College Football Week 4 Best Betting Tips, Picks: Odds, Spreads, Player Props

, ,
Written By Brett Gibbons | Last Updated
college football best bets

Week 4 of the college football season offers the best feast of games yet. In the FBS ranks, six ranked matchups grace the schedule, the most on a Saturday since 2018. But with so many high-profile matchups comes less value across college football odds boards on those big games. To find value, we’ll have to dig deep and make some gut-check plays. Let’s dive into my three favorite college football picks with bets at numbers you can still find.

On the season, college football best bets from this article are a profitable 18-13 (58.1%). Here’s to hoping for continued success as these bets are also beating the closing line by an average of 2.38 points per play. Looking to back some college football underdogs?

College Football Week 4 Picks, Best Bets

Don’t miss the best odds! Join’s free sports betting Discord to get real-time bets as our staff places them. Sign up for notifications in the #roles server. We’ve also ranked the best college football betting sites for this season.

Wisconsin at Purdue, FRI 7:00 p.m. ET

Wisconsin’s offense under new OC Phil Longo has taken some time to plant its roots. Through three games, the Badgers are posting an EPA per play number near zero (0.04), 71st in the nation. While back Braelon Allen is setting career marks in yards per attempt (7.1), Tanner Mordecai has fallen from being one of the top passers in the nation to 42nd in passer rating. Luckily, Mordecai has an opportunity to improve his numbers Friday against a Purdue defense that’s 102nd in EPA per pass.

The Boilermakers have shown the ability to push the ball and score, but Wisconsin’s defense provides their toughest test of the year. Purdue hasn’t been able to get their ground game going (108th in rushing success rate) and lead back Devin Mockobee has three fumbles on the year already. Wisconsin defends the run exceedingly well (17th in EPA per rush), likely pushing Purdue to crutch on Hudson Card and the passing game.

But Card hasn’t been nails this season, completing 65.5% of his passes for just 7.5 yards per attempt. Against Syracuse, Purdue stalled multiple times shy of the pylon. A combination of a Wisconsin offense trying to find its identity with the inability of Purdue to finish drives makes for a fine under bet.

Brett’s bet: Under 54 points (-112)
Best available number: Under points

Ole Miss at Alabama, 3:30 p.m. ET

Both quarterbacks in this game love to gun the ball downfield. Ole Miss’ Jaxson Dart is second nationally in yards per attempt (12.3) and Alabama’s Jalen Milroe – who once again gets the start after a dumpster fire outing from Tyler Buchner – is third nationally in average depth of target (14.4). Lane Kiffin is known for his aggressiveness and the best way to bite a down Alabama team in Tuscaloosa is to move the ball early on.

Texas was able to find openings downfield in their Week 2 win against the Tide. With Zakhari Franklin potentially making his Ole Miss debut this week, the Rebels have enough firepower offensively to take advantage. Kiffin also commented on the potential new playcaller on defense for Nick Saban. If that is true, then there may be some bumps against the high-powered Ole Miss offense in the first half.

To dig deeper into the market, 27.5 sits under an important figure (28) while some full-game 54.5s do exist (moving through the biggest key total in CFB, 55). Getting the first half under 28 is an enticing offer.

Brett’s bet: Over 27.5 1H points (-105)
Best available number: Over 1H points

Iowa at Penn State, 7:30 p.m. ET

Avert your eyes, folks. This might just be the most hard-to-stomach bet I’ll ever post to TheLines and, quite possibly, the ugliest wager I’ll ever personally place. Reminder: I’m just sharing what’s on my bet slip.

Iowa walks into Happy Valley for Penn State’s annual Whiteout game in a matchup oddsmakers predict to be low-scoring, even by NFL standards. Both teams field a top-four defensive unit, according to Kelley Ford’s KFord Ratings, and Iowa’s offense continues to be confused under Brian Ferentz. But given a team total of just 12.5 points with a 50% breakeven rate, I have to bet over it. Given Iowa’s propensity to score in all three phases of the game, I’ll take the chance that a Hawkeye finds pay dirt twice.

Penn State also fields their best quarterback in many years, five-star Drew Allar. The scoring potential for the Nittany Lions – even against the nation’s top defense – is there and I’m taking a swing with a seriously deflated total.

Brett’s bet: Over 40 (-110), Iowa Over 12.5 team points (+100)
Best available number: Over points

Watch! TheLines College Football Podcast: Week 4 College Football Picks

UP TO $1,000
In Bonus Bets
First Bet Safety Net up to $1,000, or Bet $5, Get $150 in Bonus Bets
Sign Up, Deposit and Play Today in VA!
Gambling Problem? Call or TEXT 1-800-Gambler 21+
Use Bonus Code: THELINESVA
up to $1,500
In Bonus Bets
Up to $1,500 in Bonus Bets if Your First Bet Doesn’t Win*
*Bonus Bets Expire in 7 Days. One New Customer Offer Only. Add’l terms
21+. Gambling Problem? Call 1-800-GAMBLER
Use Bonus Code: THELINES
$1,000 FIRST BET
On Caesars
Up to $1,000 Back as a Bonus Bet if Your Bet Loses
Stream NFL Games In-App for Free
21+ Gambling problem? Call 1-800-GAMBLER
Use Promo Code: THELINES1000
Bet $5
Get $150
Win or Lose
Bet $5 Get $150 in Bonus Bets Win or Lose
Available on Desktop, Android & iOS
To Claim: Click Play Now
Up to $100
Bonus Bet
Up to $100 Back if Your First Bet Doesn’t Win
Get Your Bets Boosted
To Claim: Click Play Now
$500 BONUS
2nd Chance Bet
Up To $500 in Bet Credits
ONLY 1x Play Through!
Use Exclusive Bonus Code: LINESRIV

21+ in most states to use sportsbook bonus codes; gambling problem? Call or text 1-800-GAMBLER.