College Football Week 12 Odds & Cheat Sheet: Schedule, Injuries, Weather, Betting Notes

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Written By Road to CFB | Published at November 12, 2024
college football week 12 odds

As the college football season grows old, the focus shifts. The playoff picture has become clearer (or muddier, depending on where you stand), and teams start to eye next season, making personnel shifts. The transfer portal is back in the conversation. Speculation grows, as does excitement for the final sprint to the postseason. As a result, there's more to know about Week 12 odds than any other weekend of college football.

Find the latest odds, notable line movement, matchup history, weather, injuries, trends, and more below. Dig in! Keep up with The Lines all week long for college football betting tools.

College Football Week 12 Odds

Browse college football Week 12 odds below. Click odds anywhere to place a bet.

Line Movement: College Football Week 12 Odds

Check out early movers from those and the opening lines below:

Opening Lines from College Football Week 12 Odds

Note line movements through key numbers, like Michigan State at Illinois.

Midweek MACtion College Football Week 12 Odds Rundown

GameTV (ET)Opening Odds
Ball State at BuffaloTuesday, 7:00 p.m., CBSSNBUF -5, O/U 53
Central Michigan at ToledoTuesday, 7:00 p.m., ESPNUTOL -14, O/U 48.5
Western Michigan at Bowling GreenTuesday, 7:00 p.m., ESPN2BG -7, O/U 56.5
Akron at Northern IllinoisWednesday, 7:00 p.m., CBSSNNIU -18, O/U 45
Eastern Michigan at OhioWednesday, 7:00 p.m., ESPN2OHIO -9, O/U 47.5
Kent State at Miami (OH)Wednesday, 7:00 p.m., ESPNUMOH -30.5, O/U 45

Midweek MACtion Betting Movement

Midweek MACtion Betting Notes

Coaching & Matchup Notes for College Football Week 12 odds

Wyoming at Colorado State, Friday (8:00 p.m., CBSSN)

Houston at Arizona, Friday (10:15 p.m., FS1)

Utah at No. 18 Colorado, Saturday (noon, FOX)

No. 2 Ohio State at Northwestern, Saturday (noon, Big Ten Network)

No. 17 Clemson at Pitt, Saturday (noon, ESPN)

No. 21 LSU at Florida, Saturday (3:30 p.m., ABC)

No. 1 Oregon at Wisconsin, Saturday (7:30 p.m., NBC)

No. 7 Tennessee at No. 3 Georgia, Saturday (7:30 p.m., ABC)

Kansas at No. 9 BYU, Saturday (10:15 p.m., ESPN)

Impact Injuries On College Football Week 12 Odds

All times Eastern

Michigan State at Illinois, Saturday (2:30 p.m., FS1)

Spartans QB Aidan Chiles left Week 10 with an injury only described as "not season-ending." He is unlikely to play Saturday. In his place may be North Dakota transfer Tommy Schuster, who has 29 pass attempts this season. Schuster went 4-of-8 to close out a blowout at the hands of Indiana for 36 passing yards. He has had no touchdowns or interceptions this year.

Further, Michigan State will be without corner Chance Rucker, who was confirmed to be out for the season with an injury suffered in Week 2. Two other starters in the defensive secondary left Week 10 — CB Charles Brantley and SAF Malik Spencer. Top receiver Jalon Glover missed Week 10, as well. Watch to see how these players recovered in the bye week.

Illinois lost its top rusher, Kaden Feagin, for the season in Week 8.

No. 21 LSU at Florida, Saturday (3:30 p.m., ABC)

Florida QB D.J. Lagway suffered a hamstring issue that was initially thought to be serious against Georgia. Napier said the injury isn't as serious as initially thought, and Lagway was sat last week as a precautionary measure. He may return to the lineup this weekend. Other notable starters who missed Week 11 include guard Dameion George, running back Montrell Johnson, receiver Elijah Badger, and corner Jason Marshall.

Receiver Eugene Wilson III was lost for the season.

