Cardinals vs. 49ers: Week 16 NFL Betting Preview – December 26, 2020

Posted By Staff on December 22, 2020

The San Francisco 49ers (5-9) fight to break their three-game losing streak as they are  against the Arizona Cardinals (8-6) on Saturday, December 26, at State Farm Stadium. The game has a point total of .

The betting insights in this article reflect betting data from DraftKings as of December 21, 2020, 2:41 PM ET. See table below for current betting odds and CLICK HERE to bet at DraftKings Sportsbook.

Cardinals vs 49ers Betting Odds

Cardinals vs 49ers Props

Looking to bet on props for this game? Use our prop search tool to find the best odds across legal sportsbooks in the US.

Betting the Total (Over/Under)

  • The points total average for Cardinals games this season is 51.4, 2.9 points higher than the over/under for this matchup.
  • The average total for 49ers games is 48.9 points, 0.4 more than this game’s over/under.
  • Cardinals games have gone over 48.5 points on eight occasions this season (57.1% of matchups).
  • San Francisco’s contests have gone over 48.5 points on five occasions (35.7% of games).
  • These two teams score a combined average of 51.7 points per game, higher than the total for this matchup by 3.2 points.
  • The Cardinals are the 10th-highest scoring team in the NFL this year. The 49ers have scored the 20th-most points.
  • These two teams allow a combined 48.6 points per game, 0.1 higher than the total for this matchup.
  • San Francisco has surrendered the 17th-fewest points in the league this season, while Arizona has given up the 13th-fewest.
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Cardinals Betting Insights

  • Arizona’s games have gone under the point total in eight out of 14 outings this season (57.1%).
  • Arizona has put together a 7-7 record against the spread this season.
  • The Cardinals are 3-2 ATS when favored by at least 3.5 points.

49ers Betting Insights

  • San Francisco has a losing 5-9 record against the spread.
  • The 49ers are just 1-4 ATS when an underdog by at least 3.5 points.
  • Half of San Francisco’s games this year — seven out of 14 — have gone over the point total.

Cardinals vs 49ers: Head to Head

Cardinals vs 49ers: Last 3 Meetings
Date Favorite Home Team Spread Total Favorite Moneyline Underdog Moneyline Total Yards Result
9/13/2020 49ers 49ers -6.50 48.00 -295 +255 404-366 ARI 24-20 ARI
11/17/2019 49ers 49ers -9.5 44 -455 +370 442-266 SF 36-26 SF
10/31/2019 49ers Cardinals -10.5 43.5 -500 +420 411-357 SF 28-25 SF

Check out TheLines YouTube channel to learn more about betting tips and picks for this week’s NFL action.

When the Cardinals Have the Ball

  • The Cardinals average points scored this season (27.9) and the 49ers points allowed (25.1) are within 2.8 points of each other.
  • When they meet or exceed their scoring average this season, Arizona is 6-2 and 5-3 against the spread.
  • When the San Francisco defense allows 25.1 points or fewer this year, the 49ers have accumulated a 5-3 overall record and a 5-3 record against the spread.
  • The Cardinals hold an 84.9-yard advantage in total yards gained versus total yards allowed compared to the 49ers defense this season (399.2 to 314.3). The Cardinals average 5.9 yards per play while the 49ers give up 5.2 per play.
  • When the Arizona offense puts together a game with at least their 2020 average in yardage, they are 7-1 overall and 6-2 against the spread this season.
  • When the San Francisco defense allows less than their season average for total yards, they are 5-4 against the spread and 5-4 overall.
  • The Cardinals have averaged 147.8 yards per game on the ground this season, 43.4 yards more than the 49ers have allowed to opposing rushing attacks (104.4).
  • When Arizona rushers gain at least a combined 147.8 yards this season, they are 6-1 overall and 5-2 against the spread.
  • When San Francisco holds opposing teams to 104.4 rushing yards or fewer this year, they are 3-6 against the spread and 3-6 overall.
  • This season, the 49ers have forced an average of 1.3 turnovers per game, equal to the 1.3 times Cardinals have turned the football over in each contest.
  • When Arizona turns the football over 1.3 times or fewer this season, they are 5-4 overall and 5-4 against the spread.
  • San Francisco’s record this season when they force more than 1.3 turnovers: 3-1 ATS, 3-1 overall

