Champions League Best Bets & Picks for October 22nd: Odds, Parlays, and Top Player Props
Written By Blaise Bourgeois | Last Updated at October 22, 2025
Champions League Matchweek 3 is in full swing and kicked off in exciting fashion with an astonishing 43 goals across the nine matches. If you were with us yesterday, you would have known that the favorites had a hammerlock on yesterday's action before a ball was kicked. Two of our three parlays hit impressive +939 and +736 licks yesterday.
Nine more matches are on tap for Wednesday's slate, including an exciting showcase between European giants Juventus and Real Madrid. Monaco look to break a miserable run of four straight without a win and will have to take on Tottenham. Ajax hope to get off the bottom of the Champions League table against Chelsea, while Eintracht Frankfurt will look for a statement victory as they host defending Premier League champions Liverpool.
Ahead of the action, we've conducted extensive research and have come up with the Champions League best bets for today. We have goalscorer parlays, upsets, and player props on tap. Your betting apps are going to get a workout today with all the thrilling Champions League action going on tonight!
Taking the Favorites - Parlay
📊 Parlay Odds: +342 (via FanDuel) ⭐
- Leg 1: Athletic Club ML
- Leg 2: Bayern Munich ML
- Leg 3: Chelsea ML
- Leg 4: Liverpool ML
- Leg 5: Real Madrid ML
Apart from Napoli last night and Liverpool’s shocking defeat against Galatasaray, the favorites have absolutely crushed during the Champions League this season. We expect much of the same tonight, with all of these teams being over -200 except for Liverpool, who are generally around -170 or -180, depending on where you look.
Liverpool are officially in crisis mode, having suffered an unprecedented four consecutive defeats for the first time since November 2014, before Jurgen Klopp was at the helm. This has come after spending a Premier League record £446 million ($598m) during the summer transfer window. Today, by all accounts, is considered a must-win affair at Eintracht Frankfurt, and Arne Slot's job may depend on it. Expect Liverpool to make a statement, or else suffer major consequences.
Blowouts Incoming - Team Prop Parlay
📊 Parlay Odds: +2366 (via DraftKings) ⭐
- Leg 1: Chelsea -2.5
- Leg 2: Athletic Club -2.5
- Leg 3: Bayern -3.5
Ajax are a shell of their former self and find themselves at the stone bottom of the Champions League table. Last time out in the Champions League, they were thrashed by a Marseille side 4-0, allowing three goals in the first 26 minutes. Heck, they just found themselves down 3-1 to Sparta Rotterdam and barely rescued a point. Playing away to Stamford Bridge is not what the Dutch outfit needs right now.
While Qarabağ are the surprise of the competition thus far, they've won against Benfica and Copenhagen sides that are playing at a far lower level than they have historically. Playing away to a proper La Liga side will likely give the Azerbaijani champions a rude awakening, and we could find ourselves looking at a baseball score when all is said and done.
We don't need to say much about the German champions, who have scored an eye-watering 38 goals in 11 matches so far this season. They host a Belgian side that allowed five goals to Westerlo last month. This could get ugly.
Champions League Best Bets and Player Props
📊 Parlay Odds: +1442 (via Caesars Sportsbook) ⭐
- Leg 1: Bayern -2.5
- Leg 2: Harry Kane Anytime Goalscorer
- Leg 3: Chelsea -1.5
- Leg 4: Enzo Fernandez Anytime Goalscorer
- Leg 5: Athletic Club -1.5
You should stick to the likely blowouts tonight, and Harry Kane scoring is as likely as anything these days. The England international superstar striker has scored in 12 out of 15 matches this season, already scoring 22 goals before the end of October. Kane is on a nine-match scoring run and will likely face one of his easiest defensive tests of the season.
Chelsea have been using Enzo Fernandez as more of an attacking threat lately. Despite no Chelsea player having more than three goals this season, there should be plenty of goals to go around tonight, and we think Enzo will bag at least one of them.
Bet $1, Double your Winnings on your Next 20 Wagers. Up to $25 Max Bet Per Boost Featured Image Mandatory Credit: ID 2471536179 via ph.FAB on Shutterstock
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