It was a rough week for a few teams who were ranked last week. Some dropped down the rankings, while others fell out of the top 25 altogether after poor showings in Week 4.
Washington State scored 63 points and lost. Michigan was completely embarrassed on the road at Wisconsin. Utah couldn’t handle the defensive pressure from USC and was handed another road loss in that series. And Central Florida won’t be able to hoist another fake national title banner this year after losing at Pitt.
Let’s take a look at the Top 25 betting lines in Week 5 in college football. There are some large spreads to navigate again this week.
Week 5 CFB odds
Week 5 schedule and analysis
Friday, Sept. 27
No. 11 Penn State (-6.5) at Maryland — 8 p.m. ET
Both these teams are coming off byes, but Maryland is hungry to get back on track after getting dominated in its first road game of the year at Temple two weeks ago. Penn State has won four straight in this series, but the Terps would love to get a win over a Big 10 power and get their season back on track.
Arizona State at No. 16 California (-4.5) — 10:30 p.m. ET
These two teams haven’t played since 2016 but at one point, Cal won eight of nine meetings from 2002 through 2011. Arizona State is coming off a heartbreaking loss to Colorado at home and now has to go on the road on a short week with this game on Friday night.
Cal scored a very controversial win over Ole Miss last week where the Rebels administration wanted the Pac-12 conference to review a call made by their officials at the end of the game at the goal line. Cal has a chance to be undefeated when they head to Oregon next week if they can get this victory.
Saturday, Sept. 28
Texas Tech at No. 4 Oklahoma (-27) — 12 p.m. ET
The Red Raiders and Sooners are both coming off open weeks as they open up conference play versus each other. These two offenses are going to be fun to watch. However, while Oklahoma is averaging nearly 50 points per game, Texas Tech is averaging less than 30.
Northwestern at Wisconsin (-24) — 12 p.m. ET
The most impressive team in the Big 10 not named Ohio State has been Wisconsin. The Badgers have given up 14 points in total over their first three games while scoring over 40 points per game. Northwestern is coming off a loss to Michigan State where its offensive could not find its footing. The Wildcats now have to figure out a way to slow down running back Johnathan Taylor and company. Michigan tried and found themselves down 35-0 in the 4th quarter. The home team in this series has won 10 of the last 12 meetings.
Middle Tennessee State at No. 14 Iowa (-23.5) — 12 p.m. ET
First meeting ever between these two schools and both had a week off last week. Iowa travels to Michigan next week but the Hawkeyes can’t sleep on MTSU. They only lost at Michigan by 19 to start the season, but did lose to Duke 41-18 two weeks ago.
Rutgers at No. 20 Michigan — 12 p.m. ET
Given that Rutgers lost to Iowa 30-0 on the road already this season, Michigan might be playing the best opponent possible at home this week after it got embarrassed last week at Wisconsin. Rutgers lost last week at home against Boston College. This game is not listed on New Jersey sportsbooks because of state law.
No. 21 Texas A&M (-23.5) vs. Arkansas — 12 p.m. ET
Both these teams are coming off of losses, although an SEC team losing to San Jose State is not something you expect to see. The Aggies can’t really be looked down upon for losing to Clemson and Auburn at home.
No. 1 Clemson (-27.5) at North Carolina — 3:30 p.m. ET
Clemson has yet to be tested this season after destroying all four teams it has faced. New UNC head coach Mack Brown scored a couple of early victories over South Carolina and Miami, but has lost two straight including a bad loss to Appalachian State last week at home. It’s hard to see the Tar Heels keeping this game close.
Ole Miss at No. 2 Alabama (-37.5) — 3:30 p.m. ET
The Crimson Tide still aren’t getting many 1st place votes in the polls even though they are coming off a 49-7 win over Southern Miss last week. The Rebels have lost their last two games against Alabama by a combined score of 130-10.
Virginia at No. 10 Notre Dame (-10.5) –3:30 p.m. ET
The Irish held strong last week against Georgia on the road and covered the 14.5-point spread. Notre Dame comes back to South Bend to face a Cavalier team that is a surprising 4-0 on the year. UVa has a nice win at Pitt this season but a victory against the Irish in their first trip ever to South Bend would be massive for head coach Bronco Mendenhall.
No. 24 Wake Forest (-6) at Boston College
BC was shocked at home against Kansas but was able to get back on track last week against Rutgers on the road. Wake Forest is undefeated as they head to Boston to face the Eagles. The road team has won the last 5 in this series.
No. 25 USC at No. 17 Washington (-11) — 3:30 p.m. ET
The Trojans are coming off their biggest win of the season over Utah at home. Can they beat another Top 20 conference opponent this week at Washington? The Huskies grabbed a very impressive win at BYU last week and the Washington defense will present a big test for third-string USC QB Matt Fink.
Towson at No. 8 Florida (-37.5) — 4 p.m. ET
After destroying Tennessee at home last week 34-3, UF is basically getting a week off against an FCS opponent in Week 5.
Mississippi State at No. 7 Auburn (-9.5) — 7 p.m. ET
Auburn scored another huge win last week at Texas A&M. The Tigers opened the year by beating Oregon and have become legit contenders in the SEC West. The Bulldogs won this game last year 23-9 and are coming off a big win over Kentucky. MSU has only won two of its last nine games at Auburn.
No. 22 Kansas State at Oklahoma State (-5) — 7 p.m. ET
We haven’t talked much about Kansas State yet this year but the Wildcats have been very impressive in three lopsided wins to start the season. The level of competition takes a big step up this week as Big 12 play begins. KSU is off a bye while OSU is off a loss to Texas which snapped its long winning streak over the Longhorns.
Connecticut at No. 23 UCF (-44) — 7 p.m. ET
The Golden Knights had their hopes of an undefeated season smashed at Pitt last week. UCF comes back home to play one of the worst teams in FBS who have already been blown out by Illinois and Indiana. The Huskies were off last week.
No. 6 Ohio State (-17) at Nebraska — 7:30 p.m. ET
This is where ESPN’s College Gameday will be headed for the first time since 2007. It’s been a while for Huskers fans to feel like the eyes of the college football world will be on them for a Saturday night. Ohio State has been simply incredible on offense so far this season. Last week they beat Miami (OH) 76-5. New OSU QB Justin Fields has thrown for 13 touchdowns and 0 interceptions. This line opened at -10, then was bet down as low as -6.5, and now reopens at more than two touchdowns.
Washington State at No. 19 Utah (-6) — 10 p.m. ET
How do you recover from scoring 63 points and losing? Washington State is going to have to figure that out or they’ll fall to 0-2 in conference play. Utah is also facing an 0-2 start in the Pac-12 if they lose this game after failing to beat USC last Friday night. This is a major game for both of these teams.