Red Sox vs. Blue Jays Prediction, Odds and Picks: Toronto Adds Another Win

In the second game of an AL East clash, the Toronto Blue Jays host the Boston Red Sox. In this Red Sox vs. Blue Jays prediction, you are covered with our picks and key information for the division contest.

In the opener of this series, the Blue Jays beat the Red Sox 2-1. Charles McAdoo had a solo home run in the win, and starter Jameson Taillon had a solid second outing after a trade for the Cubs, tossing four scoreless innings before leaving with forearm discomfort.

Hope springs eternal for Blue Jays fans, as while in the basement of the AL East and six games under .500, they are still only 3.5 games out of the last AL Wild Card. Boston (64-54) has lost three in a row after a nine-game win streak and currently owns the second AL Wild Card.

Bet365 Sportsbook has the Blue Jays as the favorite in this game at -140, with the Red Sox at +125 and a total of 7.5 runs.

Red Sox Lineup Has Cooled Off – Big Time 

After averaging 8 runs per game and scoring in double digits in three of four games, the Red Sox have only totaled seven runs in their last three games.

Boston has been led by their pitching this season, ranking fourth in team ERA and tied for 17th in runs scored.

Willson Contreras (.283, 23 home runs, 70 RBIs) is the clubhouse leader in home runs and RBIs, but he has only had one hit in the last three games, no RBIs, and in his last seven games against Toronto, he has two hits and one RBI. Wilyer Abreu (.253, 20 home runs, 63 RBIs) ranks second in home runs and RBIs and had six RBIs in three games before going 0 for 3 with none in this series opener.

Boston Starter for Second Game of Series 

Patrick Sandoval (1-0, 3.38 ERA, 1.67 WHIP) goes for the Red Sox, and they have won all five of his starts since coming off the IL after missing most of this season and 2025 due to elbow surgery. He has given up two runs in each of his last two outings, and in one start against the Blue Jays, he pitched 4 2/3 scoreless innings. In 24 innings this season, he has struck out 25 and walked 10.

Blue Jays Have Had Boston’s Number 

While the Blue Jays have a much worse record than the Red Sox, they have won seven of the 10 games against them this season.

One of the main reasons for Toronto’s struggles this season has been at the dish, ranking second to last in runs scored.

Vladimir Guerrero Jr. (.261, 7 home runs, 46 RBIs) and George Springer (.234, 12 home runs, 36 RBIs) have seen their production go down from last season, big time, and neither is batting over .226 this month. It also does not help that team home run and RBI leader Kazuma Okamoto (.234, 24 home runs, 70 RBIs) is only batting .162 this month with no home runs and one RBI, missed yesterday’s game, and is listed as day-to-day.

Ace to Save the Day in Game 2? 

With all of the issues the Blue Jays have in their lineup, at least they throw out ace Dylan Cease (7-5, 2.28 ERA, 1.04 WHIP) for the second game of this series. Toronto lost his last start despite tossing seven innings of scoreless ball and only giving up two hits. They had won his previous two outings, and in the last three, he has allowed a total of one run in 22 innings.

Cease pitched a complete game shutout, giving up only one hit, three starts back against the Red Sox, and after giving up four runs in his first start this season facing them, he has not given up any in the last two. He ranks third in the Majors with 184 strikeouts in 126 1/3 innings and has walked 52 batters.

Red Sox vs. Blue Jays Prediction

Blue Jays ML (-140 Bet365)

While the Blue Jays lost Cease’s last start, he was great in it, not allowing any runs in seven innings. He struck out 14 in the complete-game gem shutout in his last start against the Sox and will dominate them again. Ok, so Toronto will not do much at the dish again, but Cease will be masterful like his last outing, and unlike that one, the Jays will get the win.

Under 7.5 runs (-115) 

7.5 runs is a low total, but these teams only combined for three runs in the last game, and runs will be at a premium in this one. Cease has not given up any runs against the Red Sox in his last two starts. Sandoval has given up two runs in each of his last two starts and will face a Toronto lineup that has struggled all season. This game has the markings of a pitcher’s duel, so the Under is the pick.