2025 March Madness Betting Odds: NCAA Tournament First Round Spreads, Moneylines, Totals

The first slate of 2025 March Madness odds tips off on Tuesday with the First Four odds before first-round odds begin on Thursday in the Round of 64. Online sportsbooks have released markets for the upcoming games just after the bracket was revealed on Selection Sunday.

The single-elimination tournament continues through the Final Four in San Antonio on April 5 and the national championship game on April 7.

Find the best odds for the NCAA men’s basketball tournament after sportsbooks open them. We’re referencing DraftKings Sportsbook’s March Madness opening lines for the spread and over/under below, which were posted immediately after the bracket was released up through 6:40 p.m. ET on March 16. Click on the tables below to bet now.

SOUTH Region First-Round Odds

Opening Odds After Selection Sunday Show

Game	Favorite	Underdog	Over/Under
(1) Auburn vs. (16) Alabama St/Saint Francis (PA)	Auburn -31.5	ASU +31.5	150.5
(8) Louisville vs. (9) Creighton	Louisville -1.5	Creighton +1.5	144.5
(5) Michigan vs. (12) UC San Diego	Michigan -3.5	UC San Diego +3.5	140.5
(4) Texas A&M vs. (13) Yale	Texas A&M -7.5	Yale +7.5	140.5
(6) Ole Miss vs. (11) North Carolina	Ole Miss +1.5	SDSU/UNC -1.5	155.5
(3) Iowa State vs. (14) Lipscomb	Iowa State -13.5	Lipscomb +13.5	142.5
(7) Marquette vs. (10) New Mexico	Marquette -2.5	New Mexico +2.5	151.5
(2) Michigan State vs. (15) Bryant	MSU -19.5	Bryant +19.5	150.5

The South Region is potentially the most loaded in the NCAA Tournament. Auburn is the top overall seed and one of the favorites to win it all. Michigan is coming off a Big Ten Tournament title. Michigan State is the regular season Big Ten champ, and teams like Marquette and Iowa State have some excellent veteran guards who will be tough matchups for any opponent.

Key Matchups

No. 8 Louisville vs. No. 9 Creighton

The 8/9 matchups are always good, but each team has been in the top 25 at various points this season. Creighton has one of the best centers in college basketball in Ryan Kalkbrenner at 7-foot-1 (19.4 PPG & 8.8 RPG), and they surround him with strong scoring guards like Steven Ashworth (16.3 PPG 36.9% 3P%) and Jamiya Neal (11.5 PPG). Louisville can score the basketball as well as anyone. They have four guards averaging double figures, and when they get hot from three, they can run teams out of the gym.

No. 4 Texas A&M vs. No. 13 Yale

If you are looking for a double-digit seed to pull an upset in the South Region, keep your eyes on Yale. The Bulldogs have tournament experience, as this is their third appearance in the last four seasons. Last season, they pulled an upset as a #13 seed over Auburn, so they are not strangers to this moment. Look for John Poulakidas, who dropped 28 against Auburn last season and has had a stronger senior season for Yale, averaging 19 PPG and shooting 40.2% from three.

