College Football Week 12 Odds & Cheat Sheet: Schedule, Injuries, Weather, Betting Notes

As the college football season grows old, the focus shifts. The playoff picture has become clearer (or muddier, depending on where you stand), and teams start to eye next season, making personnel shifts. The transfer portal is back in the conversation. Speculation grows, as does excitement for the final sprint to the postseason. As a result, there’s more to know about Week 12 odds than any other weekend of college football.

Find the latest odds, notable line movement, matchup history, weather, injuries, trends, and more below. Dig in! Keep up with The Lines all week long for college football betting tools.

College Football Week 12 Odds

Browse college football Week 12 odds below. Click odds anywhere to place a bet.

Line Movement: College Football Week 12 Odds

Check out early movers from those and the opening lines below:

• UCLA fell from a +8 underdog to +3.5 at Washington
• Arkansas fell from +16.5 to +14 against Texas
• This summer, Colorado opened as a +8 underdog against Utah, but spread odds currently favor the Buffs by -10
• LSU was lined as a -5.5 road favorite at Florida but reopened at -4
• This summer, oddsmakers lined Georgia as a -17.5 favorite against Tennessee, yet the Dawgs reopened at -9
• Oregon grew from a 10.5-point road favorite at Wisconsin to -14
• Kansas quickly fell from +7 to +3 at BYU

Opening Lines from College Football Week 12 Odds

• East Carolina jumped from a -11 favorite at Tulsa to -14 (Thursday)
• Liberty, which sits 2-6 ATS on the season and lost two of its last three games outright as the favorite, grew from -12.5 to -14 at UMass
• Early bets moved Temple off a PK against FAU to -2.5
• Michigan State moved through a key number, from +3.5 to +2.5 at Illinois, which has lost two straight after a 6-1 start
• Cal moved off a key figure, from -7 to -8, against Syracuse
• Utah State moved off the key figure of +3 to +2.5 against Hawaii
• USF moved on to a key figure, from -2.5 to -3, against Charlotte
• Notre Dame rose from a -20.5 favorite against Virginia to -22.5
• Air Force took notable movement, from +7 to +4, at home against Oregon State
• Baylor flipped from a +1.5 underdog at West Virginia to a -2.5 road favorite
• Despite a lackluster showing last week, Georgia State moved from a pick’em to -2.5 against Arkansas State
• Maryland jumped from -3 to -6 against Rutgers
• Kansas State moved from -7 to -8.5 at home against Arizona State
• New Mexico State fell from +42 to +39.5 at Texas A&M
• Despite a two-game slide, Iowa State grew from -7.5 to -9 against Cincinnati
• UAB fell from +15.5 to +14 at Memphis
• New Mexico fell from a +14 home underdog to +12.5 against Washington State
• UNLV grew from -18.5 to -20 against San Diego State

Note line movements through key numbers, like Michigan State at Illinois.

Midweek MACtion College Football Week 12 Odds Rundown

Game	TV (ET)	Opening Odds
Ball State at Buffalo	Tuesday, 7:00 p.m., CBSSN	BUF -5, O/U 53
Central Michigan at Toledo	Tuesday, 7:00 p.m., ESPNU	TOL -14, O/U 48.5
Western Michigan at Bowling Green	Tuesday, 7:00 p.m., ESPN2	BG -7, O/U 56.5
Akron at Northern Illinois	Wednesday, 7:00 p.m., CBSSN	NIU -18, O/U 45
Eastern Michigan at Ohio	Wednesday, 7:00 p.m., ESPN2	OHIO -9, O/U 47.5
Kent State at Miami (OH)	Wednesday, 7:00 p.m., ESPNU	MOH -30.5, O/U 45

Midweek MACtion Betting Movement

• Ball State at Buffalo saw its over/under move up from 53 to 54.5 points
• Central Michigan at Toledo’s total rose from 48.5 to 51.5 points
• Opening on a key number, -7, Bowling Green took action and moved to -8.5, and the total moved from 56.5 to 59.5
• Bettors favored Ohio after the odds opened, moving the Bobcats up from -9 to -10.5
• The total for the EMU at Ohio matchup also moved from 47.5 to 49.5
• Akron dropped from a +18 underdog at open to +15

