College Football Betting: Notre Dame At Louisville Odds, Picks & Sportsbook Promos

The No. 25 Louisville Cardinals (5-0) host the No. 10 Notre Dame Fighting Irish (5-1) in Week 6 of the college football season. Louisville is a home underdog while Notre Dame has moneyline odds to win the game outright at the best college football betting sites. The Irish are coming off two close games, including a big win at Duke, while Louisville comes off a narrow win at NC State. Notre Dame at Louisville kicks off Saturday, Oct. 7, at 7:30 p.m. on ABC.

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Louisville Vs. Notre Dame Odds

Compare odds from top US sportsbooks below. Click on the odds in the table to place a bet now.

Louisville vs. Notre Dame Quick Look

Table key: Power (TheLines aggregate power rating), KFord (KFord Rating), PPD (points per drive scored), PPD/A (points per drive allowed), YPP (yards per play), YPP/A (yards per play allowed)

Week 6: Louisville Vs. Notre Dame Preview

While Sam Hartman and Audric Estime dominate headlines around Notre Dame, the Irish defense has propelled this team to 5-1 (and nearly 6-0). Outside of one 61-yard breakaway touchdown run, Notre Dame allowed just 65 rushing yards to Ohio State. Removed one 34-yard breakaway run against Duke, and they held running backs to just 3.2 yards per carry. The front seven so far has stifled opposing run games.

Jawhar Jordan managed 32 yards on 16 carries against NC State, breaking his three-game streak of 100+ rushing yards. The Irish will work to remove Jordan from the game plan and force the ball into Jack Plummer's hands more. His go-to receiver, Jamari Thrash, goes against his most formidable opponent in preseason All-American Benjamin Morrison. Notre Dame's secondary held the best receiver in the country, Ohio State's Marvin Harrison Jr., to just three receptions for 32 yards.

Notre Dame this season has laid out its game plan: run the football with Estime and maintain leads with ball control. The defense is good enough to slow most opposing offenses – including holding Ohio State to just 17 points and Duke to just 14 – which may cause issues for Louisville's scoring unit.

KFord Rating assessment

Find Kelley's work all season long with TheLines!

The Cardinals are No. 19 in my Most Deserving Rankings and No. 29 in my power ratings, with the No. 27 offense and No. 26 defense. That said, the Irish present the most difficult test for Louisville on both sides of the ball. Even though this game is in Louisville, my numbers suggest the Irish are going to be too much for the Cardinals on both sides of the ball.

Bottom line, I have Notre Dame -7, with a 31% chance Louisville improves to 6-0 on the season.

Kelley Ford, TheLines College Football Podcast

Louisville Football Odds: Best Bets

Though the market has moved the line far from its 48.5 opening mark, I lean under the point total. Notre Dame runs the 25th-slowest pace in the nation (non-service academies) and presents a severe mismatch in the run game. Louisville scored most of their points against Georgia Tech and Boston College, the 127th and 133rd-ranked EPA defenses, respectively. Louisville struggled to score against Indiana (104th) and NC State (46th).

Should the total hit 55, I'll be betting the under. Otherwise, I'm waiting until the last minute and betting on the best total I can find.

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