Potential College Football Upsets: ACC, Pac-12 Favorites On Alert Starting Thursday Night

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Written By Brett Gibbons | Last Updated
college football upset

As the season grows older, bye weeks are becoming a thing of the past, and championship contenders are squarely focused on the task at hand. However, this time of year is when the most devastating upsets happen in college football. This article outlines underdogs of at least 10+ points that get their opponent in difficult scheduling situations. More so in college football than the NFL; letdowns, lookaheads, and rest advantages affect favorites. Let’s dig into the upset alert picks for Week 10 from the best college football betting sites.

Upset alerts are 5-1 ATS in the last six, pushing the underdogs outlined in this article to 18-10-1 with three outright victories. We’ll make the case, and you decide if you want to make the picks on the moneyline or in your pick ’em pools. Compare college football odds from the best sports betting sites below with these upset candidates.


Browse odds from the best college football betting sites throughout this article. Click to place a wager on any of the games.

Wake Forest at Duke, THU, 7:30 p.m. ET

For the past two weeks, we’ve gotten a look at the Duke offense without a healthy Riley Leonard. A questionable decision to play the quarterback on a sprained ankle last week caused the Blue Devils to come up empty on the scoreboard. Now, they turn around on short rest to host regional rival Wake Forest. Wake currently sits second-to-last in the ACC with a 1-4 conference record. Duke plays the game at home, it should be a handle-your-business night… right?

Aside from having an offense hindered by a bum ankle, Duke plays this game after consecutive huge matchups at Florida State and Louisville. Next week, they visit arch-rival North Carolina. The focus might be all over the board with Duke.

Arizona State at Utah, 2:00 p.m. ET

With a backloaded schedule in the Pac-12, Utah has little time to collect themselves after taking a 35-6 beating at the hands of Oregon – the Utes’ first home loss at Rice Eccles since September 2018 (discounting an empty-stands COVID year). Utah shut down Cam Rising and Brant Kuthie for the season. As a result, the Utes are 128th in EPA per play offensively this year. This game comes sandwiched in a four-game run for Utah that included a date at USC, against Oregon, this game, and at Washington.

Arizona State snapped a six-game losing streak last week against Washington State and nearly picked off Washington in Seattle the week prior. Though potentially the most injured team in the country and one without much direction, the Sun Devils have been pesky.

More College Football Upset Alerts: Underdogs With Rest Advantages

  • Missouri () at Georgia
  • Arkansas () at Florida
  • Rutgers () vs. Ohio State
  • USF () at Memphis

Note: Northwestern plays their third straight opponent coming off a bye – the last two having rest advantages.


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