Buccaneers vs Bills: Best Picks, Odds, and Predictions
Written By Blaise Bourgeois | Published at November 16, 2025
The 6-3 Tampa Bay Buccaneers are hoping to steady the ship as they travel to Buffalo to take on the 6-3 Bills. Buffalo are coming off a downright embarrassing 30-13 loss against the Miami Dolphins, while Tampa Bay lost a close 28-23 game with the New England Patriots.
The Buccaneers are missing a slew of impactful players, including WR Chris Godwin, RB Bucky Irving, LB Markees Watts, LB Haason Reddick, and OT Luke Haggard.
Here are the best prop bets for Sunday's phenomenal battle.
Game Lines
Buffalo Bills -6 (-110)
📊 Odds via FanDuel
It's very hard to trust a warm-weather team in the cold. Temperatures are only going to get to 40 degrees in Buffalo today and, with a ton of injuries, the Buccaneers have little chance to beat an extremely motivated Bills team.
The Bills are coming off their worst game of the season. These are the types of games that Josh Allen has responded to with a blowout win. We expect the Bills to win in a landslide. Don't be afraid to take the Bills -11.5 at +200.
Over 46.5 Points (-110)
📊 Odds via Caesars Sportsbook
While we think that the Buccaneers are going to be far behind the Bills today, we still think this is going to be a high-scoring affair. Buffalo has scored 28 or more points in six of nine games this season (all wins), and we think they'll get to that number once again.
Tampa Bay has a 5-4 over/under record this season and has scored at least 20 points in all but one game this season.
Player Props
Josh Allen Anytime Touchdown (-109)
📊 Odds via Caesars Sportsbook
With seemingly over half of his career still yet to be played, Josh Allen already has 72 rushing touchdowns, which ranks 33rd on the all-time rushing touchdown list. He's already up to seven rushing touchdowns this season, and there's no sign of stopping him.
Bet $1, Double your Winnings on your Next 20 Wagers. Up to $25 Max Bet Per Boost Rachaad White Anytime Touchdown (+165)
📊 Odds via FanDuel
It's a bit shocking that White's odds are this high, considering how terrible Buffalo's run defense has been this season. As Tampa Bay's primary goal-line back, White is probably the odds-on favorite to get into the end zone early on in the game.
Even though he's struggled and hasn't been the starting running back that long, he has still scored four times this season. Consider also taking Sean Tucker at +220, as his responsibilities have only increased in Bucky Irving's absence.
Rachaad White Over 43.5 Rushing Yards (-112)
📊 Odds via FanDuel
While we don't love the game script, Buffalo's run defense is just that bad. White has only broken 40 rushing yards three times this season, and has been downright horrible at times.
However, teams are beginning to figure out just how vulnerable the Bills are against the run. They just let fellow dual-threat running back De'Von Achane go off for 225 total yards and two touchdowns last week.
Obviously, White is no Achane. But he's more than capable of getting 50 or 60 yards on the ground today.
Today's Best Parlay
🏈 Combined Parlay Odds: +2469 (via FanDuel) 📈
- Leg 1: Bills -11.5
- Leg 2: Josh Allen Anytime Touchdown
- Leg 3: James Cook Anytime Touchdown
- Leg 4: Josh Allen Over 33.5 Rushing Yards
- Leg 5: Rachaad White Over 43.5 Rushing Yards
Bet $5 Get $150 in Bonus Bets If Your Bet Wins! Explore Our Latest Deals
➤ Caesars Sportsbook Promo Code
All Odds as of 9:00 a.m. ET on Nov. 16
-
Best NHL Player Props & Parlay Picks Today Dec. 5
-
Expert NBA Picks and Player Props: Best NBA Bets Today Dec. 5
-
Play $5 Get $100 Bonus on Broncos vs Raiders NFL: Use Underdog Code BTSLINES
-
$1500 Bonus Bets If Lose on Seahawks vs Falcons NFL: Use BetMGM Code BTSLINES
-
$1500 Bonus Bets If Lose on Commanders vs Vikings NFL: Use BetMGM Code BTSLINES
-
Promo Code LINESWEEP for Thrillzz: Week 14 NFL: Thrillzz & Betting Odds