiver room.

Making sure Allen gets back out there and gets through a game prior to firing on L.A. would be prudent.

Monday Night Football Odds

The market has come in heavy on Bears odds in one of the more surprising Week 11 moves. They play the highly regarded Lions on the road, but the return of Justin Fields marks a potential boon for this offense. The rushing attack has looked strong in recent weeks, so Chicago might actually coalesce into the team that was expected in preseason. This fairly short line makes sense if that’s the case — Vikings odds sat at -3.5 in markets that opened before a snap was played.

Overall, the Vikings are in prime position in the NFL playoff picture with their next few games against bottom-half teams.

Vikings Upcoming Schedule

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Steelers At Bengals

This line says the Bengals are only a few points better than the Steelers, but if they can get their fully operational passing attack battle station back, that seems unlikely to be true. Monitor the statuses of Tee Higgins and Ja’Marr Chase, as the former continues to miss games while the latter hobbles through at reduced efficacy. Cincinnati trounced the 49ers and Bills when they were whole, and Bengals odds will surely reach the key number of -7 in this home game if the offense gets back on track against a smoke-and-mirrors Steelers bunch.

Rams At Cardinals

Interestingly, the return of Kyler Murray, while it went well — a win on both the scoreboard and in the box score — did not seem to move the market much. The Cardinals are bigger underdogs in Week 11 than they were on the look-ahead numbers.

And the market clearly embraces the return of Matthew Stafford wholeheartedly. Rams odds have received a bevy of steam in Week 11. L.A. also did whatever they wanted on offense last time these teams played.

Still, we’ll likely see this line closer to a pick if Murray plays another strong game.

2023 Cardinals Player Stats

Player GP Games Played CMP% Completion Percentage YDS Passing Yards YDS/G Yards Per Game YDS/C Yards Per Completion TDS Passing Touchdowns INT Interceptions thrown RTG Passer Rating
Player GP Games Played INT Interceptions PD Passes Defended FF Fumbles Forced FR Fumbles Recovered SACK QB Sacks TOT Total Tackles SOLO Solo Tackles AST Assisted Tackles


The look-ahead lines allow you a sneak peek at the projected lines for the following week’s games. This information from a leading sports betting site will help provide lessons in understanding lines and projections before the current week’s games are played.

Many bettors tend to overreact to the previous week’s scores and results. The NFL Week 12 look-ahead lines provide a sense of stability from the oddsmaker. They sometimes offer a clear, unbiased snapshot of perceived team strength.

Bettors can also gain an edge or find value in the lines once the weekend results take hold. See if you can find any over- or under-reactions by the market.

Of course, always take note of key injuries, travel and scheduling situations, and NFL power rankings. Adjustments are part of the process, along with accounting for teams’ strengths and weaknesses, against-the-spread angles, and personnel matchups.