Biggest NFL Bets: Fan Loses $324K Betting On 49ers Spread

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Written By Giovanni Shorter on October 24, 2023
Biggest NFL Bets

Another week of the NFL has ended, and some of the biggest NFL bets were wagered. It was a second consecutive brutal week for the public. According to the BetMGM, Week 6 and Week 7 were the most profitable weeks for the sportsbook this season. One bettor lost big betting on the San Francisco 49ers on Monday Night Football. This is the second consecutive week of the 49ers being highly profitable to sportsbooks. Let’s look at the most significant and most notable bets ahead of Week 8 betting.

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49ers Bettor Loses Big at Caesars Sportsbook

Remember, this post is for informational and entertainment purposes only. We advise not to blindly follow bets published that have large dollar amounts, as sportsbooks sometimes take the largest bets from non-professional bettors.

The unlucky bettor wagered $324,670 on the San Fransisco 49ers -4 alt line (-179) against the Minnesota Vikings at Caesars Sportsbooks. The Vikings would go on to win the MNF matchup 22-17. If the wager had won, it would have paid out $506,049.89 ($181,379.89 in profit).

MNF Betting Splits BetMGM

49ers bettors lost big betting on George Kittle. Both first TD and anytime TD markets were the most bet tickets for prop bets for Monday’s game. Kittle finished with zero TDs, and sportsbooks were the big winners. Brock Purdy’s total passing yards Over managed to be a big winner for sportsbooks, however.0

BetMGM NFL Highlights: 49ers-Vikings: Most bet (tickets) props

  • George Kittle to score 1st touchdown (+850) (LOSS)
  • George Kittle to score anytime touchdown (+155) (LOSS)
  • Brandon Aiyuk over 71.5 receiving yards (-115) (LOSS) 99% of bets on over
  • Brandon Aiyuk over 4.5 receptions (-165) (WON) 99% of bets on over
  • Brock Purdy over 237.5 passing yards (-115) (WON)

Week 7 Breakdown BetMGM

BetMGM released the breakdown of Week 7. The Detroit Lions vs. Baltimore Ravens game was the most wagered-on matchup of the week, with the Lions’ +3 being the most bet on team. The Ravens would go on to win this matchup 38-6.

Most bet games (tickets)


Most bet teams (tickets)

Lions +3 (LOSS)
Bills -7.5 (LOSS)
Eagles -3 (WON)

Most bet teams (handle)

Lions +3 (LOSS)
Eagles -3 (WON)
Bills -7.5 (LOSS)

While some underdogs led to big wins (Vikings, Patriots, Steelers), the most wagered-on Underdogs couldn’t pull the upset. With the exception being the Pittsburgh Steelers, the most wagered-on Underdogs in the Detroit Lions and Miami Dolphins led to big losses for fans.

Most bet underdogs outright

Lions +135 (LOSS)
Dolphins +125 (LOSS)
Steelers +145 (WON)

Week 8 NFL Odds

These were some of the most notable and biggest NFL bets for Week 7. What will be the biggest bets of Week 8?