Nebraska at USC, Saturday (4 p.m., Fox)

QB Dylan Raiola was reportedly hurt in Nebraska's last game in Week 10 against UCLA. Top running back Ramir Johnson has been limited the last two games for the Cornhuskers, too. An under-the-radar, but proving to be important, injury is to kicker Tristan Alvano. John Hohl's replacement is just 4-for-8 on field goals, including 1-of-3 in the critical 40-49 range. Hohl also missed an extra point.

Nebraska is 3-20 in one-score games since the start of 2021, although none came down to the kicking game in 2024 (0-3).

Baylor at West Virginia, Saturday (4 p.m., ESPN2)

QB Garrett Greene and WR Hudson Clement are both questionable this week. Greene missed WVU's last two games, which the Mountaineers both won on the road (Arizona, Cincinnati). Top offensive lineman Wyatt Milum returned to the lineup, a huge boost to the offense. Despite the game coming at home, Baylor is playing much better football than Arizona or Cincinnati, and if Greene doesn't go, it could present a real issue for a 5-4 WVU team seeking bowl eligibility.

Other Impact Injuries

Other Roster & Staff Impacts on College Football Week 12 Odds

Sam Houston State at Kennesaw State, Saturday (3 p.m., ESPN+)

In a shocking move this week, Kennesaw State fired head coach Brian Bohannon after a 1-8 start. Bohannon was the first and only head football coach for the Owls, who launched their football program in 2015. In that time, Bohannon won three conference championships in the FCS and transitioned Kennesaw State to the FBS. The athletic director initially said Bohannon stepped down, but Bohannon cleared things up, indicating a messy breakup.

Oregon State at Air Force, Saturday (3:30 p.m., CBSSN)

Last week, Oregon State made the shift at QB from Gevani McCoy to Ben Gulbranson. McCoy threw four interceptions in Week 7, and the Beavers are on a four-game losing skid. Gulbranson mustered just seven points against Cal and 13 against San Jose State.

Boston College at No. 14 SMU, Saturday (3:30 p.m., ESPN)

QB Thomas Castellanos was questionable for last week's game against Syracuse but did play. He was replaced in the second half by FIU transfer Grayson James. At first, it seemed to be a benching, but reports suggest Castellanos left the game due to injury. James will start Week 12, and Bill O'Brien's wording made it sound as though Castellanos was benched, hurt or not.

Nebraska at USC, Saturday (4 p.m., Fox)

Nebraska will have a new offensive coordinator: former West Virginia and Houston head coach Dana Holgorsen. Last week, Holgorsen wasn't with the program and was hired late in the weekend to be a "consultant" on Matt Rhule's offensive staff. On Monday, it was reported that Holgorsen will call the offense moving forward. Under Marcus Satterfield, Nebraska ranked 121st and 78th in offensive points per drive.

Week 13 note: Florida State fired both its offensive and defensive coordinators.

Weather Impacts On College Football Week 12 Odds

Weekly college football weather reports will be released later this week as forecasts become more certain. But here’s a few spots to keep tabs on early in the week.

Models are still uncertain, but college football might get its first taste of winter this weekend. Next week is the one to watch, but a large Arctic trough appears on most forecasting models. That could impact the far west, including Kansas at BYU. Watch for a rainy stretch for UCLA at Washington as an atmospheric river dumps rain in the Pacific Northwest. Luckily, Washington State and both Oregon schools are on the road.

Keep an eye on the forecast for MACtion and other midweek games for Week 13.

Situational Spots To Watch With College Football Week 12 Odds

No. 2 Ohio State at Northwestern, Saturday (noon, Big Ten Network)

A sleepy noon kickoff at Wrigley Field is all that stands between Ohio State and a top-10 Indiana foe coming off a bye week. With Ohio State winning 34 of the last 35 meetings between these schools, it's nearly a foregone conclusion the Buckeyes walk out of Chicago winners. Early betting favored Northwestern, who caught more than 30 points at open. Remember to disregard the last "at Northwestern" result, as the teams played in 50+ mph winds en route to a 21-7 Ohio State win (-38). Northwestern is coming off a bye and playing at "home," just seven miles down the road.

Utah at No. 18 Colorado, Saturday (noon, Fox)

Utah lost to rival BYU at home in questionable fashion. Athletic director Mark Harlan was handed a hefty fine after blasting the officiating, saying that Utah wasn't happy having joined the Big 12 due to the gaffes. The Utes fall to 1-5 in Big 12 play and are on track to miss a bowl for the first time since 2012-13 (were eligible but did not play in one in 2020).