Midweek MACtion Betting Notes

• Central Michigan’s quarterback situation is dire: starter Joey Labas suffered a season-ending injury early on, and Bert Emanuel Jr. is hurt (may not return this season). In the last game, two QBs (Tyler Jefferson and Jadyn Glasser) combined for 63 passing yards
• Despite sitting at 3-6 and 123rd in average point margin (-17 ppg), Ball State is 6-3 ATS on the season
• Ball State is 9-2 straight up and 7-4 ATS against Buffalo
• All three of Ohio’s midweek MACtion opponents come off a bye week
• Bettors backed Akron in its last three games, moving its line down each time. The Zips are 3-6 ATS on the season but did cover two of the last three opening lines
• Miami (OH) is just the third 30-point favorite in a midweek MACtion game since 2017 (favorites went 1-1 ATS)

Coaching & Matchup Notes for College Football Week 12 odds

Wyoming at Colorado State, Friday (8:00 p.m., CBSSN)

• The Border War! Teams play for the Bronze Boot trophy
• Colorado State leads the all-time series 59-51-5, but Wyoming won the last three (11-4 WYO run)
• CSU is 4-0 in Mountain West play and would play Boise State for the championship if the season ended today
• Rams star receiver Tory Horton suffered a season-ending injury in mid-October
• Wyoming returned some hurt players, namely back Harrison Waylee
• Starting guard Wes King suffered a season-ending injury for the Cowboys, and tackle Luke Sandy hasn’t played since Week 3
• Watch for temperatures dipping into the 30s!

Houston at Arizona, Friday (10:15 p.m., FS1)

• Houston leads the all-time series 3-1 (last: 2017 & 2018)
• Arizona is on a five-game losing streak with an average -20.8 point margin. The Wildcats lost by 44 points to UCF on a third-string QB
• Since beating New Mexico 63-39, Arizona has not scored more than 26 points in a game
• Houston is on a two-game winning streak and has won three of its last four games (TCU, Utah, Kansas State)
• The winning ways came with the shift to QB Zeon Chriss; he went 11-for-11 in the Cougs’ last game, beating Kansas State 24-17
• Houston ranks 35th in points per drive and has held opponents to fewer than 21 points six times this year

Utah at No. 18 Colorado, Saturday (noon, FOX)

• Utah leads the all-time series 35-32-3 but won 11 of 13 matchups in the Pac-12
• QB Brandon Rose will start for Utah, his second start of the year
• Against Big 12 foes this year (including Baylor, though that did not count toward conference standings), Utah is scoring an average of 15.7 points per game
• Colorado stands 7-2 ATS this season, and four of its five Big 12 wins this year have been by more than one score
• The Buffs have scored fewer than 28 points just once this season
• In a total turnaround from last year, Colorado stands 36th in points per drive allowed

No. 2 Ohio State at Northwestern, Saturday (noon, Big Ten Network)

• Game played at Wrigley Field
• Ohio State has dominated the all-time series 65-14-1, including wins in the 2018 and 2020 Big Ten championship games
• Northwestern is coming off a bye
• Despite playing with a rebuilt offensive line, the Buckeyes rushed for 173 and 176 yards in their last two games (Purdue, Penn State)
• Northwestern’s two Big Ten wins came against Maryland and Purdue, who have a combined 1-11 Big Ten record
• The Wildcats have been held to under 21 points in regulation six times this season
• Watch for a potential lookahead spot to Indiana for Ohio State!

