College Football Week 6 Odds & Cheat Sheet: Schedule, Injuries, Weather, Betting Notes

Week 6 presents a prime opportunity for many teams to go on bye. After all, next week's slate features a packed schedule of blockbuster matchups. But this weekend offers plenty of intriguing games, including several trap spots for its teams. CFB betting sites offer a wide range of Week 6 college football odds. Top games include Missouri at Texas A&M, Iowa at Ohio State, and Miami (FL) at Cal. Before diving into the betting board, let's catch up on what's happened in the first five full weeks of college football (warning: it's a lot!).

Included are the latest odds, notable line movement, matchup history, weather, injuries, trends, and much more. Dig in! Keep up with TheLines all week long for college football betting tools.

College Football Week 6 Odds

Browse college football Week 6 odds below. Click odds anywhere to place a bet.

Line Movement: College Football Week 6 Odds

Look-ahead lines for Week 6 were posted last week. Check out early movers from those and opening lines below:

• Missouri opened a +4 road underdog at Texas A&M and re-opened at +1
• Ohio State opened a -24 favorite against Iowa on lookahead lines, but that number fell to -20.5 at re-open
• Clemson was lined as low as -9.5 against Florida State last week, but that number reopened Clemson -15. The number opened FSU -4 this summer
• Oklahoma State opened a -8 home favorite against West Virginia earlier this year and re-opened -4.5

Opening Lines from College Football Week 6 Odds

• Texas State opened as a -13.5 favorite at Troy, but that number was up as high as -15.5 by Monday morning
• Kennesaw State moved from a +15.5 home underdog to +13.5 against Jacksonville State
• Michigan State moved from +26.5 at Oregon down to +23.5
• Pitt opened a PK at North Carolina and quickly moved to a -2.5 road favorite
• SMU opened a +11 road underdog at Louisville, but that was bet heavily down to +7
• Virginia was bet against Boston College, from -2.5 to -3.5
• Navy moved from a -7 road favorite against Air Force to -9.5
• Army was also bet up, from -8.5 to -10.5, at Tulsa
• Wisconsin moved to as high as -13.5 after opening as a -10 favorite vs. Purdue
• Tulane moved from -13.5 at open to -14.5 by Monday
• South Carolina moved from a +11.5 home underdog against Ole Miss to +9
• Miami (OH) moved from a +8 underdog at Toledo to +6.5
• Indiana quickly moved from a -10.5 favorite at Northwestern to -14
• UConn moved quickly from a -10.5 home favorite vs. Temple to -14.5
• At some books, Nebraska moved from -5.5 to -7.5 against Rutgers
• James Madison moved from a -13.5 road favorite at ULM to -15.5
• Louisiana also moved from a -11.5 road favorite to -14.5 at Southern Miss
• Nevada moved from a +10 to +7 road underdog at San Jose State
• Tennessee jumped from a -10.5 road favorite at Arkansas to -13.5
• Arizona State moved from -1.5 at home vs. Kansas to -3
• Hawaii fell from a +5 road underdog at San Diego State to +3
• Cal was bet early on, from a +14 home underdog to +12.5

Note line movements through key figures of 3 and 7, like Boston College at Virginia and Miami (OH) at Toledo.

Totals Movement

• Syracuse at UNLV jumped from 57.5 points to 60
• Auburn at Georgia moved from 51 points to 52.5 by Monday

Coaching Notes & Matchup History For college football week 6 odds

Sam Houston State at UTEP, Thursday (9:00 p.m., CBSSN)

• UTEP owns 3-0 all-time series lead
• Miners are the third team in four weeks to have a rest advantage over Sam Houston State
• Bearkats (+10.5) completed a 40-39 comeback win vs. Texas State last week, making this a short week
• Sam Houston State is 4-1 ATS this year, beating the closing line by an average 10.4 points
• UTEP is 1-3 ATS, failing to cover by 2.5 points per game

