College Basketball Odds & Picks: Duke vs. UNC, Cooper Flagg's Injury

Written By Carson Mundy | Published at March 14, 2025
Duke UNC Odds

On Friday's college basketball odds board, the top-seeded Duke Blue Devils (29-3, 19-1) square off against the fifth-seeded North Carolina Tar Heels (22-12, 13-7) in the 2025 ACC Tournament semifinals. The Cooper Flagg injury looms large, as the Blue Devils opened as 7.5-point favorites. Let's assess the betting odds and my picks for Duke vs. UNC odds, including potential same-game parlay options.

Click any odds below to place a wager. We highly recommend checking out the best sportsbook promos at the best sports betting sites for more offers.

Duke vs. unc odds: spread, moneyline, total

March Madness Odds

With our March Madness odds comparison table at hand, bettors can sift through the best futures betting odds for Duke, UNC, or any other team.

Duke vs. UNC odds: will Cooper Flagg play?

Duke coach Jon Scheyer told the media that Flagg's X-rays were negative, indicating a left sprain. However, Scheyer also noted that it's a "real long shot" that he will return for Friday's semifinal.

Flagg's potential absence is already baked into the spread, but I wouldn't be surprised to see this line shift in UNC's direction if Flagg is officially ruled out. While the Blue Devils are fighting for the No. 1 overall seed in the NCAA tournament, they have their eyes set on cutting down the nets. Hence, Flagg could wind up resting his ankle until the second round of March Madness.

acc semifinals betting prediction

Without Flagg for much of the ACC tourney quarterfinals against Georgia Tech, Duke's offense was underwhelming, accruing a 23.3% clip from deep. His absence would again loom large for the nation's second-ranked adjusted offensive efficiency (AdjD), yet Duke is certainly talented enough to undergo positive 3-point variance and cover for a third time against its arch-rivals this year.

Granted, the Tar Heels will showcase their fair share of desperation, with their at-large hopes on the line. Situationally, that will favor Hubert Davis' bunch.

If you have not encountered situational spots, they attempt to uncover matchups in which teams exceed or underperform their usual efficiency level — relative to the moneyline or spread. 

R.J. Davis and Co. have notched a 45.5% clip from behind the arc over their last nine games, winning eight outright. They should hang within the spread if their hot shooting continues against the Blue Devils' drop coverage.

sportsbook promos for Duke vs. UNC odds

#
Sportsbook
Bonus
Features
Bet
1
BetMGM Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
  • Wide coverage of US and international sports
  • Linked to MGM Rewards loyalty program
  • Regular odds boosts and promos
Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, Massachusetts, New York, Ontario, or Puerto Rico.
2
DraftKings New DraftKings Customers: Bet $5, Get $200 + 3 Months of NBA League Pass!
  • Wide coverage of US and international sports
  • High-quality iOS and Android apps
  • Very fast withdrawal times
GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/NH/PR/WY). Void in CAN. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new Sportsbook customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets. Stake removed from payout. Reward issued as $50 in Bonus Bets every 7 days via click-to-claim for 21 days. Bonus Bets and click-to-claims expire 7 days (168hrs) after issuance. Terms: dkng.co/offer. Get 1 promo code to redeem a 3-month NBA League Pass subscription, complimentary of DraftKings. Subscription auto-renews monthly at then-current price (currently $16.99/mo); cancel anytime. Terms, restrictions, and eligibility requirements apply. Redeem League Pass by 12/19/26 at 11:59 PM ET. Addt’l terms: support.watch.nba.com/hc/en-us/articles/9165532876183-League-Pass-Terms-of-Use_. Ends 11/29/26 at 11:59 PM ET. Sponsored by DK.
3
FanDuel New Users – Get $350 in Bonus Bets when you wager $5 for 7 days
  • Offers one of the best same-game parlays
  • Highly rated mobile app
  • Impressive sports coverage
Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Call 1-888-789-7777 or visit ccpgg.org/chat (CT). Hope is here. GamblingHelpLineMA.org or call (800) 327-5050 for 24/7 support (MA). Visit www.mdgamblinghelp.org (MD). Call 1-877-8HOPE-NY or text HOPENY (NY). 21+ (18+ DC, WY) and present in select states (for KS, in affiliation with Kansas Star Casino). Find online real money wagering only. Min $5 wager required for 7 consecutive days. $5 free play credit. Bonus issued as non-withdrawable bonus with cash withdrawable bonus with cash withdrawable. Bonus bets which expire 7 days after receipt. Restrictions apply. See terms at sportsbook.fanduel.com. Call 1-877-770-7867 (LA).
4
Fanatics Get Up to $1,000 Matched in FanCash
  • Unique FanCash loyalty program
  • Variety of bonuses and ongoing promos
  • Fast, reliable app with live betting and streaming
Must be 21+. GAMBLING PROBLEM? CALL 1-800-GAMBLER OR CALL 1-800-MY-RESET, www.mdgamblinghelp.org (MD), (800)-327-5050 or gamblinghelplinema.org (MA), Call (877)8-HOPENY or text HOPENY (467369) (NY), (888) 789-7777 or ccpg.org (CT), morethanagame.nc.gov (NC), 1800gambler.net (WV)