Coming off that emotional loss, Utah plays locally at a red-hot Colorado team at 10 a.m.

Syracuse at Cal, Saturday (3 p.m., The CW)

Syracuse completes its arduous road stretch that featured five road games in its last six contests (one bye week). This time, it hits the Pacific Time Zone for the second time this year (at UNLV earlier). Syracuse is 2-2 in its last four road games, both wins coming by a score (UNLV, NC State), and it lost its last two (Pitt, Boston College). Exhaustion on the road could set in quickly with this noon local kickoff at a stadium with little support for its football team and a game crammed on The CW.

Nebraska at USC, Saturday (4 p.m., Fox)

USC is the fourth straight opponent coming off a bye and the second straight new West Coast Big Ten foe for Nebraska. The Huskers are coming off a bye but will travel to L.A. for the game. They'll have a new offensive play-caller, Dana Holgorsen, who joined the program during the bye week. How quickly does Holgorsen integrate with this system? Without any tape on the offense he called, perhaps Nebraska has an edge offensively.

James Madison at Old Dominion, Saturday (4 p.m., ESPNU)

This season, JMU is 5-0 at home (+29.8 ppg) and 2-2 on the road (+1.5 ppg). Both losses at Georgia Southern and ULM came as favorites of 10-plus points. Coming off an easy 38-7 win over Georgia State, JMU hits the road to play Old Dominion, down its star linebacker in Jason Henderson and potentially starting QB Grant Wilson. ODU must win two of its final three games to become bowl-eligible, and the next two games will be at home. Expect an exceptional effort from ODU against a JMU team that often underplays away from Harrisonburg.

Additionally, ODU is coming off a bye and has a rest advantage at home.

South Alabama at Louisiana, Saturday (7 p.m., ESPN+)

Like ODU, South Alabama must win two of its final three games to make a bowl. Few teams have the volatility that South Alabama has — an 87-10 historic beatdown was negated by an 18-16 loss at Arkansas State two weeks later; a 48-14 blowout of App State was canceled by losing 34-30 to Georgia Southern. QB Gio Lopez is banged up and questionable to play.

However, Louisiana is finishing an arduous run of playing teams off a bye, on the road, or both. That streak dates back to September and includes five opponents off a bye (including South Alabama) and four road games in six weeks. Volatility paired with desperation in South Alabama makes this game a real wild card against a team that can afford a loss (two games up on Texas State in the Sun Belt West).

No. 7 Tennessee at No. 3 Georgia, Saturday (7:30 p.m., ABC)

Josh Huepel is just 1-4 ATS as a road dog in Tennessee. This season, the Vols are 1-1 ATS on the road, including an outright loss at Arkansas and a more-or-less flat second-half performance against an Oklahoma team with a QB identity crisis. Georgia is coming off its first loss to someone other than Alabama since the start of 2021 and gets a home crowd to face rival Tennessee.

Beck is much better at home (12:5 TD:INT) than on the road this year (3:7 TD:INT), but he has struggled mightily when pressured. Tennessee ranks 92nd in sack rate despite placing fifth in points per drive allowed.

Kansas at No. 9 BYU, Saturday (10:15 p.m., ESPN)

Rather than being a letdown spot for Kansas, this is a matchup between two teams moving in different directions. Since its first bye week, Kansas won two of three games, and nearly all three, which would have included two wins over ranked Big 12 foes, are going 3-0 ATS. The Jayhawks' ground game is back to what we expected in the preseason, rushing for over 200 yards per game in that stretch.

Conversely, the 9-0 BYU Cougars skirted by two of their last three opponents, Oklahoma State (35-32 with a walk-off field goal) and Utah (22-21 with a walk-off field goal and aforementioned questionable calls). Those two combined to go 1-12 in Big 12 play this year. Perhaps an intersection of opposite movement and the odds reflect that, as KU dropped from a +7 underdog to +3.

Teams Around Bowl Eligibility

Best of luck betting college football Week 12 odds!

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