College Basketball Odds & Picks: Duke vs. UNC, Cooper Flagg's Injury

On Friday's college basketball odds board, the top-seeded Duke Blue Devils (29-3, 19-1) square off against the fifth-seeded North Carolina Tar Heels (22-12, 13-7) in the 2025 ACC Tournament semifinals. The Cooper Flagg injury looms large, as the Blue Devils opened as 7.5-point favorites. Let's assess the betting odds and my picks for Duke vs. UNC odds, including potential same-game parlay options.

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Duke vs. unc odds: spread, moneyline, total

March Madness Odds

With our March Madness odds comparison table at hand, bettors can sift through the best futures betting odds for Duke, UNC, or any other team.

Duke vs. UNC odds: will Cooper Flagg play?

Duke coach Jon Scheyer told the media that Flagg's X-rays were negative, indicating a left sprain. However, Scheyer also noted that it's a "real long shot" that he will return for Friday's semifinal.

Flagg's potential absence is already baked into the spread, but I wouldn't be surprised to see this line shift in UNC's direction if Flagg is officially ruled out. While the Blue Devils are fighting for the No. 1 overall seed in the NCAA tournament, they have their eyes set on cutting down the nets. Hence, Flagg could wind up resting his ankle until the second round of March Madness.

acc semifinals betting prediction

Without Flagg for much of the ACC tourney quarterfinals against Georgia Tech, Duke's offense was underwhelming, accruing a 23.3% clip from deep. His absence would again loom large for the nation's second-ranked adjusted offensive efficiency (AdjD), yet Duke is certainly talented enough to undergo positive 3-point variance and cover for a third time against its arch-rivals this year.

Granted, the Tar Heels will showcase their fair share of desperation, with their at-large hopes on the line. Situationally, that will favor Hubert Davis' bunch.

If you have not encountered situational spots, they attempt to uncover matchups in which teams exceed or underperform their usual efficiency level — relative to the moneyline or spread. 

R.J. Davis and Co. have notched a 45.5% clip from behind the arc over their last nine games, winning eight outright. They should hang within the spread if their hot shooting continues against the Blue Devils' drop coverage.

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