Syracuse at No. 25 UNLV, Friday (9:00 p.m., FS1)

• First-ever matchup
• Syracuse's first road game of the year is also its first trip to the Pacific Time Zone since 2011
• This is also the first of three straight road games (Week 8 bye) and five road games in the next six games
• Under QB Hajj-Malik Williams, UNLV (-2.5) crushed Fresno State, 59-10

No. 9 Missouri at Texas A&M, Saturday (12:00 p.m., ABC)

• Mike Elko is 0-5 straight up against ranked opponents coming into this game (0-1 this year)
• Eliah Drinkwitz is 7-3 straight up coming off a bye week (5-3 at Missouri)
• Missouri comes off a bye week, while A&M played to a 31-24 finish against rival Arkansas last week
• The Tigers went 4-0 ATS on the road against SEC foes last season. This is their first road game on the year
• Since switching from Conner Weigman to Marcel Reed, A&M is 3-0, but scored 33, 26, and 21 points in those games
• A&M is just 1-4 against the closing spread this season – 1-3 against FBS competition (only cover: at Florida)

Purdue at Wisconsin, Saturday (12:00 p.m., Big Ten Network)

• Wisconsin has won 17 straight games in this series (14-3 ATS) with an average 20-point margin of victory
• Purdue fired offensive coordinator Graham Harrell on Sunday (125th in points per drive)
• QB Braedyn Locke completed just 13 of 26 passes for 180 yards, 1 TD, and 1 INT last week at USC
• Each of the last five matchups went over the total (average 61.4 points per game!)

Tulane at UAB, Saturday (1:00 p.m., ESPN+)

• Head coach Jon Sumrall is 23-9 ATS as an FBS head coach, including 4-1 this year
• In back-to-back home conference stands, UAB is 9-0 straight up at 5-3-1 ATS
• Last year, Trent Dilfer went 5-2 ATS after a straight-up loss. UAB lost to Navy, 41-18, last week
• Last season, Tulane (-21) found themselves down 20-7 early but rallied to win, 35-23

Auburn at No. 5 Georgia, Saturday (3:30 p.m., ABC)

• Rivalry game, named "Deep South's Oldest Rivalry." It is tied with Tennessee-Vanderbilt as the oldest rivalry between two current SEC programs
• Georgia leads the all-time series, 64-56-8, which dates back to 1892
• In the last 11 meetings, Georgia is 9-2 ATS against Auburn
• Last week, Auburn (+2) fell to Oklahoma at home, 27-20, despite out-gaining OU 482-291
• Georgia fell at Alabama in what might stand as the game of the year. UGA erased a 30-7 deficit but lost, 41-34
• Last year, Auburn (+14.5) was flagged for just one penalty and won the turnover battle 2-1 but narrowly lost to Georgia, 27-20
• Bulldogs are just 1-3 ATS on the season, failing to cover vs. Tennessee Tech (-55.5), at Kentucky (-23.5), and at Alabama (-2)

Iowa at No. 3 Ohio State, Saturday (3:30 p.m., CBS)

• Ohio State leads the all-time series, 47-15-3
• Iowa comes off a bye, while Ohio State comes off a 38-7 win over Michigan State (-23.5)
• Only two meetings since 2017 were split – Iowa (+18) shocked Ohio State, 55-24, in 2017 and Ohio State (-29) won the rubber match, 54-10
• Iowa games are 4-0 to the over this season, and the Hawkeyes are up from 132nd to 64th in points per drive under Tim Lester
• Kaleb Johnson's 685 rushing yards and nine touchdowns are second-most behind Ashton Jeanty
• Conversely, Ohio State's defense ranks fifth in yards per rush allowed (1.9)

No. 23 Indiana at Northwestern, Saturday (3:30 p.m., Big Ten Network)

