Week 5 was one of the biggest weekends of college football, but there’s no time to rest– Week 6 highlights several excellent matchups itself. The first of college football’s major rivalries takes center stage at noon EST between #21 Texas and #6 Oklahoma. Top-four Penn State and Iowa highlight the afternoon slate while #1 Alabama and Texas A&M cap Saturday.
This article will break down College Football Week 6 and its top games. As odds are released and the season progresses, the list may expand. Check back for page updates and odds on the best games of the week.
College Football Week 6 Odds
College Football Week 6 Top Games
#4 Penn State at #3 Iowa ()
This was already an intriguing matchup before the season started. Penn State pits a nine-game win streak against Iowa’s 11 games in a row, some of the highest streaks in college football. The Iowa Hawkeyes field one of the nation’s most daunting defenses, allowing just 4.0 yards per play (fourth). Penn State also fields a stiff defense, allowing 4.2 yards per play (11th).
Penn State’s Jahan Dotson has his toughest test of the season against an Iowa secondary that’s top-20 in yards per completion allowed (10.1). The Hawkeyes have only allowed one receiver over 65 yards this season (Ty Fryfogle, 84 yards). On the flip side, Iowa’s Tyler Goodson is top-15 in rush attempts this season and should see a bulk of the offensive workload in this one.
Bettors may take interest in the point total, set at .
#6 Oklahoma () vs. #21 Texas
Spencer Rattler and the Oklahoma Sooners are one of the biggest stories in college football, but not in a good way. They have yet to separate themselves from an FBS opponent by more than one score on the season. Rattler, once a Heisman frontrunner, went from eighth in yards per pass (9.6) in 2020 to 55th in 2021 (7.9). The defense, which stands 25th in scoring (19.2), has been the saving grace for this undefeated team.
Bijan Robinson looks to exploit the defensive front, which is top-20 in yards per rush allowed. Robinson is second in the nation in rush yards (652) and has 819 total yards of scrimmage and nine touchdowns in just five games. Texas will look to get Robinson in space any way possible as they’ve been doing all year long.
This rivalry, notoriously one of the biggest in the nation, takes place at Cotton Bowl Stadium in Dallas at noon EST.
#1 Alabama () at Texas A&M
While this isn’t the game it was thought to be two weeks ago, Texas A&M lines up another home game against Alabama. Kyle Field is one of the toughest and loudest environments to play in, but Alabama has won the last four in College Station. Jimbo Fisher is also 0-3 against the Tide as acting coach of Texas A&M.
Alabama is coming off a statement win over Ole Miss behind four touchdowns from running back Brian Robinson. The Tide have won by more than a touchdown in every meeting since 2013, including by an average point margin of +15 at Kyle Field. The Aggies are down to their backup quarterback Zach Calzada, who fills in for the injured Haynes King.
In three games against Power Five opponents, Calzada has mustered just 14 points per game, a bottom-five mark in the FBS.
Stanford at #22 Arizona State ()
Stanford is coming off a massive upset of #3 Oregon– their fourth straight win against AP-top three opponents. Sophomore Tanner McKee has been playing excellent football, throwing 11 touchdowns and no interceptions so far this year. He faces a tough test in Arizona State, a defense that’s allowing just a 102.2 average passer rating (10th). Coach David Shaw is 4-1 in his career against the Sun Devils.
Jayden Daniels was a preseason Heisman hopeful, but hasn’t quite popped like expected. He’s thrown just four touchdowns against three interceptions this season, but Arizona State leads the Pac-12 South at 4-1. They’re coming off a statement win over #20 UCLA, one of the hottest teams early this season.
Arizona State is 3-0 at home this season while Stanford is 2-0 in true road games this season.