No. 17 Clemson at Pitt, Saturday (noon, ESPN)

• Pitt leads the all-time series 3-2, but the teams split four meetings as ACC foes
• After starting 7-0, Pitt lost two straight (at SMU, versus Virginia)
• Clemson rebounded with a 24-14 win against a banged-up Virginia Tech after a 33-21 loss to Louisville
• Before those games, Clemson scored 40+ in five of six games
• This is Clemson’s final ACC game. A loss doesn’t end the Tigers’ ACC championship hopes, but they would need outside help

No. 21 LSU at Florida, Saturday (3:30 p.m., ABC)

• LSU leads the all-time series 34-33-3
• Despite playing 70 times since 1937 and being an accepted rivalry, this game is not played for any hardware, nor does it have an official title
• Since the Shoe Game in 2020, LSU has won four straight
• A couple of days after affirming head coach Billy Napier, Florida lost to Texas, 49-17
• Florida played two straight top-five opponents before this game, Georgia and Texas
• Brian Kelly has a career 41-25 ATS record following a straight-up loss (62%)

No. 1 Oregon at Wisconsin, Saturday (7:30 p.m., NBC)

• The all-time series is tied 3-3, but all three Oregon wins came in the last three matchups (the last two in Rose Bowls)
• Wisconsin lost its last two matchups after beating Purdue, Rutgers, and Northwestern by a combined 117-16
• Wisconsin has zero wins over Power Conference foes with winning records
• Preseason starting QB Tyler Van Dyke suffered a season-ending injury back in Week 3
• Since beating Ohio State in Week 7, Oregon is 3-1 ATS, all games against Big Ten foes (Purdue, Illinois, Michigan, Maryland)
• The Ducks have scored between 30 and 40 points in every Big Ten contest this year; they allowed 20+ points once (against Ohio State)
• Watch for injuries to Tez Johnson and Jordan Burch for Oregon

No. 7 Tennessee at No. 3 Georgia, Saturday (7:30 p.m., ABC)

• Georgia leads the all-time series 28-23-2 but has won seven straight
• In those seven straight wins, UGA won by an average of 26.4 points per game
• Georgia QB Carson Beck has thrown nine interceptions in his last five games
• In that stretch, Beck has five passing touchdowns but none against Ole Miss or Texas
• At home, Beck has a 12:5 TD:INT ratio (3:7 on the road) but has been abysmal when pressured
• QB Nico Iamaleava left last week with an injury, a move Josh Huepel described as “precautionary,” and he should play this week
• Tennessee has not allowed 20 points in a game this season

Kansas at No. 9 BYU, Saturday (10:15 p.m., ESPN)

• Kansas has won both previous matchups, last year and in 1992
• Kansas looked much better off its first bye week in Week 7. Since then, the Jayhawks are 3-0 ATS, beating No. 17 Iowa State and nearly upsetting No. 16 Kansas State
• During that stretch, Kansas had a +4 turnover margin and averages over 200 rushing yards per game
• Jalon Daniels has just one interception in his last four games (he threw eight in the first five games!)
• Conversely, BYU failed to cover two of its last three games, escaping with wins against Utah and Oklahoma State at home (combined 1-12 in Big 12 play)
• The Cougars are still down starting center Connor Pay, who’s been out since Week 5

Impact Injuries On College Football Week 12 Odds

All times Eastern

Michigan State at Illinois, Saturday (2:30 p.m., FS1)

Spartans QB Aidan Chiles left Week 10 with an injury only described as “not season-ending.” He is unlikely to play Saturday. In his place may be North Dakota transfer Tommy Schuster, who has 29 pass attempts this season. Schuster went 4-of-8 to close out a blowout at the hands of Indiana for 36 passing yards. He has had no touchdowns or interceptions this year.

Further, Michigan State will be without corner Chance Rucker, who was confirmed to be out for the season with an injury suffered in Week 2. Two other starters in the defensive secondary left Week 10 — CB Charles Brantley and SAF Malik Spencer. Top receiver Jalon Glover missed Week 10, as well. Watch to see how these players recovered in the bye week.

Illinois lost its top rusher, Kaden Feagin, for the season in Week 8.

No. 21 LSU at Florida, Saturday (3:30 p.m., ABC)

Florida QB D.J. Lagway suffered a hamstring issue that was initially thought to be serious against Georgia. Napier said the injury isn’t as serious as initially thought, and Lagway was sat last week as a precautionary measure. He may return to the lineup this weekend. Other notable starters who missed Week 11 include guard Dameion George, running back Montrell Johnson, receiver Elijah Badger, and corner Jason Marshall.