• Indiana last beat Northwestern in Evanston in 1993 (2-6 ATS in those games)
• Hoosiers are 4-1 ATS this year; the only blown cover against the closing number came in Week 1 against FIU (-25.5, won 31-7)
• Indiana has beaten their closing number by an average of 14 points through five weeks
• Conversely, Northwestern is 1-3 ATS with its lone cover in Week 1 (beat Miami-OH, 13-9, as -3 favorites)
• This game will be played at lakeside Martin Stadium in Evanston (12,000 capacity)

Colorado State at Oregon State, Saturday (6:30 p.m., The CW)

• Colorado State owns a 2-1 series lead (last: 2017, CSU, -3, won 58-27)
• As an FBS head coach, Jay Norvell is just 11-20 ATS against non-conference foes (1-3 this year), 3-9 at CSU
• Both teams come off a bye week

Louisiana at Southern Miss, Saturday (7:00 p.m., ESPN+)

• Southern Miss has won 11 straight matchups dating back to 1994 (0-8 ATS since '98)
• Louisiana (+3) beat Wake Forest, 41-38, last week on the road
• Southern Miss comes off a bye week. Head coach Will Hall is just 1-3 straight coming off a bye at Southern Miss
• Including Wake Forest last week, five of Louisiana's next seven opponents come off a bye
• This is Game 2 of a four-game road streak in six weeks for the Ragin' Cajuns
• Last year, Southern Miss (+10) beat Louisiana in overtime, 34-31

UCF at Florida, Saturday (7:45 p.m., SEC Network)

• Gators lead the all-time series, 2-1 (last: UCF won 29-17 in Gasparilla Bowl)
• In the last two years, Florida is just 1-5-1 ATS against in-state opponents
• Billy Napier is 0-3 straight up coming off bye weeks at UF and 5-8 overall coming off a bye
• Last week, UCF lost the turnover battle, 4-1, and – despite only being out-gained by six yards – lost to Colorado at home, 48-21
• At 2-2, Napier has his back against a wall and has an extra week to prepare for this one. Many predicted this could be his last game at Florida should the Gators lose
• Major recruiting battle between Florida teams picking from the same player pool

Impact Injuries On College Football Week 6 Odds

All kick times below are listed in ET.

No. 12 Ole Miss at South Carolina, Saturday (3:30 p.m., ABC)

QB LaNorris Sellers missed South Carolina's Week 4 game after leaving early both in Week 2 and 3. Top RB Raheim Sanders left the Gamecocks' 50-7 win over Akron in Week 4 and did not return. Both players had a bonus week to heal up. Based on early line movement (South Carolina moved from +11.5 to +9), at least Sellers should return. But his status is worth keeping an eye on.

Ole Miss saw running back Henry Parrish exit and then return against Kentucky. He was held to 62 yards on just 13 carries and leads the Rebels with 70 carries and 489 yards on the season. Top pass rusher Jared Ivey is out for an extended period of time after leaving Week 3 on a cart. Starting offensive lineman Jeremy James left Week 1 with a broken hand and has not played since.

No. 23 Indiana at Northwestern, Saturday (3:30 p.m., Big Ten Network)

Northwestern has played its first four games without two starting offensive linemen, guard Jordan Knox and tackle Matt Keeler. Starting defensive tackle Carmine Bastone has yet to play this year, either. Workhorse back Cam Porter did not play at Washington in Week 4 and Northwestern failed to score a touchdown. On the season, Porter has 44 rushes. Last year, he finished with 167.

Virginia Tech at Stanford, Saturday (3:30 p.m., ACC Network)

Injuries mounted in Virginia Tech's 37-34 loss at Miami last week. Most notably, star pass rusher Antwaun Powell-Ryland (five sacks) exited and did not return Friday night. Starting safety Jalen Stroman has not played since Week 1, and tight end Nick Gallo has not played since suffering a season-ending injury last year. Top receiver Ali Jennings played just six snaps last week after missing Week 4. Jennings missed last year with an injury but returned to full snaps in Week 1. He left Week 3 hurt and has not fully returned since.

