College Football Week 7 Best Betting Tips, Picks: Odds, Spreads, Props

This weekend in college football offers some of the highest-stakes games of the entire season. Usually, I look at the smaller-market games and find edges among them while the focus leans into the blockbuster games. But this week, I have leans on some of the bigger games, like USC at Notre Dame. On the season, my college football picks from this article are a profitable 25-19 (56.8%). Here’s to hoping for continued success, as these bets have also beaten the closing line by an average of 2.31 points per play. Browse our college football odds boards to find lines on every game.
COLLEGE FOOTBALL WEEK 7 PICKS, BEST BETS
Ohio State at Purdue, 12:00 p.m. ET
I fully explain the reasoning behind this bet in my weekly college football upset picks. The bottom line is Ohio State’s offense is struggling, particularly in the first halves. They’ve been slow to start, even if the Buckeyes end up covering up their tracks at the end of the day, and talent wins out (and even covers).
Brett’s bet: Purdue 1H +10.5 (-110)
Best available odds: Purdue 1H
BYU at TCU, 3:30 p.m. ET
As the week went on, the market went away from my placed bet. That’s not typically a good sign, but I stand by it and would take the points with BYU at this even better number. I’m not confident the market is fully up to speed with how bad TCU could be.
The Horned Frogs lost starting QB Chandler Morris to an MCL injury last week. In his place rises inexperienced Josh Hoover, a large drop-off in my assessment. Offensive play calling (particularly in short-yardage situations), special teams gaffes, and self-inflicted losses have been the story of the early season for the Horned Frogs. Rumors are circulating that the locker room doesn’t have a ton of confidence in OC Kendall Briles, especially since he brought noise and baggage with him to the program in the first place.
BYU, though on the road, has a rest advantage. They last played Friday in Week 5, while TCU has battled two back-to-back one-score games. The Cougars are disciplined, with few penalties or turnovers. Their defense has taken one of the biggest steps forward nationally under new DC Jay Hill.
Brett’s bet: BYU +5 (-110)
Best available odds: BYU
- We’ve ranked the best college football betting sites this season so you can be confident you are betting on the best apps.
Auburn at LSU, 7:00 p.m. ET
I also laid out the full explanation for this bet in my upset bid article. The logic here is that Auburn comes off a bye week well-rested and LSU has played three consecutive one-score, last-second finishes with point totals in the 60s. Their defense is bad enough to keep anybody in the game.
Brett’s bet: Auburn +12 (-112)
Best available odds: Auburn
USC at Notre Dame, 7:30 p.m. ET
All game long, but particularly in the second half in last week’s loss to Louisville, Notre Dame was very apparently tired. The offensive line got no push and the defense was out of gas. It’s hard to blame them – this season, the Fighting Irish traveled to Ireland, then ran a triple-header of Ohio State, at Duke (with College GameDay), and at Louisville. The first two games of that triple-header were 60-minute fights.
Now, the Irish have to turn around and face Heisman frontrunner Caleb Williams and rival USC. Notre Dame was around a -2 favorite on the lookahead line last week and, thanks to a triple-overtime near-loss to Arizona, remained that way heading into this week. USC and their defense have let bad teams hang around all season long. But the talent on offense is undeniable.
With Notre Dame’s defense needing to chase around Williams as he dances around the field, I’m concerned about how much gas is left in the tank.
Brett’s bet: USC +3 (-115)
Best available odds: USC
- Join TheLines.com’s free sports betting Discord with more than 4,000 community members and our staff sharing betting ideas every day. Go to the #roles server to get push notifications to the Discord app from TheLines.com staff when they lock in a bet.
Watch! TheLines College Football Podcast: Week 7 CFB Picks
21+ in most states; Gambling problem? Call 1-800-GAMBLER