NFL Week 7 Betting Preview: New Orleans Saints at Arizona Cardinals

Written By Eli Hershkovich on October 20, 2022 - Last Updated on October 21, 2022
Cardinals Saints Odds

The New Orleans Saints visit the Arizona Cardinals at 8:20 p.m. ET on Thursday, Oct. 20. This primetime game, which kicks off NFL Week 7 odds, showcases the Cardinals as spread favorites and on the moneyline.

Cardinals – Saints odds also features a total set at .

In this post, we’ll dig into everything you need to know before placing a bet on Thursday Night Football odds, including matchups, key metrics, and the best available odds. Click on any of the Cardinals – Saints odds in this preview to bet now.

Saints at Cardinals: Spread, Moneyline, Over/Under

When using the odds table above, click the dropdown menu and select the type of bet you wish to make. 

Betting on the point spread is when you wager on how many points a team will win or lose by. A “plus” sign in front of the spread is the underdog, and a “minus” sign is the favorite. The Cardinals need to win by three points or more if you bet on them against the spread, as they’re priced as 2/2.5-point favorite at most shops. Conversely, a spread bet on the Saints would need New Orleans to win outright, lose by one or two points (depending on the spread you bet), or tie in overtime.

The total is the number of combined points that the two teams will score. Bettors can bet “over” or “under” on how many total points will be scored in the game.

Saints at Cardinals: Player Props

In the props tool search bar, type in a team or player and hit enter. You’ll see the various proposition bets offered by leading online sportsbooks. 

This is a valuable tool that allows bettors to compare odds and stats when considering a prop bet. 

Saints at Cardinals: Betting News

As of Thursday, the Cardinals have manufactured 70% of the spread handle and 68% of the tickets, respectively. This data comes from BetMGM Sportsbook, which is trading the Cardinals at . Additional updates can be found below.

Saints at Cardinals: Weather Report

This game could be played indoors because State Farm Stadium has a retractable roof, but the weather report for Glendale on Thursday is dry (scattered clouds) and relatively calm (2 mph winds), with a high temperature of 86 degrees.

Arizona Injuries

Jalen ThompsonSSHamstringQuestionable
Marquise BrownWRFootOut
Trayvon MullenCBHamstringQuestionable
Darrel WilliamsRBKneeOut
Dennis GardeckOLBAnkleOut
James ConnerRBRibsQuestionable
Justin PughLGACLOut
Rodney HudsonCKneeOut
Matt PraterKHipQuestionable
Cody FordRGAnkleQuestionable

New Orleans Injuries

Adam TrautmanTEFootOut
Michael ThomasWRFootOut
Marshon LattimoreCBAbdomenOut
Jarvis LandryWRAnkleOut
Andrus PeatLGChestOut
Calvin ThrockmortonLGHipQuestionable
Payton TurnerDEChestQuestionable
Paulson AdeboCBKneeQuestionable
Keith KirkwoodWRAnkleQuestionable

Free Pick’Em Contests! Compete for prizes every day by entering our free betting games. NFL, NBA, college basketball and more!

Arizona Offense Vs. New Orleans Defense

Cardinals OffenseStats (Rank)Saints Defense
19.0 (22)Points/Gm26.3 (29)
0.3 (16)Points/Play0.4 (18)
346.0 (16)Yards/Gm342.8 (17)
226.7 (16)Pass Yards/Gm222.0 (16)
119.3 (15)Rush Yards/Gm120.8 (20)
4.8 (29)Yards/Play5.6 (17)
5.3 (32)Yards/Pass6.9 (22)
4.4 (13)Yards/Rush4.6 (20)
34.1% (28)3rd Down %33.8% (5)
50.0% (20)Red Zone %46.7% (7)
5 (2)Turnovers6 (23)
14 (17)Sacks13 (17)

New Orleans Offense vs. Arizona Defense

Saints OffenseStats (Rank)Cardinals Defense
23.5 (11)Points/Gm23.7 (22)
0.4 (3)Points/Play0.4 (18)
382.3 (5)Yards/Gm337.3 (12)
230.5 (15)Pass Yards/Gm233.5 (20)
151.8 (7)Rush Yards/Gm103.8 (7)
5.9 (6)Yards/Play5.6 (17)
6.8 (10)Yards/Pass6.8 (20)
5.4 (2)Yards/Rush4.3 (13)
41.2% (10)3rd Down %40.6% (19)
65.0% (6)Red Zone %56.5% (18)
13 (31)Turnovers7 (17)
15 (21)Sacks11 (23)

Beat The Closing Line Podcast Goes In-Depth On Cardinals – Saints Odds

For the audio-only version of the pod, subscribe to “Beat The Closing Line” on Apple Podcasts.