South Region Betting: Current Odds

No. 1 Auburn vs. No. 16 Alabama State

No. 2 Michigan State vs. No. 15 Bryant

No. 3 Iowa State vs. No. 14 Lipscomb

No. 4 Texas A&M vs. No. 13 Yale

No. 5 Michigan vs. No. 12 UC San Diego

No. 6 Ole Miss vs. No. 11 North Carolina

No. 7 Marquette vs. No. 10 New Mexico

No. 8 Louisville vs. No. 9 Creighton

EAST Region first-round odds

Opening Odds After Selection Sunday Show

Game	Favorite	Underdog	Over/Under
(1) Duke vs. American/MSM	Duke TBD	American/MSM	TBD
(8) Mississippi State vs. (9) Baylor	Baylor -1.5	MSU +1.5	146.5
(5) Oregon vs. (12) Liberty	Oregon -4.5	Liberty +4.5	139.5
(4) Arizona vs. (13) Akron	Arizona -15.5	Akron +15.5	166.5
(6) BYU vs. (11) VCU	BYU -2.5	VCU +2.5	142.5
(3) Wisconsin vs. (14) Montana	Wisconsin -18.5	Montana +18.5	148.5
(7) Saint Mary’s vs. (10) Vanderbilt	Saint Mary’s -5.5	Vanderbilt +5.5	135.5
(2) Alabama vs. (15) Robert Morris	Alabama -22.5	Robert Morris +22.5	164.5

The East Region is led by most sportsbooks betting favorite to win it all: the Duke Blue Devils. It will be crucial for Duke to get Cooper Flagg back if they want to make a run. Teams like Oregon, BYU, and Wisconsin have shown that when at their best, they can beat anyone in the country.

Key Matchups

No. 8 Mississippi State vs. No. 9 Baylor

This is a fantastic eight-nine matchup between two power conference schools that each stand a great chance to give Duke all they can handle in the second round. The matchup between two of the most talented guards in the country in Baylor’s VJ Edgecombe (15 PPG) and Mississippi State’s Josh Hubbard (18.7 PPG), should be a great watch. Expect at least one of these two guys to go off for a huge scoring game, maybe even both.

No. 4 Arizona vs. No. 13 Akron

Arizona’s season has been a roller coaster, and they are as likely to go on a deep run as they are to lose in the first round. Meanwhile, Akron is playing some of the best basketball in the country, having won 21 of its last 22 games. If Caleb Love for Arizona has one of his high-volume, low-scoring games, the Zips could put the Wildcats on upset watch.

East Region Betting Odds

No. 1 Duke vs. No. 16 American/Mount St. Mary’s

Odds post after American vs. Mount St. Mary’s is settled in the play-in game.

No. 2 Alabama vs. No. 15 Robert Morris

No. 3 Wisconsin vs. No. 14 Montana

No. 4 Arizona vs. No. 13 Akron

No. 5 Oregon vs. No. 12 Liberty

No. 6 BYU vs. No. 11 VCU

No. 7 Saint Mary’s vs. No. 10 Vanderbilt

No. 8 Mississippi State vs. No. 9 Baylor

MIDWest Region First-Round odds

Opening Odds After Selection Sunday Show

Game	Favorite	Underdog	Over/Under
(1) Houston vs. (16) SIU-Edwardsville	Houston -25.5	SIU-Edwardsville +25.5	127.5
(8) Gonzaga vs. (9) Georgia	Gonzaga -4.5	Georgia +4.5	150.5
(5) Clemson vs. (12) McNeese	Clemson -7.5	McNeese +7.5	133.5
(4) Purdue vs. (13) High Point	Purdue -10.5	High Point +10.5	151.5
(6) Illinois vs. (11) Texas/Xavier	Illinois TBD	Texas/Xavier TBD	TBD
(3) Kentucky vs. (14) Troy	Kentucky -10.5	Troy +10.5	152.5
(7) UCLA vs. (10) Utah State	UCLA -5.5	Utah State +5.5	144.5
(2) Tennessee vs. (15) Wofford	Tennessee -18.5	Wofford +18.5	133.5

The Midwest region has good sleeper teams like Georgia, McNeese, Illinois, and UCLA. If we had to pick one region for the number one seed and not go to the Final Four, this is it, as Houston has a tough path.

Key Matchups

No. 8 Gonzaga vs. No. 9 Georgia

This matchup should be a lot of fun, and don’t be shocked if the winner of this game upsets Houston in the second round. The post-matchup between senior Graham Ike (17.1 PPG & 7.5 RPG) of Gonzaga and freshman Asa Newell (15.3 PPG & 6.8 RPG) of Georgia could be explosive. Will the crafty veteran get the job done, or will the talented freshman’s athleticism be too much?