Rutgers at Nebraska, Saturday (4:00 p.m., FS1)

Nebraska is dealing with multiple injuries to key players. Starting left tackle Teddy Prochazka was lost to a torn ACL in fall camp and his backup, Turner Corcoran, will be out "a while" after leaving Week 4. Left guard Micah Mazzccua played just five snaps between Weeks 3-5 (did not play in Week 3 of 5 at all) and is uncertain for this coming week. Starting kicker Tristan Alvano missed the last two games. Replacement kicker John Hohl is just 1/5 kicking field goals this year.

Rutgers is without star LB Mo Toure, who tore his ACL in summer camp. Another linebacker, Tyreem Powell, finally returned to full snaps in Week 5.

Utah State at No. 21 Boise State, Saturday (7:00 p.m., FS2)

Despite rolling opponents, Boise State is dealing with a handful of notable injuries. Center Mason Randolph and right guard Roger Carreon both sat out the Broncos' Week 5 win over Washington State. The injuries were made known as Ashton Jeanty had just one yard before contact, on average, in the game. Fortunately, Jeanty continues his ridiculous tear, averaging nine yards after contact. Top receiver Latrell Caples also missed the game.

No. 15 Clemson at Florida State, Saturday (7:00 p.m., ESPN)

Clemson is dealing with injuries to some key players. WR Tyler Brown was seriously limited last week after sitting Week 4. Star defensive tackle Peter Woods and starting guard Collin Sadler both missed the 40-14 win over Stanford.

On the other sideline, tackle Jeremiah Byers played his first snaps since Week 0 but was limited to just 29 of them. His backup, Robert Scott Jr., did not play in Week 5. Running back Roydell Williams was also inactive.

No. 10 Michigan at Washington, Saturday (7:30 p.m., NBC)

Star TE Colston Loveland missed Michigan's Week 4 win over USC and was limited to just 18 snaps against Minnesota last week. All-America corner Will Johnson missed Week 5 entirely. Both impact players are worth monitoring this week, as Johnson was a surprise scratch to many. Potential All-America safety Rod Moore is out for the season after tearing his ACL in the spring.

No. 11 USC at Minnesota, Saturday (7:30 p.m., Big Ten Network)

Minnesota could be without a handful of starters this weekend. Corner Justin Walley missed his second straight game and safety Darius Green sat Week 5. Tight end Jameson Geers also sat out the Michigan loss.

Across the way, USC lost TE Lake McRee, who was the leading receiver at the time of his injury. While not out for the season, McRee is expected to miss multiple weeks. Starting safety Akili Arnold missed USC's Week 5 win over Wisconsin. Starting WR Makai Lemon missed his second straight game last week. Defensive tackle Bear Alexander made headlined when he opted out of the season to take a redshirt and transfer this winter.

Other Impact Injuries

• Dequan Finn, QB, Baylor
• Richard Reese, RB, Baylor
• Thomas Castellanos, QB, Boston College
• Corey Kiner, RB, Cincinnati
• Tory Horton, WR, Colorado State
• Mykel Williams, DE, Georgia (limited in Week 5)
• Caleb Bacon, LB, Iowa
• Chip Trayanum, RB, Kentucky
• Zy Alexander, CB, LSU
• Chris Hilton, WR, LSU
• Reuben Bain Jr., DE, Miami (FL)
• Grayson McCall, QB, NC State
• Jake Springfield, OT, Oklahoma State
• Jason Henderson, LB, Old Dominion
• Sal Wormley, RG, Penn State
• J.B. Nelson, RG, Penn State
• L.J. Johnson, RB, SMU
• Conner Weigman, QB, Texas A&M
• Bryce Anderson, SAF, Texas A&M
• Ben Bell, EDGE, Texas State
• Bralyn Lux, CB, Texas Tech
• Javeon Wilcox, SAF, Texas Tech
• Andre Fuller, CB, Toledo
• Luke Pawlak, K, Toledo
• Goose Crowder, QB, Troy
• Shazz Preston, WR, Tulane
• Keanu Williams, DT, UCLA
• Nick Evers, QB, UConn
• Jalen Buckley, RB, Western Michigan
• Kenneth Womack, WR, Western Michigan
• Jaylan Knighton, RB, SMU (season)
• Devin Kargman, QB, Kent State (season)
• JD Sherrod, QB, Kent State (season)
• Matthew Sluka, QB, UNLV (season, opted for redshirt)
• Bear Alexander, DT, USC (season, opted for redshirt)

