Blue Jays vs. Orioles Prediction, Odds & Props for Sept. 22: Baltimore Gets W

Written By Jason Green | Published at September 22, 2026
Blue Jays vs. Orioles prediction for second game of AL East series. in the series opener the Orioles beat the Blue Jays 4-3.
Sep 12, 2026; Toronto, Ontario, CAN; Baltimore Orioles first baseman Pete Alonso (25) is greeted in the dugout by team mates after hitting a two run home run against the Toronto Blue Jays in the seventh inning at Rogers Centre. Mandatory Credit: Dan Hamilton-Imagn Images

The Baltimore Orioles beat the Toronto Blue Jays last night, and every remaining game is big since each team is chasing the last AL Wild Card. We found some great player prop bets, and this Blue Jays vs. Orioles prediction will also show the starting pitching matchup and the latest odds for this AL East matchup.

The Blue Jays (77-80) have lost three of their last four games, and with five games remaining in the regular season, they are three games back of the Chicago White Sox for the final AL Wild Card.

The Orioles (76-81) are coming off a series sweep before winning Game 1 yesterday, and they are a half game back of Toronto.

Blue Jays vs. Orioles Odds 

Toronto is the betting favourite in Game 2 of this division series at -120 at Betway Sportsbook, with the Orioles at +100 and a total of 7.5 runs.

The Blue Jays Get Nothing After the First 

In the opener of this series, the Blue Jays lost to the Orioles 4-3 after scoring three runs in the first inning and then being shut out for the rest of the game. George Springer was 2-for-4 with an RBI, and Nathan Lukes and Sean Keys also had an RBI.

Toronto ranks ninth in the Majors in team ERA, only 29th in runs, and has failed to score more than three runs in its three losses in its last four games.

Vladimir Guerrero Jr. (.263, 9 home runs, 56 RBIs) missed yesterday’s game with a back injury and is listed as day-to-day.

This season, the Blue Jays are 6-5 against the Orioles.

Blue Jays’ Starter for Second Game of Series 

Max Scherzer (3-8, 6.07 ERA, 1.36 WHIP) gets the nod for Toronto, who won his last start, giving up one run on only three hits in five innings. While The Jays have won three of his last four starts, the one loss came against Baltimore, where the three-time Cy Young Award winner was tagged for six runs. This season, he has worked 72 2/3 innings, striking out 54 and walking 31.

Alonso Comes Up Clutch for Orioles 

In yesterday's 4-3 win, Pete Alonso came up clutch with two home runs, including a two-run shot in the eighth inning, and Gunnar Henderson also had an RBI.

Baltimore ranks 14th in team ERA, tied for 15th in runs, and is averaging only 2.3 runs over its last four games.

Alonso (.265, 40 home runs, 108 RBIs) has had a great first season in Baltimore, ranks third in the Majors in home runs and tied for fourth in RBIs, and has hit five home runs and driven in seven runs over the last six games.

Orioles’ Starter for Second Game of Series 

Chris Bassitt (8-5, 4.64 ERA, 1.55 WHIP) takes the hill for Baltimore, and they have won four of his last five starts, including the last two, in which he allowed only three runs over 11 2/3 innings. He opposed Scherzer in the start before the last one, giving up two runs, and in his first start of the season facing the Blue Jays, he allowed only one run in a 2-1 loss.

Blue Jays vs. Orioles Prediction 

Orioles ML: (+100, Betway)

The Orioles got the win in the opener of this series and will get the win again tonight. Bassitt has been pitching well lately, and while Scherzer has been pretty good in three of his last four starts, the one he was not was facing Baltimore giving up six runs. Bassitt will have the better outing, and like Game 1, the Orioles will get some clutch hits, which is why they will get the W and keep their faint playoff hopes alive.

You can find some great bonus offers at the top Canadian sportsbooks.

Blue Jays vs. Orioles Prop Bets 

Here are some solid value prop bets via Betway.