Promo Code From BetMGM: BTSLINES Week 15 NFL Weekend

Written By thelines.com | Published at December 11, 2025

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Weekend Betting Lines for Week 15 NFL Slate

Now, let us have a look at the most exciting games ahead of week 15.

Bills vs. Patriots: The Patriots beat the Bills earlier this year, but it is the Bills that come into this one as slight favorites. It is important to note that this is solely down to the offensive output, so it will be crucial to see how the Patriots’ defense competes in early drives. Tournovers and red-zone efficiency will be the decider in this close battle.

Bills moneyline at 1.87
Patriots moneyline at 1.95

Cardinals vs. Texans: The Cardinals' season is all but over, so you could see a slight change to how they would usually line up. Now is the time to test things out in real time ahead of next season, which could lead to a few surprise plays and points on the board. However, the Texans are a well-drilled and physical team that plays true. The offense is in top-10 territory, and they will soon put the Cardinals’ defense to the test.

Cardinals moneyline at 5.00
Texans moneyline at 1.19

Vikings vs. Cowboys: The Vikings ran riot at Washington last week, and their aggressive line will add pressure to a balanced Cowboys offense. Eric Wilson (Vikings) leads the league in pressure rate, and it is this heavy approach that will lead to big plays – we are just interested to see which side of the ball they come on. Is it sacks galore? Or will this blitz-heavy defense leave gaps?