Other Roster & Staff Impacts on Week 6 Odds

Purdue at Wisconsin, Saturday (12:00 p.m., Big Ten Network)

Purdue relieved offensive coordinator Graham Harrell of his duties over the weekend. The Boilermakers rank 125th in points per drive and scored 10 or fewer points against two of its three FBS opponents. As of Sunday, no substitute play-caller has been named.

No. 15 Clemson at Florida State, Saturday (7:00 p.m., ESPN)

Monday's depth chart for Florida State listed D.J. Uiagalelei as OR, with Brock Glenn for QB1. This year, DJ U posted just a 66.5 NFL QB rating and has more interceptions (6) than touchdowns thrown (4). However, few QBs have dealt with the same frequency of drops as Uiagalelei (13!). Glenn is a redshirt freshman with 19 career pass attempts (34.5% completion, zero TDs). Glenn replaced DJ U last week in a 42-16 loss to SMU.

Weather Impacts On College Football Week 6 Odds

Weekly college football weather reports will be released later this week as forecasts become more certain. But here’s a few spots to keep tabs on early in the week.

Weather across the U.S. this week is expected to be extremely quiet – a much needed reprieve from the devastation brought to the panhandle of Florida and southern Appalachia by Hurricane Helene last weekend. However, forecast models note the Gulf of Mexico as an area of interest yet again. As of Monday, there's a 50% chance a tropical system will develop. Models are unsure of intensity and direction.

Some models forecast a system to develop and make landfall near where Helene did. Others push it west towards Texas. Others still forecast nothing organized. However, most are in agreement that rain and thunder are likely in the southeast this coming weekend into next week. Unfortunately, that forecast rain is in areas still drying out and trying to recover from Helene.

Be sure to keep a close eye on the southeast as the week develops.

Situational Spots To Watch With College Football Week 6 Odds

Sam Houston State at UTEP, Thursday (9:00 p.m., CBSSN)

Sam Houston State has a short week to play at UTEP (740 miles away despite being in the same state). The Bearkats come off an impressive 40-39 comeback upset win over Texas State last week. UTEP is the second straight opponent coming off a bye week Sam Houston State has to face. Given that the Miners were on a bye, they had a major rest advantage Thursday night. UTEP owns a 3-0 all-time series lead over Sam Houston State.

Syracuse at No. 25 UNLV, Friday (8:00 p.m., FS1)

Up until this point, Syracuse hasn't played away from the JMA Wireless Dome. It hits the road to play in the Pacific Time Zone for the first time since 2011 and won't return to the JMA Wireless Dome until November. The Rebels cut through the noise after QB Matthew Sluka very publicly redshirted due to NIL disputes and walloped Fresno State 59-10. Under the new direction, Hajj-Malik Williams, UNLV looks to roll forward anyway. This is a tricky Friday night spot for 'Cuse.

Following this, the Orange play on the road in five of their next seven games.

Navy at Air Force, Saturday (12:00 p.m., CBS)

Did someone say, "10:00 a.m. local kickoff"? Thanks to that sweet TV money, Navy and Air Force kick things off at 10:00 a.m. MT on CBS. Coming off a straight-up loss, Troy Calhoun has struggled to rally his troops. In Colorado Springs, Calhoun is just 30-45-1 ATS coming off a loss (40%). They play a hungry Navy team swinging the pendulum the opposite direction of Air Force. The Midshipmen have only taken one Commander-in-Chief's trophy in the last eight years (2019) but, at 4-0, are in a position to contend this year.