When the 49ers Have the Ball

  • The 49ers average just 0.3 more points per game (23.8) than the Cardinals give up (23.5).
  • When San Francisco scores at least 23.8 points, it is 4-3 against the spread and 4-3 overall.
  • This season, Arizona has a 5-3 record against the spread and a 6-2 record overall in games when it holds opponents to 27.9 or fewer points.
  • The 49ers collect 21.4 more yards per game (371.4), than the Cardinals allow per outing (350). On average, the 49ers pick up 5.6 yards per play, while the Cardinals give up 5.3 per play.
  • In games Arizona keeps its opponents to 350 or fewer yards, it has a 4-4 record ATS and a 4-4 record overall.
  • This season, the 49ers average 112.8 yards per game on the ground, just 6.6 fewer yards per game than the Cardinals allow per contest (119.4).
  • When San Francisco rushes for at least 112.8 yards, it recorded a 4-4 ATS record and a 4-4 overall record.
  • Arizona is 4-5 against the spread and 5-4 overall when holding opponents to 119.4 rushing yards or less.
  • This year, the 49ers turn the ball over 2.1 times per game, 0.8 more turnovers per game than the 1.3 the Cardinals force on average.
  • San Francisco is 4-4 against the spread and 4-4 overall when it turns the ball over 2.1 or fewer times.
  • When it forces 1.3 or more turnovers, Arizona has a 4-2 record against the spread and a 5-1 record overall.

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Cardinals Players to Watch

  • Kyler Murray has thrown for 3,637 yards while completing 67.6% of his passes (336-of-497), with 26 touchdowns and 11 interceptions (259.8 yards per game). He’s also carried the ball 123 times for 741 yards and 11 touchdowns, averaging 52.9 yards per game.
  • Kenyan Drake has taken 211 attempts for a team-leading 874 rushing yards (67.2 yards per game) while scoring nine touchdowns in 13 games.
  • DeAndre Hopkins has hauled in 103 passes to lead the team with 1,324 yards while scoring six touchdowns. He has been targeted 138 times and averages 94.6 yards per game.
  • Christian Kirk’s statline this year shows 41 grabs for 545 yards and six touchdowns in 13 games. He puts up 41.9 receiving yards per game and has been targeted 69 times.
  • Larry Fitzgerald has caught 48 passes on 64 targets for 381 yards and one touchdown, averaging 27.2 yards per game.
  • Haason Reddick has 11 sacks to lead the team, and has also added 14 TFL and 54 tackles this year.
  • This season, Jordan Hicks has collected 107 tackles and 11 TFL and leads the team in tackles.
  • Patrick Peterson has a team-high three interceptions and has tacked on 54 tackles and eight passes defended this season.

49ers Players to Watch

  • This year, Nick Mullens has racked up 2,437 passing yards (243.7 yards per game) while going 211-for-326 (64.7% completion percentage) and throwing 12 touchdowns and 12 interceptions in 10 games.
  • Raheem Mostert has churned out a team-high 521 rushing yards (65.1 yards per game) and scored two touchdowns in eight games. He has tacked on 16 catches for 156 yards (19.5 receiving yards per game) with one receiving touchdown.
  • Jeff Wilson Jr. has 344 yards on 84 carries (38.2 ypg), with six rushing touchdowns over the course of nine games.
  • This season, Brandon Aiyuk has 59 catches (on 94 targets) to lead the team with 733 yards (56.4 per game) with five touchdowns in 13 games.
  • Kendrick Bourne’s statline this year shows 43 catches for 575 yards and two touchdowns. He averages 41.1 receiving yards per game and has been targeted 67 times.
  • Kerry Hyder has collected a team-leading 7.5 sacks, while adding eight TFL and 45 tackles.
  • This season, Fred Warner has 103 tackles, three TFL, and two interceptions.

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