College Football Week 7 Best Bets, Picks & Odds: Favorites, Underdogs and Value Spots

Written By Nick Crain | Last Updated at October 11, 2025

Texas Longhorns quarterback Arch Manning (16) runs with the ball against the Florida Gators during the first half at Ben Hill Griffin Stadium.

The college football Week 7 schedule is here, and by this point in the season, we’ve got a firm sense of who these teams really are. The early-season volatility has settled, conference races are heating up and the college football betting lines are tighter than ever. Even then, oddsmakers continue to react quickly to recent results, which often opens the door for sharp bettors to find value on teams that have been mispriced on the top sports betting apps.

This week’s college football best bets focus on a few key edges — teams undervalued in the market, point spreads that feel a touch inflated, and situations where one side’s consistency or physicality should shine through. That's especially true when you also have the latest sportsbook promos on your side.

Here are the top Week 7 college football picks and where the numbers provide the most value today.

Pitt (+10) at Florida State (-110)

Odds via bet365

Pitt enters this matchup as a double-digit underdog, but that line feels a bit heavy given how these two teams have performed the past few weeks. The Seminoles have looked inconsistent offensively, struggling to sustain drives, while Pitt has been more competitive than their record suggests.

Bet $5 & Get $200 in bonus bets

Bet365 Review

Play Now

Minimum $10 deposit required. Minimum odds -500 of greater. Bonus Bets wager excluded from returns. New customers only. T&CS, time limits and exclusions apply. This Referral Code is used for marketing/tracking purposes only. $10 minimum deposit. Paid in Bonus Bets. Bonus Bets wager excluded from returns. New customers only. Available in app only. Max. prize, game restrictions, time limits and T&Cs apply. GAMBLING PROBLEM? CALL OR TEXT 1-800-GAMBLER (AZ/CO/IL/IN/KS/KY/LA/MD/NC/NJ/OH/PA/TN/VA) or 1-800-BETS OFF (IA). 21+ (18+ KY). Must be present in AZ/CO/IA/IL/IN/KS/KY/LA (select parishes)/MD/NC/NJ/OH/PA/TN/VA.

The Panthers’ defense has been disruptive, and if they can limit explosive plays early, this could stay close throughout. Florida State might win, but Pitt catching 10 points feels like the right side of the value, espcially if you're using bet365's latest welcome offers.

Texas (-105) vs Oklahoma

Odds via Caesars Sportsbooks

The Red River rivalry never lacks drama, and to this point, Oklahoma looks like the more complete football team. With that in mind, it's a neutral-site showdown between rivals that always ends up being an unpredictable game.

Bet $1, Double your Winnings on your Next 20 Wagers. Up to $25 Max Bet Per Boost

Caesars Review

Play Now

21+ New users only. Must register using eligible promo code. First bet after registration must qualify. Max. Bonus Bet: $1,000. Bonus Bet expires 14 days after receipt. Void where prohibited. See Caesars.com/promos for full terms. Gambling Problem? 1-800-GAMBLER (1-800-426-2537)

This feels like a desperate moment for the Longhorns, who will effectively be eliminated from CFP contention with a second straight loss today. As such, even with the Sooners expecting to get their starting QB back, may be in for an upset.

Iowa State (-2.5) at Colorado (-120)

Odds via BetMGM

The Cyclones are one of the most disciplined teams in the Big 12, and that’s exactly the type of profile that wins on the road, even if they had their worst game of the season last week. Colorado has improved under Deion Sanders, but the Buffs have struggled with consistency and defensive breakdowns against more physical opponents.

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

BetMGM Review

Play Now

Gambling problem? Call 1-800-GAMBLER (Available in the US) Call 877-8-HOPENY or text HOPENY (467369) (NY) Call 1-800-327-5050 (MA) 21+ only. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). Rewards are non-withdrawable bonus bets that expire in 7 days. In partnership with Kansas Crossing Casino and Hotel. See BetMGM.com for Terms. US promotional offers not available in DC, Mississippi, New York, Nevada, Ontario, or Puerto Rico.

Iowa State’s dynamic offense and defensive fundamentals give them a major edge in controlling time of possession. Laying less than a field goal with the more stable team is strong value.

Oregon (-7) vs Indiana (-115)

Odds via bet365

Oregon remains one of the most complete teams in the country, capable of scoring at will and locking down defensively when needed. Indiana has had moments of promise, but hasn't proven near as much as the Ducks.

Bet $5 & Get $200 in bonus bets

Bet365 Review

Play Now

Although this is a contest between two highly-ranked teams, Oregon is a strong favorite for a reason. This is a team capable of winning today's contest by multiple scores, so covering seven shouldn't be a problem.

As the Week 7 college football previews unfold, the betting board continues to reflect perception more than reality. Teams that have been overvalued by recent results are starting to regress, while others are still flying under the radar. The college football Week 7 odds feature several spots where sharp bettors can find mispriced lines, especially with underdogs that can keep games tight or favorites built to pull away late.

Ultimately, identifying value in college football Week 7 predictions comes down to understanding momentum, coaching edges and the hidden situational factors that move markets. These Week 7 college football picks represent the best blend of form, matchup value, and price heading into another pivotal weekend on the gridiron.

Odds as of 11:59 p.m. ET on Oct. 10

Mandatory Photo Credit: Matt Pendleton-Imagn Images