To make sure Army vs. Navy is for all the marbles, watch for the Midshipmen to take care of business here. But also watch for a trap spot as Air Force is extremely familiar with Navy, has won the last four outings, and may use a sleepy morning environment to spring the upset.

No. 9 Missouri at Texas A&M, Saturday (12:00 p.m., ABC)

Missouri enters this game off a bye week, while Texas A&M comes off a big 31-24 victory over rival Arkansas ("Southwest Classic"). The rest gave Mizzou an extra week to prep for A&M, who may again be forced to play Marcel Reed over Conner Weigman. In their last three wins, the Aggies only managed 33, 26, and 21 points and barely snuck by Bowling Green at home.

These are uncommon foes, last having played in 2021 and, before that, 2014. Missouri has a greater advantage in prepping for an unfamiliar opponent here.

Auburn at No. 5 Georgia, Saturday (3:30 p.m., ABC)

Georgia comes off a major letdown in Tuscaloosa, where it nearly erased a 30-7 deficit in a high-octane environment. After finally taking the lead, the Bulldogs allowed a long TD to fall behind 41-34, the final nail in the coffin. This week, they host rival Auburn in the Deep South's Oldest Rivalry. Auburn comes off back-to-back home losses – games the Tigers had a 92.3% and 75.3% postgame win expectancy, per SP+ – to face a Georgia team ready to get back on the right track.

The last two times in Athens, Auburn lost a combined 69-16.

Virginia Tech at Stanford, Saturday (3:30 p.m., ACC Network)

Stanford made back-to-back Eastern Time Zone trips with an overtime win at Syracuse and a blowout loss at Clemson. The Cardinal return home to play Virginia Tech, who gets an extra day to travel having played Friday, before setting back out for a third Eastern Time Zone trip at rival Notre Dame. The Hokies come off a tough loss at Miami (FL), losing on a tossup Hail Mary.

Stanford did fly back home in between the Syracuse and Clemson trips.

Appalachian State at Marshall, Saturday (3:30 p.m., ESPN+)

App State's Week 5 game was cancelled due to catastrophic flooding in Boone. There's no word on how this affects the Mountaineers practice schedule this week. But with App State off last week, Marshall plays four straight opponents coming off a bye – three of which had the rest advantage. Marshall is 4-0 ATS this year, a potential indicator that the market is mis-pricing the Herd. Marshall has upset App State at home the last two times in Huntington (2022, +2, 2020, +5).

No. 1 Alabama at Vanderbilt, Saturday (4:15 p.m., SEC Network)

Alabama comes off an incredible and emotional win at home over Georgia last weekend to travel to quieter FirstBank Stadium and face Vanderbilt. The Tide played in what could amount to the game of the year. Alabama reported a near-capacity of 100,077 fans, a far cry from Vanderbilt's average 64% capacity (~25,000) from last year. The Commodores have been a frisky team this year, going 3-1 ATS so far. While talent likely wins out with Alabama, there's a chance Vanderbilt could keep this one closer in the first half. Vandy comes off a bye.

Louisiana at Southern Miss, Saturday (7:00 p.m., ESPN+)

Louisiana has not won in Hattiesburg since 1994, losing 11 straight trips. In the last eight meetings, the Ragin' Cajuns are 0-8 ATS, including losing outright last year as -10 favorites (34-31 in OT). Southern Miss is the second straight road opponent with a rest advantage against Louisiana. Including last week, six of Louisiana's seven next opponents either come on the road, off a bye, or both. Coming off a big upset win at Wake Forest (41-38), the Golden Eagles could be in a prime position to pull the home upset.

Best of luck betting college football Week 6 odds.