Receiver Eugene Wilson III was lost for the season.

Nebraska at USC, Saturday (4 p.m., Fox)

QB Dylan Raiola was reportedly hurt in Nebraska’s last game in Week 10 against UCLA. Top running back Ramir Johnson has been limited the last two games for the Cornhuskers, too. An under-the-radar, but proving to be important, injury is to kicker Tristan Alvano. John Hohl’s replacement is just 4-for-8 on field goals, including 1-of-3 in the critical 40-49 range. Hohl also missed an extra point.

Nebraska is 3-20 in one-score games since the start of 2021, although none came down to the kicking game in 2024 (0-3).

Baylor at West Virginia, Saturday (4 p.m., ESPN2)

QB Garrett Greene and WR Hudson Clement are both questionable this week. Greene missed WVU’s last two games, which the Mountaineers both won on the road (Arizona, Cincinnati). Top offensive lineman Wyatt Milum returned to the lineup, a huge boost to the offense. Despite the game coming at home, Baylor is playing much better football than Arizona or Cincinnati, and if Greene doesn’t go, it could present a real issue for a 5-4 WVU team seeking bowl eligibility.

Other Impact Injuries

• Cam Skattebo, RB, Arizona State
• Ja’Quinden Jackson, RB, Arkansas
• Payton Thorne, QB, Auburn
• Thomas Castellanos, QB, Boston College
• Nick Reimer, OG, Bowling Green
• Connor Pay, C, BYU
• Peter Woods, DT, Clemson
• Haynes King, QB, Georgia Tech
• Jamal Haynes, QB, Georgia Tech
• Luke Lachey, TE, Iowa
• Benjamin Brahmer, TE, Iowa State
• Jay Hardy, DT, Liberty
• Donerio Davenport, RB, Louisiana Tech
• Will Johnson, CB, Michigan
• Omari Kelly, WR, Middle Tennessee
• Howard Cross, DT, Notre Dame
• Anthony Tyus, RB, Ohio
• Zen Michalski, LT, Ohio State
• Dalton Cooper, OT, Oklahoma State
• Tre Harris, WR, Ole Miss
• Tez Johnson, WR, Oregon
• Nicholas Singleton, RB, Penn State
• Kyle Monangai, RB, Rutgers
• Gio Lopez, QB, South Alabama
• Chase Bisontis, OL, Texas A&M
• Jacob Zeno, QB, UAB
• Nick Evers, QB, UConn
• Eric Gentry, LB, USC
• Byrum Brown, QB, USF
• Kyron Drones, QB, Virginia Tech
• Kaedin Robinson, WR, Appalachian State (season)
• Cam Fancher, QB, FAU (season)
• Drew Evans, G, Indiana (season)
• Connor Tollison, C, Missouri (season)
• Henry Parrish, RB, Ole Miss (season)
• Wesley Bailey, DE, Rutgers (season)
• Taisun Phommachanh, QB, UMass (season)
• Jalen Royals, WR, Utah State (season)

Other Roster & Staff Impacts on College Football Week 12 Odds

Sam Houston State at Kennesaw State, Saturday (3 p.m., ESPN+)

In a shocking move this week, Kennesaw State fired head coach Brian Bohannon after a 1-8 start. Bohannon was the first and only head football coach for the Owls, who launched their football program in 2015. In that time, Bohannon won three conference championships in the FCS and transitioned Kennesaw State to the FBS. The athletic director initially said Bohannon stepped down, but Bohannon cleared things up, indicating a messy breakup.

Oregon State at Air Force, Saturday (3:30 p.m., CBSSN)

Last week, Oregon State made the shift at QB from Gevani McCoy to Ben Gulbranson. McCoy threw four interceptions in Week 7, and the Beavers are on a four-game losing skid. Gulbranson mustered just seven points against Cal and 13 against San Jose State.