No. 5 Clemson vs. No. 12 McNeese

Clemson is excellent but might lack the guard scoring to make a run, while McNeese is in its second NCAA Tournament and is a trendy upset pick. What makes McNeese so strong is that they are incredibly balanced, with not a player to identify as the go-to guy but five players averaging double figures, making it hard to slow them down.

Midwest Region Betting Odds

No. 1 Houston vs. No. 16 SIU Edwardsville

No. 2 Tennessee vs. No. 15 Wofford

No. 3 Kentucky vs. No. 14 Troy

No. 4 Purdue vs. No. 13 High Point

No. 5 Clemson vs. No. 12 McNeese State

No. 6 Illinois vs. No. 11 Texas/Xavier

Odds post after Texas vs. Xavier is settled in the play-in game.

No. 7 UCLA vs. No. 10 Utah State

No. 8. Gonzaga vs. No. 9 Georgia

west Region First-Round odds

Opening Odds After Selection Sunday Show

Game	Favorite	Underdog	Over/Under
(1) Florida vs. (16) Norfolk State	Florida -25.5	Norfolk State +25.5	153.5
(8) UConn vs. (9) Oklahoma	UConn -4.5	Oklahoma +4.5	147.5
(5) Memphis vs. (12) Colorado State	Colorado State -2.5	Memphis +2.5	146.5
(4) Maryland vs. (13) Grand Canyon	Maryland -11.5	Grand Canyon +11.5	149.5
(6) Missouri vs. (11) Drake	Missouri -4.5	Drake +4.5	132.5
(3) Texas Tech vs. (14) UNC Wilmington	Texas Tech -15.5	UNC Wilmington +15.5	142.5
(7) Kansas vs. (10) Arkansas	Kansas -4.5	Arkansas +4.5	144.5
(2) St. John’s vs. (15) Omaha	St. John’s -18.5	Omaha +18.5	147.5

The West Region is Florida’s to lose, but two-seed St. Johns is playing as well as anyone in the country. One of the favorite sleeper teams in the field is in the region with Drake, and teams like Memphis, Kansas, and Texas Tech have the talent to make a run.

Key Matchup

No. 6 Missouri vs. No. 11 Drake

A few weeks ago, Missouri looked like a potential two or three-seed but only won two of their final six games. They get a horrible matchup, too, facing Drake, who is 30-3 on the season and, simply put, is better than their seed, but they play in the MVC. Drake beat every team they faced from power conferences, including Miami, Vanderbilt, and Kansas State. Bennet Stirtz is a star, and don’t be surprised if he drops 25+ points as Drake pulls off the upset.

West Region Betting Odds

No. 1 Florida vs. No. 16 Norfolk State

No. 2 St. John’s vs. No. 15 Omaha

No. 3 Texas Tech vs. No. 14 UNC Wilmington

No. 4 Maryland vs. No. 13 Grand Canyon

No. 5 Memphis vs. No. 12 Colorado State

No. 6 Missouri vs. No. 11 Drake

No. 7 Kansas vs. No. 10 Arkansas

No. 8. UConn vs. No. 9 Oklahoma

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Where Can You Bet On College Basketball Player Props?

Among CBB online betting regulations, Arizona, Colorado, Florida, Illinois, Indiana, Iowa, Louisiana, Maryland, Massachusetts, New York, Ohio, Pennsylvania, Tennessee, Virginia, and West Virginia prohibit gambling on college basketball player props.

Connecticut, Illinois, Maine, New York, Tennessee, and Virginia don’t allow betting on in-state schools (some exceptions for playing in the tournament) and/or in-state player props. The remaining states with legal online sportsbooks, such as new bet365 state Tennessee, authorize wagering on college basketball player prop odds, including in-state teams.

Oregon does not allow online wagering on college sports. Sorry, Ducks flock.