Saints at Cardinals: Betting Insights

Why Cardinals Can Cover The Spread

You could make the case that this game represents a buy-low spot for Arizona’s offense. After generating the ninth-highest EPA per play last season, Kyler Murray & Co. are below league average in that category thus far. All-Pro wideout DeAndre Hopkins, who missed the first six games because of a PED suspension, is returning, too.

Murray has also struggled individually after signing a five-year contract extension in the offseason. His EPA + CPOE (Completion Percentage Over Expected) composite slots in at No. 25 among all signal callers — with names like Russell Wilson, Carson Wentz, and Justin Fields behind him. The latter metric adjusts for contextual factors that make a pass more or less likely to be completed.

Meanwhile, the Saints have surrendered the seventh-most Dropback EPA/play — one spot ahead of the Cardinals. Per the injury report, they’ll be without Marshon Lattimore (abdomen). Fellow corner Paulson Adebo (knee) is questionable.

However, Dennis Allen mixes in a zone defense, which is more intact with reliable safeties. That’s where Marcus Maye, who returned in Week 6 after missing three straight games, comes into play. He’s paired with Tyron Mathieu, who boasts a top-five coverage grade at his position thus far (via Pro Football Focus).

Combine those factors with Murray historically underperforming against zone defenses — as opposed to man-to-man looks. He won’t have “Hollywood” Brown (knee) at his disposal, either. Wideout Robbie Anderson, who was acquired on Monday, won’t be up to speed on a short week.

Why Saints Can Cover The Spread

Despite Jameis Winston returning to practice in limited fashion, Andy Dalton is reportedly expected to keep the starting job under center. But the known variable is Arizona’s vulnerable defense.

Not only have the Cardinals scuffled in regards to opponents’ Dropback EPA/play, but safety Jalen Thompson and corner Trayvon Mullen may miss this matchup as well.

Moreover, their run defense has yielded an above-average Success Rate (SR). For context, a play is successful if teams produce:

  • 50 percent of the yards needed to move the chains on first down
  • 70 percent of yards to gain on second down
  • 100 percent of yards to gain on third or fourth down

New Orleans’ ground game, driven by star tailback Alvin Kamara, is positioned to continue its recent success. That’ll set up the aerial attack, which should be more explosive with the reinstated Chris Olave (concussion).

Pete Carmichael’s offense will be without both Michael Thomas and Jarvis Landry, though.

On the other side of the ball, the Saints have failed to generate consistent pressure. But given the talent along the front-seven, this contest presents a get-right spot. The Cardinals’ pass protection is roughly league average, and it won’t have left guard Justin Pugh (ACL) nor center Rodney Hudson (knee) in the lineup.

On top of their aforementioned secondary receiving a recent boost, the savvy Allen is a clear-cut advantage over Kingsbury. Arizona is just 4-11 ATS (26.7%) as a home favorite under the fourth-year coach. The market appears to be overvaluing this team once again.

Related: Super Bowl 57 Odds

Reasons To Bet The Over

If you don’t foresee Murray’s issues extending against Allen’s defensive scheme, the over would certainly be in play. As a result of injuries and the Saints’ offense facing a negative game script, the total has gone over in four of their six games.

Reasons To Bet The Under

The betting market for Cardinals – Saints odds has bumped the total down from 46 to — with 80% of BetMGM’s overall handle on the under.

As I previously mentioned, New Orleans’ offense is the more likelier of the two to excel. That would allow for a unit — with a below-average tempo — to milk the clock on the ground. It’s notched the NFL’s sixth-highest rushing rate (54.0%) in Dalton’s three starts, too.

Final Thoughts

Although both teams are desperate to avoid a 2-5 start, I was low on the Cardinals entering the season. Considering the betting market is still overvaluing them, I bet Saints +1.5 on Monday. The Cardinals – Saints odds available now are even better.

Eli Hershkovich Avatar
Written by
Eli Hershkovich

View all posts by Eli Hershkovich