Boston College at No. 14 SMU, Saturday (3:30 p.m., ESPN)

QB Thomas Castellanos was questionable for last week’s game against Syracuse but did play. He was replaced in the second half by FIU transfer Grayson James. At first, it seemed to be a benching, but reports suggest Castellanos left the game due to injury. James will start Week 12, and Bill O’Brien’s wording made it sound as though Castellanos was benched, hurt or not.

Nebraska at USC, Saturday (4 p.m., Fox)

Nebraska will have a new offensive coordinator: former West Virginia and Houston head coach Dana Holgorsen. Last week, Holgorsen wasn’t with the program and was hired late in the weekend to be a “consultant” on Matt Rhule’s offensive staff. On Monday, it was reported that Holgorsen will call the offense moving forward. Under Marcus Satterfield, Nebraska ranked 121st and 78th in offensive points per drive.

Week 13 note: Florida State fired both its offensive and defensive coordinators.

Weather Impacts On College Football Week 12 Odds

Weekly college football weather reports will be released later this week as forecasts become more certain. But here’s a few spots to keep tabs on early in the week.

Models are still uncertain, but college football might get its first taste of winter this weekend. Next week is the one to watch, but a large Arctic trough appears on most forecasting models. That could impact the far west, including Kansas at BYU. Watch for a rainy stretch for UCLA at Washington as an atmospheric river dumps rain in the Pacific Northwest. Luckily, Washington State and both Oregon schools are on the road.

Keep an eye on the forecast for MACtion and other midweek games for Week 13.

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Situational Spots To Watch With College Football Week 12 Odds

No. 2 Ohio State at Northwestern, Saturday (noon, Big Ten Network)

A sleepy noon kickoff at Wrigley Field is all that stands between Ohio State and a top-10 Indiana foe coming off a bye week. With Ohio State winning 34 of the last 35 meetings between these schools, it’s nearly a foregone conclusion the Buckeyes walk out of Chicago winners. Early betting favored Northwestern, who caught more than 30 points at open. Remember to disregard the last “at Northwestern” result, as the teams played in 50+ mph winds en route to a 21-7 Ohio State win (-38). Northwestern is coming off a bye and playing at “home,” just seven miles down the road.

Utah at No. 18 Colorado, Saturday (noon, Fox)

Utah lost to rival BYU at home in questionable fashion. Athletic director Mark Harlan was handed a hefty fine after blasting the officiating, saying that Utah wasn’t happy having joined the Big 12 due to the gaffes. The Utes fall to 1-5 in Big 12 play and are on track to miss a bowl for the first time since 2012-13 (were eligible but did not play in one in 2020).

Coming off that emotional loss, Utah plays locally at a red-hot Colorado team at 10 a.m.

Syracuse at Cal, Saturday (3 p.m., The CW)

Syracuse completes its arduous road stretch that featured five road games in its last six contests (one bye week). This time, it hits the Pacific Time Zone for the second time this year (at UNLV earlier). Syracuse is 2-2 in its last four road games, both wins coming by a score (UNLV, NC State), and it lost its last two (Pitt, Boston College). Exhaustion on the road could set in quickly with this noon local kickoff at a stadium with little support for its football team and a game crammed on The CW.

Nebraska at USC, Saturday (4 p.m., Fox)

USC is the fourth straight opponent coming off a bye and the second straight new West Coast Big Ten foe for Nebraska. The Huskers are coming off a bye but will travel to L.A. for the game. They’ll have a new offensive play-caller, Dana Holgorsen, who joined the program during the bye week. How quickly does Holgorsen integrate with this system? Without any tape on the offense he called, perhaps Nebraska has an edge offensively.

James Madison at Old Dominion, Saturday (4 p.m., ESPNU)

This season, JMU is 5-0 at home (+29.8 ppg) and 2-2 on the road (+1.5 ppg). Both losses at Georgia Southern and ULM came as favorites of 10-plus points. Coming off an easy 38-7 win over Georgia State, JMU hits the road to play Old Dominion, down its star linebacker in Jason Henderson and potentially starting QB Grant Wilson. ODU must win two of its final three games to become bowl-eligible, and the next two games will be at home. Expect an exceptional effort from ODU against a JMU team that often underplays away from Harrisonburg.

