2025 MLB Division Series Preview: Betting Odds, Schedules and Key Insights
The 2025 MLB Playoffs have rolled into the Division Series after a Wild Card Series packed with drama and the bracket is now down to eight teams. The Los Angeles Dodgers made quick work of the Cincinnati Reds with a sweep, while the Chicago Cubs, Detroit Tigers, and New York Yankees all advanced after gritty three-game battles with their respective opponents.
Now, the stakes rise with four best-of-five matchups that feature elite rotations, powerhouse lineups and familiar October faces that bring exciting betting opportunities. These four squads that advanced to the Divisional Series will now take on the No. 1 and No. 2 seeds from each league that earned a bye and a few days off.
Game 1 of each series begins Saturday, with the road to the pennant heating up fast. By next Saturday, we'll be gearing up for the Championship Series.
Yankees vs Blue Jays
In what should be a pretty evenly matched series, the No. 1-seeded Toronto Blue Jays will host the New York Yankees, who had an impressive Wild Card Series against the Boston Red Sox.
Schedule
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Game 1: Saturday, 4:08 p.m. ET (Toronto)
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Game 2: Sunday, 4:08 p.m. ET (Toronto)
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Game 3: Tuesday, Time TBD (New York)
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Game 4: Wednesday, Time TBD (New York)*
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Game 5: Next Friday, Time TBD (Toronto)*
*if necessary
Odds & Insight
Series Odds: Yankees −150 | Blue Jays +125 (via Bet365)
The Toronto Blue Jays earned the No. 1 seed in the American League by having a regular season that leaned on consistent hitting, elite defense and efficient pitching to win games on the margins. New York’s path is built on power and bullpen leverage, especially if the Yankees can grab one of the first two games in Toronto. This series feels evenly matched and could swing on late-game execution and home-field edge in a potential Game 5.
Mariners vs Tigers
Despite being the underdog in this series, don't be surprised if the Detroit Tigers get back to the dominant form they showed earlier in the regular season as they face a Seattle Mariners team that got hot late in the season.
Schedule
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Game 1: Saturday, 8:38 p.m. ET (Seattle)
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Game 2: Sunday, 8:03 p.m. ET (Seattle)
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Game 3: Tuesday, Time TBD (Detroit)
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Game 4: Wednesday, Time TBD (Detroit)*
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Game 5: Next Friday, Time TBD (Seattle)*
*if necessary
Odds & Insight
Series Odds: Mariners −170 | Tigers +145 (via Bet365)
Seattle’s rested rotation and bullpen depth make them favorites in this series, but rest isn't always a good thing in the MLB Playoffs. Momentum is also important, and Detroit certainly has that after finally getting back on track in the Wild Card Series against the Cleveland Guardians following what was a collapse at the end of the regular season. Tarik Skubal’s dominance is the Tigers' best chance to steal a road game early, but Seattle’s home field and top-tier staff give them multiple paths to win.
Phillies vs Dodgers
In what will be undoubtedly the best series of this round, two powerhouse contenders will clash as the Philadelphia Phillies look to dethrone the reigning champion Los Angeles Dodgers.
Schedule
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Game 1: Saturday, 6:38 p.m. ET (Philadelphia)
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Game 2: Monday, 6:08 p.m. ET (Philadelphia)
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Game 3: Wednesday, Time TBD (Los Angeles)
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Game 4: Thursday, Time TBD (Los Angeles)*
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Game 5: Next Saturday, Time TBD (Philadelphia)*
*if necessary
Odds & Insight
Series Odds: Dodgers −125 | Phillies +105 (via Bet365)
Being at home is a significant advantage for Philadelphia in this series, as the regular success has paid off. If this goes the distance, Game 5 will be played at Citizens Bank Park with a chance to cap off the series with a win. Shohei Ohtani is expected to start Game 1, setting up a marquee pitching duel against Cristopher Sanchez. The Dodgers boast the deepest roster in the field, but Philly’s lineup is built to punish mistakes and thrives in big October moments.
Brewers vs Cubs
The Milwaukee Brewers are the No. 1 seed from the National League, but the Chicago Cubs are riding into this series with some momentum following a hard-fought Wild Card Series win over the San Diego Padres.
Schedule
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Game 1: Saturday, 2:08 p.m. ET (Milwaukee)
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Game 2: Monday, 9:08 p.m. ET (Milwaukee)
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Game 3: Wednesday, Time TBD (Chicago)
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Game 4: Thursday, Time TBD (Chicago)*
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Game 5: Next Saturday, Time TBD (Milwaukee)*
*if necessary
Odds & Insight
Series Odds: Brewers −120 | Cubs +100 (via Bet365)
These division rivals know each other inside and out, as they both finished in the top two spots of the National League Central. Chicago only scored six runs in the Wild Card Series, so the bats will need to get going to have success now, especially against this Milwaukee pitching staff. This has all the ingredients for a scrappy five-game set.
The Division Series is often where postseason narratives shift. Contenders either prove their regular season dominance or fall victim to hot underdogs riding momentum. With stacked pitching matchups, star power in every lineup and several evenly matched series, this round has all the ingredients for classic October baseball. As you make your predictions for each of these series, make sure to compare odds at different sportsbooks to ensure you get the most value.
All Odds as of 12:00 p.m. ET on Oct. 3
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