College Football Week 6 Look-Ahead Lines: Iowa vs. Ohio State Headlines Odds

Ahead of one of the biggest Saturdays on the college football schedule (Oct. 12), Week 6 is a popular weekend to take one of two allotted bye weeks this year. Sportsbooks already posted look-ahead lines for Week 6 of the college football season. Top billing goes to No. 11 Missouri at No. 24 Texas A&M, Iowa at No. 3 Ohio State, and No. 17 Clemson at Florida State.

Other games of interest include No. 12 Michigan at Washington, UCF at Florida, and Auburn at No. 2 Georgia. This weekend gives college football fans a chance to catch their breaths, garner brownie points for next week, or attend a fall wedding.

College Football Week 6 Look-Ahead Lines

Here are the best available opening odds across several betting apps.

No. 11 Missouri at No. 24 Texas A&M, Saturday (12:00 p.m., ABC)

Week 6’s only current ranked matchup features Missouri (4-0) and Texas A&M (3-1). The Aggies opened a -2 home favorite but have multiple roster questions for Weeks 5 and 6.

Find a full assessment of Missouri at Texas A&M odds here.

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Iowa at No. 3 Ohio State, Saturday (3:30 p.m. ET, CBS)

Despite a stud run game and improved offensive unit, Iowa (3-1) opens a +23 underdog at Ohio State (3-0). The Buckeyes haven’t had much tape to look at, having played Akron (131st-ranked FBS team, per aggregated power ratings), Western Michigan (112th), and Marshall (92nd) ahead of Week 5. This should be a good matchup between Ohio State’s second-ranked defense (2.9 yards per play) against Kaleb Johnson and the Iowa offense. Entering Week 5, Johnson leads the nation with 685 rush yards and nine touchdowns. Watch for adjustments on this line as the Buckeyes visit Michigan State while the Hawkeyes rest.

No. 17 Clemson at Florida State, Saturday (7:00 or 7:30 p.m. ET, ESPN or ABC)

Florida State (1-3) notched its first win of the season, beating Cal 14-9. What was pinned as a top game with major ACC implications this summer has since fizzled into Clemson (4-0) being favored by nearly double digits on the road. The Tigers opened a -9.5 favorite at FSU and, depending on both results in Week 5, that number may grow. Clemson hosts Stanford while Florida State visits SMU. Week 1 is becoming more and more fleeting as Clemson hung 66 and 59 in its last two outings (App State, NC State) while the pessimism for Florida State rebounded a bit. Should the ‘Noles lose this weekend, this line could take off in the direction of the visitors.

No. 12 Michigan at Washington, Saturday (7:30 p.m. ET, NBC)

Following a huge win at home against USC, Michigan (3-1) moved up the AP Top 25, checking in at No. 12 for Week 5. Following a home game against Minnesota, the Wolverines travel cross-country to face Washington (3-1), who returns from a cross-country trip of its own, at Rutgers. Michigan opened a slight -2 favorite on the road, but that number could seriously change following two intriguing Week 5 games. The Wolverines survived Week 4 despite just 32 yards passing from QB Alex Orji. With another game in the books to check out the QB situation, watch for Michigan’s outlook to move considerably.

College Football Week 6 Look-Ahead Lines: Odds COmparison

As more college football look-ahead lines become available at sportsbooks, this odds comparison table will update.

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