Additionally, ODU is coming off a bye and has a rest advantage at home.

South Alabama at Louisiana, Saturday (7 p.m., ESPN+)

Like ODU, South Alabama must win two of its final three games to make a bowl. Few teams have the volatility that South Alabama has — an 87-10 historic beatdown was negated by an 18-16 loss at Arkansas State two weeks later; a 48-14 blowout of App State was canceled by losing 34-30 to Georgia Southern. QB Gio Lopez is banged up and questionable to play.

However, Louisiana is finishing an arduous run of playing teams off a bye, on the road, or both. That streak dates back to September and includes five opponents off a bye (including South Alabama) and four road games in six weeks. Volatility paired with desperation in South Alabama makes this game a real wild card against a team that can afford a loss (two games up on Texas State in the Sun Belt West).

No. 7 Tennessee at No. 3 Georgia, Saturday (7:30 p.m., ABC)

Josh Huepel is just 1-4 ATS as a road dog in Tennessee. This season, the Vols are 1-1 ATS on the road, including an outright loss at Arkansas and a more-or-less flat second-half performance against an Oklahoma team with a QB identity crisis. Georgia is coming off its first loss to someone other than Alabama since the start of 2021 and gets a home crowd to face rival Tennessee.

Beck is much better at home (12:5 TD:INT) than on the road this year (3:7 TD:INT), but he has struggled mightily when pressured. Tennessee ranks 92nd in sack rate despite placing fifth in points per drive allowed.

Kansas at No. 9 BYU, Saturday (10:15 p.m., ESPN)

Rather than being a letdown spot for Kansas, this is a matchup between two teams moving in different directions. Since its first bye week, Kansas won two of three games, and nearly all three, which would have included two wins over ranked Big 12 foes, are going 3-0 ATS. The Jayhawks’ ground game is back to what we expected in the preseason, rushing for over 200 yards per game in that stretch.

Conversely, the 9-0 BYU Cougars skirted by two of their last three opponents, Oklahoma State (35-32 with a walk-off field goal) and Utah (22-21 with a walk-off field goal and aforementioned questionable calls). Those two combined to go 1-12 in Big 12 play this year. Perhaps an intersection of opposite movement and the odds reflect that, as KU dropped from a +7 underdog to +3.

Teams Around Bowl Eligibility

• Ball State at Buffalo: Buffalo needs one more win; Ball State is one loss away from being eliminated
• Western Michigan at Bowling Green: Both teams are one win away
• Kent State at Miami (OH): Miami is one win away (Kent State is eliminated)
• East Carolina at Tulsa: ECU is one win away from eligibility, and Tulsa is one loss away from being eliminated
• North Texas at UTSA: North Texas needs to win one; UTSA needs to win two of three
• Hawaii at Utah State: Hawaii is one loss away from being eliminated (Utah State is eliminated)
• LSU at Florida: The Gators need to win two of their last three, perhaps to save Napier’s job
• USF at Charlotte: USF needs to win two of its last three (Charlotte is eliminated)
• UCLA at Washington: UCLA needs to win two of its last three, and Washington needs one more win
• Baylor at West Virginia: Both teams need one more win
• James Madison at Old Dominion: ODU needs to win two of its last three
• Rutgers at Maryland: Maryland needs to win two of its last three, and Rutgers needs one more win
• South Alabama at Louisiana: Jags need to win two of their last three; Louisiana has a two-game lead in the Sun Belt West
• Wake Forest at North Carolina: UNC needs one more win, and Wake Forest needs to win two of its last three
• Cincinnati at Iowa State: Cincinnati needs one more win while Iowa State is on a two-game losing streak
• Kansas at BYU: Kansas is one loss away from being eliminated from bowl eligibility

Best of luck betting college football Week 12 odds!

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